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1. 发明申请

WO2007105229A1 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION AND PROCESS THEREOF 审中-公开
标题翻译：控制释放药物组合物及其过程
公开(公告)号：WO2007105229A1
公开(公告)日：2007-09-20
申请号：PCT/IN2007/000085
申请日：2007-03-07
申请人： PANACEA BIOTEC LTD. , JAIN, Rajesh , JINDAL, Kour, Chand , DEVARAJAN, Sampath, Kumar , BOLDHANE, Sanjay
发明人： JAIN, Rajesh , JINDAL, Kour, Chand , DEVARAJAN, Sampath, Kumar , BOLDHANE, Sanjay
IPC分类号： A61K9/22 , A61P25/08
CPC分类号： A61K9/1623 , A61K9/1617 , A61K9/1635 , A61K9/1652
摘要： Novel controlled release pharmaceutical compositions comprising at least one active agent(s), at least one pH dependent polymer(s), at least one pH independent(s) preferably water soluble polymer, a channel forming agent(s), and optionally other pharmaceutically acceptable excipients are provided. Also described are process for preparation of such compositions and method of using such compositions. The controlled release compositions are useful in providing therapeutically effective levels of active agent(s) for extended periods of time.
摘要翻译：包含至少一种活性剂，至少一种pH依赖性聚合物，至少一种pH独立的优选水溶性聚合物，通道形成剂和任选其它药学上可接受的新型控释药物组合物提供了可接受的赋形剂。还描述了制备这种组合物的方法和使用这种组合物的方法。控释组合物可用于在长时间内提供治疗有效水平的活性剂。

2. 发明申请

WO2007000779A3 PHARMACEUTICAL SUSTAINED RELEASE COMPOSITIONS AND PROCESSES THEREOF 审中-公开
公开(公告)号：WO2007000779A3
公开(公告)日：2007-01-04
申请号：PCT/IN2006/000225
申请日：2006-06-29
申请人： PANACEA BIOTEC LTD. , JAIN, Rajesh , JINDAL, Kour, Chand , SINGH, Sukhjeet , BOLDHANE, Sanjay
发明人： JAIN, Rajesh , JINDAL, Kour, Chand , SINGH, Sukhjeet , BOLDHANE, Sanjay
IPC分类号： A61K9/20 , A61K9/16 , A61K31/522 , A61P31/12
摘要： Pharmaceutical sustained release composition comprising at least one active agent(s), or its tautomeric forms, analogues, isomers, polymorphs, solvates, or salts thereof; preferably an antiviral active agent is provided. Also provided is a process of preparation of such composition and method of using them. The sustained release compositions of the present invention are able to deliver the active agent in a desired manner for an extended period of time.

3. 发明申请

WO2008090569A1 MODIFIED RELEASE PHARMACEUTICAL COMPOSITION AND A PROCESS OF MAKING THE SAME 审中-公开
标题翻译：改性释放药物组合物及其制备方法
公开(公告)号：WO2008090569A1
公开(公告)日：2008-07-31
申请号：PCT/IN2008/000046
申请日：2008-01-24
申请人： PANACEA BIOTEC LTD , JAIN, Rajesh , JINDAL, Kour, Chand , BOLDHANE, Sanjay
发明人： JAIN, Rajesh , JINDAL, Kour, Chand , BOLDHANE, Sanjay
IPC分类号： A61K9/22 , A61K47/32 , A61K47/36 , A61K47/42
CPC分类号： A61K9/2077
摘要： The present invention refers to a modified release pharmaceutical composition comprising an in-situ gelling agent (=0,5 % w/w) and a gellation facilitating agent (e.g. calcium sulfate) in an amount of 2-17,5 % w/w. Additionally, the composition contains a release rate controlling polymer such as an acrylate and optionally a pH independent rate controlling polymer such as HPMC. A preferred active agent is mycophenolate mofetil. A process of making the above described composition is also disclosed.
摘要翻译：本发明涉及包含2-17.5％w / w的量的原位胶凝剂（= 0.5％w / w）和凝胶促进剂（例如硫酸钙）的改性释放药物组合物。此外，组合物含有释放速率控制聚合物如丙烯酸酯和任选的pH独立的速率控制聚合物如HPMC。优选的活性剂是霉酚酸酯。还公开了制备上述组合物的方法。

4. 发明申请

WO2007000778A2 MODIFIED RELEASE PHARMACEUTICAL COMPOSITIONS AND PROCESSES THEREOF 审中-公开
标题翻译：改性释放药物组合物及其制备方法
公开(公告)号：WO2007000778A2
公开(公告)日：2007-01-04
申请号：PCT/IN2006/000224
申请日：2006-06-29
申请人： PANACEA BIOTEC LTD. , JAIN, Rajesh , JINDAL, Kour, Chand , SINGH, Sukhjeet , BOLDHANE, Sanjay
发明人： JAIN, Rajesh , JINDAL, Kour, Chand , SINGH, Sukhjeet , BOLDHANE, Sanjay
IPC分类号： A61K9/20 , A61K9/16 , A61K31/366
CPC分类号： A61K31/366 , A61K9/1635 , A61K9/1652 , A61K9/2018 , A61K9/2027 , A61K9/205 , A61K9/2072 , A61K9/209 , A61K9/2095
摘要： Novel modified release pharmaceutical composition comprising at least one active agent(s); a polymer system in an amount less than about 80% w/w of the composition comprising at least two swellable pH independent polymers wherein at least one is hydrophilic; optionally other pharmaceutically acceptable excipients is provided. Process for preparation of such compositions and methods of using them is also provided. The compositions are formulated into suitable dosage forms that provide therapeutic concentrations of active agent for extended periods of time.
摘要翻译：包含至少一种活性剂的新型调释药物组合物; 组合物含量小于约80％w / w的聚合物体系，所述组合物包含至少两种可溶胀的pH独立聚合物，其中至少一种是亲水的; 提供任选的其它药学上可接受的赋形剂。还提供了这种组合物的制备方法和使用它们的方法。将组合物配制成适当的剂型，其提供治疗浓度的活性剂长时间。

5. 发明申请

WO2006126214A2 NOVEL INJECTABLE COMPOSITIONS AND PROCESS OF PREPARATION THEREOF 审中-公开
标题翻译：新型注射剂组合物及其制备方法
公开(公告)号：WO2006126214A2
公开(公告)日：2006-11-30
申请号：PCT/IN2006/000177
申请日：2006-05-25
申请人： PANACEA BIOTEC LTD. , JAIN, Rajesh , JINDAL, Kour, Chand , SINGH, Sukhjeet , BOLDHANE, Sanjay
发明人： JAIN, Rajesh , JINDAL, Kour, Chand , SINGH, Sukhjeet , BOLDHANE, Sanjay
IPC分类号： A61K9/08
CPC分类号： A61K47/183 , A61K9/0019 , A61K31/405 , A61K47/10
摘要： Novel and highly stable injectable pharmaceutical compositions comprising at least one cyclooxygenase-II enzyme (COX-II) inhibitor or non-steroidal anti-inflammatory drug (NSAID) or .COX/LOX inhibitor, or its tautomeric forms, analogues, isomers, polymorphs, solvates, prodrugs or salts thereof as active ingredient suitable for parenteral administration preferably by intramuscular (IM) or intravenous (IV) route; process of preparing such compositions and therapeutic methods of using such compositions are provided. The analgesic and anti-inflammatory injectable compositions of the present invention are very useful in mammals particularly in humans for the treatment of acute painful conditions like one or more of post-operative trauma, pain associated with cancer, sports injuries, migraine headache, neurological pain and pain associated with sciatica and spondylitis, and the like, and/or chronic painful conditions, and/or a variety of painful and inflammatory conditions like postoperative pain, primary dysmenorrhea and painful osteoarthritis, and/or other associated disorders such as inflammation, fever, allergy, or the like.
摘要翻译：包含至少一种环氧合酶II酶（COX-II）抑制剂或非甾体抗炎药（NSAID）或.COX / LOX抑制剂或其互变异构形式，类似物，异构体，多晶型物，溶剂合物，前药或其盐作为适合肠胃外给药的活性成分，优选通过肌内（IM）或静脉内（IV）途径; 提供了制备这种组合物的方法和使用这种组合物的治疗方法。本发明的镇痛和抗炎可注射组合物在哺乳动物，特别是人类中非常有用，用于治疗急性疼痛病症，如手术后创伤，与癌症相关的疼痛，运动损伤，偏头痛，神经痛和与坐骨神经痛和脊椎炎相关的疼痛等，和/或慢性疼痛病症，和/或各种疼痛和炎症状况，如手术后疼痛，原发性痛经和疼痛性骨关节炎，和/或其他相关疾病如炎症，发热，过敏等。

6. 发明申请

WO2008122993A1 CONTROLLED RELEASE FORMULATION OF COATED MICROPARTICLES 审中-公开
标题翻译：控制释放配方的包装微生物
公开(公告)号：WO2008122993A1
公开(公告)日：2008-10-16
申请号：PCT/IN2008/000232
申请日：2008-04-08
申请人： PANACEA BIOTEC LIMITED , JAIN, Rajesh , JINDAL, Kour Chand , BOLDHANE, Sanjay
发明人： JAIN, Rajesh , JINDAL, Kour Chand , BOLDHANE, Sanjay
IPC分类号： A61K9/16 , A61K9/50 , A61K47/34 , A61K47/38
CPC分类号： A61K9/5073 , A61K9/5026 , A61K9/5042
摘要： Controlled release compositions comprising microparticles which comprise a core and at least one coat, wherein the core comprises at least one active agent(s), optionally at least one water soluble polymer(s) and optionally one or more pharmaceutically acceptable excipient(s); and at least one coat comprising at least one pH independent polymer(s) along with one or more pharmaceutically acceptable excipient(s) are provided. Preferably the controlled release pharmaceutical compositions comprise microparticles along with at least one in-situ gelling agent(s), at least one cross-linking agent(s) and optionally one or more pharmaceutically acceptable excipient(s), wherein the said compositions are formulated as oral reconstitutable pharmaceutical controlled release suspensions, which can be reconstituted using a suitable reconstituting medium such as water. Further, this invention provides process of preparation of such compositions and method of using them.
摘要翻译：包含微粒的控制释放组合物包含核心和至少一个涂层，其中所述核心包含至少一种活性剂，任选的至少一种水溶性聚合物和任选的一种或多种药学上可接受的赋形剂; 并且提供至少一种包含至少一种不依赖于pH的聚合物以及一种或多种药学上可接受的赋形剂的涂层。优选地，控释药物组合物包含微粒以及至少一种原位胶凝剂，至少一种交联剂和任选的一种或多种药学上可接受的赋形剂，其中所述组合物被配制作为口服可重组的药物控制释放悬浮液，其可以使用合适的重构培养基如水重构。此外，本发明提供了这种组合物的制备方法和使用它们的方法。

7. 发明申请

WO2011077452A2 FAST DISSOLVING PHARMACEUTICAL COMPOSITION COMPRISING LORNOXICAM 审中-公开
标题翻译：快速溶解包含LORNOXICAM的药物组合物
公开(公告)号：WO2011077452A2
公开(公告)日：2011-06-30
申请号：PCT/IN2010/000832
申请日：2010-12-21
申请人： ABBOTT HEALTHCARE PRIVATE LIMITED , BOLDHANE, Sanjay , BHOKARE, Kuldeep , Dr. JATHAR, Shripad , ELLIOTT, Geraldine, Ann
发明人： BOLDHANE, Sanjay , BHOKARE, Kuldeep , Dr. JATHAR, Shripad , ELLIOTT, Geraldine, Ann
IPC分类号： A61K31/542
CPC分类号： A61K9/2013 , A61K9/2009 , A61K31/542
摘要： The present invention relates to a fast dissolving pharmaceutical composition containing lornoxicam or pharmaceutically acceptable salts thereof as an active ingredient along with at least one alkalinizer, at least one organic acid and at least one pharmaceutically acceptable excipient. The present invention also relates to processes of preparing fast dissolving pharmaceutical composition.
摘要翻译：本发明涉及含有氯诺昔康或其药学上可接受的盐作为活性成分以及至少一种碱化剂，至少一种有机酸和至少一种药学上可接受的赋形剂的快速溶解药物组合物。本发明还涉及制备快速溶解药物组合物的方法。

8. 发明申请

WO2012059937A1 MODIFIES RELEASE PHARMACEUTICAL COMPOSITONS FOR NSAIDS 审中-公开
标题翻译：修改NSAIDS的药物组合物
公开(公告)号：WO2012059937A1
公开(公告)日：2012-05-10
申请号：PCT/IN2011/000732
申请日：2011-10-24
申请人： ABBOTT HEALTHCARE PRIVATE LIMITED , YADAV, Venkat , BOLDHANE, Sanjay , JATHAR, Shripad
发明人： YADAV, Venkat , BOLDHANE, Sanjay , JATHAR, Shripad
IPC分类号： A61K9/16 , A61K31/196 , A61K31/192 , A61K47/38
CPC分类号： A61K31/192 , A61K9/0056 , A61K9/2054 , A61K9/2095 , A61K31/196
摘要： The present invention is directed to a modified release pharmaceutical composition consisting agglomerates comprising one or more NSAIDs and one or more enteric polymers and process for preparing the same.
摘要翻译：本发明涉及包含一种或多种NSAID和一种或多种肠溶性聚合物的附聚物及其制备方法的调制释放药物组合物。

9. 发明申请

WO2011077451A2 CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：控制释放药物组合物
公开(公告)号：WO2011077451A2
公开(公告)日：2011-06-30
申请号：PCT/IN2010/000829
申请日：2010-12-20
申请人： ABBOTT HEALTHCARE PRIVATE LIMITED , BOLDHANE, Sanjay , JATHAR, Shripad , NERURKAR, Maneesh
发明人： BOLDHANE, Sanjay , JATHAR, Shripad , NERURKAR, Maneesh
IPC分类号： A61K9/26
CPC分类号： A61K9/50 , A61K9/0056 , A61K9/0095 , A61K9/1676 , A61K9/2081 , A61K9/5026 , A61K9/5078
摘要： The present invention relates to pharmaceutical compositions. Particularly, the present invention relates to oral controlled release (CR) pharmaceutical compositions and processes for their preparation.
摘要翻译：本发明涉及药物组合物。特别地，本发明涉及口服释放（CR）药物组合物及其制备方法。

10. 发明申请

WO2010089772A3 CHRONOTHERAPEUTIC PHARMACEUTICAL COMPOSITION 审中-公开
公开(公告)号：WO2010089772A3
公开(公告)日：2010-08-12
申请号：PCT/IN2010/000035
申请日：2010-01-21
申请人： PIRAMAL HEALTHCARE LTD. , BOLDHANE, Sanjay , JATHAR, Shripad , NERURKAR, ManeeshP
发明人： BOLDHANE, Sanjay , JATHAR, Shripad , NERURKAR, ManeeshP
IPC分类号： A61K31/196 , A61K31/717 , A61P1/04 , A61K9/28 , A61K31/723 , A61P9/00
摘要： The present invention relates to chronotherapeutic pharmaceutical compositions and a method of preparing the same. The composition comprises of at least one active ingredient, a pH independent agent and a hydrophilic agent. The active ingredient in the composition is coated with the pH independent agent. The composition provides a dual controlled release system, which aids in an initial lag time of 4-6 hours and controlled release of the active ingredient up to 24 hours.

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