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1. 发明申请

WO2009121924A1 METASTATIC MARKERS 审中-公开
标题翻译：分类标记
公开(公告)号：WO2009121924A1
公开(公告)日：2009-10-08
申请号：PCT/EP2009/053923
申请日：2009-04-02
申请人： DRUGMODE APS , FEY, Stephen , LARSEN, Peter Mose , ZHANG, Kelan , KRZYSTOF, Wrzesinski , ROEPSTORFF, Peter
发明人： FEY, Stephen , LARSEN, Peter Mose , ZHANG, Kelan , KRZYSTOF, Wrzesinski , ROEPSTORFF, Peter
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/57423 , C12Q1/6886 , C12Q2600/118 , G01N2800/56
摘要： There is provided a protein or gene expression profile with clinical relevance to cancer metastasis. In particular, there is provided identities of proteins that are correlated with lung cancer metastasis. The protein expression profiles may be used to predict the survival of subjects afflicted with cancer and to predict cancer recurrence. The profiles may also be used in the study and/or diagnosis of cancer cells and tissue, including the grading of invasive lung cancer, as well as for the study and/or determination of prognosis of a patient. When used for diagnosis or prognosis, the profiles are used to determine the treatment of cancer based upon the likelihood of life expectancy and metastasis.
摘要翻译：提供了与癌症转移具有临床相关性的蛋白质或基因表达谱。特别地，提供与肺癌转移相关的蛋白质的同一性。蛋白质表达谱可用于预测患有癌症的受试者的存活并预测癌症复发。这些谱也可用于癌细胞和组织的研究和/或诊断，包括侵袭性肺癌的分级，以及用于研究和/或确定患者的预后。当用于诊断或预后时，根据预期寿命和转移的可能性，使用轮廓来确定癌症的治疗。

2. 发明申请

WO2007020522A2 PROTEIN MARKERS FOR DIAGNOSING OF COLON RECTAL CANCER AND USE OF SAID MARKERS AS DRUG TARGETS FOR THE TREATMENT OF SAID CANCER TYPE 审中-公开
标题翻译：用于诊断结直肠癌的蛋白质标记物和作为药物靶标用于治疗癌症类型的标记物的使用
公开(公告)号：WO2007020522A2
公开(公告)日：2007-02-22
申请号：PCT/IB2006/002235
申请日：2006-08-17
申请人： DRUGMODE APS , LARSEN, Peter, Mose , FEY, Stephen, John
发明人： LARSEN, Peter, Mose , FEY, Stephen, John
IPC分类号： G01N33/574
CPC分类号： G01N33/57419 , G01N2500/10
摘要： This invention relates to a method for diagnosing colorectal cancer (CRC) in a mammal, such as a human, the method comprising determining the presence, absence or level of expression of at least one marker protein in a biological sample from said mammal. It is demonstrated that the combination of metabolic labelling of colon biopsies from both normal and tumour tissues followed by 2 dimensional gel electrophoresis and mass spectrometry is a powerful tool in the identification of marker proteins involved in the development of CRC.
摘要翻译：本发明涉及用于诊断哺乳动物（例如人）的结肠直肠癌（CRC）的方法，所述方法包括测定来自所述哺乳动物的生物样品中至少一种标记蛋白的表达的存在，不存在或水平。证明来自正常和肿瘤组织的结肠活组织检查的代谢标记的组合随后进行二维凝胶电泳和质谱法是鉴定涉及CRC发展的标记蛋白的有力工具。

3. 发明申请

WO2012022351A1 BIOREACTOR SYSTEM 审中-公开
标题翻译：生物系统
公开(公告)号：WO2012022351A1
公开(公告)日：2012-02-23
申请号：PCT/DK2011/050294
申请日：2011-07-29
申请人： DRUGMODE APS , FEY, Stephen John
发明人： FEY, Stephen John
IPC分类号： C12M3/06 , C12M1/10 , C12M1/12 , C12M1/04
CPC分类号： C12M27/10 , C12M29/04 , C12M41/40
摘要： A bioreactor or culture vessel for incubation of one or more cell cultures, tissue biopsies, cell clusters, tissue-like structures, "prototissues" or similar samples. The bioreactor comprises an incubation chamber, a liquid reservoir and conduction means separated from each other by semipermeable membranes. Specifically, the invention provides a humidity chamber design which simplifies the construction of the bioreactor.
摘要翻译：用于孵育一种或多种细胞培养物，组织活检，细胞簇，组织样结构，“原始组织”或类似样品的生物反应器或培养容器。生物反应器包括孵育室，液体储存器和通过半透膜隔离的传导装置。具体地说，本发明提供一种简化生物反应器结构的湿度室设计。

4. 发明申请

WO2012079577A1 BIOREACTOR WITH LID FOR EASY ACCESS TO INCUBATION CAVITY 审中-公开
标题翻译：生物反应器，易于进入孵化处理
公开(公告)号：WO2012079577A1
公开(公告)日：2012-06-21
申请号：PCT/DK2011/050466
申请日：2011-12-07
申请人： DRUGMODE APS , FEY, Stephen John , WRZESINSKI, Krzysztof
发明人： FEY, Stephen John , WRZESINSKI, Krzysztof
IPC分类号： C12M3/06 , C12M1/10 , C12M1/12
CPC分类号： C12M23/24 , C12M23/38 , C12M27/10 , C12M33/14 , C12M35/04
摘要： There is provided a bioreactor which is provided with a lid (13) that facilitates access to the incubation cavity. Specifically the end wall of the incubation cavity is constituted by the lid (13) so that removal of the cap renders the incubation cavity fully accessible.
摘要翻译：提供了一种生物反应器，该生物反应器具有便于进入培养腔的盖子（13）。特别地，孵化腔的端壁由盖（13）构成，使得帽的移除使得孵育腔完全可接近。

5. 发明申请

WO2007076865A1 BIOREACTOR FOR CELL AND TISSUE CULTURE 审中-公开
标题翻译：细胞和组织培养物的生物反应器
公开(公告)号：WO2007076865A1
公开(公告)日：2007-07-12
申请号：PCT/DK2006/000740
申请日：2006-12-22
申请人： DrugMode ApS , LARSEN,Peter Mose , FEY, stephen John
发明人： LARSEN,Peter Mose , FEY, stephen John
IPC分类号： C12M3/02 , C12M3/06 , G01N33/50 , C12Q1/68 , C12N5/06 , C12M3/04
CPC分类号： G01N33/502 , C12M23/16 , C12M27/10 , C12M29/04 , C12N5/0671 , C12Q1/6809
摘要： The present invention provides a bioreacto 1r for incubation of cell cultures, tissue biopsies, cell clusters, tissue-like structures, "prototissues" or similar samples. The bioreactor is generally adapted for rotation for use in microgravity conditions and equipped with an incubation cavity having a small internal fluid volume, generally less than 1 ml. To avoid problems associated with small volume incubation, the bioreactor may include a humidity chamber or other means of avoiding dehydration as well as substantially fluid-tight closures for access ports that avoid introduction of air bubbles to the incubation cavity. The small-volume bioreactor permits long term maintenance of tissue differentiation states in cultures. Also provided are methods of incubating cells or tissues using the bioreactor including methods of creating molecular profiles of biological effects of chemical compositions on differentiated cell or tissue samples maintained in long term culture.
摘要翻译：本发明提供了用于孵育细胞培养物，组织活检，细胞簇，组织样结构，“原始组织”或类似样品的生物反应器1r。生物反应器通常适于旋转用于微重力条件，并配备有通常小于1ml的小内部流体体积的孵育腔。为了避免与小体积孵育相关的问题，生物反应器可以包括湿度室或避免脱水的其它手段以及用于进入端口的基本上流体密封的封闭件，以避免将气泡引入培养腔。小批量生物反应器允许长期维持组织分化状态在文化中。还提供了使用生物反应器来孵育细胞或组织的方法，包括产生化学组成对保持在长期培养物中的分化细胞或组织样品的生物学效应的分子谱的方法。

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