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1. 发明申请

WO2008041246A3 INJECTABLE DEPOT COMPOSITION AND ITS' PROCESS OF PREPARATION 审中-公开
标题翻译：可注射成分及其制备方法
公开(公告)号：WO2008041246A3
公开(公告)日：2008-05-29
申请号：PCT/IN2007000473
申请日：2007-10-03
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , JINDAL KOUR CHAND , DEVARAJAN SAMPATH KUMAR
发明人： JAIN RAJESH , JINDAL KOUR CHAND , DEVARAJAN SAMPATH KUMAR
IPC分类号： A61K9/10 , A61K9/50 , A61K31/138 , A61K31/18 , A61K31/4196 , A61K47/34 , A61P35/00
CPC分类号： A61K9/0024 , A61K9/06 , A61K9/1647
摘要： Novel injectable compositions are provided comprising an active agent which is tarnsulosin or letrozole or its pharmaceutically acceptable salts, derivatives, isomers, polymorphs, solvates, hydrates, analogues, enantiomers, tautomeric forms or mixtures thereof and one or more pharmaceutically acceptable excipient(s) wherein the compositions are preferably formulated as biodegradable microparticles or nanoparticles which can optionally be reconstituted with an aqueous, hydro-alcoholic or oily liquid vehicle prior to administration. The novel injectable compositions of the present invention preferably form a depot upon administration in vivo and are in the form of an in situ gelling composition or an implant composition which provides a prolonged release of tamsulosin or letrozole for extended periods of time. Also described are process for preparation of such novel compositions and method of using them.
摘要翻译：提供新的可注射组合物，其包含塔尼罗辛或来曲唑或其药学上可接受的盐，衍生物，异构体，多晶型物，溶剂化物，水合物，类似物，对映异构体，互变异构形式或其混合物和一种或多种药学上可接受的赋形剂的活性剂，其中组合物优选配制成可生物降解的微粒或纳米颗粒，其可以在施用前任选地用水性，水性醇或油性液体载体重构。本发明的新型可注射组合物优选在体内施用时形成贮库，并且是呈现长时间释放坦索罗辛或来曲唑的原位胶凝组合物或植入物组合物的形式。还描述了这种新型组合物的制备方法和使用它们的方法。

2. 发明申请

WO2008041246A2 NOVEL INJECTABLE DEPOT COMPOSITIONS AND PROCESS OF PREPARATION OF SUCH COMPOSITIONS 审中-公开
标题翻译：新型注射剂组合物及其制备方法
公开(公告)号：WO2008041246A2
公开(公告)日：2008-04-10
申请号：PCT/IN2007/000473
申请日：2007-10-03
申请人： PANACEA BIOTEC LTD. , JAIN, Rajesh , JINDAL, Kour, Chand , DEVARAJAN, Sampath, Kumar
发明人： JAIN, Rajesh , JINDAL, Kour, Chand , DEVARAJAN, Sampath, Kumar
IPC分类号： A61K31/18 , A61K31/138 , A61K31/4196 , A61K47/34 , A61P35/00
CPC分类号： A61K9/0024 , A61K9/06 , A61K9/1647
摘要： Novel injectable compositions are provided comprising an active agent which is tarnsulosin or letrozole or its pharmaceutically acceptable salts, derivatives, isomers, polymorphs, solvates, hydrates, analogues, enantiomers, tautomeric forms or mixtures thereof and one or more pharmaceutically acceptable excipient(s) wherein the compositions are preferably formulated as biodegradable microparticles or nanoparticles which can optionally be reconstituted with an aqueous, hydro-alcoholic or oily liquid vehicle prior to administration. The novel injectable compositions of the present invention preferably form a depot upon administration in vivo and are in the form of an in situ gelling composition or an implant composition which provides a prolonged release of tamsulosin or letrozole for extended periods of time. Also described are process for preparation of such novel compositions and method of using them.
摘要翻译：提供新的可注射组合物，其包含塔尼罗辛或来曲唑或其药学上可接受的盐，衍生物，异构体，多晶型物，溶剂合物，水合物，类似物，对映异构体，互变异构形式或其混合物和一种或多种药学上可接受的赋形剂的活性剂，其中组合物优选配制成可生物降解的微粒或纳米颗粒，其可以在施用前任选地用水性，水性醇或油性液体载体重构。本发明的新型可注射组合物优选在体内施用时形成贮库，并且是呈现长时间释放坦索罗辛或来曲唑的原位胶凝组合物或植入物组合物的形式。还描述了这种新型组合物的制备方法和使用它们的方法。

3. 发明申请

WO2007105229A1 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION AND PROCESS THEREOF 审中-公开
标题翻译：控制释放药物组合物及其过程
公开(公告)号：WO2007105229A1
公开(公告)日：2007-09-20
申请号：PCT/IN2007/000085
申请日：2007-03-07
申请人： PANACEA BIOTEC LTD. , JAIN, Rajesh , JINDAL, Kour, Chand , DEVARAJAN, Sampath, Kumar , BOLDHANE, Sanjay
发明人： JAIN, Rajesh , JINDAL, Kour, Chand , DEVARAJAN, Sampath, Kumar , BOLDHANE, Sanjay
IPC分类号： A61K9/22 , A61P25/08
CPC分类号： A61K9/1623 , A61K9/1617 , A61K9/1635 , A61K9/1652
摘要： Novel controlled release pharmaceutical compositions comprising at least one active agent(s), at least one pH dependent polymer(s), at least one pH independent(s) preferably water soluble polymer, a channel forming agent(s), and optionally other pharmaceutically acceptable excipients are provided. Also described are process for preparation of such compositions and method of using such compositions. The controlled release compositions are useful in providing therapeutically effective levels of active agent(s) for extended periods of time.
摘要翻译：包含至少一种活性剂，至少一种pH依赖性聚合物，至少一种pH独立的优选水溶性聚合物，通道形成剂和任选其它药学上可接受的新型控释药物组合物提供了可接受的赋形剂。还描述了制备这种组合物的方法和使用这种组合物的方法。控释组合物可用于在长时间内提供治疗有效水平的活性剂。

4. 发明申请

WO2009060473A3 INJECTABLE COMPOSITIONS, PROCESSES AND USES THEREOF 审中-公开
标题翻译：可注射组合物，工艺及其用途
公开(公告)号：WO2009060473A3
公开(公告)日：2009-10-15
申请号：PCT/IN2008000757
申请日：2008-11-06
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , SINGH SUKHJEET , DEVARAJAN SAMPATH KUMAR
发明人： JAIN RAJESH , SINGH SUKHJEET , DEVARAJAN SAMPATH KUMAR
IPC分类号： A61K9/08 , A61K9/10 , A61K47/34
CPC分类号： A61K9/0024 , A61K9/06
摘要： Injectable depot gel or implant compositions comprising at least one active agent(s) selected from a group comprising antipsychotics, aromatase inhibitors, alpha-1 adrenergic blocking agents, acetylcholinesterase inhibitors, and pharmaceutically acceptable salts, derivatives, isomers, polymorphs, solvates, hydrates, analogues, enantiomers, tautomeric forms or mixtures thereof; at least one biocompatible bioerodible polymer(s); at least one biocompatible non-toxic solvent(s) and optionally one or more pharmaceutically acceptable excipient(s) are provided. The present invention also describes process for preparation of such compositions and method of using such compositions.
摘要翻译：包含至少一种选自抗精神病药，芳香酶抑制剂，α-1肾上腺素能阻断剂，乙酰胆碱酯酶抑制剂及其药学上可接受的盐，衍生物，异构体，多晶型物，溶剂合物，水合物，类似物，对映异构体，互变异构形式或其混合物; 至少一种生物相容性生物可蚀解聚合物; 提供至少一种生物相容性无毒溶剂和任选的一种或多种药学上可接受的赋形剂。本发明还描述了用于制备这种组合物的方法和使用这种组合物的方法。

5. 发明申请

WO2007086078A3 NOVEL PHARMACEUTICAL COMPOSITIONS AND PROCESS OF PREPARATION THEREOF 审中-公开
标题翻译：新型药物组合物及其制备方法
公开(公告)号：WO2007086078A3
公开(公告)日：2007-12-13
申请号：PCT/IN2007000029
申请日：2007-01-29
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , JINDAL KOUR CHAND , DEVARAJAN SAMPATH KUMAR
发明人： JAIN RAJESH , JINDAL KOUR CHAND , DEVARAJAN SAMPATH KUMAR
IPC分类号： A61K9/24 , A61K9/26 , A61K9/48
CPC分类号： A61K9/2081 , A61K9/0065 , A61K9/2077 , A61K9/209 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5026 , A61K9/5036
摘要： Novel pharmaceutical compositions comprising at least one active agent(s) or its pharmaceutically acceptable salts, polymorphs, solvates, hydrates, analogues, enantiomers, tautomeric forms or mixtures thereof; at least one permeation enhancer(s); at least one adsorbent(s) and at least one bioadhesive polymer(s); optionally at least one acid soluble polymer(s) and optionally one or more other pharmaceutically acceptable excipient(s) are provided. Preferably the compositions are in the gastro-adhesive modified release form and/or fast disintegrating dosage form which release the active agent(s) over an extended period of time. Also provided are processes of preparation of such novel compositions and methods of using them.
摘要翻译：新颖的药物组合物，其包含至少一种活性剂或其药学上可接受的盐，多晶型物，溶剂化物，水合物，类似物，对映异构体，互变异构形式或其混合物; 至少一种渗透促进剂; 至少一种吸附剂和至少一种生物粘附聚合物; 任选地提供至少一种酸溶性聚合物和任选的一种或多种其他药学上可接受的赋形剂。优选地，组合物处于胃粘附改进释放形式和/或快速崩解剂型，其在一段延长的时间内释放活性剂。还提供了这种新型组合物的制备方法和使用它们的方法。

6. 发明申请

WO2009060473A2 INJECTABLE COMPOSITIONS, PROCESSES AND USES THEREOF 审中-公开
标题翻译：可注意的组成，过程及其用途
公开(公告)号：WO2009060473A2
公开(公告)日：2009-05-14
申请号：PCT/IN2008/000757
申请日：2008-11-06
申请人： PANACEA BIOTEC LIMITED , JAIN, Rajesh , SINGH, Sukhjeet , DEVARAJAN, Sampath Kumar
发明人： JAIN, Rajesh , SINGH, Sukhjeet , DEVARAJAN, Sampath Kumar
IPC分类号： A61K9/08 , A61K9/10 , A61K47/34
CPC分类号： A61K9/0024 , A61K9/06
摘要： Injectable depot gel or implant compositions comprising at least one active agent(s) selected from a group comprising antipsychotics, aromatase inhibitors, alpha-1 adrenergic blocking agents, acetylcholinesterase inhibitors, and pharmaceutically acceptable salts, derivatives, isomers, polymorphs, solvates, hydrates, analogues, enantiomers, tautomeric forms or mixtures thereof; at least one biocompatible bioerodible polymer(s); at least one biocompatible non-toxic solvent(s) and optionally one or more pharmaceutically acceptable excipient(s) are provided. The present invention also describes process for preparation of such compositions and method of using such compositions.
摘要翻译：包含选自抗精神病药，芳香酶抑制剂，α-1肾上腺素能阻断剂，乙酰胆碱酯酶抑制剂和其药学上可接受的盐，衍生物，异构体，多晶型物，溶剂合物，水合物，类似物，对映异构体，互变异构形式或其混合物; 至少一种生物相容性生物可腐蚀的聚合物; 提供至少一种生物相容性无毒溶剂和任选的一种或多种药学上可接受的赋形剂。本发明还描述了制备这种组合物的方法和使用这种组合物的方法。

7. 发明申请

WO2009047799A1 HIGH DOSE SOLID UNIT ORAL PHARMACEUTICAL DOSAGE FORM OF MYCOPHENOLATE SODIUM AND PROCESS FOR MAKING SAME 审中-公开
标题翻译：高剂量固体单位口服药用麦芽酚钠的剂型及其制备方法
公开(公告)号：WO2009047799A1
公开(公告)日：2009-04-16
申请号：PCT/IN2008/000651
申请日：2008-10-08
申请人： PANACEA BIOTEC LIMITED , JAIN, Rajesh , SINGH, Sukhjeet , DEVARAJAN, Sampath Kumar
发明人： JAIN, Rajesh , SINGH, Sukhjeet , DEVARAJAN, Sampath Kumar
IPC分类号： A61K31/343 , A61K31/365
CPC分类号： A61K31/343 , A61K9/2054 , A61K31/365
摘要： Provided are high dose solid unit oral pharmaceutical dosage form compositions comprising mycophenolate sodium as active agent in an amount of from greater than about 720 mg to about 1500 mg, preferably from about 800 mg to about 1440 mg calculated as mycophenolic acid, and one or more pharmaceutically acceptable excipient(s). Particularly the dosage form compositions are meant for once-a-day or twice-a-day administration and provide the active agent in an extended release form which is released in a sustained manner in-vivo for a prolonged duration. The invention is also directed to process of manufacturing the high dose formulations, and prophylactic and/or therapeutic methods of using such dosage forms. The composition of the present invention are easy to formulate, safe, effective and well-tolerated, and are useful for the management such as prophylaxis, amelioration and/or treatment of immunosuppressant indicated disease(s)/disorder(s) especially for the treatment or prevention of organ, tissue or cellular allograft or xenograft rejection, e.g. after transplant, or the management of immune-mediated diseases (autoimmune diseases).
摘要翻译：提供了包含以霉酚酸计算的大于约720mg至约1500mg，优选约800mg至约1440mg的量的霉酚酸钠作为活性剂的高剂量固体单元口服药物剂型组合物，以及一种或多种药学上可接受的赋形剂。特别地，剂型组合物是指每天一次或每天两次施用，并且以延长的释放形式提供活性剂，其以持续的方式在体内长时间释放。本发明还涉及制备高剂量制剂的方法，以及使用这种剂型的预防和/或治疗方法。本发明的组合物易于配制，安全，有效和耐受性良好，并且可用于治疗，例如预防，改善和/或治疗指定的疾病/病症，特别是用于治疗的免疫抑制剂或预防器官，组织或细胞同种异体移植物或异种移植排斥，例如移植后，或免疫介导的疾病（自身免疫性疾病）的管理。

8. 发明申请

WO2004019901A2 SUSTAINED RELEASE PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：持续释放药物组合物
公开(公告)号：WO2004019901A2
公开(公告)日：2004-03-11
申请号：PCT/IB2003/003602
申请日：2003-08-29
申请人： ORCHID CHEMICALS & PHARMACEUTICALS LTD. , KSHIRSAGAR, Rajesh, Suresh , DEVARAJAN, Sampath, Kumar , JINDAL, Kour, Chand
发明人： KSHIRSAGAR, Rajesh, Suresh , DEVARAJAN, Sampath, Kumar , JINDAL, Kour, Chand
IPC分类号： A61K9/00
CPC分类号： A61K9/2027 , A61K9/2018 , A61K9/205 , A61K9/2054 , A61K9/2081 , A61K9/28 , A61K9/5047 , A61K31/43 , A61K31/545 , A61K31/546
摘要： The present invention relates to a sustained release oral pharmaceutical composition, having a beta lactam antibiotic or their pharmaceutically acceptable salts, hydrates or esters in a polymer mixture such that the beta lactam antibiotic is released over an extended period, suitable for once or twice daily oral administration. The invention preferably relates to a sustained release pharmaceutical composition of a beta lactam antibiotic having gelling tendency when in contact with the gastrointestinal fluids. The invention more preferably relates to sustained release pharmaceutical composition of prodrugs of cefpodoxime and cefuroxime such as cefpodoxime proxetil and cefuroxime axetil.
摘要翻译：本发明涉及在聚合物混合物中具有β内酰胺抗生素或其药学上可接受的盐，水合物或酯的持续释放口服药物组合物，使得β-内酰胺抗生素在延长的时间内释放，适合每天一次或两次行政。本发明优选涉及当与胃肠液接触时具有胶凝倾向的β-内酰胺抗生素的缓释药物组合物。本发明更优选涉及头孢泊肟和头孢呋辛前药的持续释放药物组合物，例如头孢泊肟酯和头孢呋辛酯。

9. 发明申请

WO2009022355A1 EXTENDED RELEASE COMPOSITIONS COMPRISING MYCOPHENOLATE SODIUM AND PROCESSES THEREOF 审中-公开
标题翻译：包含MYCOPHENOLATE SODIUM的延伸释放组合物及其过程
公开(公告)号：WO2009022355A1
公开(公告)日：2009-02-19
申请号：PCT/IN2008/000505
申请日：2008-08-11
申请人： PANACEA BIOTEC LIMITED , JAIN, Rajesh , SINGH, Sukhjeet , DEVARAJAN, Sampath Kumar
发明人： JAIN, Rajesh , SINGH, Sukhjeet , DEVARAJAN, Sampath Kumar
IPC分类号： A61K9/22 , A61K31/341 , A61K31/365
CPC分类号： A61K9/2077 , A61K9/2013 , A61K9/2846 , A61K31/365
摘要： Extended release pharmaceutical compositions comprising mycophenolate sodium as the active agent, wherein the said composition exhibits a characteristic release profile when subjected to in-vitro dissolution study, and wherein said mycophenolate sodium is released in a sustained manner in-vivo for a prolonged duration in such quantities that substantially alleviates or at least reduces the chances of causing any associated gastrointestinal side effect(s) without compromising the bioavailability of the said active agent are provided. The present invention also provides process of preparing such dosage form compositions and prophylactic and/or therapeutic methods of using such dosage form. The composition of the present indention are safe, effective and well-tolerated, and are useful for the management such as prophylaxis, amelioration and/or treatment of immunosuppressant indicated disease(s)/disorder(s) especially for the treatment or prevention of organ, tissue or cellular allograft or xenograft rejection, e.g. after transplant, or the management of immune-mediated diseases (autoimmune diseases).
摘要翻译：包含霉酚酸钠作为活性剂的延长释放药物组合物，其中当进行体外溶出研究时，所述组合物表现出特征性释放曲线，并且其中所述霉酚酸钠以持续的方式在体内以这种方式长时间释放提供了大大减轻或至少降低引起任何相关胃肠道副作用而不损害所述活性剂的生物利用度的机会的量。本发明还提供了制备这种剂型组合物的方法和使用这种剂型的预防和/或治疗方法。本发明的组合物是安全，有效和耐受性良好的，并且可用于诸如预防，改善和/或治疗免疫抑制剂，特别是用于治疗或预防器官的疾病/病症，组织或细胞同种异体移植物或异种移植物排斥，例如移植后，或免疫介导的疾病（自身免疫性疾病）的管理。

10. 发明申请

WO2008041245A3 INJECTABLE DEPOT COMPOSITION AND IT'S PROCESS OF PREPARATION 审中-公开
标题翻译：可注射成分组合物及其制备方法
公开(公告)号：WO2008041245A3
公开(公告)日：2008-05-22
申请号：PCT/IN2007000454
申请日：2007-10-03
申请人： PANACEA BIOTEC LTD , JAIN RAJESH , JINDAL KOUR CHAND , DEVARAJAN SAMPATH KUMAR
发明人： JAIN RAJESH , JINDAL KOUR CHAND , DEVARAJAN SAMPATH KUMAR
IPC分类号： A61K9/16 , A61K47/34
CPC分类号： A61K9/0024 , A61K9/06 , A61K9/1647
摘要： Novel injectable depot compositions are provided comprising at least one active agent(s) optionally with one or more pharmaceutically acceptable excipient(s) in the form of a multi-component system preferably comprising at least two components which when administered to a subject in need thereof fonns an in situ gel depot or implant at the site of injection upon contact with body fluids. Also described are process for preparation of such compositions and method of using such compositions.
摘要翻译：提供了新的可注射贮库组合物，其包含至少一种活性剂，其任选地具有多组分体系形式的一种或多种药学上可接受的赋形剂，优选包含至少两种组分，当其施用于有需要的受试者时在与体液接触时，在注射部位进行原位凝胶储存或植入。还描述了制备这种组合物的方法和使用这种组合物的方法。

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