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1. 发明申请

WO2011080538A1 METHOD FOR MAKING AND USING A DIAGNOSTIC ELEMENT 审中-公开
标题翻译：制造和使用诊断元件的方法
公开(公告)号：WO2011080538A1
公开(公告)日：2011-07-07
申请号：PCT/IB2009/055968
申请日：2009-12-28
申请人： ACHIRA LABS PVT. LTD. , DENDUKURI, Dhananjaya , KANDASWAMY, Srinivasan , KURUBAR, Malatesh
发明人： DENDUKURI, Dhananjaya , KANDASWAMY, Srinivasan , KURUBAR, Malatesh
IPC分类号： B01L3/00
CPC分类号： B01L1/00 , B01L3/50 , B01L3/502 , B01L3/5021 , B01L3/5023 , B01L2300/069
摘要： The invention relates to a method for making a diagnostic element. The method comprises providing a shaped channel comprising at least one holding port and an inlet passage and outlet passage on either side of the holding port; flowing in a diagnostic gel into the inlet passage of the shaped channel; and encapsulating the diagnostic gel in the at least one holding port to form a diagnostic element. The invention also provides a method for using a diagnostic element, wherein the method comprises flowing sample through the diagnostic gel to provide an analyte diagnostic gel; analyzing the analyte diagnostic gel.
摘要翻译：本发明涉及一种制造诊断元件的方法。该方法包括提供成形通道，该通道包括至少一个保持口和在保持口两侧的入口通道和出口通道; 在诊断凝胶中流入成形通道的入口通道; 并将所述诊断凝胶封装在所述至少一个保持端口中以形成诊断元件。本发明还提供了一种使用诊断元件的方法，其中所述方法包括使样品流过诊断凝胶以提供分析物诊断凝胶; 分析分析物诊断凝胶。

2. 发明申请

WO2012004636A1 METHODS OF MAKING A DIAGNOSTIC DEVICE BY INTERWEAVING HYDROPHOBIC AND HYDROPHILIC FIBERS, AND DIAGNOSTIC DEVICE THEREFROM 审中-公开
标题翻译：通过干扰疏水性和疏水性纤维制造诊断装置的方法及其诊断装置
公开(公告)号：WO2012004636A1
公开(公告)日：2012-01-12
申请号：PCT/IB2010/053976
申请日：2010-09-03
申请人： ACHIRA LABS PVT. LTD. , BHANDARI, Paridhi , DENDUKURI, Dhananjaya , GANAPATHY, Vijayakumar , KANDASWAMY, Srinivasan , LEWIS, Diya
发明人： BHANDARI, Paridhi , DENDUKURI, Dhananjaya , GANAPATHY, Vijayakumar , KANDASWAMY, Srinivasan , LEWIS, Diya
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/5023 , B01L3/502707 , B01L2200/10 , B01L2200/12 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/161 , B01L2400/0406 , D03D25/00 , G01N33/5302
摘要： In one aspect, the invention provides a method for making a hydrophilic-silk composition. The method includes providing at least one strand of silk fiber, treating the silk fiber with an alkaline solution to provide at least one strand of degummed silk fiber, and treating the degummed silk fiber with a treatment solution to provide a hydrophilic-silk composition. The degummed silk fiber or the hydrophilic-silk composition is further immobilized with at least one reagent to make a silk-based diagnostic composition. The invention provides a silk-based diagnostic composition made by the method of the invention, and a diagnostic device that comprises the silk- based diagnostic composition. In another aspect, the invention provides a method of making a diagnostic device. The method includes providing at least one strand of a diagnostic-fiber composition, providing at least one strand of a hydrophobic-fiber composition, inter-weaving the at least one strand of the diagnostic-fiber composition and the at least one strand of the hydrophobic-fiber composition. In one embodiment, the diagnostic-fiber composition and the hydrophobic-fiber composition are both based on silk.
摘要翻译：一方面，本发明提供了一种制备亲水丝组合物的方法。所述方法包括提供至少一股丝纤维，用碱性溶液处理丝纤维，以提供至少一股脱胶丝纤维，用处理溶液处理脱胶丝纤维以提供亲水丝组合物。脱胶丝纤维或亲水丝组合物进一步用至少一种试剂固定，制成丝状诊断组合物。本发明提供了一种通过本发明的方法制备的基于丝绸的诊断组合物，以及包括基于丝的诊断组合物的诊断装置。另一方面，本发明提供一种制造诊断装置的方法。该方法包括提供诊断纤维组合物的至少一条链，提供疏水纤维组合物的至少一条链，编织诊断纤维组合物的至少一条链和疏水性纤维组合物的至少一条链 - 纤维成分。在一个实施方案中，诊断纤维组合物和疏水 - 纤维组合物均基于丝。

3. 发明申请

WO2012004635A1 METHODS OF MAKING A DIAGNOSTIC COMPOSITION AND COMPOSITIONS THEREFROM 审中-公开
标题翻译：制备诊断组合物的方法及其组合物
公开(公告)号：WO2012004635A1
公开(公告)日：2012-01-12
申请号：PCT/IB2010/053974
申请日：2010-09-03
申请人： ACHIRA LABS PVT. LTD. , BHANDARI, Paridhi , DENDUKURI, Dhananjaya , GANAPATHY, Vijayakumar , KANDASWAMY, Srinivasan , LEWIS, Diya
发明人： BHANDARI, Paridhi , DENDUKURI, Dhananjaya , GANAPATHY, Vijayakumar , KANDASWAMY, Srinivasan , LEWIS, Diya
IPC分类号： D01C3/02 , G01N33/50 , G01N33/53
CPC分类号： C07K17/02 , C07K14/435 , D01C3/02 , G01N33/544 , G01N2333/43578 , Y02A50/58
摘要： In one aspect, the invention provides a method for making a hydrophilic-silk composition. The method includes providing at least one strand of silk fiber, treating the silk fiber with an alkaline solution to provide at least one strand of degummed silk fiber, and treating the degummed silk fiber with a treatment solution to provide a hydrophilic-silk composition. The degummed silk fiber or the hydrophilic-silk composition is further immobilized with at least one reagent to make a silk-based diagnostic composition. The invention provides a silk-based diagnostic composition made by the method of the invention, and a diagnostic device that comprises the silk- based diagnostic composition. In another aspect, the invention provides a method of making a diagnostic device. The method includes providing at least one strand of a diagnostic-fiber composition, providing at least one strand of a hydrophobic-fiber composition, inter- weaving the at least one strand of the diagnostic-fiber composition and the at least one strand of the hydrophobic-fiber composition. In one embodiment, the diagnostic-fiber composition and the hydrophobic-fiber composition are both based on silk.
摘要翻译：一方面，本发明提供了一种制备亲水丝组合物的方法。所述方法包括提供至少一股丝纤维，用碱性溶液处理丝纤维，以提供至少一股脱胶丝纤维，用处理溶液处理脱胶丝纤维以提供亲水丝组合物。脱胶丝纤维或亲水丝组合物进一步用至少一种试剂固定，制成丝状诊断组合物。本发明提供了一种通过本发明的方法制备的基于丝绸的诊断组合物，以及包括基于丝的诊断组合物的诊断装置。另一方面，本发明提供一种制造诊断装置的方法。该方法包括提供诊断纤维组合物的至少一条链，提供疏水纤维组合物的至少一条链，其缠绕诊断纤维组合物的至少一条链和疏水性纤维组合物的至少一条链 - 纤维成分。在一个实施方案中，诊断纤维组合物和疏水 - 纤维组合物均基于丝。

4. 发明申请

WO2012150487A1 LOW-COST DIAGNOSTIC DEVICES 审中-公开
标题翻译：低成本诊断装置
公开(公告)号：WO2012150487A1
公开(公告)日：2012-11-08
申请号：PCT/IB2011/052753
申请日：2011-06-23
申请人： ACHIRA LABS PVT. LTD. , BHANDARI, Paridhi , DENDUKURI, Dhananjaya , NARAHARI, Tanya
发明人： BHANDARI, Paridhi , DENDUKURI, Dhananjaya , NARAHARI, Tanya
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L3/5023 , B01L2300/0845 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/161 , B01L2400/0406
摘要： The invention provides a diagnostic device comprising: a hydrophobic matrix (60); a hydrophilic matrix (62) comprising: a sample inlet zone (64), a flow zone (66), a testing zone, and a sample absorption zone (70); wherein the hydrophilic matrix (62) is contained within the hydrophobic matrix (60), and wherein the hydrophilic matrix (62) is characterized by having at least one thread derived from degummed silk and at least one thread made of a hydrophilic material that are interwoven.
摘要翻译：本发明提供了一种诊断装置，包括：疏水基质（60）; 亲水基质（62），包括：样品入口区（64），流动区（66），测试区和样品吸收区（70）; 其中所述亲水基质（62）包含在所述疏水基质（60）内，并且其中所述亲水基质（62）的特征在于具有至少一种衍生自脱胶丝的丝线和至少一个由交联的亲水材料制成的丝线。

5. 发明申请

WO2011080539A1 DIAGNOSTIC ELEMENT, AND A DIAGNOSTIC DEVICE COMPRISING A DIAGNOSTIC ELEMENT 审中-公开
标题翻译：诊断元件和包含诊断元件的诊断装置
公开(公告)号：WO2011080539A1
公开(公告)日：2011-07-07
申请号：PCT/IB2009/055969
申请日：2009-12-28
申请人： ACHIRA LABS PVT. LTD. , DENDUKURI, Dhananjaya , KANDASWAMY, Srinivasan , KURUBAR, Malatesh , KATIYAR, Reeta , SIVAKUMARAN, Lakshmi Priyadharisini , VASTAREY, Nikhil
发明人： DENDUKURI, Dhananjaya , KANDASWAMY, Srinivasan , KURUBAR, Malatesh , KATIYAR, Reeta , SIVAKUMARAN, Lakshmi Priyadharisini , VASTAREY, Nikhil
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01L3/502 , B01L2200/027 , B01L2200/10 , B01L2300/069 , B01L2300/0825
摘要： The invention relates to a diagnostic element. The diagnostic element comprises an inlet passage, a holding port and an outlet passage. The holding port is capable of encapsulating a diagnostic gel. The invention also relates to a diagnostic device that comprises at least one inlet port, a preparation port, a diagnostic element that comprises an inlet passage, a holding port, an outlet passage and an outlet port.
摘要翻译：本发明涉及诊断元件。诊断元件包括入口通道，保持口和出口通道。保持口能够封装诊断凝胶。本发明还涉及一种诊断装置，其包括至少一个入口，准备口，诊断元件，其包括入口通道，保持口，出口通道和出口。

6. 发明申请

WO2011080537A1 DIAGNOSTIC GEL COMPOSITION, METHOD FOR MAKING A DIAGNOSTIC GEL COMPOSITION 审中-公开
标题翻译：诊断性凝胶组合物，制造诊断性凝胶组合物的方法
公开(公告)号：WO2011080537A1
公开(公告)日：2011-07-07
申请号：PCT/IB2009/055967
申请日：2009-12-28
申请人： ACHIRA LABS PVT. LTD. , DENDUKURI, Dhananjaya , KATIYAR, Reeta , SIVAKUMARAN, Lakshmi Priyadharisini
发明人： DENDUKURI, Dhananjaya , KATIYAR, Reeta , SIVAKUMARAN, Lakshmi Priyadharisini
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , Y10T428/2982 , Y10T428/2998
摘要： The invention relates to a diagnostic gel composition for use as a diagnostic element in diagnostic devices. The diagnostic gel composition is derived from a compound having a formula D-Sp-Po wherein D is a diagnostic group; Sp is a hydrophilic spacer group; and Po is a polymerizable group. The diagnostic gel composition of the invention has dimensions ranging from about 250 nanometers to about 1000 micrometers, and a Young's modulus ranging from about 10 kilopascals to about 200 kilopascals. The invention also provides method for making the diagnostic gel composition. The method comprises providing a composition comprising a porogen, an initiator and a compound having a formula D-Sp-Po; polymerizing the composition to form a polymerized composition; and washing the polymerized composition to form the diagnostic gel composition.
摘要翻译：本发明涉及用作诊断装置中的诊断元件的诊断凝胶组合物。诊断凝胶组合物衍生自具有式D-Sp-Po的化合物，其中D是诊断基团; Sp是亲水间隔基团; 而Po为可聚合基团。本发明的诊断性凝胶组合物的尺寸范围为约250纳米至约1000微米，杨氏模量为约10千帕至约200千帕。本发明还提供了制备诊断凝胶组合物的方法。该方法包括提供包含致孔剂，引发剂和具有式D-Sp-Po的化合物的组合物; 聚合组合物以形成聚合组合物; 并洗涤聚合的组合物以形成诊断凝胶组合物。

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