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1. 发明申请

WO1998018827A1 INCLUSION COMPLEXES OF BETA-2-ANDRENERGICS FOR ORAL MUCOSAL DELIVERY 审中-公开
标题翻译：包含用于口腔粘膜递送的β-2-ANDRENERGICS的复合物
公开(公告)号：WO1998018827A1
公开(公告)日：1998-05-07
申请号：PCT/GB1997002947
申请日：1997-10-27
申请人： FARMARC NEDERLAND B.V. , DYER, Alison, Margaret , PENKLER, Lawrence, John , DE KOCK, Luéta-Ann
发明人： FARMARC NEDERLAND B.V. , DYER, Alison, Margaret
IPC分类号： C08B37/00
CPC分类号： A61K31/472 , A61K31/00 , A61K31/137 , A61K31/17 , A61K31/235 , A61K31/27 , A61K31/44 , A61K31/4458 , A61K31/4704 , A61K31/4725 , A61K31/522 , A61K47/6951 , B82Y5/00 , C08B37/0015
摘要： A pharmaceutical composition for oral mucosal delivery comprises an active ingredient, an inclusion complex of (a) a selective beta 2-adrenergic agonist or a pharmaceutically acceptable salt thereof such as salbutamol, and (b) an unsubstituted or substituted beta- or gamma-cyclodextrin, and a pharmaceutically acceptable carrier for oral mucosal delivery. The pharmaceutical composition is of use in the treatment of reversible obstructive airways diseases such as asthma.
摘要翻译：用于口腔粘膜递送的药物组合物包含活性成分，（a）选择性β2-肾上腺素能激动剂或其药学上可接受的盐如沙丁胺醇的包合物，和（b）未取代或取代的β-或γ-环糊精和用于口腔粘膜递送的药学上可接受的载体。药物组合物可用于治疗可逆性阻塞性气道疾病如哮喘。

2. 发明申请

WO1997049525A1 AN ABRASIVE BLASTING APPARATUS 审中-公开
标题翻译：抛光设备
公开(公告)号：WO1997049525A1
公开(公告)日：1997-12-31
申请号：PCT/GB1997001733
申请日：1997-06-27
申请人： WIZARD TECHNOLOGY LIMITED , DYER, Alison, Margaret , LIVERSEDGE, Steven, Charles
发明人： WIZARD TECHNOLOGY LIMITED , DYER, Alison, Margaret
IPC分类号： B24C07/00
CPC分类号： B24C7/0053 , B24C3/12 , B24C5/02
摘要： An abrasive blasting apparatus comprises a hopper (12) for an abrasive medium such as sodium bicarbonate. The hopper vents to atmosphere and has a lowermost abrasive media outlet (22). A control valve assembly (24) communicates with the outlet, and includes an ambient air inlet port (36), a suction outlet port (54) and an adjustable three-way valve member (24) for allowing selective communication between the inlet and outlet ports. A spray gun assembly (58) is connected to the suction outlet port (54) via a suction hose (52). The three-way valve member is arranged simultaneously to adjust the sizes of both the media inlet and the ambient inlet ports whilst communicating with the suction outlet port, thereby controlling the flow of abrasive media and air through the suction outlet port. The spray gun assembly (58) includes a housing having a venturi chamber (86) into which the suction outlet hose (52) is connected. The venturi chamber is in turn coupled to a high pressure air hose (44) which creates a venturi effect so as to propel the media from an outlet nozzle (92) via the suction outlet hose.
摘要翻译：喷砂设备包括用于研磨介质如碳酸氢钠的料斗（12）。料斗通向大气并具有最低的磨料介质出口（22）。控制阀组件（24）与出口连通，并且包括环境空气入口（36），抽吸出口（54）和可调节三通阀构件（24），用于允许入口和出口之间的选择性连通端口。喷枪组件（58）经由抽吸软管（52）连接到抽吸出口（54）。三通阀构件被同时设置以调节介质入口和环境入口端口的尺寸，同时与吸入口连通，从而通过吸入口控制研磨介质和空气的流动。喷枪组件（58）包括具有文丘里室（86）的壳体，吸入出口软管（52）连接到该腔室中。文丘里室又耦合到高压空气软管（44），其产生文丘里效应，以便经由抽吸出口软管从出口喷嘴（92）推动介质。

3. 发明申请

WO1997019048A1 SYNTHESIS OF PROPIONIC ACID DERIVATIVES 审中-公开
标题翻译：丙酸衍生物的合成
公开(公告)号：WO1997019048A1
公开(公告)日：1997-05-29
申请号：PCT/GB1996002708
申请日：1996-11-05
申请人： AECI LIMITED , DYER, Alison, Margaret
发明人： AECI LIMITED , MARAIS, Stephanus, Francois , KHAILE, Thebeeapelo, John , NJAMELA, Owen, Lungile , BRAITHWAITE, Dana, Helen , DAVIDSON, Deborah, Nicole , JUNGMANN, Christa, Maria , PARKINSON, Christopher, John , GARDINER, Neil, Stockenstrom , STEENKAMP, Lucia, Hendrina , SKEIN, Etienne, Van Eeden
IPC分类号： C07C69/734
CPC分类号： C12P41/005 , C07C69/734
摘要： A process for the production of disubstituted propionic acid derivatives which are intermediates in the synthesis of alpha -arylpropionic acids such as naproxen, involves the reaction of a naphthalene derivative such as 2-methoxynaphthalene, with an alkylating agent such as an alkyl pyruvate in the presence of a catalyst, and then dehydrating and hydrogenolising, or directly hydrogenolising, or derivatising and then hydrogenolising the product thereof, to produce the desired compound.
摘要翻译：制备作为α-芳基丙酸如萘普生合成中的中间体的二取代的丙酸衍生物的方法涉及萘衍生物如2-甲氧基萘与烷基化剂如丙酮酸烷基酯的反应，其存在下的催化剂，然后脱水和氢化，或直接氢化，或衍生化，然后氢化其产物，以产生所需化合物。

4. 发明申请

WO9706787A3 CONTROLLED RELEASE PRODUCTS 审中-公开
标题翻译：控制释放产品
公开(公告)号：WO9706787A3
公开(公告)日：1997-04-03
申请号：PCT/GB9602016
申请日：1996-08-16
申请人： DYER ALISON MARGARET , CSIR , ROLFES HEIDI , MERWE THILO LOTHAR V D , TRUTER PATRICIA ANN
发明人： ROLFES HEIDI , VAN DER MERWE THILO LOTHAR , TRUTER PATRICIA-ANN
IPC分类号： A61K9/14 , A61K9/20 , A61K9/22
CPC分类号： A61K9/2027 , A61K9/146 , A61K9/2031 , A61K9/2054
摘要： A method of making a solid interpolymer for use as a controlled release matrix for a controlled release product for oral administration, involves dissolving a first polymer in a solvent therefor, dissolving one or more second complementary polymers capable of complexing with the first polymer to form the interpolymer complex, in a solvent therefor, adding a complexation inhibitor, mixing together the solutions, adjusting the pH if necessary, and spraying the product into a vessel to remove at least partially the solvents and thereby to produce solid particles of the interpolymer complex. An active agent such as a drug is preferably embedded or encapsulated in the interpolymer complex before spray drying or may be incorporated by suitable means at a later stage.
摘要翻译：制备用作用于口服给药的控制释放产品的控释基质的固体互聚物的方法包括将第一聚合物溶解在溶剂中，溶解一种或多种能够与第一聚合物络合的第二互补聚合物，形成互溶物络合物，在其溶剂中，加入络合抑制剂，将溶液混合在一起，根据需要调节pH，并将产物喷射到容器中以至少部分地除去溶剂，从而产生互聚物络合物的固体颗粒。活性剂如药物优选在喷雾干燥之前嵌入或包封在互聚物络合物中，或者可以在稍后阶段通过合适的方式引入。

5. 发明申请

WO1996014839A1 PHARMACEUTICAL COMPOSITION COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS 审中-公开
标题翻译：包含非消毒性抗炎药物的药物组合物
公开(公告)号：WO1996014839A1
公开(公告)日：1996-05-23
申请号：PCT/GB1995002679
申请日：1995-11-14
申请人： SOUTH AFRICAN DRUGGISTS LIMITED , DYER, Alison, Margaret , PENKLER, Lawrence, John , GLINTEKAMP, Lueta, Ann , NICHOLSON, Douglas, George, Murray , VAN OUDTSHOORN, Michiel, Coenraad, Bosch
发明人： SOUTH AFRICAN DRUGGISTS LIMITED , DYER, Alison, Margaret
IPC分类号： A61K31/19
CPC分类号： B82Y5/00 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/5415 , A61K31/542 , A61K47/6951
摘要： A pharmaceutical composition for oral administration for the treatment of acute pain and inflammation comprises an inclusion complex of a non-steroidal anti-inflammatory drug or a pharmaceutically acceptable salt thereof and a cyclodextrin, and a physiologically acceptable alkali agent selected from the group consisting of alkali and alkaline earth metal carbonates, bicarbonates, phosphates and hydroxides, and water-soluble amines, in an amount equivalent to between 2 and 30 molar equivalents inclusive of the non-steroidal anti-inflammatory drug, the alkali agent being capable of forming an alkaline diffusion layer around the composition in the gastrointestinal tract.
摘要翻译：用于治疗急性疼痛和炎症的口服给药用药物组合物包含非甾体抗炎药或其药学上可接受的盐和环糊精的包合络合物和选自碱的生理学上可接受的碱剂和碱土金属碳酸盐，碳酸氢盐，磷酸盐和氢氧化物以及水溶性胺，其量相当于2至30摩尔当量，包括非甾体抗炎药物，碱剂能够形成碱性扩散围绕胃肠道组成。

6. 发明申请

WO1996011172A1 AN EXPLOSIVE COMPOSITION 审中-公开
标题翻译：爆炸性成分
公开(公告)号：WO1996011172A1
公开(公告)日：1996-04-18
申请号：PCT/GB1995002390
申请日：1995-10-10
申请人： DANTEX EXPLOSIVES (PROPRIETARY) LIMITED , DYER, Alison, Margaret , ZIMMERMANN, Leon, Michael
发明人： DANTEX EXPLOSIVES (PROPRIETARY) LIMITED , DYER, Alison, Margaret
IPC分类号： C06B47/14
CPC分类号： C06B47/14
摘要： A watergel explosive composition is described which contains an oxidiser salt, a sensitiser, a thickener, a crosslinking agent, a fuel and less than 8 %, by mass, of the composition of water. The explosive composition is cap sensitive in packages or cartridges having a diameter of about 26 mm or less at temperatures below about 5 DEG C when detonated with a standard number 6 strength detonator. The explosive composition does not require a supplementary sensitisor or a perchlorate salt to achieve this cap sensitivity. A method of producing the explosive composition by separately preparing a thickened aqueous phase and a dry phase, and allowing the thickened phase to stand for a period of time before the mixing of the two phases, as well as explosive paper cartridge containing the watergel explosive composition, are also described.
摘要翻译：描述了一种水凝胶炸药组合物，其包含氧化剂盐，敏化剂，增稠剂，交联剂，燃料和小于组合物的8质量％。爆炸性组合物在使用标准6号强度雷管引爆时，在低于5℃的温度下直径约26mm或更小的包装或药筒中具有帽敏感性。该炸药组合物不需要补充敏感剂或高氯酸盐来达到这种上限敏感性。通过分别制备增稠的水相和干相，并使增稠相在两相混合前静置一段时间，以及含有水凝胶炸药组合物的爆炸性纸盒，制备炸药组合物的方法，也被描述。

7. 发明申请

WO1998023952A1 NEBULIZER 审中-公开
标题翻译：喷雾器
公开(公告)号：WO1998023952A1
公开(公告)日：1998-06-04
申请号：PCT/GB1996002908
申请日：1996-11-26
申请人： ANGLO AMERICAN RESEARCH LABORATORIES (PROPRIETARY) LIMITED , DYER, Alison, Margaret
发明人： ANGLO AMERICAN RESEARCH LABORATORIES (PROPRIETARY) LIMITED , DYER, Alison, Margaret , DE BRUYN, Johannes, David
IPC分类号： G01N30/72
CPC分类号： H01J49/0468 , G01N30/7246 , H01J49/045
摘要： The method and nebulizer of the invention provide effective means for providing an atomised sample of a liquid such as an oil suitable for a variety of analytical methods such as, for example, introduction into an inductively coupled plasma atomic emission spectrometer. The method includes the step of heating the liquid prior to atomisation. The nebulizer includes a chamber (40), an inlet (46) for introducing a liquid into the chamber (40), a gas inlet (52) and a heater block (64) for heating the liquid and gas prior to entry into the chamber (40). Atomisation of the liquid is caused by entraining the liquid in a stream of fast-moving gas in region (54) of the chamber (40).
摘要翻译：本发明的方法和雾化器提供了有效的方式来提供液体的雾化样品，例如适用于各种分析方法的油，例如引入到电感耦合等离子体原子发射光谱仪中。该方法包括在雾化之前加热液体的步骤。雾化器包括一个腔室（40），一个用于将液体引入腔室（40）的入口（46），一个气体入口（52）和加热器块（64），用于在进入腔室之前加热液体和气体（40）。液体的雾化是通过将液体夹带在腔室（40）的区域（54）中的快速移动气体流中引起的。

8. 发明申请

WO1998016411A1 VEHICLE SECURITY SYSTEM 审中-公开
标题翻译：车辆安全系统
公开(公告)号：WO1998016411A1
公开(公告)日：1998-04-23
申请号：PCT/GB1996002517
申请日：1996-10-14
申请人： NYLOTECHNICS (PROPRIETARY) LIMITED , DYER, Alison, Margaret , ROBJANT, Graham, Edgar
发明人： NYLOTECHNICS (PROPRIETARY) LIMITED , DYER, Alison, Margaret
IPC分类号： B60R25/04
CPC分类号： B60R25/043
摘要： A vehicle security system comprises a main control circuit (10) and first and second enabling/disabling circuits (39, 45) linked to the control circuit by means of first and second fibre optic cables (31, 34). The enabling/disabling circuits may be arranged to control a solenoid-operated fuel valve (46) and a starter motor (42) of the vehicle. First and second coded infrared signals are transmitted from the control circuit to the enabling/disabling circuits, and the enabling/disabling circuits are maintained in an enabled mode only on continuous receipt of the coded infrared signals, with the break in transmission of the signals causing the enabling/disabling circuits to become disabled. A remote keypad (12) is provided for generating a coded enabling signal for receipt at the control circuit, which in turn generates the first and second coded enabling signals. Door and ignition sensors (18, 22) are provided for sensing the turning on of the vehicle or the opening of the vehicle door, and logic circuitry is arranged to selectively arm, disarm or immobilise the vehicle, depending on the condition of the vehicle door and ignition sensors, with the armed vehicle being arranged to become immobilised on receipt (60) of a remote disabling signal.
摘要翻译：车辆安全系统包括通过第一和第二光纤电缆（31,34）链接到控制电路的主控制电路（10）和第一和第二使能/禁止电路（39,45）。启用/禁用电路可以被布置成控制车辆的电磁操作燃料阀（46）和起动电动机（42）。第一和第二编码的红外线信号从控制电路发送到使能/禁止电路，只有连续接收编码的红外信号，使能/禁止电路才能保持在使能模式，导致信号的传输中断使能/禁止电路变得禁用。提供远程键盘（12），用于产生用于在控制电路处接收的编码使能信号，控制电路又产生第一和第二编码使能信号。提供门和点火传感器（18,22），用于感测车辆的开启或车门的打开，并且逻辑电路被布置成根据车门的状况选择性地布置，撤防或固定车辆以及点火传感器，其中所述武装车辆被布置成在远程禁用信号的接收（60）上变得固定。

9. 发明申请

WO1995032737A1 PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：药物组合物
公开(公告)号：WO1995032737A1
公开(公告)日：1995-12-07
申请号：PCT/GB1995001152
申请日：1995-05-22
申请人： SOUTH AFRICAN DRUGGISTS LIMITED , DYER, Alison, Margaret , PENKLER, Lawrence, John , GLINTENKAMP, Luéta-Ann , BODLEY, Mark, David , VAN OUDTSHOORN, Michiel, Coenraad, Bosch , STUBBS, Christopher
发明人： SOUTH AFRICAN DRUGGISTS LIMITED , DYER, Alison, Margaret
IPC分类号： A61K47/40
CPC分类号： A61K9/0095 , A61K31/192 , A61K31/196 , A61K31/5415 , A61K31/545 , A61K47/6951 , B82Y5/00
摘要： A method of making a pharmaceutical composition comprising an inclusion complex of a beta -cyclodextrin or a derivative thereof and a sparingly water-soluble non-steroidal anti-inflammatory drug such as diclofenac sodium, the composition being in solid form which is adapted to be dissolved in water to provide a clear or slightly opaque solution for oral administration, includes the steps of forming a paste from the beta -cyclodextrin or the derivative thereof and the NSAID with a wetting solution, mixing the paste with addition of further wetting solution if necessary, and drying the product to produce the inclusion complex which dissolves in water to provide a clear or slightly opaque solution.
摘要翻译：制备包含β-环糊精或其衍生物的包合络合物和微量水溶性非甾体抗炎药如双氯芬酸钠的药物组合物的方法，所述组合物为固体形式，其适于溶解在水中以提供用于口服给药的透明或略微不透明的溶液，包括用湿润溶液从β-环糊精或其衍生物和NSAID形成糊剂的步骤，如果需要，将糊剂加入另外的润湿溶液，并干燥产物以产生溶解在水中以提供透明或略微不透明溶液的包合络合物。

10. 发明申请

WO1996031839A1 STOCK LABELLING 审中-公开
标题翻译：标签标签
公开(公告)号：WO1996031839A1
公开(公告)日：1996-10-10
申请号：PCT/GB1996000846
申请日：1996-04-09
申请人： CSIR , DYER, Alison, Margaret , MYNHARDT, Gerhard
发明人： CSIR , DYER, Alison, Margaret
IPC分类号： G06K17/00
CPC分类号： G06K17/00 , G06K1/126 , G06K2017/0083 , G06K2019/06281
摘要： A labelling apparatus comprises a printing unit and at least one printing label. The printing unit includes a heatable printing head for printing erasable indiciae such as pricing information on a zone of thermo-chromic film defined on the label. A heatable erasing head is provided for erasing the pricing indiciae. A barcode reader on the printing unit reads a barcode located on the label alongside the thermo-chromic zone. The label also includes pictorial or written representations of an item of stock on a shelf. The barcode is read by the printing unit and updated pricing information stored in the printing unit is then downloaded onto the thermo-chromic film via the printing head.
摘要翻译：标签装置包括印刷单元和至少一个印刷标签。打印单元包括用于打印可擦除标记的可加热打印头，例如在标签上定义的热铬膜区域上的定价信息。提供了可擦除擦除头，用于擦除定价标记。打印单元上的条形码读取器读取位于热色区域旁边的标签上的条形码。该标签还包括在货架上的库存物品的图示或书面表示。条形码由打印单元读取，并且存储在打印单元中的更新的定价信息然后经由打印头下载到热铬膜上。

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