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1. 发明申请

WO2005021568B1 NOVEL TRICYCLIC NUCLEOSIDES OR NUCLEOTIDES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：新型三核核苷酸或核苷酸作为治疗药物
公开(公告)号：WO2005021568B1
公开(公告)日：2005-06-09
申请号：PCT/US2004027819
申请日：2004-08-27
申请人： BIOTA INC , COOK PHILLIP DAN , EWING GREGORY , JIN YI , LAMBERT JOHN , PRHAVC MARIJA , RAJAPPAN VASANTHAKUMAR , RAJWANSHI VIVEK K , SAKTHIVEL KANDASAMY
发明人： COOK PHILLIP DAN , EWING GREGORY , JIN YI , LAMBERT JOHN , PRHAVC MARIJA , RAJAPPAN VASANTHAKUMAR , RAJWANSHI VIVEK K , SAKTHIVEL KANDASAMY
IPC分类号： A61P31/12 , C07H19/23 , A61K31/7064
CPC分类号： C07H19/04 , C07H19/23
摘要： Nucelosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
摘要翻译：含有三环碱基的核酸酶和核苷酸分别用于治疗感染性疾病和增殖性病症，例如病毒感染或癌症。

2. 发明申请

WO2003100017A3 OLIGONUCLEOTIDES HAVING MODIFIED NUCLEOSIDE UNITS 审中-公开
公开(公告)号：WO2003100017A3
公开(公告)日：2003-12-04
申请号：PCT/US2003/016526
申请日：2003-05-23
申请人： ISIS PHARMACEUTICALS, INC. , ELDRUP, Anne , COOK, Phillip, Dan , PARSHALL, Lynne, B.
发明人： ELDRUP, Anne , COOK, Phillip, Dan , PARSHALL, Lynne, B.
IPC分类号： C07H21/04
摘要： Disclosed are oligonucleotide that include one or more modified nucleoside units. The oligonucleotides are particularly useful as antisense agents, ribozymes aptamer, siRNA agents, probes and primers or, when hybridized to an RNA, as a substrate for RNA cleaving enzymes including Rnase H and dsRNase.

3. 发明申请

WO2003099840A1 OLIGONUCLEOTIDES HAVING MODIFIED NUCLEOSIDE UNITS 审中-公开
标题翻译：具有改性核苷酸单体的寡核苷酸
公开(公告)号：WO2003099840A1
公开(公告)日：2003-12-04
申请号：PCT/US2003/016502
申请日：2003-05-23
申请人： ISIS PHARMACEUTICALS, INC. , ELDRUP, Anne , COOK, Phillip, Dan , PARSHALL, B., Lynne
发明人： ELDRUP, Anne , COOK, Phillip, Dan , PARSHALL, B., Lynne
IPC分类号： C07H21/04
CPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , Y02P20/582
摘要： Disclosed are oligonucleotides and oligonucleosides that include one or more modified nucleoside units. The oligonucleotides and oligonucleosides are particularly useful as antisense agents, ribozymes, aptamer, siRNA agents, probes and primers or, when hybridized to an RNA, as a substrate for RNA cleaving enzymes including RNase H and dsRNase.
摘要翻译：公开了包含一个或多个修饰的核苷单位的寡核苷酸和寡核苷。寡核苷酸和寡核苷酸特别可用作反义剂，核酶，适体，siRNA试剂，探针和引物，或当与RNA杂交时作为RNA切割酶的底物，包括RNA酶H和dsRNase。

4. 发明申请

WO2002057287A3 NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
公开(公告)号：WO2002057287A3
公开(公告)日：2002-07-25
申请号：PCT/US2002/003086
申请日：2002-01-18
申请人： MERCK & CO., INC. , ISIS PHARMACEUTICALS, INC. , CARROLL, Steven, S. , MACCOSS, Malcolm , OLSEN, David, B. , BHAT, Balkrishen , BHAT, Neelima , COOK, Phillip Dan , ELDRUP, Anne, B. , PRAKASH, Thazha, P. , PRHAVC, Marija , SONG, Quanlai
发明人： CARROLL, Steven, S. , MACCOSS, Malcolm , OLSEN, David, B. , BHAT, Balkrishen , BHAT, Neelima , COOK, Phillip Dan , ELDRUP, Anne, B. , PRAKASH, Thazha, P. , PRHAVC, Marija , SONG, Quanlai
IPC分类号： C07H19/14
摘要： The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

5. 发明申请

WO1993017717A1 COMPOSITIONS AND METHODS FOR MODULATING RNA 审中-公开
标题翻译：用于调节RNA的组合物和方法
公开(公告)号：WO1993017717A1
公开(公告)日：1993-09-16
申请号：PCT/US1993002057
申请日：1993-03-05
申请人： ISIS PHARMACEUTICALS, INC. , COOK, Phillip, Dan , BRUICE, Thomas , GUINOSSO, Charles, John , KAWASAKI, Andrew, Mamoru , GRIFFEY, Richard
发明人： ISIS PHARMACEUTICALS, INC.
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C07K14/005 , C12N9/0069 , C12N15/1137 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3511 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2740/16322 , C12Q1/68 , C12Q1/6813 , C12Y113/11012
摘要： Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
摘要翻译：公开了调节RNA活性的组合物和方法。根据优选实施方案，制备包含靶向和反应部分的反义组合物。反应性部分优选包含通过具有或不具有插入插入部分的接头与靶向寡核苷酸缀合的一个或两个咪唑官能团。还公开了治疗学，诊断和研究方法，合成核苷和可以被制成寡核苷酸的核苷片段也是公开的。

6. 发明申请

WO2005021568A3 NOVEL TRICYCLIC NUCLEOSIDES OR NUCLEOTIDES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：新型三环核苷或核苷作为治疗剂
公开(公告)号：WO2005021568A3
公开(公告)日：2005-04-21
申请号：PCT/US2004027819
申请日：2004-08-27
申请人： BIOTA INC , COOK PHILLIP DAN , EWING GREGORY , JIN YI , LAMBERT JOHN , PRHAVC MARIJA , RAJAPPAN VASANTHAKUMAR , RAJWANSHI VIVEK K , SAKTHIVEL KANDASAMY
发明人： COOK PHILLIP DAN , EWING GREGORY , JIN YI , LAMBERT JOHN , PRHAVC MARIJA , RAJAPPAN VASANTHAKUMAR , RAJWANSHI VIVEK K , SAKTHIVEL KANDASAMY
IPC分类号： A61P31/12 , C07H19/23 , A61K31/7064
CPC分类号： C07H19/04 , C07H19/23
摘要： Nucelosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
摘要翻译：核黄素和含有其三环基部分的核苷酸分别用于治疗感染性疾病和增殖性病症，例如病毒感染或癌症。

7. 发明申请

WO2005021568A2 NOVEL TRICYCLIC NUCLEOSIDES OR NUCLEOTIDES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：新型三环核苷或核苷作为治疗剂
公开(公告)号：WO2005021568A2
公开(公告)日：2005-03-10
申请号：PCT/US2004/027819
申请日：2004-08-27
申请人： BIOTA, INC. , COOK, Phillip, Dan , EWING, Gregory , JIN, Yi , LAMBERT, John , PRHAVC, Marija , RAJAPPAN, Vasanthakumar , RAJWANSHI, Vivek, K. , SAKTHIVEL, Kandasamy
发明人： COOK, Phillip, Dan , EWING, Gregory , JIN, Yi , LAMBERT, John , PRHAVC, Marija , RAJAPPAN, Vasanthakumar , RAJWANSHI, Vivek, K. , SAKTHIVEL, Kandasamy
IPC分类号： C07H19/00
CPC分类号： C07H19/04 , C07H19/23
摘要： Nucelosides and nucleotides containing a tricyclic base portion thereof are useful for treating infectious diseases and proliferative disorders, such as viral infections or cancer respectively.
摘要翻译：核糖核苷和含有其三环基部分的核苷酸分别用于治疗感染性疾病和增殖性病症，例如病毒感染或癌症。

8. 发明申请

WO2004009020A2 THIONUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE 审中-公开
标题翻译：作为RNA依赖性RNA病毒聚合酶抑制剂的硫代胞苷衍生物
公开(公告)号：WO2004009020A2
公开(公告)日：2004-01-29
申请号：PCT/US0322556
申请日：2003-07-18
申请人： MERCK & CO INC , ISIS PHARMACEUTICALS INC , OLSEN DAVID B , BHAT BALKRISHEN , COOK PHILLIP DAN
发明人： OLSEN DAVID B , BHAT BALKRISHEN , COOK PHILLIP DAN
IPC分类号： A61K45/06 , A61P31/12 , A61P31/14 , C07H19/14 , A61K
CPC分类号： A61K45/06 , C07H19/14
摘要： The present invention provides thionucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such thionucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the thionucleoside compounds of the present invention.
摘要翻译：本发明提供作为RNA依赖性RNA病毒聚合酶抑制剂的核苷类化合物及其某些衍生物。这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用于治疗RNA依赖性RNA病毒感染。它们特别可用作丙型肝炎病毒（HCV）NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和/或用于治疗丙型肝炎感染。本发明还描述了单独或与其它对RNA依赖性RNA病毒感染（特别是HCV感染）有活性的试剂组合含有这样的硫代核苷化合物的药物组合物。还公开了用本发明的硫代核苷化合物抑制RNA依赖性RNA聚合酶，抑制RNA依赖性RNA病毒复制和/或治疗RNA依赖性RNA病毒感染的方法。

9. 发明申请

WO2003072711A2 METHOD OF USING MODIFIED OLIGONUCLEOTIDES FOR HEPATIC DELIVERY 审中-公开
标题翻译：使用修饰的寡核苷酸进行肝脏递送的方法
公开(公告)号：WO2003072711A2
公开(公告)日：2003-09-04
申请号：PCT/US2003/005066
申请日：2003-02-21
申请人： ISIS PHARMACEUTICALS, INC. , COOK, Phillip, Dan , MANOHARAN, Muthiah , BENNETT, Frank, C.
发明人： COOK, Phillip, Dan , MANOHARAN, Muthiah , BENNETT, Frank, C.
IPC分类号： C12N
CPC分类号： C12N15/113 , C12N15/1138 , C12N15/87 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/3515 , C12N2310/3525 , C12N2310/3529
摘要： A method of modulating the expression of a nucleic acid in the hepatic system of a mammal is disclosed. In addition, a method of preferentially targeting an oligonucleotide to liver cells in a mammal is disclosed. Also, a method of treating an animal having a hepatic disease or disorder associated with a protein encoded by a gene is disclosed. A composition containing an oligonucleotide is disclosed.
摘要翻译：公开了一种调节哺乳动物肝脏系统中核酸表达的方法。另外，公开了一种优先将寡核苷酸靶向哺乳动物的肝细胞的方法。此外，还公开了治疗患有与由基因编码的蛋白质相关的肝病或病症的动物的方法。公开了含有寡核苷酸的组合物。

10. 发明申请

WO0102423A9 2'-GUANIDINYL-SUBSTITUTED OLIGONUCLEOTIDES AND GENE EXPRESSION MODULATION THEREWITH 审中-公开
标题翻译： 2'-胍基取代的寡核苷酸和基因表达调控
公开(公告)号：WO0102423A9
公开(公告)日：2002-05-02
申请号：PCT/US0018609
申请日：2000-07-07
申请人： ISIS PHARMACEUTICALS INC , MANOHARAN MUTHIAH , COOK PHILLIP DAN , PRAKASH THAZHA P , MOHAN VENKATRAMAN
发明人： MANOHARAN MUTHIAH , COOK PHILLIP DAN , PRAKASH THAZHA P , MOHAN VENKATRAMAN
IPC分类号： C07H21/02 , A61K31/712 , A61K48/00 , A61P35/00 , C07C335/38 , C07F9/24 , C07H21/00 , C07H21/04 , C12Q1/68 , A61K31/70 , C07H19/067 , C07H19/073 , C07H19/10 , C07H19/167 , C07H19/173 , C07H19/20
CPC分类号： C07H21/00
摘要： The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative purposes.
摘要翻译：本发明提供了与选定的RNA或DNA序列特异性杂交的寡聚体，其中低聚物的至少一个核苷部分被修饰成包括胍基。这些低聚物可用于诊断，治疗和调查目的。

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