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2. 发明申请

WO2003083044A2 TISSUE ANALOGS FOR IN VITRO TESTING AND METHOD OF USE THEREFOR 审中-公开
标题翻译：用于体外测试的组织模拟及其使用方法
公开(公告)号：WO2003083044A2
公开(公告)日：2003-10-09
申请号：PCT/US2003/010105
申请日：2003-03-21
申请人： CONDROS, INC. , JOHNS HOPKINS UNIVERSITY , FRONDOZA, Carmelita, G. , FINK, David, J.
发明人： FRONDOZA, Carmelita, G. , FINK, David, J.
IPC分类号： C12N
CPC分类号： C12N5/0697 , C12N5/0655 , C12N2501/23 , C12N2501/25 , C12N2503/04 , C12N2531/00 , G01N33/5082
摘要： A test system and method are disclosed for using tissue analogs The method includes the following steps: (1) isolating the cells to be implanted from donor tissue; (2) seeding the cells onto a particulate microcarrier bead; (3) culturing the cells on the microcarriers to achieve an expansion in the number of cells; and (4) further culturing the cell-particle aggregates to form a tissue analog. The resulting tissue analog and test system may be used for use in screening drugs for diseases and pathological conditions, for testing for toxicity of chemical agents, or for genomic or proteomic screening. The tissue analogs may also be subjected to conditions that will induce disease-like conditions such that the resulting diseased tissue analogs may be used to screen for therapeutic drugs that modify the diseased tissue analog physiology or block progression of the diseased conditions. Kits may be developed for the purpose of conducting multiple tests in conventional multi-well plate systems.
摘要翻译：公开了使用组织类似物的测试系统和方法。该方法包括以下步骤：（1）从供体组织中分离待植入的细胞; （2）将细胞接种到微粒载体珠粒上; （3）在微载体上培养细胞以实现细胞数量的扩大; 和（4）进一步培养细胞 - 颗粒聚集体以形成组织类似物。所得到的组织类似物和测试系统可用于筛选用于疾病和病理状况的药物，用于测试化学试剂的毒性，或用于基因组或蛋白质组学筛选。组织类似物还可以经受将引起疾病状况的条件，使得所得到的患病组织类似物可用于筛选改变患病组织的类似生理学或阻断疾病状态进展的治疗药物。可以开发用于在常规多孔板系统中进行多次测试的试剂盒。

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