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1. 发明申请

WO2013062881A1 PROCESS FOR MAKING BETA 3 AGONISTS AND INTERMEDIATES 审中-公开
标题翻译：制作BETA 3激动剂和中间体的方法
公开(公告)号：WO2013062881A1
公开(公告)日：2013-05-02
申请号：PCT/US2012/061252
申请日：2012-10-22
申请人： MERCK SHARP & DOHME CORP. , YASUDA, Nobuyoshi , LIU, Zhuqing , ZHONG, Yong-Li , CHUNG, John Y., L. , DUNN, Robert, F. , MALONEY, Kevin, M. , CAMPOS, Kevin , HOERRNER, R., Scott , LYNCH, Joseph , XU, Feng , CLEATOR, Edward , GIBSON, Andrew , KEEN, Stephen , LIEBERMAN, Dave , YOSHIKAWA, Naoki
发明人： YASUDA, Nobuyoshi , LIU, Zhuqing , ZHONG, Yong-Li , CHUNG, John Y., L. , DUNN, Robert, F. , MALONEY, Kevin, M. , CAMPOS, Kevin , HOERRNER, R., Scott , LYNCH, Joseph , XU, Feng , CLEATOR, Edward , GIBSON, Andrew , KEEN, Stephen , LIEBERMAN, Dave , YOSHIKAWA, Naoki
IPC分类号： A61K31/427
CPC分类号： C07D487/04 , A61K31/4196 , A61K31/519 , C07B2200/13 , C07D207/09 , C07D263/06 , C07D403/12
摘要： The present invention is directed to processes for preparing beta 3 agonists of Formula (I) and Formula (II) and their intermediates. The beta 3 agonists are useful in the treatment of certain disorders, including overactive bladder, urinary incontinence, and urinary urgency.
摘要翻译：本发明涉及制备式（I）和式（II）及其中间体的β3激动剂的方法。 β3激动剂可用于治疗某些疾病，包括膀胱过动症，尿失禁和尿急。

2. 发明申请

WO2010021797A1 CONDENSED HETEROCYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY 审中-公开
标题翻译：具有5-HT6受体亲和性的稠合的杂环化合物
公开(公告)号：WO2010021797A1
公开(公告)日：2010-02-25
申请号：PCT/US2009/050799
申请日：2009-07-16
申请人： MEMORY PHARMACEUTICALS CORPORATION , DANCA, Mihaela, Diana , DUNN, Robert , TEHIM, Ashok , XIE, Wenge
发明人： DANCA, Mihaela, Diana , DUNN, Robert , TEHIM, Ashok , XIE, Wenge
IPC分类号： C07D519/00 , A61K31/4985 , A61P25/00 , A61P29/00 , A61P3/00
CPC分类号： C07D519/00
摘要： The present disclosure provides compounds having affinity for the 5-HT 6 receptor which are of the formula (I) wherein R 1 , A, B, D, E, G, Q, Ar, n, m, and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.
摘要翻译：本公开内容提供了具有式（I）的5-HT 6受体的亲和力的化合物，其中R 1，A，B，D，E，G，Q，Ar，n，m和p如本文所定义。本公开还涉及制备这种化合物的方法，含有这些化合物的组合物及其使用方法。

3. 发明申请

WO2010003084A2 PHOSPHODIESTERASE 4 INHIBITORS 审中-公开
标题翻译：磷酸二酯酶4抑制剂
公开(公告)号：WO2010003084A2
公开(公告)日：2010-01-07
申请号：PCT/US2009/049558
申请日：2009-07-02
申请人： MEMORY PHARMACEUTICALS CORPORATION , ROCHE PALO ALTO LLC , HOPPER, Allen, T. , CAROON, Joan, Marie , CHIN, Elbert , DUNN, Robert , LABADIE, Sharada, Shenvi , LI, Jim , SCHUMACHER, Richard, Allen , TALAMAS, Francisco, Xavier
发明人： HOPPER, Allen, T. , CAROON, Joan, Marie , CHIN, Elbert , DUNN, Robert , LABADIE, Sharada, Shenvi , LI, Jim , SCHUMACHER, Richard, Allen , TALAMAS, Francisco, Xavier
IPC分类号： C07D257/08 , A61K31/395 , A61K31/41 , A61P25/28
CPC分类号： C07D277/28 , C07C217/92 , C07C229/60 , C07C255/58 , C07C2601/04 , C07C2601/08 , C07D213/36 , C07D213/64 , C07D213/74 , C07D231/12 , C07D237/08 , C07D239/26 , C07D263/32 , C07D307/20 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula I: wherein R 1 , R 2 , R 3 , and R 4 are as defined herein.
摘要翻译：通过新化合物，例如N-取代的苯胺和二苯胺类似物来实现PDE4的抑制。本发明的化合物具有式I：其中R 1，R 2，R 3和R 4如本文所定义。

4. 发明申请

WO2006104548A3 CONTAINER APPARATUS, CONTAINER CLOSURE AND METHOD 审中-公开
标题翻译：集装箱装置，集装箱封闭和方法
公开(公告)号：WO2006104548A3
公开(公告)日：2007-09-07
申请号：PCT/US2006002532
申请日：2006-01-25
申请人： TRIPLE CROWN DOG ACADEMY INC , WOLFE JERRY JOE JR , BENSON HAROLD KEITH , DUNN ROBERT TROY , GABRIEL JESSY B
发明人： WOLFE JERRY JOE JR , BENSON HAROLD KEITH , DUNN ROBERT TROY , GABRIEL JESSY B
IPC分类号： A01K29/00
CPC分类号： A01K15/026 , A01K5/0114
摘要： A container apparatus includes a container having an interior compartment and an opening communicating with the interior compartment. A first interlocking closure member extends at least partially within the compartment through the opening to an exterior of the container, A second interlocking closure member is removably secured to the first interlocking closure member and covering the opening, such that items placed within the interior compartment are restricted from being dispensed via the opening.
摘要翻译：容器装置包括具有内部隔室和与内部隔间连通的开口的容器。第一互锁闭合构件至少部分地在隔室内通过开口延伸到容器的外部。第二互锁闭合构件可移除地固定到第一互锁闭合构件并覆盖开口，使得放置在内部隔间内的物品为禁止通过开口分配。

5. 发明申请

WO2006135828A2 PHOSPHODIESTERASE 4 INHIBITORS 审中-公开
标题翻译：磷酸二酯酶4抑制剂
公开(公告)号：WO2006135828A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022655
申请日：2006-06-09
申请人： MEMORY PHARMACEUTICALS CORPORATION , F. HOFFMANN-LA ROCHE AG , TALAMAS, Francisco, Xavier , CAROON, Joan, Marie , DUNN, Robert , HOPPER, Allen , KUESTER, Eric , SCHUMACHER, Richard , TEHIM, Ashok
发明人： TALAMAS, Francisco, Xavier , CAROON, Joan, Marie , DUNN, Robert , HOPPER, Allen , KUESTER, Eric , SCHUMACHER, Richard , TEHIM, Ashok
IPC分类号： C07D211/58 , C07D401/12 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/4427 , A61K31/4468 , A61P29/00
CPC分类号： C07D211/58 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： PDE4 inhibition is achieved by novel compounds,' e.g., N-substituted diarylamine analogs. The compounds of the present invention are of Formulas I-III; (I), (II) and (III) wherein A, B, D, E, G, J, K, R 1 , R 2 , R 3 , R 4 , R 11 , R 12 , R 13 , R 14 , R 21 , R 22 , R 23 and R 24 are as defined herein.
摘要翻译：新的化合物，例如N-取代的二芳基胺类似物可以实现PDE4抑制。本发明的化合物是式I-III的化合物; （I），（II）和（III）其中A，B，D，E，G，J，K，R 1，R 2， R 4，R 4，R 11，R 12，R 13，R 12， 14，R 21，R 22，R 23和R 24如本文所定义。

6. 发明申请

WO2005061458A3 PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS 审中-公开
标题翻译：磷酸二酯酶4抑制剂，包括N-取代的二芳胺类似物
公开(公告)号：WO2005061458A3
公开(公告)日：2005-10-13
申请号：PCT/US2004041068
申请日：2004-12-10
申请人： MEMORY PHARM CORP , SCHUMACHER RICHARD , HOPPER ALLEN , DUNN ROBERT , KUESTER ERIK , TEHIM ASHOK , RENAU THOMAS E , CAROON JOAN , TALAMAS FRANCISCO , LABADIE SHARADA
发明人： SCHUMACHER RICHARD , HOPPER ALLEN , DUNN ROBERT , KUESTER ERIK , TEHIM ASHOK , RENAU THOMAS E , CAROON JOAN , TALAMAS FRANCISCO , LABADIE SHARADA
IPC分类号： A61K31/444 , A61K31/4545 , C07D213/74 , C07D213/75 , C07D277/28 , C07D401/12 , C07D405/12 , C07D405/14 , A61K31/443 , A61K31/506 , A61P25/00
CPC分类号： C07D213/74 , A61K31/444 , A61K31/4545 , C07C229/60 , C07D213/36 , C07D213/75 , C07D277/28 , C07D401/12 , C07D405/12 , C07D405/14
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted diarylamine analogs. The compounds of the present invention are of Formula (I), wherein A, B, D, R , R , R and R are as defined herein.
摘要翻译：通过新化合物，例如N-取代的二芳基胺类似物实现PDE4抑制。本发明的化合物具有式（I），其中A，B，D，R 1，R 2，R 3和R 4如本文所定义。

7. 发明申请

WO2005061458A2 PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS 审中-公开
标题翻译：磷酸二酯酶4抑制剂，包括N-取代的二胺类似物
公开(公告)号：WO2005061458A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/041068
申请日：2004-12-10
申请人： MEMORY PHARMACEUTICALS CORPORATION , SCHUMACHER, Richard , HOPPER, Allen , DUNN, Robert , KUESTER, Erik , TEHIM, Ashok , RENAU, Thomas, E. , CAROON, Joan , TALAMAS, Francisco , LABADIE, Sharada
发明人： SCHUMACHER, Richard , HOPPER, Allen , DUNN, Robert , KUESTER, Erik , TEHIM, Ashok , RENAU, Thomas, E. , CAROON, Joan , TALAMAS, Francisco , LABADIE, Sharada
IPC分类号： C07D213/74
CPC分类号： C07D213/74 , A61K31/444 , A61K31/4545 , C07C229/60 , C07D213/36 , C07D213/75 , C07D277/28 , C07D401/12 , C07D405/12 , C07D405/14
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted diarylamine analogs. The compounds of the present invention are of Formula (I), wherein A, B, D, R 1 , R 2 , R 3 and R 4 are as defined herein.
摘要翻译： PDE4抑制通过新化合物例如N-取代的二芳基胺类似物来实现。本发明的化合物具有式（I），其中A，B，D，R 1，R 2，R 3和R 4如本文所定义。

8. 发明申请

WO2004009552A1 PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED ANILINE AND DIPHENYLAMINE ANALOGS 审中-公开
标题翻译：磷酸二酯酶4抑制剂，包括N-取代的苯胺和二苯胺类似物
公开(公告)号：WO2004009552A1
公开(公告)日：2004-01-29
申请号：PCT/US2003/022543
申请日：2003-07-21
申请人： MEMORY PHARMACEUTICALS CORPORATION , SCHUMACHER, Richard, A. , HOPPER, Allen, T. , TEHIM, Ashok , HESS, Hans-Jurgen, Ernst , UNTERBECK, Axel , KUESTER, Erik , BRUBAKER, William, Frederick, Jr. , DUNN, Robert, F.
发明人： SCHUMACHER, Richard, A. , HOPPER, Allen, T. , TEHIM, Ashok , HESS, Hans-Jurgen, Ernst , UNTERBECK, Axel , KUESTER, Erik , BRUBAKER, William, Frederick, Jr. , DUNN, Robert, F.
IPC分类号： C07D213/38
CPC分类号： C07D241/12 , C07C217/84 , C07C217/86 , C07C217/88 , C07C217/92 , C07C229/60 , C07C2601/08 , C07C2601/14 , C07D213/38 , C07D213/61 , C07D213/68 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/80 , C07D215/12 , C07D215/14 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D261/08 , C07D261/14 , C07D277/28 , C07D295/13 , C07D307/14 , C07D307/20 , C07D317/58 , C07D333/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14
摘要： PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula (I): wherein R 1 , R 2 R 3 and R 4 are as defined herein.
摘要翻译：通过新化合物，例如N-取代的苯胺和二苯胺类似物来实现PDE4的抑制。本发明的化合物具有式（I）：其中R 1，R 2 R 3和R 4如本文所定义。

9. 发明申请

WO1996022757A1 AN INVALID HOIST 审中-公开
标题翻译：一个无效的房间
公开(公告)号：WO1996022757A1
公开(公告)日：1996-08-01
申请号：PCT/GB1995002090
申请日：1995-09-05
申请人： ARJO LIMITED , DUNN, Robert , SOMERTON, Bruce, Edward
发明人： ARJO LIMITED
IPC分类号： A61G07/10
CPC分类号： A61G7/1074 , A61G7/1017 , A61G7/1046 , A61G7/1061 , A61G7/1067 , A61G7/1076
摘要： An invalid hoist comprises a telescopic mast (11) having a lower part (18) and an upper part (19), power operated means for raising and lowering the upper part relative to the lower part, a lifting arm (12) pivotably connected to the upper part of the mast, the lifting arm having a sling hanger (23) or at least one sling attachment point at or adjacent to one end thereof, and a manually extendible/retractable stay (30) between the lifting arm and the lower mast part. The lifting arm is pivotally connected to the upper part of the mast at a position intermediate its ends and the extendible/retractable stay is connected to the lifting arm on the side of the pivotable connection between the lifting arm and the upper part of the mast remote from said one end of the lifting arm. The stay can be extended, if the power operated means fails with the upper part of the mast in a raised position, to lower a user to a position in which he/she can be released from a sling supported by the lifting arm. It can also be extended, when the upper mast part is in its lowermost position, to move the lifting arm to a storage position alongside the telescopic mast.
摘要翻译：无效升降机包括具有下部（18）和上部（19）的伸缩式桅杆（11），用于相对于下部升高和降低上部的动力操作装置，可枢转地连接到桅杆的上部，提升臂具有吊架（23）或在其一端处或与其一端相邻的至少一个悬挂附接点，以及在提升臂和下桅杆之间的可手动延伸/可缩回的撑杆（30）部分。提升臂在其端部之间的位置枢转地连接到桅杆的上部，并且可伸缩的支架连接到提升臂在提升臂和桅杆远程的上部之间的可枢转连接侧从提升臂的一端。如果电动操作装置在桅杆的上部处于升高位置的情况下失败，则可以延长停留时间，以将使用者降低到能够从提升臂支撑的吊索上释放的位置。当上桅杆部件处于其最低位置时，也可以延伸，以将提升臂移动到可伸缩桅杆旁边的存储位置。

10. 发明申请

WO1996002139A1 METHOD FOR TREATING ANXIETY 审中-公开
标题翻译：治疗厌食症的方法
公开(公告)号：WO1996002139A1
公开(公告)日：1996-02-01
申请号：PCT/US1995008373
申请日：1995-06-30
申请人： DUNN, Robert, W.
发明人： LaMARCA, Suzanne
IPC分类号： A01N43/56
CPC分类号： A61K31/416 , A61K31/00 , A61K31/198 , A61K31/223
摘要： A method of treating anxiety in a warm blooded animal by administering an anti-anxiety effective amount of a nitric oxide synthase inhibitor, and compositions containing the same.
摘要翻译：通过施用抗焦虑有效量的一氧化氮合酶抑制剂和含有该组合物的组合物来治疗温血动物中的焦虑症的方法。

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