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1. 发明申请

WO2008135855A2 NANOPARTICLES COMPRISING A CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR AND A NONIONIZABLE POLYMER 审中-公开
标题翻译：包含乙醇转移蛋白抑制剂和不可分解聚合物的纳米颗粒
公开(公告)号：WO2008135855A2
公开(公告)日：2008-11-13
申请号：PCT/IB2008001145
申请日：2008-04-23
申请人： PFIZER PROD INC , BLOOM COREY JAY , CREW MARSHALL DAVID , SMITHEY DANIEL TOD , MILLER WARREN KENYON , MORGEN MICHAEL MARK
发明人： BLOOM COREY JAY , CREW MARSHALL DAVID , SMITHEY DANIEL TOD , MILLER WARREN KENYON , MORGEN MICHAEL MARK
IPC分类号： A61K9/51 , A61K31/4706 , A61K45/08
CPC分类号： A61K9/5146 , A61K9/5161 , A61K9/5192 , A61K31/4706
摘要： A pharmaceutical composition comprises nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a poorly aqueous soluble non-ionizable polymer.
摘要翻译：药物组合物包含包含胆固醇酯转移蛋白抑制剂和不良水溶性不可离子化聚合物的纳米颗粒。

2. 发明申请

WO2008135829A2 NANOPARTICLES COMPRISING COX-2 INHIBITORS AND A NON-IONIZABLE POLYMER 审中-公开
标题翻译：包含COX-2抑制剂和非离子聚合物的纳米颗粒
公开(公告)号：WO2008135829A2
公开(公告)日：2008-11-13
申请号：PCT/IB2008001061
申请日：2008-04-21
申请人： PFIZER PROD INC , BLOOM COREY JAY , CREW MARSHALL DAVID , MILLER WARREN KENYON , MORGEN MICHAEL MARK , SMITHEY DANIEL TOD
发明人： BLOOM COREY JAY , CREW MARSHALL DAVID , MILLER WARREN KENYON , MORGEN MICHAEL MARK , SMITHEY DANIEL TOD
IPC分类号： A61K9/51 , A61K31/415 , A61K31/42
CPC分类号： A61K9/5123 , A61K9/5146 , A61K9/5161 , A61K9/5169 , A61K9/5192 , A61K31/415 , A61K31/42
摘要： A pharmaceutical composition comprises nanoparticles comprising a COX-2 inhibitor and a poorly aqueous soluble non-ionizable polymer.
摘要翻译：药物组合物包含包含COX-2抑制剂和不良水溶性不可离子化聚合物的纳米颗粒。

3. 发明申请

WO2005065656A3 STABILIZED PHARMACEUTICAL SOLID COMPOSITIONS OF LOW-SOLUBILITY DRUGS, POLOXAMERS, AND STABILIZING POLYMERS 审中-公开
标题翻译：低溶解性药物，POLOXAMERS和稳定聚合物稳定的药物固体组合物
公开(公告)号：WO2005065656A3
公开(公告)日：2006-07-13
申请号：PCT/IB2004004260
申请日：2004-12-20
申请人： PFIZER PROD INC , CREW MARSHALL DAVID , SHANKER RAVI MYSORE , SMITHEY DANIEL TOD , MILLER WARREN KENYON , FRIESEN DWAYNE THOMAS
发明人： CREW MARSHALL DAVID , SHANKER RAVI MYSORE , SMITHEY DANIEL TOD , MILLER WARREN KENYON , FRIESEN DWAYNE THOMAS
IPC分类号： A61K9/16
CPC分类号： A61K9/1652 , A61K9/1635 , A61K9/1641 , A61K31/47
摘要： Solid compositions with improved physical stability comprise an amorphous, low-solubility drug, a poloxamer, and a stabilizing polymer. The compositions provide good physical stability during storage and concentration enhancement of dissolved drug when administered to an aqueous environment of use.
摘要翻译：具有改善的物理稳定性的固体组合物包括无定形，低溶解度药物，泊洛沙姆和稳定聚合物。当给予使用的水性环境时，所述组合物在溶解药物的储存和浓缩增强期间提供良好的物理稳定性。

4. 发明申请

WO2005053650A1 AZITHROMYCIN DOSAGE FORMS WITH REDUCED SIDE EFFECTS 审中-公开
标题翻译：阿奇霉素剂型减少副作用
公开(公告)号：WO2005053650A1
公开(公告)日：2005-06-16
申请号：PCT/IB2004/001654
申请日：2004-05-14
申请人： PFIZER PRODUCTS INC. , HAGEN, Timothy, Arthur , HERBIG, Scott, Max , LO, Julian, Belknap , THOMBRE, Avinash, Govind , APPEL, Leah, Elizabeth , CREW, Marshall, David , FRIESEN, Dwayne, Thomas , LYON, David, Keith , MCCRAY, Scott, Baldwin , WEST, James, Blair
发明人： HAGEN, Timothy, Arthur , HERBIG, Scott, Max , LO, Julian, Belknap , THOMBRE, Avinash, Govind , APPEL, Leah, Elizabeth , CREW, Marshall, David , FRIESEN, Dwayne, Thomas , LYON, David, Keith , MCCRAY, Scott, Baldwin , WEST, James, Blair
IPC分类号： A61K9/16
CPC分类号： A61K9/1611 , A61K9/143 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1694 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K31/7052
摘要： An oral dosage form comprising azithromycin and an effective amount of an alkalizing agent. Preferably, said oral dosage form comprises an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate, and a poloxamer. Typically, the oral dosage form includes any suitable oral dosing means such as a powder for oral suspension, a unit dose packet or sachet, a tablet or a capsule.Additionally disclosed is an oral suspension comprising azithromycin, an effective amount of an alkalizing agent and a vehicle. Preferably, the azithromycin is in multiparticulate form wherein said multiparticulate comprises azithromycin, a mixture of glyceryl monobehenate, glyceryl dibehenate and glyceryl tribehenate,and a poloxamer. Also disclosed is a method for reducing gastrointestinal side effects, associated with administering azithromycin to a mammal, comprising contiguously administering azithromycin and an effective amount of alkalizing agent to said mammal wherein the frequency of gastrointestinal side effects is lower than that experienced by administering an equal dose of azithromycin without said alkalizing agent.Further disclosed is a method of treating a bacterial or protozoal infection in a mammal in need thereof comprising contiguously administering to said mammal a single dose of an oral dosage form wherein said oral dosage form comprises azithromycin and an effective amount of an alkalizing agent.Additionally disclosed are azithromycin multiparticulates comprising azithromycin, a surfactant; and a pharmaceutically acceptable carrier.
摘要翻译：口服剂型包含阿奇霉素和有效量的碱化剂。优选地，所述口服剂型包含有效量的碱化剂和阿奇霉素多颗粒，其中所述多颗粒包含阿奇霉素，单山gly酸甘油酯，二山ate酸甘油酯和三山gly酸甘油酯的混合物以及泊洛沙姆。典型地，口服剂型包括任何合适的口服给药方式，例如用于口服悬浮液的粉剂，单位剂量小包或小药囊，片剂或胶囊。另外公开的是口服悬浮液，其包含阿奇霉素，有效量的碱化剂和一辆车。优选地，阿奇霉素为多颗粒形式，其中所述多颗粒包含阿奇霉素，单山gly酸甘油酯，二山ate酸甘油酯和三山gly酸甘油酯以及泊洛沙姆的混合物。还公开了用于减少与阿奇霉素给予哺乳动物有关的胃肠副作用的方法，包括向所述哺乳动物连续施用阿奇霉素和有效量的碱化剂，其中胃肠副作用的频率低于施用等剂量进一步公开了在有需要的哺乳动物中治疗细菌或原生动物感染的方法，其包括向所述哺乳动物连续施用单剂量的口服剂型，其中所述口服剂型包含阿奇霉素和有效量另外公开的是阿奇霉素多微粒，其包含阿奇霉素，表面活性剂; 和药学上可接受的载体。

5. 发明申请

WO2005053640A2 AZITHROMYCIN MULTIPARTICULATE DOSAGE FORMS BY LIQUID-BASED PROCESSES 审中-公开
标题翻译： AZITHROMYCIN基于液体过程的多重剂量形式
公开(公告)号：WO2005053640A2
公开(公告)日：2005-06-16
申请号：PCT/IB2004003911
申请日：2004-11-29
申请人： PFIZER PROD INC , APPEL LEAH ELIZABETH , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , LYON DAVID KEITH , MCCRAY SCOTT BALDWIN , RAY RODERICK JACK , WEST JAMES BLAIR
发明人： APPEL LEAH ELIZABETH , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , LYON DAVID KEITH , MCCRAY SCOTT BALDWIN , RAY RODERICK JACK , WEST JAMES BLAIR
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K9/52 , A61K31/7048 , B29B9/00
CPC分类号： A61K9/1652 , A61K9/1676 , A61K31/7048
摘要： Liquid-based processes are disclosed for forming azithromycin multiparticulates having minimal amounts of azithromycin esters.
摘要翻译：公开了用于形成具有最少量的阿奇霉素酯的阿奇霉素多颗粒的基于液体的方法。

6. 发明申请

WO2003063832A1 PHARMACEUTICAL COMPOSITIONS COMPRISING A SOLID AMORPHOUS DISPERSION OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS 审中-公开
标题翻译：包含乙醇转运蛋白抑制剂的固体非晶分散体的药物组合物
公开(公告)号：WO2003063832A1
公开(公告)日：2003-08-07
申请号：PCT/IB2003/000310
申请日：2003-01-28
申请人： PFIZER PRODUCTS INC. , CURATOLO, William, John , GUMKOWSKI, Michael, Jon , RUGGERI, Roger, Benjamin , SHANKER, Ravi, Mysore , CREW, Marshall, David , FRIESEN, Dwayne, Thomas , LORENZ, Douglas, Alan , NIGHTINGALE, James, Alan, Schriver
发明人： CURATOLO, William, John , GUMKOWSKI, Michael, Jon , RUGGERI, Roger, Benjamin , SHANKER, Ravi, Mysore , CREW, Marshall, David , FRIESEN, Dwayne, Thomas , LORENZ, Douglas, Alan , NIGHTINGALE, James, Alan, Schriver
IPC分类号： A61K9/16
CPC分类号： A61K31/4196 , A61K9/146 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K31/41 , A61K31/47
摘要： A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
摘要翻译：药物组合物包含胆固醇酯转移蛋白抑制剂和浓度增强聚合物的固体无定形分散体。

7. 发明申请

WO2009010842A2 NANOPARTICLES COMPRISING IONIZABLE, POORLY WATER SOLUBLE CELLULOSIC POLYMERS 审中-公开
标题翻译：包含可离子化，微溶水溶性纤维素聚合物的纳米颗粒
公开(公告)号：WO2009010842A2
公开(公告)日：2009-01-22
申请号：PCT/IB2008/001801
申请日：2008-06-30
申请人： PFIZER PRODUCTS INC. , BLOOM, Corey, Jay , CREW, Marshall, David , FRIESEN, Dwayne, Thomas , MILLER, Warren, Kenyon , MORGEN, Michael, Mark , SMITHEY, Daniel, Tod
发明人： BLOOM, Corey, Jay , CREW, Marshall, David , FRIESEN, Dwayne, Thomas , MILLER, Warren, Kenyon , MORGEN, Michael, Mark , SMITHEY, Daniel, Tod
IPC分类号： A61K9/51 , A61K47/38
CPC分类号： A61K9/5161 , A61K9/5192 , A61K47/38
摘要： A pharmaceutical composition comprises nanoparticles comprising ionizable, poorly water soluble cellulosic polymers.
摘要翻译：药物组合物包含纳米颗粒，所述纳米颗粒包含可离子化的水溶性差的纤维素聚合物。

8. 发明申请

WO2008135855A3 NANOPARTICLES COMPRISING A CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR AND A NONIONIZABLE POLYMER 审中-公开
公开(公告)号：WO2008135855A3
公开(公告)日：2008-11-13
申请号：PCT/IB2008/001145
申请日：2008-04-23
申请人： PFIZER PRODUCTS INC. , BLOOM, Corey, Jay , CREW, Marshall, David , SMITHEY, Daniel, Tod , MILLER, Warren, Kenyon , MORGEN, Michael, Mark
发明人： BLOOM, Corey, Jay , CREW, Marshall, David , SMITHEY, Daniel, Tod , MILLER, Warren, Kenyon , MORGEN, Michael, Mark
IPC分类号： A61K9/51 , A61K31/4706 , A61K45/08
摘要： A pharmaceutical composition comprises nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a poorly aqueous soluble non-ionizable polymer.

9. 发明申请

WO2008125940A2 NANOPARTICLES COMPRISING NON-CRYSTALLINE DRUG 审中-公开
标题翻译：包含非晶体药物的纳米颗粒
公开(公告)号：WO2008125940A2
公开(公告)日：2008-10-23
申请号：PCT/IB2008/000844
申请日：2008-04-07
申请人： PFIZER PRODUCTS INC. , CREW, Marshall, David , FRIESEN, Dwayne, Thomas , SMITHEY, Daniel, Tod , MORGEN, Michael, Mark , TADDAY, Ralph
发明人： CREW, Marshall, David , FRIESEN, Dwayne, Thomas , SMITHEY, Daniel, Tod , MORGEN, Michael, Mark , TADDAY, Ralph
IPC分类号： A61K9/51
CPC分类号： A61K9/5123 , A61K9/1617 , A61K9/5146 , A61K9/5192
摘要： A pharmaceutical composition comprises nanoparticles comprising a core of non-crystalline drug and surface stabilizers consisting of a phospholipid and a bile salt.
摘要翻译：药物组合物包含包含非结晶药物核心和由磷脂和胆汁盐组成的表面稳定剂的纳米颗粒。

10. 发明申请

WO2008065506A2 PHARMACEUTICAL COMPOSITIONS COMPRISING NANOPARTICLES COMPRISING ENTERIC POLYMERS AND CASEIN 审中-公开
标题翻译：包含肠溶聚合物和壳聚糖的纳米颗粒的药物组合物
公开(公告)号：WO2008065506A2
公开(公告)日：2008-06-05
申请号：PCT/IB2007003632
申请日：2007-11-16
申请人： PFIZER PROD INC , BEYERINCK RONALD ARTHUR , BLOOM COREY JAY , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , MORGEN MICHAEL MARK , SMITHEY DANIEL TOD
发明人： BEYERINCK RONALD ARTHUR , BLOOM COREY JAY , CREW MARSHALL DAVID , FRIESEN DWAYNE THOMAS , MORGEN MICHAEL MARK , SMITHEY DANIEL TOD
IPC分类号： A61K9/16 , A61K9/50 , A61K9/51 , A61K31/135
CPC分类号： A61K31/135 , A61K9/5161 , A61K9/5169 , A61K9/5192
摘要： A pharmaceutical composition comprises nanoparticles comprising the poorly water soluble lipophilic compound (2R)-3-[[3-(4-chloro-3-ethylphenoxy)phenyl][[3-(1,1,2,2- tetrafluoroethoxy)phenyl]methyl]amino]-1,1,1-trifluoro-2-propanol, and an enteric polymer.
摘要翻译：药物组合物包含包含难溶于水的亲脂性化合物（2R）-3 - [[3-（4-氯-3-乙基苯氧基）苯基] [[3-（1,1,2,2-四氟乙氧基）苯基] 甲基]氨基] -1,1,1-三氟-2-丙醇和肠溶性聚合物。

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