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1. 发明申请

WO2008072956A1 CAPSULE, FILLED WITH A MEDICINE, IN PARTICULAR AN INHALABLE MEDICINE 审中-公开
标题翻译：胶囊，与药物，特别是一个可吸入的药物
公开(公告)号：WO2008072956A1
公开(公告)日：2008-06-19
申请号：PCT/NL2007/000314
申请日：2007-12-12
申请人： PHARMACHEMIE B.V. , DE VOS, Dick
发明人： DE VOS, Dick
IPC分类号： A61J3/07 , A61M15/00
CPC分类号： A61M15/0028 , A61J3/072 , A61M15/0021 , A61M15/0035
摘要： An assembly of a tube-shaped basic body (10) and a tube-shaped cap (20), which are open at one distal side (12, 22), is provided to manufacture a capsule for enclosing a medicine. At least one recess (13) is arranged in an outer surface of the basic body (10), wherein at least one fixating bulge (23) is arranged in an inner surface of the cap (20), which is destined to be snugly received in the recess (13) in the outer surface of the basic body (10) in order to realize a fixed snap connection between the basic body (10) and the cap (20). A smallest inner diameter of the fixating bulge (23) of the cap (20) is equal to or smaller than a smallest outer diameter of the recess (13) in the basic body (10), which contributes to realizing a fixed snap connection which is firm to such an extent that the capsule is suitable for application in an inhalation apparatus comprising means for piercing the capsule at at least one place.
摘要翻译：提供了在一个远侧（12,22）处开口的管状基体（10）和管状帽（20）的组件，以制造用于封闭药物的胶囊。至少一个凹部（13）布置在基体（10）的外表面中，其中至少一个固定凸起（23）布置在盖（20）的内表面中，该内表面旨在贴合地接收在基体（10）的外表面的凹部（13）中，以实现基体（10）和盖（20）之间的固定卡扣连接。帽（20）的固定凸起（23）的最小内径等于或小于基体（10）中的凹部（13）的最小外径，这有助于实现固定卡扣连接，坚固到使胶囊适用于吸入装置的程度，包括用于在至少一个地方刺穿胶囊的装置。

2. 发明申请

WO2006019292A1 PROTECTED VIAL, AND METHOD FOR MANUFACTURING SAME 审中-公开
标题翻译：保护眼及其制造方法
公开(公告)号：WO2006019292A1
公开(公告)日：2006-02-23
申请号：PCT/NL2005/000591
申请日：2005-08-17
申请人： PHARMACHEMIE B.V. , DE VOS, Dick
发明人： DE VOS, Dick
IPC分类号： B65B53/02
CPC分类号： B65D51/002 , B65B7/2842 , B65B53/00 , B65D75/002
摘要： For the prevention of contamination of a vial (2) with traces of medicinal fluids, for example cytostatics and antibiotics, which may be spilt on the outside of the vial (2) while filling, the vial (2) is provided with a tight-fitting protective envelope (6) as a last step in the production process. The envelope (6) comprises a bottom sticker (602) which is attached to a bottom (202) of the vial (2) and a tight-fitting sleeve (601), which is shrunk on a side wall (201) of the vial (2), while partly overlapping the bottom sticker (602) along a circumferential edge of the bottom (202) of the vial (2) As a result of the arrangement of the envelope (6), a possible contamination which remains on the outside of the vial (2) is encapsulated between the vial (2) and the envelope (6). Consequently, a user is no longer exposed to toxic substances, because the user will not touch the vial (2) itself, but will touch the envelope (6).
摘要翻译：为了防止小瓶（2）被污染痕量的药液（例如细胞抑制剂和抗生素），其在填充时可能溢出在小瓶（2）的外侧上，小瓶（2）作为生产过程的最后一步，安装保护膜（6）。信封（6）包括附接到小瓶（2）的底部（202）的底部贴纸（602）和紧凑的套筒（601），其收缩在小瓶的侧壁（201）上（2），同时沿着小瓶（2）的底部（202）的周向边缘部分地重叠底部贴纸（602）。由于外壳（6）的布置，残留在外部的可能的污染小瓶（2）被封装在小瓶（2）和外壳（6）之间。因此，用户不再暴露于有毒物质，因为用户不会碰到小瓶本身，而是会碰到信封（6）。

3. 发明申请

WO2002083180A1 ELONGATED AND MULTIPLE SPACERS IN ACTIVATIBLE PRODRUGS 审中-公开
标题翻译：可活动产品中的延长和多个间隔
公开(公告)号：WO2002083180A1
公开(公告)日：2002-10-24
申请号：PCT/EP2002/003591
申请日：2002-03-25
申请人： DE GROOT, Franciscus, Marinus, Hendrikus , BEUSKER, Patrick, Henry , SCHEEREN, Johannes, Wilhelm , DE VOS, Dick , VAN BERKOM, Leonardus, Wilhelmus, Adriaan , BUSSCHER, Guuske, Frederike , SEELEN, Antoinette, Eugenie , KOEKKOEK, Ralph , ALBRECHT, Carsten
发明人： DE GROOT, Franciscus, Marinus, Hendrikus , BEUSKER, Patrick, Henry , SCHEEREN, Johannes, Wilhelm , DE VOS, Dick , VAN BERKOM, Leonardus, Wilhelmus, Adriaan , BUSSCHER, Guuske, Frederike , SEELEN, Antoinette, Eugenie , KOEKKOEK, Ralph , ALBRECHT, Carsten
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/65 , A61K47/67 , A61K47/6889 , A61K47/6899
摘要： This invention is directed to prodrugs that can be activated at the preferred site of action in order to selectively deliver the corresponding therapeutic parent drugs to target cells or to the target site. This invention will therefore primarily but not exclusively relate to tumor cells as target cells. More specifically the prodrugs are compounds of the formula V-(W) k -(X) 1 -A-Z, wherein: V is a specifier; (W) k -(X) 1 -A is an elongated self-elimination spacer system; W and X are each a 1,(4+2n) electronic cascade spacer, being the same or different; A is either a spacer group of formula (Y) m wherein: Y is a 1,(4+2n) electronic cascade spacer, or a group of formula U being a cyclisation elimination spacer; Z is a therapeutic drug; k, 1 and m are integers from 0 (included) to 5 (included); n is an integer of 0 (included) to 10 (included), with the provisos that: - when A is (Y) m : k+1+m ≥ 1, and if k+1+m = 1; - when A is U: k+1 ≥ 1.
摘要翻译：本发明涉及可以在优选的作用位点被活化的前药，以便选择性地将相应的治疗性母体药物递送至靶细胞或靶位点。因此，本发明主要但不完全涉及作为靶细胞的肿瘤细胞。更具体地，前药是式V-（W）k-（X）1-A-Z的化合物，其中：V是说明符; （W）k-（X）1-A是细长的自消除间隔体系; W和X分别为1（4 + 2n）个电子级联间隔物，相同或不同; A是式（Y）m的间隔基团，其中：Y是1，（4 + 2n）电子级联间隔基，或者是一组式U是环化消除间隔基; Z是治疗药物; k，1和m是从0（包括）到5（包括）的整数; n是0（包括）到10（包括）的整数，条件是：当A是（Y）m：k + 1 + m> / = 1，并且如果k + 1 + m = 1， - 当A为U时：k + 1> / = 1。

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