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1. 发明申请

WO2007046811A2 DIAGNOSTIC MARKERS OF STROKE AND CEREBRAL INJURY AND METHODS OF USE THEREOF 审中-公开
标题翻译：诊断和颅脑损伤的诊断标记及其使用方法
公开(公告)号：WO2007046811A2
公开(公告)日：2007-04-26
申请号：PCT/US2005/038225
申请日：2005-10-20
申请人： BIOSITE, INC. , VALKIRS, Gunars, E. , DAHLEN, Jeffrey, R. , KIRCHICK, Howard, J. , BUECHLER, Kenneth, F.
发明人： VALKIRS, Gunars, E. , DAHLEN, Jeffrey, R. , KIRCHICK, Howard, J. , BUECHLER, Kenneth, F.
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2871
摘要： The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.
摘要翻译：本发明涉及中风和短暂性脑缺血发作的诊断和评估方法。公开了用于组装用于这种诊断和评估的面板的各种标记。在各个方面，本发明提供了用于早期检测和分化卒中类型和短暂性脑缺血发作的方法，用于确定患有中风症状的患者的预后，以及鉴定患有脑血管痉挛风险的患者。本发明方法提供快速，灵敏和特异性的测定以大大增加可以接受有益的中风治疗和治疗的患者的数量，并且降低与不正确的中风诊断相关的成本。

2. 发明申请

WO2005033327A3 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF SEPSIS 审中-公开
标题翻译： SEPSIS诊断的方法和组合
公开(公告)号：WO2005033327A3
公开(公告)日：2006-08-17
申请号：PCT/US2004031769
申请日：2004-09-27
申请人： BIOSITE INC , VALKIRS GUNARS E , DAHLEN JEFFREY R , KIRCHICK HOWARD J , BUECHLER KENNETH F
发明人： VALKIRS GUNARS E , DAHLEN JEFFREY R , KIRCHICK HOWARD J , BUECHLER KENNETH F
IPC分类号： C12Q1/00 , C12Q20060101 , C12Q1/68 , G01N33/00 , G01N33/53 , G01N33/554 , G01N33/569 , G01N33/68
CPC分类号： G01N33/6893 , G01N2800/26
摘要： The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, and/or septic shock from each other and/or from non-infectious SIRS.
摘要翻译：本发明涉及用于基于症状的鉴别诊断，预后和测定受试者治疗方案的方法和组合物。特别地，本发明涉及选择用于排除或排除SIRS的方法和组合，或用于区分败血症，严重败血症和/或败血性休克和/或非传染性SIRS。

3. 发明申请

WO2005033327A2 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF SEPSIS 审中-公开
标题翻译：用于诊断SEPSIS的方法和组合
公开(公告)号：WO2005033327A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/031769
申请日：2004-09-27
申请人： BIOSITE INCORPORATED , VALKIRS, Gunars, E. , DAHLEN, Jeffrey, R. , KIRCHICK, Howard, J. , BUECHLER, Kenneth, F.
发明人： VALKIRS, Gunars, E. , DAHLEN, Jeffrey, R. , KIRCHICK, Howard, J. , BUECHLER, Kenneth, F.
IPC分类号： C12Q
CPC分类号： G01N33/6893 , G01N2800/26
摘要： The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, and/or septic shock from each other and/or from non-infectious SIRS.
摘要翻译：本发明涉及用于受试者的基于症状的鉴别诊断，预后和治疗方案的方法和组合物。特别地，本发明涉及选择用于规定SIRS或外源性SIRS的方法和组合，或用于分化脓毒病，严重败血症和/或败血性休克和/或非传染性SIRS。

4. 发明申请

WO2004058055A3 METHOD AND SYSTEM FOR DISEASE DETECTION USING MARKER COMBINATIONS 审中-公开
标题翻译：使用标记组合进行疾病检测的方法和系统
公开(公告)号：WO2004058055A3
公开(公告)日：2005-04-07
申请号：PCT/US0341426
申请日：2003-12-23
申请人： BIOSITE INC , ANDERBERG JOSEPH MICHAEL , BUECHLER KENNETH F , MCPHERSON PAUL H , KIRCHICK HOWARD J , DAHLEN JEFFREY R
发明人： ANDERBERG JOSEPH MICHAEL , BUECHLER KENNETH F , MCPHERSON PAUL H , KIRCHICK HOWARD J , DAHLEN JEFFREY R
IPC分类号： A61B20060101 , G01N33/48 , G01N33/68
CPC分类号： G01N33/6803
摘要： The present invention relates to methods and system for the diagnosis diseases or conditions. In a particular aspect, a disclosed method for determining a panel includes calculating a panel response for each patient in a set of diseased patients and in a set of non-diseased patients. The panel response is a function of the value of each of a plurality of markers in a panel of markers. The method also includes calculating a value for an objective function. The objective function is indicative of the effectiveness of the panel. The steps of calculating a panel response for each patient and calculating a value for an objective function are iterated by varying at least one of the parameters relating to the panel response function and a sense of each marker to facilitate optimization of the objective function. The objective function may be a measure of an overlap of panel responses of diseased patients and panel responses of non-diseased patients. The contribution of each marker to the objective function may be determined, and the panel size may be reduced by removing the poorest markers. Thus, an optimum panel of markers and an optimal panel response function for the diagnosis of a disease or condition may be determined.
摘要翻译：本发明涉及用于诊断疾病或病症的方法和系统。在特定方面，公开的用于确定面板的方法包括计算一组患病患者和一组非患病患者中的每个患者的面板响应。面板响应是一组标记中的多个标记中的每一个的值的函数。该方法还包括计算目标函数的值。目标函数表明该小组的有效性。通过改变与面板响应函数相关的参数中的至少一个参数和每个标记的感觉以便于目标函数的优化来迭代计算每个患者的面板响应并计算目标函数的值的步骤。目标函数可以是患病患者的面板反应和非患病患者的面板反应的重叠的度量。可以确定每个标记对目标函数的贡献，并且可以通过去除最差的标记来减少面板尺寸。因此，可以确定用于诊断疾病或病症的最佳标记组和最佳面板响应函数。

5. 发明申请

WO2003016910A1 DIAGNOSTIC MARKERS OF STROKE AND CEREBRAL INJURY AND METHODS OF USE THEREOF 审中-公开
标题翻译：诊断和颅脑损伤的诊断标记及其使用方法
公开(公告)号：WO2003016910A1
公开(公告)日：2003-02-27
申请号：PCT/US2002/026604
申请日：2002-08-20
申请人： BIOSITE, INC. , VALKIRS, Gunars, E. , DAHLEN, Jeffrey, R. , BUECHLER, Kenneth, F. , KIRCHICK, Howard, J.
发明人： VALKIRS, Gunars, E. , DAHLEN, Jeffrey, R. , BUECHLER, Kenneth, F. , KIRCHICK, Howard, J.
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N33/573 , G01N2333/96486 , G01N2800/2871 , Y10S436/811
摘要： The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. In a particular aspect, patient samples are analyzed for the presence or amount of a panel of markers comprising one or more specific markers for cerebral injury and one or more non-specific markers for cerebral injury. In an alternative aspect, samples are analyzed for B-type natriuretic peptide. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.
摘要翻译：本发明涉及中风和短暂性脑缺血发作的诊断和评估方法。在特定方面，分析患者样品的一组标志物的存在或量，其包含一种或多种用于脑损伤的特异性标志物和一种或多种用于脑损伤的非特异性标志物。在另一方面，分析B型利尿钠肽的样品。公开了用于组装用于这种诊断和评估的面板的各种标记。在各个方面，本发明提供了用于早期检测和分化卒中类型和短暂性脑缺血发作的方法，用于确定患有中风症状的患者的预后，以及鉴定患有脑血管痉挛风险的患者。本发明方法提供快速，灵敏和特异性的测定以大大增加可以接受有益的中风治疗和治疗的患者的数量，并且降低与不正确的中风诊断相关的成本。

6. 发明申请

WO02089657A3 DIAGNOSTIC MARKERS OF ACUTE CORONARY SYNDROMES AND METHODS OF USE THEREOF 审中-公开
标题翻译：急性冠状动脉综合征的诊断标记及其使用方法
公开(公告)号：WO02089657A3
公开(公告)日：2003-02-27
申请号：PCT/US0214219
申请日：2002-05-04
申请人： BIOSITE INC , VALKIRS GUNARS E , DAHLEN JEFFREY R , KIRCHICK HOWARD , BUECHLER KENNETH F
发明人： VALKIRS GUNARS E , DAHLEN JEFFREY R , KIRCHICK HOWARD , BUECHLER KENNETH F
IPC分类号： C12N15/09 , C12Q1/25 , C12Q1/37 , C12Q1/48 , C12Q1/50 , C12Q1/527 , C12Q1/533 , C12Q1/70 , G01N33/53 , G01N33/68 , A61K38/00
CPC分类号： G01N33/53 , G01N33/6887 , G01N33/6893 , G01N2333/58 , G01N2800/324
摘要： The present invention relates to methods for the diagnosis and evaluation of acute coronary syndromes. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for myocardial injury and one or more non-specific markers for myocardial injury. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. In various aspects, the invention provides methods for the early detection and differentiation of stable angina, unstable angina, and myocardial infarction. Invention methods provide rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, reduce the costs associated with incorrect diagnosis, and provide important information about the prognosis of the patient.
摘要翻译：本发明涉及急性冠脉综合征的诊断和评估方法。特别地，分析患者测试样品中包含一个或多个心肌损伤特异性标志物和一个或多个非特异性心肌损伤标记物的标记组的成员的存在和量。公开了用于组装用于这种诊断和评价的标记物的各种标记。在各方面，本发明提供了用于早期检测和分化稳定性心绞痛，不稳定心绞痛和心肌梗死的方法。本发明的方法提供快速，灵敏和特异性的测定，其可以大大增加可以接受有益治疗和治疗的患者数量，降低与错误诊断相关的成本，并提供有关患者预后的重要信息。

7. 发明申请

WO2002089657A2 DIAGNOSTIC MARKERS OF ACUTE CORONARY SYNDROMES AND METHODS OF USE THEREOF 审中-公开
标题翻译：急性冠状动脉综合征的诊断标记及其使用方法
公开(公告)号：WO2002089657A2
公开(公告)日：2002-11-14
申请号：PCT/US2002/014219
申请日：2002-05-04
申请人： BIOSITE, INC. , VALKIRS, Gunars, E. , DAHLEN, Jeffrey, R. , KIRCHICK, Howard , BUECHLER, Kenneth, F.
发明人： VALKIRS, Gunars, E. , DAHLEN, Jeffrey, R. , KIRCHICK, Howard , BUECHLER, Kenneth, F.
IPC分类号： A61B
CPC分类号： G01N33/53 , G01N33/6887 , G01N33/6893 , G01N2333/58 , G01N2800/324
摘要： The present invention relates to methods for the diagnosis and evaluation of acute coronary syndromes. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for myocardial injury and one or more non-specific markers for myocardial injury. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. In various aspects, the invention provides methods for the early detection and differentiation of stable angina, unstable angina, and myocardial infarction. Invention methods provide rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, reduce the costs associated with incorrect diagnosis, and provide important information about the prognosis of the patient.
摘要翻译：本发明涉及急性冠脉综合征的诊断和评估方法。特别地，分析患者测试样品中包含一个或多个心肌损伤特异性标志物和一个或多个非特异性心肌损伤标记物的标记组的成员的存在和量。公开了用于组装用于这种诊断和评价的标记物的各种标记。在各方面，本发明提供了用于早期检测和分化稳定性心绞痛，不稳定心绞痛和心肌梗死的方法。本发明的方法提供快速，灵敏和特异性的测定，其可以大大增加可以接受有益治疗和治疗的患者数量，降低与错误诊断相关的成本，并提供关于患者预后的重要信息。

8. 发明申请

WO2004059293A3 MARKERS FOR DIFFERENTIAL DIAGNOSIS AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于差异诊断的标记及其使用方法
公开(公告)号：WO2004059293A3
公开(公告)日：2005-03-31
申请号：PCT/US0341453
申请日：2003-12-23
申请人： BIOSITE INC , BUECHLER KENNETH F , MAISEL ALAN , ANDERBERG JOSEPH MICHAEL , MCPHERSON PAUL H , DAHLEN JEFFREY R , KIRCHICK HOWARD J
发明人： BUECHLER KENNETH F , MAISEL ALAN , ANDERBERG JOSEPH MICHAEL , MCPHERSON PAUL H , DAHLEN JEFFREY R , KIRCHICK HOWARD J
IPC分类号： C12Q1/68 , G01N33/68 , C12Q1/70
CPC分类号： G01N33/6887 , C12Q1/6883 , G01N2333/4737 , G01N2333/475 , G01N2333/52 , G01N2333/58 , G01N2333/9123 , G01N2333/96486 , G01N2333/974 , G01N2800/2871
摘要： The present invention provides methods for the identification and use of diagnostic markers for differential diagnosis of diseases and/or conditions. In a various aspects, the invention relates to methods and compositions able to determine the presence or absence of one, and preferably a plurality, of diseases or conditions that exhibit one or more similar or identical symptoms. Such methods and compositions can be used to provide assays and assay devices for use in determining the disease or condition underlying one or more non-specific symptoms exhibited in a clinical setting.
摘要翻译：本发明提供用于识别和使用用于疾病和/或病症鉴别诊断的诊断标记物的方法。在各个方面，本发明涉及能够确定呈现一种或多种相似或相同症状的一种，优选多种疾病或病症的存在或不存在的方法和组合物。这样的方法和组合物可用于提供用于确定临床环境中显示的一种或多种非特异性症状的疾病或病症的测定和测定装置。

9. 发明申请

WO2002083913A1 USE OF B-TYPE NATRIURETIC PEPTIDE AS A PROGNOSTIC INDICATOR IN ACUTE CORONARY SYNDROMES 审中-公开
标题翻译：在急性冠状动脉综合征中使用B型鼻塞肽作为预防指标
公开(公告)号：WO2002083913A1
公开(公告)日：2002-10-24
申请号：PCT/US2002/011441
申请日：2002-04-11
申请人： BIOSITE DIAGNOSTICS, INC. , DAHLEN, Jeffrey, R. , VALKIRS, Gunars, E. , BUECHLER, Kenneth, F.
发明人： DAHLEN, Jeffrey, R. , VALKIRS, Gunars, E. , BUECHLER, Kenneth, F.
IPC分类号： C12P19/34
CPC分类号： G01N33/6887 , G01N33/6893 , G01N2333/58 , G01N2800/324
摘要： The present invention relates to materials and procedures for evaluating the prognosis of patients suffering from acute coronary syndromes. In particular, the level of BNP, or a marker related to BNP, in a patient sample, alone or in combination with one or more other prognostic markers, provides prognostic information useful for predicting near-term morbidity and/or mortality across the entire spectrum of acute coronary syndromes, including unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.
摘要翻译：本发明涉及用于评估患有急性冠状动脉综合征的患者的预后的材料和程序。特别地，在患者样品中单独或与一种或多种其他预后标志物组合的BNP或与BNP相关的标志物的水平提供了可用于预测整个频谱中的近期发病率和/或死亡率的预后信息急性冠状动脉综合征，包括不稳定型心绞痛，非ST段抬高型非Q波心肌梗死，ST段抬高型非Q波心肌梗死和透壁（Q波）MI。

10. 发明申请

WO2007046811A3 DIAGNOSTIC MARKERS OF STROKE AND CEREBRAL INJURY AND METHODS OF USE THEREOF 审中-公开
标题翻译：诊断和颅脑损伤的诊断标记及其使用方法
公开(公告)号：WO2007046811A3
公开(公告)日：2009-04-02
申请号：PCT/US2005038225
申请日：2005-10-20
申请人： BIOSITE INC , VALKIRS GUNARS E , DAHLEN JEFFREY R , KIRCHICK HOWARD J , BUECHLER KENNETH F
发明人： VALKIRS GUNARS E , DAHLEN JEFFREY R , KIRCHICK HOWARD J , BUECHLER KENNETH F
IPC分类号： A61K49/00 , A61K39/395 , C07H21/04
CPC分类号： G01N33/6896 , G01N2800/2871
摘要： The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. A variety of markers are disclosed for assembling a panel for such diagnosis and evaluation. In various aspects, the invention provides methods for early detection and differentiation of stroke types and transient ischemic attacks, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for cerebral vasospasm. Invention methods provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.
摘要翻译：本发明涉及中风和短暂性脑缺血发作的诊断和评估方法。公开了用于组装用于这种诊断和评估的面板的各种标记。在各个方面，本发明提供了用于早期检测和分化卒中类型和短暂性脑缺血发作的方法，用于确定患有中风症状的患者的预后，以及鉴定患有脑血管痉挛风险的患者。本发明方法提供快速，灵敏和特异性的测定以大大增加可以接受有益的中风治疗和治疗的患者的数量，并且降低与不正确的中风诊断相关的成本。

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