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1. 发明申请

WO2020264188A4 REACTIVE DRY POWDERED HEMOSTATIC MATERIALS COMPRISING A NUCLEOPHILE AND A MULTIFUNCTIONAL MODIFIED POLYETHYLENE GLYCOL BASED CROSSLINKING AGENT 审中-公开
公开(公告)号：WO2020264188A4
公开(公告)日：2020-12-30
申请号：PCT/US2020/039660
申请日：2020-06-25
申请人： DAVOL INC.
发明人： GREENAWALT, Keith , STRICKLER, Frederick H.
IPC分类号： A61F2/02 , A61L24/10 , C07K14/76 , A61K9/14
摘要： Compositions and methods related to powdered hemostats that crosslink during and/or after application to a bleeding site are described. The compositions may comprise a first component comprising a polyalkylene oxide-based polymer functionalized with electrophilic reactive groups, and a second component that comprises a protein such as albumin and an optional crosslinking initiator — which may be a base or basic salt such as sodium bicarbonate. The compositions may in certain applications act as hemostats when applied in dry powder form to a bleeding wound, whereupon the first component and the second component of the composition crosslink to form a hydrogel.

2. 发明申请

WO2009157908A1 ENDOSCOPIC VACUUM CONTROLLER 审中-公开
标题翻译：内窥镜真空控制器
公开(公告)号：WO2009157908A1
公开(公告)日：2009-12-30
申请号：PCT/US2008/008104
申请日：2008-06-27
申请人： DAVOL, INC. , FERREIRA, Danial , BATTLES, Christopher
发明人： FERREIRA, Danial , BATTLES, Christopher
IPC分类号： A61B1/00
CPC分类号： A61B1/015 , A61B1/00128 , A61B1/00133
摘要： An endoscopic vacuum controller may include a housing having a vacuum inlet, a vacuum outlet configured to be coupled to a vacuum source, and a vacuum passage fluidly coupling the vacuum inlet to the vacuum outlet. The vacuum controller may also include an actuator supported by the housing and configured to control the flow of fluid through the vacuum passage. An indicator may be supported by the housing to provide an indication that a predetermined vacuum level is being drawn at the vacuum inlet. The vacuum controller may include a connector to detachably couple the housing to an endoscope shaft. The connector may be configured to slidably couple the housing to the endoscope shaft to allow adjustment of the controller along the length of the shaft while the housing remains coupled to the shaft.
摘要翻译：内窥镜真空控制器可以包括具有真空入口的壳体，被配置为耦合到真空源的真空出口以及将真空入口流体地耦合到真空出口的真空通道。真空控制器还可以包括由壳体支撑并构造成控制通过真空通道的流体的流动的致动器。指示器可以由壳体支撑以提供在真空入口处正在抽取预定真空水平的指示。真空控制器可以包括用于将壳体可拆卸地联接到内窥镜轴的连接器。连接器可以被配置为将壳体可滑动地联接到内窥镜轴，以允许在壳体保持联接到轴的同时沿着轴的长度来调节控制器。

3. 发明申请

WO2006034117A1 IMPLANTABLE PROSTHESIS FOR SOFT TISSUE REPAIR 审中-公开
标题翻译：软组织修复的可塑性优势
公开(公告)号：WO2006034117A1
公开(公告)日：2006-03-30
申请号：PCT/US2005/033334
申请日：2005-09-19
申请人： DAVOL, INC. , PELISSIER, Edouard , VADURRO, Valerie, L. , CLARKE, Stephen, T. , DAROIS, Roger, E. , HASS, David, W.
发明人： PELISSIER, Edouard , VADURRO, Valerie, L. , CLARKE, Stephen, T. , DAROIS, Roger, E. , HASS, David, W.
IPC分类号： A61F2/00
CPC分类号： A61F2/0063
摘要： An implantable prosthesis (20) for repairing or augmenting anatomical defects, including an inguinal hernia. The prosthesis includes a repair fabric having a body portion (22) and a support member (24) that may be arranged in or on the repair fabric to help deploy the repair fabric at the surgical site and/or help inhibit folding or buckling of the repair fabric. The support member may first and second ends (28, 30) that are spaced apart to form an interruption (32) so that a slit or keyhole arrangement may be formed in the repair fabric through the interruption and into an interior region of the body portion to receive a body structure. A portion of the support member may deviate inwardly toward the body portion to form an indentation (34) that is adapted to be positioned adjacent to a body structure, such as the femoral vessels. The indentation may be offset to one side of the prosthesis.
摘要翻译：一种用于修复或增加解剖缺陷的可植入假体（20），包括腹股沟疝。假体包括具有主体部分（22）和支撑构件（24）的修复织物，其可布置在修复织物中或修复织物上以帮助将修复织物部署在手术部位和/或有助于抑制修复织物的折叠或屈曲维修面料。支撑构件可以间隔开以形成中断（32）的第一和第二端（28,30），使得缝隙或锁眼布置可以通过中断形成在修复织物中并进入主体部分的内部区域接受身体结构。支撑构件的一部分可向内朝向主体部分偏离，以形成适于邻近身体结构（例如股骨血管）定位的凹陷（34）。该凹痕可以偏移到假体的一侧。

4. 发明申请

WO2022211804A1 VIBRATIONAL POWDER APPLICATOR 审中-公开
公开(公告)号：WO2022211804A1
公开(公告)日：2022-10-06
申请号：PCT/US2021/025139
申请日：2021-03-31
申请人： DAVOL INC.
发明人： TREXLER, Jonathan, Bruce , CAULDWELL, Nathan, Stewart , SOWERBY, Oliver , MCLELLAN, Steve , ETHERIDGE, Tom , HERD, Michael , ALLWRIGHT, Julia , BOWLEY, Christopher
IPC分类号： A61M35/00 , B05B7/14 , B05B9/03 , B65D83/06
摘要： Vibrational powder applicators and related methods are disclosed. In some embodiments, a vibrational powder applicator may include a powder storage chamber, a powder (e.g., a therapeutic powder) disposed within the powder storage chamber, an actuator operatively coupled to the powder storage chamber and configured to vibrationally agitate the powder when activated, and an outlet in fluid communication with the powder storage chamber. In some embodiments, a vibrational powder applicator may include a flow restrictor and/or a valve.

5. 发明申请

WO2022146917A1 REACTIVE DRY POWDERED HEMOSTATIC MATERIALS COMPRISING A PROTEIN AND A MULTIFUNCTIONALIZED MODIFIED POLYETHYLENE GLYCOL BASED CROSSLINKING AGENT 审中-公开
公开(公告)号：WO2022146917A1
公开(公告)日：2022-07-07
申请号：PCT/US2021/065204
申请日：2021-12-27
申请人： DAVOL INC.
发明人： GREENAWALT, Keith , STRICKLER, Frederick, H., Jr.
IPC分类号： A61L26/00 , A61L24/00 , A61L24/04
摘要： Compositions and methods related to powdered hemostats that crosslink during and/or after application to a bleeding site are described. The compositions may comprise a first component comprising a multifunctionalized polymeric composition (e.g., multifunctionalized polyethylene glycol) functionalized with electrophilic reactive groups, and a second component that comprises a protein such as albumin. The compositions may in certain applications act as hemostats when applied in dry powder form to a bleeding wound, whereupon the first component and the second component of the composition crosslink to form a hydrogel.

6. 发明申请

WO2020072742A1 SURGICAL PROSTHETIC 审中-公开
公开(公告)号：WO2020072742A1
公开(公告)日：2020-04-09
申请号：PCT/US2019/054439
申请日：2019-10-03
申请人： DAVOL INC.
发明人： GUO, Joshua, Yao
IPC分类号： A61F2/02
摘要： Embodiments disclosed herein relate to prosthetics for augmenting or repairing a tissue defect, such as a ventral or incisional hernia. In some embodiments, a repair prosthetic may include a patch body and a first fastener attached to a first portion of the patch body. A coupler may be attached to and extend from a second portion of the patch body, and a second fastener may be attached to the second portion of the patch body via the coupler. The coupler may be retracted relative to the second portion of the patch body or the second fastener to apply tension to the patch body in some embodiments.

7. 发明申请

WO2008010948A2 METHOD AND APPARATUS FOR SURGICAL FASTENING 审中-公开
标题翻译：手术治疗方法与装置
公开(公告)号：WO2008010948A2
公开(公告)日：2008-01-24
申请号：PCT/US2007/015952
申请日：2007-07-13
申请人： DAVOL INC. , COLESANTI, Anthony , FELIX, Gus , BACHMAN, Alan , ADAMS, Ray , PAUL, Joe , CHESTER, Ed , LEHMAN, Adam , SMITH, Barry , STEIN, Jeff
发明人： COLESANTI, Anthony , FELIX, Gus , BACHMAN, Alan , ADAMS, Ray , PAUL, Joe , CHESTER, Ed , LEHMAN, Adam , SMITH, Barry , STEIN, Jeff
IPC分类号： A61B17/00
CPC分类号： A61B17/064 , A61B17/0642 , A61B17/068 , A61B17/86 , A61B17/864 , A61B2017/0646 , A61B2017/0648
摘要： A surgical fastener system includes a plurality of fasteners having a throughbore with a non-circular cross section portion. The fasteners may engage with a splined mandrel that passes through the throughbore of the fasteners and rotates the fasteners relative to the mandrel to move at least one of the fasteners along the mandrel, e.g., along the mandrel's longitudinal axis. A distal end of the mandrel may be inserted into a material, such as a tissue, prosthetic or other, and a fastener may be deployed from the distal end of the mandrel while the distal end is positioned in the material.
摘要翻译：外科紧固件系统包括多个紧固件，所述紧固件具有带有非ci的通孔

8. 发明申请

WO2022231603A1 TISSUE APERTURE CLOSURE DEVICE 审中-公开
公开(公告)号：WO2022231603A1
公开(公告)日：2022-11-03
申请号：PCT/US2021/030037
申请日：2021-04-30
申请人： DAVOL INC.
发明人： MCCORMICK, Daniel F. , BOYLE, Kevin
IPC分类号： A61B17/04
摘要： A tissue aperture closure device may include more than one suture deployed in multiple directions around a perimeter of a tissue aperture. The sutures may be pulled through a suture lock to tension the sutures and close the tissue aperture. The suture lock may be transitioned between a locked configuration and an unlocked configuration in which the tension of the sutures may be adjusted.

9. 发明申请

WO2022005806A1 MULTI-CHAMBER SYRINGE 审中-公开
公开(公告)号：WO2022005806A1
公开(公告)日：2022-01-06
申请号：PCT/US2021/038398
申请日：2021-06-22
申请人： DAVOL INC.
发明人： TREXLER, Jonathan, Bruce , GRIDER, Keith, A. , BELTON, Antonio
IPC分类号： A61M5/19 , A61M5/315 , A61M5/38 , A61M3/00 , A61C5/64 , A61M2005/3128 , A61M2205/0238 , A61M3/005 , A61M5/178 , A61M5/31511 , B01F33/50112 , B05C17/00596
摘要： Systems and methods for multi-chambered syringes are described. In some embodiments, a multi-chamber syringe includes a housing with an internal cavity and first and second plungers disposed at least partially within the internal cavity. The first and second plungers are slidably displaceable relative to the housing, and are associated with first and second chambers respectively. A barrier is disposed at least partially between the first and second plungers to form the first and second chambers. The barrier is slidably displaceable relative to the plungers and barrel to selectively place the first and second chambers including first and second materials respectively in fluid communication. When the barrier is displaced, the first and second materials mix in a combined volume of the first and second chambers. Displacing the first plunger, the second plunger, and the barrier may dispense the mixed materials from the combined volume.

10. 发明申请

WO2021257501A1 PROSTHETIC REPAIR FABRIC 审中-公开
公开(公告)号：WO2021257501A1
公开(公告)日：2021-12-23
申请号：PCT/US2021/037320
申请日：2021-06-15
申请人： DAVOL INC.
发明人： FELIX, Augustus , LIGEIKIS, Michael
IPC分类号： D04B21/10 , D04B21/12 , A61F2/00 , A61F2/0063 , A61F2002/0068 , D10B2509/08
摘要： The repair fabric includes a dual bar warp knit mesh for use in repairing soft tissue and muscle wall defects, including hernia repair and chest wall reconstruction. The repair fabric may be produced according to a first bar pattern chain of 4/24/64/2 6/8 6/4 6/8 of first filaments and a second bar pattern chain of 6/8 2/06/8 4/2 8/104/2 of second filaments. The diameter of the first filaments being different from the diameter of the second filaments.

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