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1. 发明申请

WO2011036457A1 PEPTIDE CLEARING AGENTS 审中-公开
标题翻译：肽清除剂
公开(公告)号：WO2011036457A1
公开(公告)日：2011-03-31
申请号：PCT/GB2010/001796
申请日：2010-09-23
申请人： MOLOGIC LTD , DAVIS, Paul, James , SCHOUTEN, James, Alexander
发明人： DAVIS, Paul, James , SCHOUTEN, James, Alexander
IPC分类号： A61K47/48 , C07K5/02
CPC分类号： A61K47/48353 , A61K47/549 , A61K47/665 , B82Y5/00 , C07K5/0202
摘要： A peptide clearing agent is provided for clearance of a conjugate of an enzyme and a binding molecule which binds specifically at a target location from a non-target location in a subject. The peptide clearing agent binds the active site of the enzyme. The peptide also binds to the asialoglycoprotein receptor expressed by hepatic cells to facilitate clearance through the liver. The peptide may be glycosylated to facilitate clearance through the liver by binding to hepatic cells expressing an asialoglycoprotein receptor. Typically, the peptide prevents or inhibits enzyme activity upon binding to the enzyme and is not substantially modified by the enzyme activity. The peptide may be based upon the dipeptide amino-naphthoic acid (ANA) - glutamate (GIu) and may comprise the amino acid sequence serine (Ser) - Alanine (Ala) - amino-naphthoic acid (ANA) - glutamate (GIu). In such cases, the enzyme of interest is typically CPG2.
摘要翻译：提供肽清除剂用于清除酶和结合分子的缀合物，所述结合物与目标位置特异性地结合在受试者的非目标位置。肽清除剂结合酶的活性位点。肽还结合肝细胞表达的脱唾液酸糖蛋白受体，以促进通过肝脏的清除。肽可以被糖基化以促进通过结合表达脱唾液酸糖蛋白受体的肝细胞通过肝脏的清除。通常，肽在结合酶时预防或抑制酶活性，并且基本上不被酶活性修饰。肽可以基于二肽氨基 - 萘甲酸（ANA） - 谷氨酸（Glu），并且可以包含氨基酸序列丝氨酸（Ser） - 丙氨酸（Ala） - 氨基 - 萘甲酸（ANA） - 谷氨酸（Glu）。在这种情况下，感兴趣的酶通常是CPG2。

2. 发明申请

WO2010063996A3 ANTIBACTERIAL COMPOUNDS 审中-公开
标题翻译：抗菌化合物
公开(公告)号：WO2010063996A3
公开(公告)日：2010-12-29
申请号：PCT/GB2009002792
申请日：2009-12-01
申请人： SUMMIT CORP PLC , WILSON FRANCIS XAVIER , JOHNSON PETER DAVID , VICKERS RICHARD , STORER RICHARD , WYNNE GRAHAM MICHAEL , ROACH ALAN GEOFFREY , DE MOOR OLIVIER , DORGAN COLIN RICHARD , DAVIS PAUL JAMES
发明人： WILSON FRANCIS XAVIER , JOHNSON PETER DAVID , VICKERS RICHARD , STORER RICHARD , WYNNE GRAHAM MICHAEL , ROACH ALAN GEOFFREY , DE MOOR OLIVIER , DORGAN COLIN RICHARD , DAVIS PAUL JAMES
IPC分类号： C07D235/18 , A61K31/4184 , A61P31/04 , C07D401/14
CPC分类号： A61K31/444 , A61K31/4439 , C07D235/18 , C07D401/14
摘要： Disclosed are compounds of formula (I), which are of use in the treatment of bacterial diseases and infections, to compositions containing those compounds and to methods of treating bacterial diseases and infections using the compounds. In particular, the compounds are useful for the treatment of infection with, and diseases caused by, Clostridium difficile.
摘要翻译：公开了用于治疗细菌性疾病和感染的式（I）化合物，含有这些化合物的组合物以及使用该化合物治疗细菌性疾病和感染的方法。特别地，这些化合物可用于治疗由艰难梭菌引起的感染和疾病。

3. 发明申请

WO2008009925A2 HYDROGEN PEROXIDE DELIVERY SYSTEM 审中-公开
标题翻译：过氧化氢输送系统
公开(公告)号：WO2008009925A2
公开(公告)日：2008-01-24
申请号：PCT/GB2007/002706
申请日：2007-07-18
申请人： INSENSE LIMITED , DAVIS, Paul, James , AUSTIN, Andrew, John
发明人： DAVIS, Paul, James , AUSTIN, Andrew, John
IPC分类号： A61L15/24 , A61L15/44 , A61L15/46 , A61L15/60
CPC分类号： A61L15/44 , A61L15/24 , A61L15/46 , A61L15/60 , C08L29/04
摘要： A delivery system, e.g. a skin dressing, comprising an upper component, comprising hydrogen peroxide, and a lower component in hydrated condition, such that when the upper and lower components are placed in contact with each other, hydrogen peroxide migrates towards the lower component is provided.
摘要翻译：传送系统，例如传送系统皮肤敷料，其包含含有过氧化氢的上部组分和含水状态的下部组分，使得当上部和下部组分彼此接触时，提供过氧化氢向下部组分迁移。

4. 发明申请

WO2004064881A1 SKIN TREATMENT FORMULATIONS 审中-公开
标题翻译：皮肤治疗配方
公开(公告)号：WO2004064881A1
公开(公告)日：2004-08-05
申请号：PCT/GB2004/000179
申请日：2004-01-21
申请人： INSENSE LIMITED , DAVIS, Paul, James , AUSTIN, Andrew, John
发明人： DAVIS, Paul, James , AUSTIN, Andrew, John
IPC分类号： A61L24/00
CPC分类号： A61L24/0015 , A61L15/46 , A61L2300/11 , A61L2300/404
摘要： A skin treatment formulation, e.g. in the form of an ointment or gel or a skin dressing, comprises a photocatalytic agent, e.g. flavine mononucleotide, and an electron donor substance, e.g. ethylene diamine tetra acetic acid, conveniently in the form of an agar gel (10). On exposure to light in the presence of oxygen (e.g. from the ambient atmosphere) the photocatalytic agent acts to cause conversion of oxygen to hydrogen peroxide. If this reaction occurs on or in the vicinity of skin, the hydrogen peroxide so produced can have a localised antibacterial effect. By controlling exposure to light, so hydrogen peroxide can be generated in situ in the vicinity of skin in a way that has not hitherto been possible.
摘要翻译：皮肤处理制剂，例如以软膏或凝胶或皮肤敷料的形式，包含光催化剂，例如，黄烷单核苷酸和电子供体物质，例如，乙二胺四乙酸，方便地以琼脂（10）的形式存在。在氧气存在下（例如从环境气氛中）暴露于光时，光催化剂起氧气作用，导致氧气转化为过氧化氢。如果该反应发生在皮肤上或皮肤附近，则如此产生的过氧化氢可具有局部抗菌作用。通过控制暴露于光，因此过氧化氢可以以迄今为止尚未成形的方式在皮肤附近原地产生。

5. 发明申请

WO2003056292A2 DETECTION OF ODOURS 审中-公开
标题翻译：检测气味
公开(公告)号：WO2003056292A2
公开(公告)日：2003-07-10
申请号：PCT/GB2002/005879
申请日：2002-12-20
申请人： INSENSE LIMITED , DAVIS, Paul, James , WADHAMS, Lester , BAYLISS, Justin, Sheldon
发明人： DAVIS, Paul, James , WADHAMS, Lester , BAYLISS, Justin, Sheldon
IPC分类号： G01N
CPC分类号： G01N33/0047 , G01N33/0057
摘要： Apparatus for detecting a specific target odour comprises: a detector unit adapted to have removably associated therewith a holding unit for housing at least one insect in a predetermined position; means for exposing an insect in a holding unit associated with the detector unit to a sample of gas to be tested; and means for enabling monitoring of a response of the insect to the sample thereby to detect a response indicative of the target odour. In use of the apparatus, a holding unit housing at lest one insect that responds in a detectable manner to the target odour is associated with the detector unit. A sample of gas to be tested is supplied to the apparatus, for exposure to the insect or insects in the holding unit. The insect is monitored for a response indicative of the target odour, thus enabling determination as to whether or not the target odour is present in the sample. Because the holding unit is not part of the detector unit but is removably associated with therewith, the holding unit can be used to transport an insect or insects housed therein from a first, remote location, e.g. where insects are raised and conditioned, to a point of use at a second location where the detector unit is located. The detector unit may be a permanent or semi-permanent fixture at a point of use, or may be in the form of a portable unit. Also disclosed is a method of detecting a specific target odour.
摘要翻译：用于检测特定目标气味的装置包括：检测器单元，其适于具有可移除地与其相关联的保持单元，用于将至少一个昆虫容纳在预定位置，用于将与所述检测器单元相关联的保持单元中的昆虫暴露于气体样本被测试和用于使得能够监测昆虫对样品的响应的装置，从而检测到指示目标气味的响应。在使用该装置时，将至少一个以可检测的方式响应于目标气味的昆虫的保持单元与检测器单元相关联。将待测试的气体样品供应给设备，用于暴露在保持单元中的昆虫或昆虫。监测昆虫的指示目标气味的响应，从而能够确定样品中目标气味是否存在。由于保持单元不是检测器单元的一部分，而是与其可拆卸地相关联，所以保持单元可以用于从第一远程位置（例如，第二位置）运送容纳在其中的昆虫或昆虫。其中昆虫被升起和调节，到达检测器单元所在的第二位置处的使用点。检测器单元可以是在使用点处的永久或半永久性固定装置，或者可以是便携式装置的形式。还公开了检测特定目标气味的方法。

6. 发明申请

WO2003055301A3 INSECT HOLDER 审中-公开
公开(公告)号：WO2003055301A3
公开(公告)日：2003-07-10
申请号：PCT/GB2002/005880
申请日：2002-12-20
申请人： INSENSE LIMITED , DAVIS, Paul, James , TOMKINS, Peter, William , CHERRY, Kenneth, Alan , BAYLISS, Justin, Sheldon
发明人： DAVIS, Paul, James , TOMKINS, Peter, William , CHERRY, Kenneth, Alan , BAYLISS, Justin, Sheldon
IPC分类号： A01K49/00
摘要： An insect holder for holding an insect of a particular type, e.g. a forager honey bee, comprises a housing with a chamber adapted to receive an insect of the particular type, an inlet to the chamber through which an insect of the particular type can pass to enter the chamber, a head opening to the chamber adapted to permit the head of an insect of the particular type in the chamber to pass therethrough to the exterior of the housing while retaining the insect in the housing, and retaining means for retaining an insect of the particular type in the chamber with the head of the insect protruding through the head opening to the exterior of the housing, such that the insect is unable to turn around in the chamber. In use, an insect of the particular type enters the chamber via the inlet, and is then retained in the holder by the retaining means. The insect is retained in the chamber, with its head protruding through the head opening of the chamber. The insect is constrained to be unable to turn around in the chamber or withdraw its head into the chamber, so the head of the insect must remain outside the chamber. The insect is thus held in the holder with the head visible, so that observations can be made on the insect head, e.g. monitoring proboscis movement in known manner. When observations are finished, the retaining means can be removed or deactivated so that the insect is able to leave the chamber, with the insect unharmed and undamaged.

7. 发明申请

WO1997014719A1 A BIFUNCTIONAL OR BIVALENT ANTIBODY FRAGMENT ANALOGUE 审中-公开
标题翻译：双功能或双重抗体片段模拟
公开(公告)号：WO1997014719A1
公开(公告)日：1997-04-24
申请号：PCT/EP1996003605
申请日：1996-08-14
申请人： UNILEVER N.V. , UNILEVER PLC , DAVIS, Paul, James , VAN DER LOGT, Cornelis, Paul, Erik , VERHOEIJEN, Martine, Elisa , WILSON, Steve
发明人： UNILEVER N.V. , UNILEVER PLC
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , C07K16/00 , C07K2319/00
摘要： The invention relates to a bispecific or bivalent antibody fragment analogue comprising a binding complex containing two polypeptide chains, whereby one polypeptide chain comprises two heavy chain variable domains (VH) in series and the other polypeptide chain comprises two light chain variable domains (VL) in series, the binding complex further containing two pairs of variable domains (VH-A//VL-A and VH-B//VL-B). The two VH's and/or the two VL's are connected directly or via an intermediate peptide linker. Also a production method for such antibody fragment analogues is disclosed.
摘要翻译：本发明涉及包含含有两条多肽链的结合复合物的双特异性或二价抗体片段类似物，其中一个多肽链包含两个串联的重链可变结构域（VH），另一个多肽链包含两个轻链可变结构域（VL）系列，还包含两对可变结构域（VH-A // VL-A和VH-B // VL-B）的结合复合体。两个VH和/或两个VL直接连接或通过中间肽接头连接。还公开了这种抗体片段类似物的制备方法。

8. 发明申请

WO1986001899A1 PROCESSES AND MATERIALS FOR CARRYING OUT SPECIFIC BINDING ASSAYS 审中-公开
标题翻译：执行特定绑定测试的过程和材料
公开(公告)号：WO1986001899A1
公开(公告)日：1986-03-27
申请号：PCT/GB1985000428
申请日：1985-09-16
申请人： UNILEVER PLC , UNILEVER NV , DAVIS, Paul, James , BOSLEY, John, Anthony
发明人： UNILEVER PLC , UNILEVER NV
IPC分类号： G01N33/53
CPC分类号： G01N33/581 , G01N33/53 , G01N33/54306 , G01N33/582 , G01N33/583
摘要： A process for carrying out a label-linked specific binding assay, e.g. an immunoassay, comprising the steps of: providing in an aqueous reaction zone a member of a specific binding pair to participate in the assay, linked to a label which either is a first coreagent which is reactive with a second coreagent in a reaction to produce a detectable assay result, or is a generator of said coreagent; providing a dispersed quantity of said second coreagent in said reaction, or of a generator of said coreagent, within a discretely bounded zone adjacent to said aqueous reaction zone and formed by a zone-forming carrier material, which also carries in immobilised form a member of said specific binding pair; providing in said aqueous reaction zone a consumer of one of said coreagents in said reaction, thereby to ensure the substantial absence of said coreagent in said aqueous reaction zone; wherein said discretely bounded zone comprises a barrier sufficient to prevent entry of the consumer reagent from said aqueous reaction zone into the bounded zone, thereby to separate the consumer reagent from the dispersed quantity of second coreagent or generator thereof in the bounded zone; and allowing the specific binding reactions to take place whereby the assay reaction results in the binding of a variable quantity, dependent on the quantity of labelled member of said specific binding pair directly or indirectly to said immobilised specific binding material, so that said detectable assay result is produced by reaction of bound label or said coreagent generated by said bound label with said coreagent in said bounded zone.

9. 发明申请

WO2010063996A2 ANTIBACTERIAL COMPOUNDS 审中-公开
标题翻译：抗菌化合物
公开(公告)号：WO2010063996A2
公开(公告)日：2010-06-10
申请号：PCT/GB2009/002792
申请日：2009-12-01
申请人： SUMMIT CORPORATION PLC , WILSON, Francis, Xavier , JOHNSON, Peter, David , VICKERS, Richard , STORER, Richard , WYNNE, Graham, Michael , ROACH, Alan, Geoffrey , DE MOOR, Olivier , DORGAN, Colin, Richard , DAVIS, Paul, James
发明人： WILSON, Francis, Xavier , JOHNSON, Peter, David , VICKERS, Richard , STORER, Richard , WYNNE, Graham, Michael , ROACH, Alan, Geoffrey , DE MOOR, Olivier , DORGAN, Colin, Richard , DAVIS, Paul, James
IPC分类号： C07D235/18 , C07D401/14 , A61K31/4184 , A61P31/04
CPC分类号： A61K31/444 , A61K31/4439 , C07D235/18 , C07D401/14 , Y02A50/473
摘要： Disclosed are compounds of formula (I), which are of use in the treatment of bacterial diseases and infections, to compositions containing those compounds and to methods of treating bacterial diseases and infections using the compounds. In particular, the compounds are useful for the treatment of infection with, and diseases caused by, Clostridium difficile.
摘要翻译：公开了用于治疗细菌疾病和感染的式（I）化合物，含有这些化合物的组合物以及使用该化合物治疗细菌疾病和感染的方法。特别是，这些化合物可用于治疗由艰难梭菌引起的感染和疾病。

10. 发明申请

WO2010057833A1 COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY 审中-公开
标题翻译：用于治疗杜邦肌肉晶状体的化合物
公开(公告)号：WO2010057833A1
公开(公告)日：2010-05-27
申请号：PCT/EP2009/065118
申请日：2009-11-13
申请人： BioMarin IGA, Ltd. , WREN, Stephen Paul , WYNNE, Graham Michael , LECCI, Cristina , WILSON, Francis Xavier , DAVIS, Paul James
发明人： WREN, Stephen Paul , WYNNE, Graham Michael , LECCI, Cristina , WILSON, Francis Xavier , DAVIS, Paul James
IPC分类号： C07D213/64 , C07D213/70 , C07D213/74 , C07D213/75 , C07D239/42 , A61P21/00 , A61K31/44 , C07D409/04 , C07D213/643 , A61K31/443 , A61K31/4436 , A61K31/444 , A61K31/505 , C07D405/04 , C07D405/12
CPC分类号： C07D213/64 , C07D213/643 , C07D213/70 , C07D213/74 , C07D213/75 , C07D239/42 , C07D405/04 , C07D405/12 , C07D409/04
摘要： Compounds of formula (I): wherein R 1 , R 2 , R 3 , L 1 , L 2 , and Y are as defined herein, are useful for the treatment or prophylaxis of conditions such as Duchenne muscular dystrophy, Becker muscular dystrophy, and cachexia.
摘要翻译：式（I）化合物：其中R1，R2，R3，L1，L2和Y如本文所定义，可用于治疗或预防诸如杜氏肌营养不良症，贝克肌营养不良症和恶病质之类的病症。

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