专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1988003526A1 NEW PROCESS FOR MANUFACTURING OPTICALLY ACTIVE CARBOCYCLINE INTERMEDIATES 审中-公开
标题翻译：制造光学活性炭中间体的新工艺
公开(公告)号：WO1988003526A1
公开(公告)日：1988-05-19
申请号：PCT/DE1987000515
申请日：1987-11-12
申请人： SCHERING AKTIENGESELLSCHAFT , SKUBALLA, Werner , DAHL, Helmut
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07C177/00
CPC分类号： C07D319/08 , C07C405/0083
摘要： Process for manufacturing cis-bicyclo[3.3.0]octane-2-aldehydes of formula (I), in which R1 and R2 jointly represent the double-bound residue -O-X-O-, with X as straight or branched-chain alkylene with 1-7 C-atoms or R1 and R2 accordingly represent the residue OR with R as a straight or branched-chain alkyl with 1-7 C atoms and R3 represents hydrogen, a saturated alkyl residue with 1-7 C atoms, an aralkyl residu with 7-10 C atoms, a tetrahydropyranyl residue, a trialkylsilyl residue with 1-6 C atoms in the alkyl whereby alkyl also can be substituted by phenyl, a dialkylphenylsilyl residue or alkyldiphenylsilyl residue with 1-16 C atoms in the alkyl, characterized by the fact that the diastereomeric amides of formula (II) are separated, whereby in said formula R1, R2 and R3 have the stated meanings, and in that the enantiomerically pure amide of formula (II) is reduced.
摘要翻译：制备式（I）的顺式 - 双环[3.3.0]辛烷-2-醛的方法，其中R 1和R 2共同代表双键残基-OXO-，X为直链或支链亚烷基， 7个C原子或R 1和R 2相应地表示残基OR，其中R为具有1-7个C原子的直链或支链烷基，R 3表示氢，具有1-7个C原子的饱和烷基残基，残基为7 -10 C原子，四氢吡喃基残基，烷基中含有1-6个C原子的三烷基甲硅烷基残基，其中烷基也可以被苯基，二烷基苯基甲硅烷基残基或烷基中具有1-16个碳原子的烷基二苯基甲硅烷基残基取代，其特征在于分离式（II）的非对映体酰胺，其中在所述式R1中，R2和R3具有所述含义，并且由式（II）的对映体纯的酰胺还原。

2. 发明申请

WO1988003568A1 STEREOSPECIFIC KETO-REDUCTION OF BICYCLOOCTANDIONE-CARBOXYLIC ACID ESTERS BY MICROORGANISMS 审中-公开
标题翻译：通过微生物降解双酚A羧酸酯的立体化学方法
公开(公告)号：WO1988003568A1
公开(公告)日：1988-05-19
申请号：PCT/DE1987000517
申请日：1987-11-12
申请人： SCHERING AKTIENGESELLSCHAFT , PETZOLDT, Karl , DAHL, Helmut , VORBRÜGGEN, Helmut
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C12P41/00
CPC分类号： C07D317/72 , C07C405/0083 , C07D319/08 , C12P7/62 , C12P17/02 , C12P41/002 , Y10S435/911 , Y10S435/921 , Y10S435/939
摘要： Process for the production of 3 alpha -hydroxy-prostacyclin intermediates of formula (+)-I, where A is the residue -CH2- or >CH-COOR, B is oxygen or the double-bond residue -O-X-O- with X as a straight or branched-chain alkylene with 1-7 C atoms and R is a straight or branched-chain alkyl group with 1-6 C atoms or benzyl. The process is characterized in that a racemic bicyclooctandione of formula (+/-)-II, where A, B and R have the above notations, is treated with rhizopus-, rhodotorula- or candida strains, and in the case that the strain used reduces the form (-)- from the racemate (+/-)-II, a chemical or microbiological reduction of the unmodified bicyclooctandion of formula (+)-II follows said treatment.
摘要翻译：制备式（+） - I的3α-羟基 - 前列环素中间体的方法，其中A为残基-CH 2 - 或> CH-COOR，B为氧或双键残基-OXO-，X为具有1-7个C原子的直链或支链亚烷基，R是具有1-6个C原子的直链或支链烷基或苄基。该方法的特征在于式（+/-） - II的外消旋二环辛二酮，其中A，B和R具有上述符号，用根霉，rhodotorula或念珠菌菌株进行处理，并且在使用菌株的情况下根据所述处理，式（+） - II的未修饰双环化合物的化学或微生物学降低可以从外消旋体（+/-） - II中减少形式（ - ）。

3. 发明申请

WO1988003527A1 IMPROVED KETO-REDUCTION OF CARBACYCLINE INTERMEDIATES 审中-公开
标题翻译：改善卡巴肼中间体的减少
公开(公告)号：WO1988003527A1
公开(公告)日：1988-05-19
申请号：PCT/DE1987000519
申请日：1987-11-12
申请人： SCHERING AKTIENGESELLSCHAFT , DAHL, Helmut , BÜTTNER, Gabriele , PESCHEL, Dieter
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07C177/00
CPC分类号： C07D317/72 , C07C405/0083 , C07D319/08
摘要： Process for the production of alpha-hydroxy-bicyclo[3.3.0]octane derivatives of formula (I), where A is the double-bound residue -O-X-O-, X having the notation of a straight or branched-chain alkalin with 1-7 C atoms or the residue =CH-(CH2)3-COOR', =CH-CH2-O-CH2-COOR' or = CH-(CH2)3-O-CH2-CH2-COOR', with R' as C1-C7 alkyl; R is the residue (a), R'' having the notation of a hydrogen or phenyl, or the residue - SiR1, R2, R3, whereby R1, R2 and R3 can be the same or different and a straight or branched-chain alkyl group with 1-7 C atoms or phenyl; B is a trans-CH=C(X), with X as hydrogen or bromine, whereby the trans configuration relates to the C network; and D is an alkyl group with 1-10 C atoms, an alkenyl group with 1-10 C atoms or an alkinyl group with 1-10 C atoms. This process is characterized in that keto-bicyclo[3.3.0]octane derivatives of formula (II) are reduced in the presence of Cer-III salts.

4. 发明申请

WO9967212A2 OXIDATION INHIBITORS FOR PROSTANE DERIVATIVES 审中-公开
标题翻译：氧化抑制剂prostane衍生品
公开(公告)号：WO9967212A2
公开(公告)日：1999-12-29
申请号：PCT/EP9904278
申请日：1999-06-22
申请人： SCHERING AG , WAGNER TORSTEN , WESSEL MARTIN , LIPP RALPH , IFFERT BERND , MICHEL HEINRICH , WESTERMANN JUERGEN , DAHL HELMUT , SKUBALLA WERNER
发明人： WAGNER TORSTEN , WESSEL MARTIN , LIPP RALPH , IFFERT BERND , MICHEL HEINRICH , WESTERMANN JUERGEN , DAHL HELMUT , SKUBALLA WERNER
IPC分类号： A61K31/557 , A61K9/16 , A61K31/5575 , A61K31/5578 , A61K31/5585 , C07C59/46 , C07C405/00 , C08B37/00
CPC分类号： A61K31/5585 , A61K9/1694 , A61K31/5575 , C08B37/0015
摘要： The invention relates to the use of an oxidation inhibitor, i.e. active carbon, for ambient air in industrial manufacturing, especially in the processing of prostane derivatives, whereby the oxidation inhibitor removes ozone from the process air before contact with said prostane derivatives. The concentration of decomposition products is reduced.
摘要翻译：即，本发明包括使用氧化抑制剂活性炭工业制造环境空气，特别是prostane衍生物的处理，由此从处理空气中的氧化抑制剂臭氧与prostane衍生物接触之前去除。分解产物的浓度被降低。

5. 发明申请

WO1988003570A1 RACEMIC SEPARATION OF 7'alpha'-ACYLOXY-6'beta'-HYDROXYMETHYL-2-OXABICYCLO[3.3.0]OCTANE-3-ONES BY STEREO-SPECIFIC ENZYMATIC ACYLATE HYDROLYSIS 审中-公开
标题翻译： 7种α-乙酰基-6β-羟基甲基-2-氧杂环戊烯[3.3.0]季铵盐的异构分离通过立体特异性乙酸酯水解
公开(公告)号：WO1988003570A1
公开(公告)日：1988-05-19
申请号：PCT/DE1987000520
申请日：1987-11-12
申请人： SCHERING AKTIENGESELLSCHAFT , PETZOLDT, Karl , DAHL, Helmut
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C12P41/00
CPC分类号： C12P17/02 , C12P41/004
摘要： Process for the manufacture of (-)-oxabicyclo[3.3.0]octanolones of formula (-)-I, where R is hydrogen or the residue (a), in which R1 has the notation of a hydrogen, alkyl with 1-7 C atoms, or phenyl. The process is characterized in that a racemic oxabicyclo[3.3.0]-octanolone-acylate of formula (U)-II, where R1 has the above notation, is subjected to a stereo-specific acylate hydrolysis and the (-)-I (R = (a)) is separated from the saponified (+)-I (R = H) or the saponified (-)-I (R = H) is separated from the unsaponified (+)-II.

6. 发明申请

WO1988003567A1 RACEMIC DISSOCIATION OF 3-ACYLOXILIC-BICYCLO[3.3.0]OCTANE-7-ONE-2-CARBOXYLIC ACID ESTERS BY STEREOSPECIFIC ENZYME OR MICROBIOLOG ICAL ACYLATE HYDROLYSIS 审中-公开
标题翻译： 3-ACYLOXILIC-BICYCLO [3.3.0]季铵化合物的7-二-2-羧酸酯的立体解离通过立体酶或微生物酸性水解
公开(公告)号：WO1988003567A1
公开(公告)日：1988-05-19
申请号：PCT/DE1987000513
申请日：1987-11-12
申请人： SCHERING AKTIENGESELLSCHAFT , PETZOLDT, Karl , DAHL, Helmut , SKUBALLA, Werner
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C12P41/00
CPC分类号： C07D317/72 , C07C405/0083 , C07D319/08 , C12P7/26 , C12P7/42 , C12P7/62 , C12P17/02 , C12P41/004
摘要： Process for the production of optically active (+)-bicyclo[3.3.0]octanol derivatives of formula (+)-I, in which R1 and R2 represent jointly an oxygen atom or the double-bond residue -O-X-O-, with X as a straight or branched-chain alkylene with 1-7 C-atoms, or R1 and R2 represent separately the residue OR5, with R5 as a straight or branched-chain alkyl with 1-7 C-atoms, and R3 the residue COOZ with Z as a hydrogen atom, straight or branched chain alkyl with 1-7 C atoms, cycloalkyl with 3-6 C atoms, phenyl or aralkyl with 7-10 C atoms or R3 is the residue -(CH2)n-O-COR4, with n having the meaning 1-4 and R4 as a straight or branched-chain alkyl with 1-7 C atoms, cycloalkyl with 3-6 C atoms, phenyl or aralkyl with 7-10 C atoms. The process is characterized in that racemic 3 alpha -cyloxy-cis-bicyclo[3.3.0]-octane derivatives of formula (+/-)-II, wherein R1, R2, R3 and R4 have the above meanings, are subjected enzymatically or microbiologically to a stereospecific acylate hydrolysis and the (+)-bicyclo[3.3.0]-octanol derivative produced is separated from the unsaponified bicyclo[3.3.0]-octanol acylate of formula (-)-II or the unsaponified enantiomers (+)-II are separated from the saponified bicyclo[3.3.0]octanol derivative (-)-I and then subjected to chemical acylate hydrolysis.
摘要翻译：制备式（+） - I的光学活性（+） - 双环[3.3.0]辛醇衍生物的方法，其中R 1和R 2共同表示氧原子或双键残基-OXO-，其中X为具有1-7个C原子的直链或支链亚烷基，或R1和R2分别表示残基OR5，R5表示具有1-7个C原子的直链或支链烷基，R3表示残基COOZ与Z 作为氢原子，具有1-7个C原子的直链或支链烷基，具有3-6个C原子的环烷基，具有7-10个C原子的苯基或芳烷基或R3是残基 - （CH 2）n O-COR 4，其中n具有含1-4个碳原子的直链或支链烷基，含3-6个碳原子的环烷基，含有7-10个C原子的苯基或芳烷基。该方法的特征在于其中R1，R2，R3和R4具有上述含义的式（+/-） - II的外消旋3α-甲氧基 - 顺式 - 二环[3.3.0] - 辛烷衍生物经酶促或将微生物学上的立体定向酰化物水解，并将所产生的（+） - 双环[3.3.0] - 辛醇衍生物与式（ - ） - II的未皂化的双环[3.3.0] - 辛醇酰化物或未掺杂的对映异构体（+） -II与皂化的双环[3.3.0]辛醇衍生物（ - ） - I分离，然后进行化学酰化物水解。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式