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1. 发明申请

WO2006001944A1 SUBSTITUTED AZAPORPHYRINS AS FLUORESCENCE LABELS 审中-公开
标题翻译：作为荧光标记的替代吡唑并吡啶
公开(公告)号：WO2006001944A1
公开(公告)日：2006-01-05
申请号：PCT/US2005/017352
申请日：2005-05-18
申请人： HERETH, Hannjorg , DANDLIKER, Walter, B. , HSU, Mao, Lin , MURPHY, William, P., Jr.
发明人： DANDLIKER, Walter, B. , HSU, Mao, Lin , MURPHY, William, P., Jr.
IPC分类号： C07H21/02
CPC分类号： C07D487/22 , C07H21/04 , G01N33/582 , Y10S435/968
摘要： The present invention relates to marker components, fluorescent probes, oligonucleotides, hybridization assays, and immunoassays using such products, and methods for making such products. According to the present invention, detectably labeled marker components are provided that comprise a fluorescent moiety coupled to two small solubilizing groups, one on each side of the molecular plane, said fluorescent moiety having substituents to control net charge so as to reduce or remove the problems of solvent sensitivity and nonspecific binding.
摘要翻译：本发明涉及标记组分，荧光探针，寡核苷酸，杂交测定和使用这些产品的免疫测定，以及制备这些产品的方法。根据本发明，提供了可检测标记的标记组分，其包含与分子平面每侧一个的两个小增溶基团连接的荧光部分，所述荧光部分具有用于控制净电荷的取代基，以减少或消除问题的溶剂敏感性和非特异性结合。

2. 发明申请

WO0031187A9 WATER SOLUBLE FLUORESCENT DYES FREE OF AGGREGATION AND SERUM BINDING AND RELATED PRODUCTS AND METHODS 审中-公开
标题翻译：不含聚集物和血清结合相关产品和方法的水溶性荧光染料
公开(公告)号：WO0031187A9
公开(公告)日：2000-11-30
申请号：PCT/US9926983
申请日：1999-11-12
申请人： HYPERION INC , DANDLIKER WALTER B , HSU MAO LIN
发明人： DANDLIKER WALTER B , HSU MAO LIN
IPC分类号： G01N21/64 , C07D487/22 , C09B47/00 , C09B47/06 , C09B47/08 , G01N33/533 , G01N33/543 , G01N33/566 , G01N33/58 , C09B47/04
CPC分类号： C09B47/00 , C09B47/065 , C09B47/08
摘要： The present invention thus relates to marker components, fluorescent probes, oligonucleotides, hybridization assays, and immunoassays using such products and methods for making such products. According to the present invention, detectably labeled marker components are provided that comprise a fluorophore moiety coupled to two or more small solubilizing axial ligands, [define] which preferably reduce or remove the problems of solvent sensitivity and non-specific binding.
摘要翻译：因此，本发明涉及标记物组分，荧光探针，寡核苷酸，杂交分析和使用这些产物的免疫分析以及制备这些产物的方法。根据本发明，提供了可检测地标记的标记物组分，其包含与两个或更多个小溶解性轴向配体偶联的荧光团部分，[优选地]减少或消除溶剂敏感性和非特异性结合的问题。

3. 发明申请

WO9966915A3 THERAPEUTIC APPLICATIONS OF ESTROGENIC CARBOXYLIC ACIDS 审中-公开
标题翻译：雌激素羧酸的治疗应用
公开(公告)号：WO9966915A3
公开(公告)日：2000-06-15
申请号：PCT/US9913940
申请日：1999-06-22
申请人： SOUTHERN ILLINOIS UNIVERSITY A , ADLER STUART R , DANDLIKER WALTER B
发明人： ADLER STUART R , DANDLIKER WALTER B , MEYERS CAL Y , BANZ WILLIAM J , WINTERS TODD A , YUQING HOU
IPC分类号： A61K31/19
CPC分类号： A61K31/19
摘要： Provided are methods employing estrogenic compounds for: repressing weight gain or reducing weight in male patients; treating or preventing prostate cancer and peri- or post-menopausal symptoms; treating estrogen-responsive conditions that no longer respond to treatment with conventional steroidal estrogens; treating or preventing estrogen-responsive uterine cancer, breast cancer, and ovarian follicle atresia; inducing ovulation to increase fertility; oral contraception; treating or preventing diseases or conditions caused or prolonged by free radicals; treating or preventing cardiovascular disease, hyperlipidemia or hypercholesterolemia, and hyperglycemia; improving body fat distribution; and treating or preventing Alzheimer's disease, osteoporosis, and pattern baldness. Also provided are methods for treating or preventing prostatic diseases including benign prostate hyperplasia and other related conditions, androgen-responsive pathological conditions in males, and methods for male birth control and chemical castration, employing estrogenic carboxylic acids.
摘要翻译：提供使用雌激素化合物的方法：抑制男性患者的体重增加或减轻体重; 治疗或预防前列腺癌和绝经后或绝经后症状; 治疗不再响应于常规甾体雌激素治疗的雌激素反应性病症; 治疗或预防雌激素反应性子宫癌，乳腺癌和卵巢卵泡闭锁; 诱导排卵增加生育能力; 口服避孕药治疗或预防由自由基引起或延长的疾病或病症; 治疗或预防心血管疾病，高脂血症或高胆固醇血症和高血糖症; 改善身体脂肪分布; 以及治疗或预防阿尔茨海默病，骨质疏松症和模式秃发。还提供了用于治疗或预防前列腺疾病的方法，包括良性前列腺增生和其他相关病症，男性的雄激素反应性病理状况，以及使用雌激素羧酸的男性避孕和化学阉割的方法。

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