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1. 发明申请

WO2001093307A3 SAMPLE COLLECTION PREPARATION METHODS FOR TIME-OF-FLIGHT MINIATURE MASS SPECTROMETER 审中-公开
公开(公告)号：WO2001093307A3
公开(公告)日：2001-12-06
申请号：PCT/US2001/016697
申请日：2001-05-23
申请人： THE JOHNS HOPKINS UNIVERSITY , ECELBERGER, Scott, A. , ANDERSON, Charles, W. , SCHOLL, Peter, F. , CHAPPELL, Ronald, G. , BRYDEN, Wayne, A. , KO, Harvey, W.
发明人： ANDERSON, Charles, W. , SCHOLL, Peter, F. , CHAPPELL, Ronald, G. , BRYDEN, Wayne, A. , KO, Harvey, W.
IPC分类号： H01J49/04
摘要： A field portable mass spectrometer system comprising a sample collector and a sample transporter. The sample transporter interfaces with the sample collector to receive sample deposits thereon. The system further comprises a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer has a sealable opening that receives the sample transported via the sample transporter in an extraction region of the mass spectrometer. The system further comprises a control unit that processes a time series output by the mass spectrometer for a received sample and identifies one or more agents contained in the sample.

2. 发明申请

WO2001093306A3 MICROCHANNEL PLATE DETECTOR ASSEMBLY FOR A TIME-OF-FLIGHT MASS SPECTROMETER 审中-公开
公开(公告)号：WO2001093306A3
公开(公告)日：2001-12-06
申请号：PCT/US2001/016695
申请日：2001-05-23
申请人： THE JOHNS HOPKINS UNIVERSITY , CORNISH, Timothy, J. , ECELBERGER, Scott, A.
发明人： CORNISH, Timothy, J. , ECELBERGER, Scott, A.
IPC分类号： H01J49/40
摘要： A method is provided for reducing signal ringing in a microchannel plate detector assembly having a cylindrical mount with a center tube extending through at least a portion of the assembly, in a mass spectrometer including the steps of providing the microchannel plate detector assembly with a pin anode extending from the cylindrical mount and located in proximity to the center tube; holding a front portion of the assembly at ground potential; setting a middle portion of the assembly between the front portion and a rear portion to a first voltage potential for accelerating ions; holding the rear portion of the assembly to a second voltage potential; holding the pin anode at a third voltage potential; and accelerating electrons emitted from the middle portion of the assembly toward the pin anode. The third voltage potential is established by an amplifier of an oscilloscope connected to the detector assembly.

3. 发明申请

WO2003024572A3 A MASS SPECTROMETER FOR SIMULTANEOUS DETECTION OF REFLECTED AND DIRECT IONS 审中-公开
公开(公告)号：WO2003024572A3
公开(公告)日：2003-03-27
申请号：PCT/US2002/029982
申请日：2002-09-20
申请人： THE JOHNS HOPKINS UNIVERSITY , CORNISH, Timothy J., , ECELBERGER, Scott A.,
发明人： CORNISH, Timothy J., , ECELBERGER, Scott A.,
IPC分类号： B01D59/44
摘要： Techniques for simultaneously detecting direct and reflected ions in a time-of-flight tube (120) and a source (110) for generating an ion beam of ions of a sample and introducing the ion beam into a first portion of the flight tube. A reflector (126) reflects ions from the ion beam in a second portion of the flight tube. A plate (140) substantially perpendicular to an axis of the ion beam is located between the first portion of the flight tube and the second portion of the flight tube. The plate has a hole through which some ions in the ion beam may pass from the first portion to the second portion of the flight tube. Each of two opposite faces of the plate includes a set of one or more ion detectors (140). The technique allows rapid, reliable detection of complex agents in a small number of samples.

4. 发明申请

WO0192863A3 PORTABLE TIME-OF-FLIGHT MASS SPECTROMETER SYSTEM 审中-公开
标题翻译：便携式飞行时间质谱仪系统
公开(公告)号：WO0192863A3
公开(公告)日：2002-06-20
申请号：PCT/US0116692
申请日：2001-05-23
申请人： UNIV JOHNS HOPKINS , ANDERSON CHARLES W , BRYDEN WAYNE A , ECELBERGER SCOTT A , MCLOUGHLIN MICHAEL P , ALLMON WILLIAM R , CARLSON MICAH A , DECICCO DANIEL J , EVANCICH NICHOLAS H , VELKY JAMES T
发明人： MCLOUGHLIN MICHAEL P , ALLMON WILLIAM R , CARLSON MICAH A , DECICCO DANIEL J , EVANCICH NICHOLAS H , VELKY JAMES T
IPC分类号： G01N27/62 , G01N1/00 , G01N1/02 , H01J49/00 , H01J49/04 , H01J49/10 , H01J49/16 , H01J49/24 , H01J49/40
CPC分类号： H01J49/0409 , H01J49/0022 , H01J49/40 , Y10T436/24
摘要： A field portable mass spectrometer system comprising a sample collector and a sample transporter. The sample transporter interfaces with the sample collector to receive sample deposits thereon. The system further comprises a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer has a sealable opening that receives the sample transported via the sample transporter in an extraction region of the mass spectrometer. The system further comprises a control unit that processes a time series output by the mass spectrometer for a received sample and identifies one or more agents contained in the sample.
摘要翻译：一种现场便携式质谱仪系统，包括样品收集器和样品转运器。样品转运器与样品收集器接口以在其上接收样品沉积物。该系统还包括飞行时间（TOF）质谱仪。飞行时间质谱仪具有可密封的开口，其接收在质谱仪的提取区域中通过样品转运器传送的样品。该系统还包括控制单元，其处理由质谱仪输出的时间序列用于接收的样本，并识别样品中包含的一种或多种试剂。

5. 发明申请

WO2004013602A3 COMBINED CHEMICAL/BIOLOGICAL AGENT DETECTION SYSTEM AND METHOD UTILIZING MASS SPECTROMETRY 审中-公开
标题翻译：组合化学/生物学试剂检测系统和使用质谱法的方法
公开(公告)号：WO2004013602A3
公开(公告)日：2005-02-24
申请号：PCT/US0322313
申请日：2003-07-17
申请人： UNIV JOHNS HOPKINS , BRYDEN WAYNE A , COTTER ROBERT J , ECELBERGER SCOTT A
发明人： BRYDEN WAYNE A , COTTER ROBERT J , ECELBERGER SCOTT A
IPC分类号： B01D59/44 , G01N20060101 , H01J49/00 , H01J49/04 , H01J49/10 , H01J49/16 , H01J49/40
CPC分类号： H01J49/147 , H01J49/107
摘要： A mass spectrometer having a MALDI ionization source (52) and Electron Impact Ionization source (54) useable together or independently to produce ions for analysis in Time of Flight Mass spectrometer.
摘要翻译：具有MALDI电离源（52）和电子轰击电离源（54）的质谱仪可一起使用或独立地产生用于在飞行时间质谱仪中分析的离子。

6. 发明申请

WO0193307A2 SAMPLE COLLECTION PREPARATION METHODS FOR TIME-OF-FLIGHT MINIATURE MASS SPECTROMETER 审中-公开
标题翻译：用于飞行时间小型质谱仪的样品采集准备方法
公开(公告)号：WO0193307A2
公开(公告)日：2001-12-06
申请号：PCT/US0116697
申请日：2001-05-23
申请人： UNIV JOHNS HOPKINS , ECELBERGER SCOTT A , ANDERSON CHARLES W , SCHOLL PETER F , CHAPPELL RONALD G , BRYDEN WAYNE A , KO HARVEY W
发明人： ANDERSON CHARLES W , SCHOLL PETER F , CHAPPELL RONALD G , BRYDEN WAYNE A , KO HARVEY W
IPC分类号： H01J49/04 , H01J49/40 , H01J49/00
CPC分类号： H01J49/0445 , H01J49/0022 , H01J49/40
摘要： A field portable mass spectrometer system comprising a sample collector and a sample transporter. The sample transporter interfaces with the sample collector to receive sample deposits thereon. The system further comprises a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer has a sealable opening that receives the sample transported via the sample transporter in an extraction region of the mass spectrometer. The system further comprises a control unit that processes a time series output by the mass spectrometer for a received sample and identifies one or more agents contained in the sample.
摘要翻译：一种现场便携式质谱仪系统，包括样品收集器和样品转运器。样品转运器与样品收集器接口以在其上接收样品沉积物。该系统还包括飞行时间（TOF）质谱仪。飞行时间质谱仪具有可密封的开口，其接收在质谱仪的提取区域中通过样品转运器传送的样品。该系统还包括控制单元，其处理由质谱仪输出的时间序列用于接收的样本，并识别样品中包含的一种或多种试剂。

7. 发明申请

WO2004013602A2 COMBINED CHEMICAL/BIOLOGICAL AGENT DETECTION SYSTEM AND METHOD UTILIZING MASS SPECTROMETRY 审中-公开
标题翻译：组合化学/生物学试剂检测系统和使用质谱法的方法
公开(公告)号：WO2004013602A2
公开(公告)日：2004-02-12
申请号：PCT/US2003/022313
申请日：2003-07-17
申请人： THE JOHNS HOPKINS UNIVERSITY , BRYDEN, Wayne, A. , COTTER, Robert, J. , ECELBERGER, Scott, A.
发明人： BRYDEN, Wayne, A. , COTTER, Robert, J. , ECELBERGER, Scott, A.
IPC分类号： G01N
CPC分类号： H01J49/147 , H01J49/107
摘要： A mass spectrometer is provided herein and is configured to have two ionization sources, in which a first ionization source, such as MALDI, ESI and the like, which is capable of providing in addition to ions a set of normally intractable desorbed neutrals that are ionized by a second EI source coupled with the first source.
摘要翻译：本文提供了一种质谱仪，并且被配置为具有两个电离源，其中第一离子源如MALDI，ESI等能够提供除了离子之外的一组正常难溶的解吸的中性粒子，其被离子化通过与第一源耦合的第二EI源。

8. 发明申请

WO2003024572A2 TECHNIQUES FOR SIMULTANEOUSLY DETECTING DIRECT AND REFLECTED IONS IN A MASS SPECTROMETER 审中-公开
标题翻译：同时检测质谱仪中直接和反射离子的技术
公开(公告)号：WO2003024572A2
公开(公告)日：2003-03-27
申请号：PCT/US2002/029982
申请日：2002-09-20
申请人： THE JOHNS HOPKINS UNIVERSITY , CORNISH, Timothy J., , ECELBERGER, Scott A.,
发明人： CORNISH, Timothy J., , ECELBERGER, Scott A.,
IPC分类号： B01D59/44
CPC分类号： H01J49/025 , H01J49/405
摘要： Techniques for simultaneously detecting direct and reflected ions in a time-of-flight mass spectrometer include a flight tube and a source for generating an ion beam of ions of a sample and introducing the ion beam into a first portion of the flight tube. A reflector reflects ions from the ion beam in a second portion of the flight tube. A plate substantially perpendicular to an axis of the ion beam is located between the first portion of the flight tube and the second portion of the flight tube. The plate has a hole through which some ions in the ion beam may pass from the first portion to the second portion of the flight tube. Each of two opposite faces of the plate includes a set of one or more ion detectors. The technique allows rapid, reliable detection of complex agents in a small number of samples.
摘要翻译：在飞行时间质谱仪中同时检测直接和反射离子的技术包括飞行管和用于产生样品的离子离子束并将离子束引入飞行管的第一部分的源。反射器在飞行管的第二部分中反射离子束的离子。基本上垂直于离子束的轴线的板位于飞行管的第一部分和飞行管的第二部分之间。该板具有一个孔，离子束中的一些离子可以从该孔穿过飞行管的第一部分到第二部分。板的两个相对面中的每一个包括一组一个或多个离子检测器。该技术允许在少量样品中快速，可靠地检测复合物。

9. 发明申请

WO0193306A2 MICROCHANNEL PLATE DETECTOR ASSEMBLY FOR A TIME-OF-FLIGHT MASS SPECTROMETER 审中-公开
标题翻译：用于飞行时间质谱仪的微通道板检测器总成
公开(公告)号：WO0193306A2
公开(公告)日：2001-12-06
申请号：PCT/US0116695
申请日：2001-05-23
申请人： UNIV JOHNS HOPKINS , CORNISH TIMOTHY J , ECELBERGER SCOTT A
发明人： CORNISH TIMOTHY J , ECELBERGER SCOTT A
IPC分类号： H01J49/02 , H01J49/40 , H01J49/00
CPC分类号： H01J43/246 , H01J49/025 , H01J49/40
摘要： A method is provided for reducing signal ringing in a microchannel plate detector assembly having a cylindrical mount with a center tube extending through at least a portion of the assembly, in a mass spectrometer including the steps of providing the microchannel plate detector assembly with a pin anode extending from the cylindrical mount and located in proximity to the center tube; holding a front portion of the assembly at ground potential; setting a middle portion of the assembly between the front portion and a rear portion to a first voltage potential for accelerating ions; holding the rear portion of the assembly to a second voltage potential; holding the pin anode at a third voltage potential; and accelerating electrons emitted from the middle portion of the assembly toward the pin anode. The third voltage potential is established by an amplifier of an oscilloscope connected to the detector assembly.
摘要翻译：提供了一种用于减小微通道板检测器组件中的信号振铃的方法，所述微通道板检测器组件具有圆柱形安装件，所述圆柱形安装件具有延伸穿过所述组件的至少一部分的中心管，质谱仪包括以下步骤：为所述微通道板检测器组件提供引脚阳极从圆柱形支架延伸并位于中心管附近; 将组件的前部部分保持在地电位; 将组件的前部和后部之间的中间部分设置为用于加速离子的第一电压电位; 将组件的后部保持在第二电压电位; 将引脚阳极保持在第三电压电位; 并且将从组件的中间部分发射的电子加速到针状阳极。第三电压电位由连接到检测器组件的示波器的放大器建立。

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