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1. 发明申请

WO2010083532A8 FATTY ACID BINDING PROTEINS AS DRUG TARGETS FOR MODULATION OF ENDOCANNABINOIDS 审中-公开
公开(公告)号：WO2010083532A8
公开(公告)日：2010-07-22
申请号：PCT/US2010/021431
申请日：2010-01-19
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , DEUTSCH, Dale , KACZOCHA, Martin , GLASER, Sherrye
发明人： DEUTSCH, Dale , KACZOCHA, Martin , GLASER, Sherrye
IPC分类号： G01N33/53
摘要： The invention provides a method of modulating the level of an endocannabinoid in a subject in need thereof comprising administering an effective amount of an agent that inhibits the interaction of the endocannabinoid with an intracellular fatty acid binding protein (FABP). The invention also provides a method of identifying an agent for modulating the level of an endocannabinoid in a subject comprising testing the agent for its ability to modulate binding of the endocannabinoid with an intracellular FABP. The invention also provides a method of identifying an agent for modulating the level of an endocannabinoid in a subject comprising testing the agent for its ability to modulate expression of an intracellular FABP. The invention also provides a method of identifying an agent for treatment of a neurological disorder comprising testing the agent for its ability to modulate the interaction of an endocannabinoid with an intracellular FABP. The invention also relates to modulation of levels of fatty acid amides for treatment or amelioration of diseases or disorders by modulating binding of the fatty acid amides to fatty acid binding proteins. In one embodiment, the fatty acid binding protein is one or more of FABP3, FABP5, and FABP7. In one embodiment, the level of an endocannabinoid is modulated.

2. 发明申请

WO2010083532A1 FATTY ACID BINDING PROTEINS AS DRUG TARGETS FOR MODULATION OF ENDOCANNABINOIDS 审中-公开
标题翻译：脂肪酸结合蛋白作为用于调节内联蛋白的药物目标
公开(公告)号：WO2010083532A1
公开(公告)日：2010-07-22
申请号：PCT/US2010021431
申请日：2010-01-19
申请人： RES FOUNDATON OF STATE UNIVERS , DEUTSCH DALE , KACZOCHA MARTIN , GLASER SHERRYE
发明人： DEUTSCH DALE , KACZOCHA MARTIN , GLASER SHERRYE
IPC分类号： G01N33/53
CPC分类号： G01N33/948 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： The invention provides a method of modulating the level of an endocannabinoid in a subject in need thereof comprising administering an effective amount of an agent that inhibits the interaction of the endocannabinoid with an intracellular fatty acid binding protein (FABP). The invention also provides a method of identifying an agent for modulating the level of an endocannabinoid in a subject comprising testing the agent for its ability to modulate binding of the endocannabinoid with an intracellular FABP. The invention also provides a method of identifying an agent for modulating the level of an endocannabinoid in a subject comprising testing the agent for its ability to modulate expression of an intracellular FABP. The invention also provides a method of identifying an agent for treatment of a neurological disorder comprising testing the agent for its ability to modulate the interaction of an endocannabinoid with an intracellular FABP. The invention also relates to modulation of levels of fatty acid amides for treatment or amelioration of diseases or disorders by modulating binding of the fatty acid amides to fatty acid binding proteins. In one embodiment, the fatty acid binding protein is one or more of FABP3, FABP5, and FABP7. In one embodiment, the level of an endocannabinoid is modulated.
摘要翻译：本发明提供调节有需要的受试者中内源性大麻素水平的方法，包括施用有效量的抑制内源性大麻素与细胞内脂肪酸结合蛋白（FABP）相互作用的药剂。本发明还提供了鉴定用于调节受试者中内源性大麻素水平的药剂的方法，包括测试该药剂调节内源性大麻素与细胞内FABP结合的能力。本发明还提供了鉴定用于调节受试者中内源性大麻素水平的药剂的方法，所述方法包括测试所述药剂调节细胞内FABP表达的能力。本发明还提供鉴定用于治疗神经障碍的药剂的方法，包括测试该药剂调节内源性大麻素与细胞内FABP的相互作用的能力。本发明还涉及通过调节脂肪酸酰胺与脂肪酸结合蛋白的结合来调节用于治疗或改善疾病或病症的脂肪酸酰胺的水平。在一个实施方案中，脂肪酸结合蛋白是FABP3，FABP5和FABP7中的一种或多种。在一个实施方案中，调节内源性大麻素的水平。

3. 发明申请

WO2014015276A1 α-AND γ-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF 审中-公开
标题翻译： α-和γ-三磷酸衍生物及其药物组合物
公开(公告)号：WO2014015276A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/051337
申请日：2013-07-19
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , OJIMA, Iwao , DEUTSCH, Dale , KACZOCHA, Martin , BERGER, William T. , RIZZO, Robert , BALIUS, Trent E.
发明人： OJIMA, Iwao , DEUTSCH, Dale , KACZOCHA, Martin , BERGER, William T. , RIZZO, Robert , BALIUS, Trent E.
IPC分类号： C07C43/21 , C07C69/74 , C07C69/757 , C07C211/58 , C07C233/81 , C07C67/08 , C07C231/02 , A61K31/085 , A61K31/21 , A61K31/36 , A61P43/00
CPC分类号： A61K31/216 , A61K31/194 , C07B2200/07 , C07C67/08 , C07C67/48 , C07C69/753 , C07C69/757 , C07C69/76 , C07C211/58 , C07C233/11 , C07C233/58 , C07C235/38 , C07C235/40 , C07C2601/04 , G01N33/566 , G01N33/68 , G01N2333/47 , G01N2500/04 , G01N2500/20
摘要： The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, having the structure: Formula (I).
摘要翻译：本发明提供一种化合物和抑制脂肪酸结合蛋白（FABP）活性的方法，包括使FABP与具有以下结构的化合物接触：式（I）。

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