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1. 发明申请

WO2007106576A3 METHODS AND MATERIALS FOR IMMUNIZATION AGAINST CANCER 审中-公开
标题翻译：用于免疫癌的方法和材料
公开(公告)号：WO2007106576A3
公开(公告)日：2007-11-22
申请号：PCT/US2007006578
申请日：2007-03-15
申请人： UNIV LOUISVILLE RES FOUND , EATON JOHN W , MITCHELL ROBERT A
发明人： EATON JOHN W , MITCHELL ROBERT A
IPC分类号： A61K31/353 , C07D305/14
CPC分类号： C07K16/30 , A61K35/545 , A61K38/193 , A61K2300/00
摘要： Disclosed are compositions comprising embryonic stem cells. In some embodiments, the compositions include a plurality of pluripotent cells and one or more pharmaceutically acceptable carriers or excipients. Also disclosed are methods for prophylaxis and/or treatment of subjects using the disclosed compositions, and methods for identifying an antigen shared by a pluripotent cell and a neoplastic or pre-neoplastic cell.
摘要翻译：公开了包含胚胎干细胞的组合物。在一些实施方案中，组合物包括多种多能细胞和一种或多种药学上可接受的载体或赋形剂。还公开了使用所公开的组合物预防和/或治疗受试者的方法，以及用于鉴定由多能细胞和肿瘤前或肿瘤前细胞共享的抗原的方法。

2. 发明申请

WO9833429A3 STEERING MECHANISM AND STEERING LINE FOR A CATHETER-MOUNTED ULTRASONIC TRANSDUCER 审中-公开
标题翻译：转向机构和导向线用于导管安装的超声波传感器
公开(公告)号：WO9833429A3
公开(公告)日：1998-10-29
申请号：PCT/US9801947
申请日：1998-01-28
申请人： ACUSON , EATON JOHN W , ROSA DAVID J , MARIAN VAUGHN , PLUGGE JAY
发明人： EATON JOHN W , ROSA DAVID J , MARIAN VAUGHN , PLUGGE JAY
IPC分类号： A61B1/005 , A61B8/12 , A61M25/01 , A61B
CPC分类号： A61M25/0147 , A61B1/0052 , A61B8/12 , A61B8/4461 , A61B8/4466 , A61B2018/00916 , A61M25/0136
摘要： An ultrasonic transducer includes an elongated catheter (12) that carries a phased linear array of ultrasonic transducer elements (20) at a distal end (14). This array is aligned with the azimuthal axis of the array oriented substantially parallel to a longitudinal axis of the catheter (12) near the distal end (14). Two sets of steering lines (42) are carried by the catheter (12), and coupled to the catheter (12) near the distal end (14). The first set of steering lines is effective to steer the distal end (14) in a first plane, and the second set of steering lines is effective to steer the distal end (14) in a second plane, transverse to the first plane. The steering mechanism (26) can include a housing (22) having a longitudinal axis (A) that extends generally parallel to the proximal end (16) of the catheter (12). An annular steering ring (28, 30) can be mounted to the housing (20) for rotation about the longitudinal axis (A). A steering hub (50, 52) can be mounted for rotation in the housing (22), and coupled to the steering ring (28, 30) such that rotation of the steering ring (28, 30) with respect to the housing (22) causes rotation of the steering hub (50, 52).

3. 发明申请

WO9838486A3 ULTRASONIC PROBE, SYSTEM AND METHOD FOR TWO-DIMENSIONAL IMAGING OR DIMENSIONAL RECONSTRUCTION 审中-公开
标题翻译：超声波探头，用于二维成像或尺寸重构的系统和方法
公开(公告)号：WO9838486A3
公开(公告)日：1998-12-03
申请号：PCT/US9803820
申请日：1998-02-27
申请人： ACUSON , HOSSACK JOHN A , EATON JOHN W
发明人： HOSSACK JOHN A , EATON JOHN W
IPC分类号： A61B8/12 , G01S15/89 , G01N
CPC分类号： A61B8/12 , A61B8/145 , A61B8/4488 , G01S7/52074 , G01S15/8915 , G01S15/892 , G01S15/8993
摘要： This invention is an ultrasonic probe (10) that includes at least two ultrasonic arrays (20, 22) and allows three-dimensional images to be constructed of the region examined by the probe (10) in a precise and facile manner.

4. 发明申请

WO9833430A3 CATHETER-MOUNTED, PHASED-ARRAY ULTRASOUND TRANSDUCER WITH IMPROVED IMAGING 审中-公开
标题翻译：带有改进的成像装置的超声波超声波传感器
公开(公告)号：WO9833430A3
公开(公告)日：1998-11-26
申请号：PCT/US9801956
申请日：1998-01-28
申请人： ACUSON , CURLEY MICHAEL G , TASKER DIANA M , BECKER CYNTHIA C , SCHLESINGER RANDALL L , EATON JOHN W
发明人： CURLEY MICHAEL G , TASKER DIANA M , BECKER CYNTHIA C , SCHLESINGER RANDALL L , EATON JOHN W
IPC分类号： A61B1/005 , A61B8/12 , A61M25/01 , A61B
CPC分类号： A61B8/12 , A61B1/0052 , A61B8/445 , A61B8/4488 , A61B2018/00916 , A61M25/0133 , A61M25/0136
摘要： A phased-array ultrasonic transducer assembly (10) includes a catheter (12). An end portion (26) is mounted to the catheter (12) around a transducer array (16), and the end portion (26) defines an acoustic window (28) which is essentially non-focusing to ultrasonic energy passing through. Because the acoustic window (28) is non-focusing, a relatively small radius of curvature can be used on the radially outer surface of this window (28).

5. 发明申请

WO1998037812A1 ULTRASONIC CATHETER, SYSTEM AND METHOD FOR TWO-DIMENSIONAL IMAGING OR THREE-DIMENSIONAL RECONSTRUCTION 审中-公开
标题翻译：超声波导管，用于二维成像或三维重建的系统和方法
公开(公告)号：WO1998037812A1
公开(公告)日：1998-09-03
申请号：PCT/US1998003841
申请日：1998-02-27
申请人： ACUSON CORPORATION , EATON, John, W. , HOSSACK, John, A.
发明人： ACUSON CORPORATION
IPC分类号： A61B08/12
CPC分类号： A61B8/12 , A61B8/145 , A61B8/445 , A61B8/4488 , A61B8/463 , A61B8/483 , G01S7/52034 , G01S15/8918 , G01S15/892 , G01S15/8922 , G01S15/894 , G01S15/8993
摘要： An ultrasonic catheter (10) having at least two ultrasonic arrays (20, 22) is provided which has good near and far field resolution, and provides an outline of the heart chamber which assists in understanding and interpreting the images obtained by the catheter (10). Also the ultrasonic catheter (10) allows three-dimensional images to be constructed of the region examined by the catheter (10) in a precise but facile manner.
摘要翻译：提供了具有至少两个超声波阵列（20,22）的超声波导管（10,22），其具有良好的近场和远场分辨率，并且提供了心室的轮廓，其有助于理解和解释由导管（10 ）。此外，超声波导管（10）允许以精确且容易的方式由导管（10）检查的区域构成三维图像。

6. 发明申请

WO2007106576A2 METHODS AND MATERIALS FOR IMMUNIZATION AGAINST CANCER 审中-公开
标题翻译：免疫抗癌方法和材料
公开(公告)号：WO2007106576A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/006578
申请日：2007-03-15
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , EATON, John, W. , MITCHELL, Robert, A.
发明人： EATON, John, W. , MITCHELL, Robert, A.
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K35/545 , A61K38/193 , A61K2300/00
摘要： Disclosed are compositions comprising embryonic stem cells. In some embodiments, the compositions include a plurality of pluripotent cells and one or more pharmaceutically acceptable carriers or excipients. Also disclosed are methods for prophylaxis and/or treatment of subjects using the disclosed compositions, and methods for identifying an antigen shared by a pluripotent cell and a neoplastic or pre-neoplastic cell.
摘要翻译：公开了包含胚胎干细胞的组合物。在一些实施方案中，组合物包含多种多能细胞和一种或多种药学上可接受的载体或赋形剂。还公开了使用所公开的组合物预防和/或治疗受试者的方法，以及用于鉴定由多能细胞和肿瘤或肿瘤前细胞共有的抗原的方法。

7. 发明申请

WO9900145A9 ANTIGENIC MODULATION OF VIRAL PARTICULES 审中-公开
标题翻译：抗病毒颗粒的抗原调节
公开(公告)号：WO9900145A9
公开(公告)日：1999-04-15
申请号：PCT/US9813198
申请日：1998-06-25
申请人： ALBANY MEDICAL COLLEGE , SCOTT MARK D , EATON JOHN W
发明人： SCOTT MARK D , EATON JOHN W
IPC分类号： A61K47/48 , C12N15/86 , C12N15/88
CPC分类号： C12N15/88 , A61K47/6901 , C12N15/86 , C12N2710/10343
摘要： The present invention is directed to a non-immunogenic cellular composition comprising: a cell, particularly a viral particles or virus, having a cell surface and antigenic determinants on the cell surface; an optional linker molecule covalently attached to the cell surface; and a non-immunogenic compounds (e.g., polyethylene glycol or a derivative thereof) covalently attached to the linker molecule or directly to the cell. In one embodiment, the linker molecule is covalently attached directly to the antigenic determinant on the cell surface. In an alternate embodiment, the linker molecule may be covalently attached to a non-antigenic site on the cell surface, but will camouflage the antigenic determinant on the cell surface. Various uses of the resulting non-immunogenic viral cell are also provided, including a method of decreasing phagocytosis of a viral cell, a method of decreasing an adverse reaction to a transfusion, a method of decreasing rejection of a transplanted viral cell, tissue or organ, and a method of decreasing antibody-induced aggregation of cells.
摘要翻译：本发明涉及非免疫原性细胞组合物，其包含：细胞，特别是病毒颗粒或病毒，其在细胞表面上具有细胞表面和抗原决定簇; 任选的连接分子共价连接到细胞表面; 和共价连接至接头分子或直接连接至细胞的非免疫原性化合物（例如聚乙二醇或其衍生物）。在一个实施方案中，接头分子直接共价连接至细胞表面上的抗原决定簇。在一个替代实施方案中，接头分子可以共价连接到细胞表面上的非抗原性位点，但会伪装细胞表面上的抗原决定簇。还提供了所得非免疫原性病毒细胞的各种用途，包括减少病毒细胞的吞噬作用的方法，减少对输血的不良反应的方法，减少移植的病毒细胞，组织或器官排斥的方法以及减少抗体诱导的细胞聚集的方法。

8. 发明申请

WO1990007950A1 BIOCOMPATIBLE MATERIALS COMPRISING ALBUMIN-BINDING DYES 审中-公开
标题翻译：包含ALBUMIN-BINDING DYES的生物成分材料
公开(公告)号：WO1990007950A1
公开(公告)日：1990-07-26
申请号：PCT/US1990000236
申请日：1990-01-12
申请人： EATON, John, W.
IPC分类号： A61M25/00
CPC分类号： A61L33/128 , Y10S623/92 , Y10S623/921
摘要： A biocompatible prosthetic device is provided which comprises a solid polymeric body incorporating an amount of an albumin-binding dye effective to form a coating of endogenous albumin on said device when the device is in contact with a physiological fluid containing albumin. A method of increasing the albumin-binding ability of a prosthetic device is also provided.

9. 发明申请

WO1984004679A1 METHOD AND AGENTS FOR RAISING ANIMAL TOLERANCE TO OXIDANT STRESS-INDUCING ANTIBIOTICS 审中-公开
标题翻译：提高动物抗氧化应激诱导抗生素的方法和试剂
公开(公告)号：WO1984004679A1
公开(公告)日：1984-12-06
申请号：PCT/US1984000821
申请日：1984-05-25
申请人： EATON, John, W.
IPC分类号： A61K31/54
CPC分类号： C07H15/26 , A61K31/54 , A61K31/70 , C07H15/252 , A61K2300/00
摘要： A method and agents for raising the tolerance of animal tissue to antibiotic compounds that induce oxidant stress. The method comprises administering one or more bioinert redox compounds to the locus of administration of the antibiotic in an amount sufficient to diminish the production of the potentially toxic oxidants. The redox compounds may be administered by various parenteral techniques. The agents comprise redox compounds and include redox dyes such as those of the thiazine group. Of this group methylene blue is preferred. A method for treating cancer in animals is also disclosed.

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