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1. 发明申请

WO2007076865A1 BIOREACTOR FOR CELL AND TISSUE CULTURE 审中-公开
标题翻译：细胞和组织培养物的生物反应器
公开(公告)号：WO2007076865A1
公开(公告)日：2007-07-12
申请号：PCT/DK2006/000740
申请日：2006-12-22
申请人： DrugMode ApS , LARSEN,Peter Mose , FEY, stephen John
发明人： LARSEN,Peter Mose , FEY, stephen John
IPC分类号： C12M3/02 , C12M3/06 , G01N33/50 , C12Q1/68 , C12N5/06 , C12M3/04
CPC分类号： G01N33/502 , C12M23/16 , C12M27/10 , C12M29/04 , C12N5/0671 , C12Q1/6809
摘要： The present invention provides a bioreacto 1r for incubation of cell cultures, tissue biopsies, cell clusters, tissue-like structures, "prototissues" or similar samples. The bioreactor is generally adapted for rotation for use in microgravity conditions and equipped with an incubation cavity having a small internal fluid volume, generally less than 1 ml. To avoid problems associated with small volume incubation, the bioreactor may include a humidity chamber or other means of avoiding dehydration as well as substantially fluid-tight closures for access ports that avoid introduction of air bubbles to the incubation cavity. The small-volume bioreactor permits long term maintenance of tissue differentiation states in cultures. Also provided are methods of incubating cells or tissues using the bioreactor including methods of creating molecular profiles of biological effects of chemical compositions on differentiated cell or tissue samples maintained in long term culture.
摘要翻译：本发明提供了用于孵育细胞培养物，组织活检，细胞簇，组织样结构，“原始组织”或类似样品的生物反应器1r。生物反应器通常适于旋转用于微重力条件，并配备有通常小于1ml的小内部流体体积的孵育腔。为了避免与小体积孵育相关的问题，生物反应器可以包括湿度室或避免脱水的其它手段以及用于进入端口的基本上流体密封的封闭件，以避免将气泡引入培养腔。小批量生物反应器允许长期维持组织分化状态在文化中。还提供了使用生物反应器来孵育细胞或组织的方法，包括产生化学组成对保持在长期培养物中的分化细胞或组织样品的生物学效应的分子谱的方法。

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