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1. 发明申请

WO2006113595A3 IMPLANTABLE LENSES WITH MODIFIED EDGE REGIONS 审中-公开
标题翻译：具有修改边缘区域的可植入的镜片
公开(公告)号：WO2006113595A3
公开(公告)日：2009-04-30
申请号：PCT/US2006014356
申请日：2006-04-13
申请人： REVISION OPTICS INC , MILLER TROY A , CUNANAN CRYSTAL M , VATZ ALEXANDER
发明人： MILLER TROY A , CUNANAN CRYSTAL M , VATZ ALEXANDER
IPC分类号： A61F2/16 , A61F2/14
CPC分类号： A61F2/16 , A61F2/147 , B29D11/00028 , B29D11/023 , G02C7/02
摘要： The implantable lenses described herein provide for modified edge regions. In one example embodiment an implantable lens includes an anterior surface, a posterior surface and an outer edge surface separating the anterior and posterior surfaces. The anterior surface can include a corrective portion and a beveled portion. The beveled portion can be located between the corrective portion and the outer edge surface. The outer edge surface can have a first portion and a second portion, where the first portion abuts the posterior surface and the second portion, and where the second portion further abuts the beveled portion. The modified edge region provides a more gradual transition between the anterior and posterior surfaces.
摘要翻译：本文所述的可植入透镜提供了修改的边缘区域。在一个示例性实施例中，可植入透镜包括前表面，后表面和分离前表面和后表面的外边缘表面。前表面可以包括校正部分和斜面部分。斜切部分可以位于校正部分和外边缘表面之间。外边缘表面可以具有第一部分和第二部分，其中第一部分邻接后表面和第二部分，并且其中第二部分还邻接斜面部分。改进的边缘区域在前表面和后表面之间提供更渐进的过渡。

2. 发明申请

WO2006076316A3 METHODS FOR PROCESSING BIOLOGICAL TISSUE 审中-公开
标题翻译：处理生物组织的方法
公开(公告)号：WO2006076316A3
公开(公告)日：2007-07-26
申请号：PCT/US2006000732
申请日：2006-01-09
申请人： ARBOR SURGICAL TECHNOLOGIES , CUNANAN CRYSTAL M , OCHOA ALEXANDRO , CAMBRON RONALD E
发明人： CUNANAN CRYSTAL M , OCHOA ALEXANDRO , CAMBRON RONALD E
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0226
摘要： A method for processing biological tissue used in biological prostheses includes providing a tissue procurement solution formed from a phosphate buffered saline (PBS) solution and a chelating agent. The tissue is transferred from the tissue procurement solution and undergoes chemical fixation. The fixed tissue is then immersed in a series of fresh bioburden reduction process (BRP) solutions to extract phospholipids. The tissue procurement solution reduces the bioburden on the stored tissue and preserves tissue architecture by minimizing tissue swelling. The tissue procurement solution further reduces calcium from the incoming water and/or tissue, and inhibits enzymes that digest the collagen matrix. The serial immersion of the tissue in the fresh bioburden solutions ensures optimal extraction of phospholipids thereby mitigating subsequent calcification of the tissue.
摘要翻译：用于处理生物假体中使用的生物组织的方法包括提供由磷酸盐缓冲盐水（PBS）溶液和螯合剂形成的组织采购溶液。组织从组织采购溶液转移并进行化学固定。然后将固定的组织浸入一系列新鲜的生物负载降低过程（BRP）溶液中以提取磷脂。组织采购解决方案减少存储组织的生物负载，并通过最小化组织肿胀来保持组织结构。组织采购解决方案进一步减少来自进入的水和/或组织的钙，并且抑制消化胶原蛋白基质的酶。将组织连续浸入新鲜的生物负载溶液中确保磷脂的最佳提取，从而减轻随后的组织钙化。

3. 发明申请

WO2012027515A3 BIOMATERIALS WITH ENHANCED PROPERTIES AND DEVICES MADE THEREFROM 审中-公开
标题翻译：具有增强性能的生物材料和由此制造的设备
公开(公告)号：WO2012027515A3
公开(公告)日：2012-04-19
申请号：PCT/US2011049027
申请日：2011-08-24
申请人： SOUTHERN LIGHTS VENTURES 2002 LTD , CUNANAN CRYSTAL M , HIGGINS JOHN JOSEPH , GURAZADA SAROJA NAGARAJ
发明人： CUNANAN CRYSTAL M , HIGGINS JOHN JOSEPH , GURAZADA SAROJA NAGARAJ
IPC分类号： A61L27/36 , A61L31/00
CPC分类号： A61F2/2412 , A61F2/2427 , A61K35/34 , A61L27/3604 , A61L27/3695 , A61L27/507 , A61L31/005 , A61L2430/40 , Y10S623/918
摘要： Biomaterials with enhanced properties such as improved strength, flexibility, durability and reduced thickness are useful in the fabrication of biomedical devices, particularly those subjected to continuous or non-continuous loads where repeated flexibility and long-term durability are required. These enhanced properties can be attributed to elevated levels of elastin, altered collagen types, and other biochemical changes which contribute to these enhanced properties. Examples of devices which would be improved by use of such tissue include heart valves, including percutaneous heart valves, and vascular grafts, patches and the like. Such enhanced materials can be sourced from specific populations of animals, such as neonatal calves, or in range-fed adult cattle, or can be fabricated or created from cell populations exhibiting such properties. In one embodiment, glutaraldehyde-fixed neonatal pericardial tissue is used to create leaflets in a percutaneous heart valve, and may be used without chemical fixation, with or without processes to remove residual cellular membranes, and utilized as a scaffold material for tissue engineering
摘要翻译：具有改进的强度，柔韧性，耐用性和减小的厚度等性能的生物材料可用于制造生物医学装置，特别是需要反复柔韧性和长期耐久性的连续或非连续负载的生物医学装置。这些增强的特性可以归因于弹性蛋白水平的升高，改变的胶原蛋白类型和其他生物化学变化，这些变化有助于这些增强的性质。通过使用这种组织可以改善的装置的实例包括心脏瓣膜，包括经皮心脏瓣膜，以及血管移植物，贴片等。这种增强的材料可以来自特定的动物种群，例如新生小牛，或者在喂食牧场的成年牛中，或者可以由表现出这种性质的细胞群制造或制造。在一个实施方案中，戊二醛固定的新生儿心包组织用于在经皮心脏瓣膜中产生小叶，并且可以在没有化学固定的情况下使用，有或没有过程去除残余细胞膜，并且用作组织工程的支架材料

4. 发明申请

WO2006113595A2 IMPLANTABLE LENSES WITH MODIFIED EDGE REGIONS 审中-公开
标题翻译：具有修改边缘区域的可植入的镜片
公开(公告)号：WO2006113595A2
公开(公告)日：2006-10-26
申请号：PCT/US2006/014356
申请日：2006-04-13
申请人： INTRALENS VISION, INC. , MILLER, Troy A. , CUNANAN, Crystal M. , VATZ, Alexander
发明人： MILLER, Troy A. , CUNANAN, Crystal M. , VATZ, Alexander
IPC分类号： A61F2/14 , B29D11/00
CPC分类号： A61F2/16 , A61F2/147 , B29D11/00028 , B29D11/023 , G02C7/02
摘要： The implantable lenses described herein provide for modified edge regions. In one example embodiment an implantable lens includes an anterior surface, a posterior surface and an outer edge surface separating the anterior and posterior surfaces. The anterior surface can include a corrective portion and a beveled portion. The beveled portion can be located between the corrective portion and the outer edge surface. The outer edge surface can have a first portion and a second portion, where the first portion abuts the posterior surface and the second portion, and where the second portion further abuts the beveled portion. The modified edge region provides a more gradual transition between the anterior and posterior surfaces.
摘要翻译：本文所述的可植入透镜提供了修改的边缘区域。在一个示例性实施例中，可植入透镜包括前表面，后表面和分离前表面和后表面的外边缘表面。前表面可以包括校正部分和斜面部分。斜切部分可以位于校正部分和外边缘表面之间。外边缘表面可以具有第一部分和第二部分，其中第一部分邻接后表面和第二部分，并且其中第二部分还邻接斜面部分。改进的边缘区域在前表面和后表面之间提供更渐进的过渡。

5. 发明申请

WO2006113474A2 CORNEAL IMPLANT INJECTOR ASSEMBLY AND METHODS OF USE 审中-公开
标题翻译：角膜植入式注射器装配及使用方法
公开(公告)号：WO2006113474A2
公开(公告)日：2006-10-26
申请号：PCT/US2006/014142
申请日：2006-04-14
申请人： INTRALENS VISION, INC. , LE, Alan, Ngoc , FORSBERG, Jeff , CUNANAN, Crystal, M. , VATZ, Alexander
发明人： LE, Alan, Ngoc , FORSBERG, Jeff , CUNANAN, Crystal, M. , VATZ, Alexander
IPC分类号： A61F9/00
CPC分类号： A61F2/148
摘要： A corneal implant injector assembly includes a barrel, a plunger, and an injector tip with a channel having a size and orientation adapted to store and deliver a corneal implant. The corneal implant is preferably stored in the channel in a contracted state. The plunger has an implant engagement tip for engaging and moving the implant within the channel and to deploy the implant. In some embodiments, the injector tip is selectively detachable from the remaining portion of the injector assembly.
摘要翻译：角膜植入物注射器组件包括筒，柱塞和具有适于存储和递送角膜植入物的尺寸和取向的通道的注射器尖端。角膜植入物优选以收缩状态存储在通道中。所述柱塞具有用于在所述通道内接合和移动所述植入物并植入所述植入物的植入物接合末端。在一些实施例中，喷射器尖端可选择性地与喷射器组件的其余部分分离。

6. 发明申请

WO2012027515A2 BIOMATERIALS WITH ENHANCED PROPERTIES AND DEVICES MADE THEREFROM 审中-公开
标题翻译：具有增强性能的生物材料和其制造的器件
公开(公告)号：WO2012027515A2
公开(公告)日：2012-03-01
申请号：PCT/US2011/049027
申请日：2011-08-24
申请人： SOUTHERN LIGHTS VENTURES 2002 LIMITED , CUNANAN, Crystal M. , HIGGINS, John Joseph , GURAZADA, Saroja Nagaraj
发明人： CUNANAN, Crystal M. , HIGGINS, John Joseph , GURAZADA, Saroja Nagaraj
IPC分类号： A61L27/36 , A61L31/00
CPC分类号： A61F2/2412 , A61F2/2427 , A61K35/34 , A61L27/3604 , A61L27/3695 , A61L27/507 , A61L31/005 , A61L2430/40 , Y10S623/918
摘要： Biomaterials with enhanced properties such as improved strength, flexibility, durability and reduced thickness are useful in the fabrication of biomedical devices, particularly those subjected to continuous or non-continuous loads where repeated flexibility and long-term durability are required. These enhanced properties can be attributed to elevated levels of elastin, altered collagen types, and other biochemical changes which contribute to these enhanced properties. Examples of devices which would be improved by use of such tissue include heart valves, including percutaneous heart valves, and vascular grafts, patches and the like. Such enhanced materials can be sourced from specific populations of animals, such as neonatal calves, or in range-fed adult cattle, or can be fabricated or created from cell populations exhibiting such properties. In one embodiment, glutaraldehyde-fixed neonatal pericardial tissue is used to create leaflets in a percutaneous heart valve, and may be used without chemical fixation, with or without processes to remove residual cellular membranes, and utilized as a scaffold material for tissue engineering
摘要翻译：具有增强性能的生物材料，例如改进的强度，柔韧性，耐久性和减小的厚度，可用于生物医学装置的制造，特别是需要连续或非连续载荷的那些，其中需要重复的柔性和长期的耐久性。这些增强的性质可归因于弹性蛋白水平升高，胶原蛋白类型改变，以及其他有助于这些增强性质的生物化学变化。将通过使用这种组织来改善的装置的实例包括心脏瓣膜，包括经皮心脏瓣膜，血管移植物，贴剂等。这种增强的材料可以来自特定动物群体，例如新生小牛，或在范围饲养的成年牛中，或者可以由表现出这种性质的细胞群体制造或产生。在一个实施方案中，戊二醛固定的新生儿心包组织用于在经皮心脏瓣膜中产生小叶，并且可以在没有化学固定的情况下使用，具有或不具有除去残留细胞膜的方法，并用作组织工程的支架材料

7. 发明申请

WO2006113474A3 CORNEAL IMPLANT INJECTOR ASSEMBLY AND METHODS OF USE 审中-公开
标题翻译：角膜植入式注射器组件及其使用方法
公开(公告)号：WO2006113474A3
公开(公告)日：2008-01-24
申请号：PCT/US2006014142
申请日：2006-04-14
申请人： REVISION OPTICS INC , LE ALAN NGOC , FORSBERG JEFF , CUNANAN CRYSTAL M , VATZ ALEXANDER
发明人： LE ALAN NGOC , FORSBERG JEFF , CUNANAN CRYSTAL M , VATZ ALEXANDER
IPC分类号： A61F9/00
CPC分类号： A61F2/148
摘要： A corneal implant injector assembly includes a barrel, a plunger, and an injector tip with a channel having a size and orientation adapted to store and deliver a corneal implant. The corneal implant is preferably stored in the channel in a contracted state. The plunger has an implant engagement tip for engaging and moving the implant within the channel and to deploy the implant. In some embodiments, the injector tip is selectively detachable from the remaining portion of the injector assembly.
摘要翻译：角膜植入物注射器组件包括镜筒，柱塞和具有适于存储和递送角膜植入物的尺寸和取向的通道的注射器尖端。角膜植入物优选以收缩状态存储在通道中。所述柱塞具有用于在所述通道内接合和移动所述植入物并植入所述植入物的植入物接合末端。在一些实施例中，喷射器尖端可选择性地与喷射器组件的其余部分分离。

8. 发明申请

WO2006076316A2 METHODS FOR PROCESSING BIOLOGICAL TISSUE 审中-公开
标题翻译：处理生物组织的方法
公开(公告)号：WO2006076316A2
公开(公告)日：2006-07-20
申请号：PCT/US2006/000732
申请日：2006-01-09
申请人： ARBOR SURGICAL TECHNOLOGIES, INC. , CUNANAN, Crystal, M. , OCHOA, Alexandro , CAMBRON, Ronald, E.
发明人： CUNANAN, Crystal, M. , OCHOA, Alexandro , CAMBRON, Ronald, E.
CPC分类号： A01N1/02 , A01N1/0226
摘要： A method for processing biological tissue used in biological prostheses includes providing a tissue procurement solution formed from a phosphate buffered saline (PBS) solution and a chelating agent. The tissue is transferred from the tissue procurement solution and undergoes chemical fixation. The fixed tissue is then immersed in a series of fresh bioburden reduction process (BRP) solutions to extract phospholipids. The tissue procurement solution reduces the bioburden on the stored tissue and preserves tissue architecture by minimizing tissue swelling. The tissue procurement solution further reduces calcium from the incoming water and/or tissue, and inhibits enzymes that digest the collagen matrix. The serial immersion of the tissue in the fresh bioburden solutions ensures optimal extraction of phospholipids thereby mitigating subsequent calcification of the tissue.
摘要翻译：用于处理生物假体中使用的生物组织的方法包括提供由磷酸盐缓冲盐水（PBS）溶液和螯合剂形成的组织采购溶液。组织从组织采购溶液转移并进行化学固定。然后将固定的组织浸入一系列新鲜的生物负载降低过程（BRP）溶液中以提取磷脂。组织采购解决方案减少存储组织的生物负载，并通过最小化组织肿胀来保持组织结构。组织采购解决方案进一步减少来自进入的水和/或组织的钙，并且抑制消化胶原蛋白基质的酶。将组织连续浸入新鲜的生物负载溶液中确保磷脂的最佳提取，从而减轻随后的组织钙化。

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