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1. 发明申请

WO2002078618A3 METHODS OF MODULATING SURFACTANT PRODUCTION 审中-公开
公开(公告)号：WO2002078618A3
公开(公告)日：2002-10-10
申请号：PCT/US2002/002695
申请日：2002-01-30
申请人： BAYER CORPORATION , MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
发明人： MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
IPC分类号： A61K38/45
摘要： The present invention provides methods for modulating surfactant production using CDPDGS polypeptides, and agonists or antagonists that are capable of modulating CDPDGS activity. More particularly, the present invention encompasses the use of CDPDGS polypeptides, or agonist or antagonist polypeptides capable of modulating CDPDGS activity, for the treatment of a disease or clinical condition where surfactant production is relevant to the causation or treatment of the disease or clinical condition, such as lung diseases, including adult/infant respiratory distress syndrome, acute lung injury, chronic obstructive pulmonary disease (emphysema and chronic bronchitis), asthma, alveolar proteinosis, small airway disease and maintaining airway patency, and related pulmonary conditions. The present invention also encompasses pharmaceutical compositions containing the CDPDGS polypeptides, or agonist or antagonist polypeptides capable of modulating CDPDGS activity, and the use of such pharmaceutical compositions for the treatment of the above-mentioned diseases or clinical conditions.

2. 发明申请

WO2002078618A2 METHODS OF MODULATING SURFACTANT PRODUCTION 审中-公开
标题翻译：调节表面活性剂生产的方法
公开(公告)号：WO2002078618A2
公开(公告)日：2002-10-10
申请号：PCT/US2002/002695
申请日：2002-01-30
申请人： BAYER CORPORATION , MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
发明人： MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
IPC分类号： A61K
CPC分类号： A61K38/45
摘要： The present invention provides methods for modulating surfactant production using CDPDGS polypeptides, and agonists or antagonists that are capable of modulating CDPDGS activity. More particularly, the present invention encompasses the use of CDPDGS polypeptides, or agonist or antagonist polypeptides capable of modulating CDPDGS activity, for the treatment of a disease or clinical condition where surfactant production is relevant to the causation or treatment of the disease or clinical condition, such as lung diseases, including adult/infant respiratory distress syndrome, acute lung injury, chronic obstructive pulmonary disease (emphysema and chronic bronchitis), asthma, alveolar proteinosis, small airway disease and maintaining airway patency, and related pulmonary conditions. The present invention also encompasses pharmaceutical compositions containing the CDPDGS polypeptides, or agonist or antagonist polypeptides capable of modulating CDPDGS activity, and the use of such pharmaceutical compositions for the treatment of the above-mentioned diseases or clinical conditions.
摘要翻译：本发明提供了使用CDPDGS多肽以及能够调节CDPDGS活性的激动剂或拮抗剂调节表面活性物质生成的方法。更具体地，本发明包括CDPDGS多肽或能够调节CDPDGS活性的激动剂或拮抗剂多肽在治疗疾病或临床状况中的用途，其中表面活性剂生产与疾病或临床病症的病因或治疗有关，如肺部疾病，包括成人/婴儿呼吸窘迫综合征，急性肺损伤，慢性阻塞性肺病（肺气肿和慢性支气管炎），哮喘，肺泡蛋白沉积，小气道疾病和维持气道通畅以及相关的肺部疾病。本发明还包括含有CDPDGS多肽或能够调节CDPDGS活性的激动剂或拮抗剂多肽的药物组合物，以及这些药物组合物用于治疗上述疾病或临床病症的药物组合物。

3. 发明申请

WO2002074786A9 METHODS OF MODULATING SURFACTANT PRODUCTION 审中-公开
公开(公告)号：WO2002074786A9
公开(公告)日：2002-09-26
申请号：PCT/US2002/002661
申请日：2002-01-30
申请人： BAYER CORPORATION , MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
发明人： MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
IPC分类号： C12N9/02

4. 发明申请

WO2002074786A2 METHODS OF MODULATING SURFACTANT PRODUCTION 审中-公开
标题翻译：调节表面活性剂生产的方法
公开(公告)号：WO2002074786A2
公开(公告)日：2002-09-26
申请号：PCT/US2002/002661
申请日：2002-01-30
申请人： BAYER CORPORATION , MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
发明人： MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
IPC分类号： C07K
CPC分类号： C12N9/0083 , A61K38/00
摘要： The present invention provides methods for modulating surfactant production using SCD polypeptides, and agonists or antagonists that are capable of modulating SCD activity. More particularly, the present invention encompasses the use of SCD polypeptides or agonist or antagonist polypeptides for the treatment of a disease or clinical condition where surfactant production is relevant to the causation or treatment of the disease or clinical condition, such as lung diseases, including adult/infant respiratory distress syndrome, acute lung injury, chronic obstructive pulmonary disease (emphysema and chronic bronchitis), asthma, alveolar proteinosis and related pulmonary conditions. The present invention also encompasses pharmaceutical compositions containing the SCD polypeptides or agonist or antagonist polypeptides and the use of such pharmaceutical compositions for the treatment of the above-mentioned diseases or clinical conditions.
摘要翻译：本发明提供了使用SCD多肽以及能够调节SCD活性的激动剂或拮抗剂来调节表面活性产生的方法。更具体地说，本发明包括SCD多肽或激动剂或拮抗剂多肽用于治疗疾病或临床状况的用途，其中表面活性剂的产生与疾病或临床病因如肺疾病的病因或治疗有关，包括成年人 /婴儿呼吸窘迫综合征，急性肺损伤，慢性阻塞性肺病（肺气肿和慢性支气管炎），哮喘，肺泡蛋白沉积和相关肺部疾病。本发明还包括含有SCD多肽或激动剂或拮抗剂多肽的药物组合物，以及这些药物组合物用于治疗上述疾病或临床病症的用途。

5. 发明申请

WO2002095008A2 METHODS OF MODULATING SURFACTANT PRODUCTION 审中-公开
标题翻译：调节表面活性剂生产的方法
公开(公告)号：WO2002095008A2
公开(公告)日：2002-11-28
申请号：PCT/US2002/002728
申请日：2002-01-30
申请人： BAYER CORPORATION , MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
发明人： MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
IPC分类号： C12N
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides methods for modulating surfactant production using SREBP/ADD-1 polypeptides, and agonists or antagonists that are capable of modulating SREBP/ADD-1 activity. More particularly, the present invention encompasses the use of SREBP/ADD-1 polypeptides or agonist or antagonist polypeptides for the treatment of a disease or clinical condition where surfactant production is relevant to the causation or treatment of the disease or clinical condition, such as lung diseases, including adult/infant respiratory distress syndrome, acute lung injury, chronic obstructive pulmonary disease (emphysema and chronic bronchitis), asthma, alveolar proteinosis and related pulmonary conditions. The present invention also encompasses pharmaceutical compositions containing the SREBP/ADD-1 polypeptides or agonist or antagonist polypeptides and the use of such pharmaceutical compositions for the treatment of the above-mentioned diseases or clinical conditions.
摘要翻译：本发明提供使用SREBP / ADD-1多肽以及能够调节SREBP / ADD-1活性的激动剂或拮抗剂来调节表面活性物质生成的方法。更具体地，本发明包括SREBP / ADD-1多肽或激动剂或拮抗剂多肽用于治疗疾病或临床状况的用途，其中表面活性剂生产与疾病或临床病症的原因或治疗相关，例如肺疾病包括成人/婴儿呼吸窘迫综合征，急性肺损伤，慢性阻塞性肺病（肺气肿和慢性支气管炎），哮喘，肺泡蛋白沉积和相关肺部疾病。本发明还包括含有SREBP / ADD-1多肽或激动剂或拮抗剂多肽的药物组合物，以及这些药物组合物用于治疗上述疾病或临床病症的用途。

6. 发明申请

WO02074907A3 METHODS OF MODULATING SURFACTANT PRODUCTION 审中-公开
标题翻译：调节表面活性剂生产的方法
公开(公告)号：WO02074907A3
公开(公告)日：2002-11-21
申请号：PCT/US0205134
申请日：2002-01-30
申请人： BAYER AG , MASON ROBERT JAMES , NEBEN STEVEN , ECKART MICHAEL R , LONGPHRE MALINDA
发明人： MASON ROBERT JAMES , NEBEN STEVEN , ECKART MICHAEL R , LONGPHRE MALINDA
IPC分类号： A61K38/00 , A61K48/00 , C12N9/10 , A01N43/04 , C07H21/04 , C07K1/00 , C12N1/20 , C12N5/00 , C12N15/00 , C12P21/06 , C12Q1/00
CPC分类号： C12N9/1029 , A61K38/00 , A61K48/00 , C12Y203/01085
摘要： The present invention provides methods of modulating surfactant production using FAS polypeptides, and agonists or antagonists that are capable of modulating FAS activity. More particularly, the present invention encompasses the use of FAS polypeptides, or agonist or antagonist polypeptides capable of modulating FAS activity, for the treatment of a disease or clinical condition where surfactant production is relevant to the causation or treatment of the disease or clinical condition, such as lung diseases, including adult/infant respiratory distress syndrome, acute lung injury, chronic obstructive pulmonary disease (emphysema and chronic bronchitis), asthma, alveolar proteinosis, small airway disease and maintaining airway patency, and related pulmonary conditions. The present invention also encompasses pharmaceutical compositions containing the FAS polypeptides, or agonist or antagonist polypeptides capable of modulating FAS activity, and the use of such pharmaceutical compositions for the treatment of the above-mentioned diseases or clinical conditions.
摘要翻译：本发明提供了使用FAS多肽和能够调节FAS活性的激动剂或拮抗剂调节表面活性剂产生的方法。更特别地，本发明包括FAS多肽或能够调节FAS活性的激动剂或拮抗剂多肽用于治疗疾病或临床病症的用途，其中表面活性剂产生与疾病或临床病症的因果关系或治疗相关，如肺部疾病，包括成人/婴儿呼吸窘迫综合征，急性肺损伤，慢性阻塞性肺病（肺气肿和慢性支气管炎），哮喘，肺泡蛋白沉积症，小气道疾病和保持呼吸道通畅以及相关的肺部疾病。本发明还包括含有FAS多肽或能够调节FAS活性的激动剂或拮抗剂多肽的药物组合物，以及这些药物组合物用于治疗上述疾病或临床症状的用途。

7. 发明申请

WO2002074907A2 METHODS OF MODULATING SURFACTANT PRODUCTION 审中-公开
标题翻译：调节表面活性剂生产的方法
公开(公告)号：WO2002074907A2
公开(公告)日：2002-09-26
申请号：PCT/US2002/005134
申请日：2002-01-30
申请人： BAYER CORPORATION , MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
发明人： MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
IPC分类号： C12N
CPC分类号： C12N9/1029 , A61K38/00 , A61K48/00 , C12Y203/01085
摘要： The present invention provides methods of modulating surfactant production using FAS polypeptides, and agonists or antagonists that are capable of modulating FAS activity. More particularly, the present invention encompasses the use of FAS polypeptides, or agonist or antagonist polypeptides capable of modulating FAS activity, for the treatment of a disease or clinical condition where surfactant production is relevant to the causation or treatment of the disease or clinical condition, such as lung diseases, including adult/infant respiratory distress syndrome, acute lung injury, chronic obstructive pulmonary disease (emphysema and chronic bronchitis), asthma, alveolar proteinosis, small airway disease and maintaining airway patency, and related pulmonary conditions. The present invention also encompasses pharmaceutical compositions containing the FAS polypeptides, or agonist or antagonist polypeptides capable of modulating FAS activity, and the use of such pharmaceutical compositions for the treatment of the above-mentioned diseases or clinical conditions.
摘要翻译：本发明提供使用FAS多肽调节表面活性剂生产的方法，以及能调节FAS活性的激动剂或拮抗剂。更具体地说，本发明包括使用能够调节FAS活性的FAS多肽或者能够调节FAS活性的激动剂或拮抗剂多肽用于治疗疾病或临床状况，其中表面活性剂的产生与疾病或临床状况的因果关系或治疗有关，如肺部疾病，包括成人/婴儿呼吸窘迫综合征，急性肺损伤，慢性阻塞性肺病（肺气肿和慢性支气管炎），哮喘，肺泡蛋白沉积，小气道疾病和维持气道通畅以及相关的肺部疾病。本发明还包括含有FAS多肽或能够调节FAS活性的激动剂或拮抗剂多肽的药物组合物，以及这些药物组合物用于治疗上述疾病或临床病症的药物组合物。

8. 发明申请

WO2002095008A3 METHODS OF MODULATING SURFACTANT PHOSPHOLIPID PRODUCTION 审中-公开
公开(公告)号：WO2002095008A3
公开(公告)日：2002-11-28
申请号：PCT/US2002/002728
申请日：2002-01-30
申请人： BAYER CORPORATION , MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
发明人： MASON, Robert, James , NEBEN, Steven , ECKART, Michael, R. , LONGPHRE, Malinda
IPC分类号： C12N15/12
摘要： The present invention provides methods for modulating surfactant production using SREBP/ADD-1 polypeptides, and agonists or antagonists that are capable of modulating SREBP/ADD-1 activity. More particularly, the present invention encompasses the use of SREBP/ADD-1 polypeptides or agonist or antagonist polypeptides for the treatment of a disease or clinical condition where surfactant production is relevant to the causation or treatment of the disease or clinical condition, such as lung diseases, including adult/infant respiratory distress syndrome, acute lung injury, chronic obstructive pulmonary disease (emphysema and chronic bronchitis), asthma, alveolar proteinosis and related pulmonary conditions. The present invention also encompasses pharmaceutical compositions containing the SREBP/ADD-1 polypeptides or agonist or antagonist polypeptides and the use of such pharmaceutical compositions for the treatment of the above-mentioned diseases or clinical conditions.

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