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1. 发明申请

WO2012106100A3 MULTI FREQUENCY AND MULTI POLARITY COMPLEX IMPEDANCE MEASUREMENTS TO ASSESS ABLATION LESIONS 审中-公开
标题翻译：多频和多极性复合阻抗测量来评估消除距离
公开(公告)号：WO2012106100A3
公开(公告)日：2012-09-20
申请号：PCT/US2012021478
申请日：2012-01-17
申请人： MEDTRONIC ABLATION FRONTIERS , SHERMAN MARSHALL L , CONDIE CATHERINE R , STEWART MARK T
发明人： SHERMAN MARSHALL L , CONDIE CATHERINE R , STEWART MARK T
IPC分类号： A61B18/12 , A61B18/00
CPC分类号： A61B5/0531 , A61B5/0536 , A61B5/4848 , A61B5/7246 , A61B18/02 , A61B18/12 , A61B18/1492 , A61B2017/00128 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00279 , A61B2018/00285 , A61B2018/00404 , A61B2018/00577 , A61B2018/00642 , A61B2018/00648 , A61B2018/00666 , A61B2018/00869 , A61B2018/00875 , A61B2018/0212
摘要： A method of assessing a tissue ablation treatment, including positioning a medical device adjacent a target tissue; the medical device measuring a first impedance magnitude at a first frequency with the medical device; measuring a first impedance phase at a second frequency with the medical device; ablating at least a portion of the target tissue with the medical device; measuring at second impedance magnitude at a third frequency with the medical device; measuring a second impedance phase at a fourth frequency with the medical device; comparing at least one of (i) the first and second impedance magnitudes and (ii) the first and second impedance phases; and providing an indication of the efficacy of the ablation treatment based at least in part on the comparison.
摘要翻译：一种评估组织消融治疗的方法，包括定位邻近靶组织的医疗装置; 所述医疗设备用所述医疗设备测量第一频率的第一阻抗幅度; 用所述医疗装置测量第二频率的第一阻抗相位; 用医疗装置切除目标组织的至少一部分; 以医疗装置在第三频率的第二阻抗幅度下测量; 用所述医疗装置测量第四频率的第二阻抗相位; 比较（i）第一和第二阻抗幅度和（ii）第一和第二阻抗相位中的至少一个; 以及至少部分地基于比较来提供消融治疗的功效的指示。

2. 发明申请

WO2012057915A1 CRYOGENIC-RADIOFREQUENCY ABLATION SYSTEM 审中-公开
标题翻译：低温无线电收缩系统
公开(公告)号：WO2012057915A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/049825
申请日：2011-08-31
申请人： MEDTRONIC ABLATION FRONTIERS LLC , LALONDE, Jean-Pierre , CONDIE, Catherine R.
发明人： LALONDE, Jean-Pierre , CONDIE, Catherine R.
IPC分类号： A61B18/02 , A61B18/14 , A61N1/18 , A61N1/40
CPC分类号： A61N1/403 , A61B18/02 , A61B18/1492 , A61B2018/0016 , A61B2018/00255 , A61B2018/00375 , A61B2018/00642 , A61B2018/00678 , A61B2018/00702 , A61B2018/00714 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/00994 , A61B2018/0212 , A61B2018/0262
摘要： A medical treatment system, including a catheter body defining a fluid flow path therethrough; an expandable element disposed on the catheter body, the expandable element defining a cooling chamber therein in fluid communication with the fluid flow path; a plurality of electrodes disposed on the expandable element; a cryogenic fluid source in fluid communication with the fluid flow path; and a radiofrequency energy source in electrical communication with the plurality of electrodes. A method of treating a cardiac tissue site proximate an orifice, including substantially occluding the orifice with an expandable element; powering a plurality of electrodes coupled to the expandable element to reach a predetermined target temperature; circulating a coolant through the expandable element to freeze portions of the cardiac tissue site located between the plurality of electrodes; and ablating the non-frozen portions of the tissue site with the plurality of electrodes.
摘要翻译：一种医疗系统，包括限定穿过其中的流体流动路径的导管主体; 设置在所述导管主体上的可扩张元件，所述可膨胀元件在其中限定与所述流体流动路径流体连通的冷却室; 设置在所述可扩张元件上的多个电极; 与流体流动路径流体连通的低温流体源; 以及与所述多个电极电连通的射频能量源。一种治疗邻近孔的心脏组织部位的方法，包括用可膨胀元件基本封闭孔; 为耦合到所述可扩展元件的多个电极供电以达到预定的目标温度; 使冷却剂循环通过可膨胀元件以冻结位于多个电极之间的心脏组织部位的部分; 以及用所述多个电极烧蚀所述组织部位的未冷冻部分。

3. 发明申请

WO2011143199A1 SYSTEM FOR SELECTING AN ABLATION PROCEDURE BASED ON COMPARING A BIOLOGICAL RESPONSE WITH A MATHEMATICAL MODEL 审中-公开
标题翻译：基于与数学模型比较生物反应的选择程序的系统
公开(公告)号：WO2011143199A1
公开(公告)日：2011-11-17
申请号：PCT/US2011/035901
申请日：2011-05-10
申请人： MEDTRONIC INC. , FRANCISCHELLI, David , CONDIE, Catherine R. , HONG, Jinback
发明人： FRANCISCHELLI, David , CONDIE, Catherine R. , HONG, Jinback
IPC分类号： A61B18/12 , A61B18/14
CPC分类号： A61B18/12 , A61B18/1492 , A61B34/10 , A61B2018/00291 , A61B2018/00642 , A61B2018/00648 , A61B2018/00702 , A61B2018/00791 , A61B2018/00875 , A61B2034/101
摘要： System (22) for ablating tissue of a heart of a patient. The tissue is characterized, then a predetermined ablation procedure is selected based on the characterization, ablation energy is delivered according to the selected procedure with the ablation device (26), and a temperature of the tissue and an impedance of the tissue are determined.
摘要翻译：用于烧蚀患者心脏的组织的系统（22）。特征在于组织，然后基于表征选择预定的消融程序，根据所选择的程序用消融装置（26）递送消融能量，并且确定组织的温度和组织的阻抗。

4. 发明申请

WO2012074729A1 SYSTEM AND METHOD FOR ADAPTIVE RF ABLATION 审中-公开
标题翻译：用于自适应射频消融的系统和方法
公开(公告)号：WO2012074729A1
公开(公告)日：2012-06-07
申请号：PCT/US2011/060610
申请日：2011-11-14
申请人： MEDTRONIC ABLATION FRONTIERS LLC , CONDIE, Catherine R. , SHERMAN, Marshall L. , KASISCHKE, Kathryn Elaine , CORVI, Timothy J. , STRUNK, Aaron R.
发明人： CONDIE, Catherine R. , SHERMAN, Marshall L. , KASISCHKE, Kathryn Elaine , CORVI, Timothy J. , STRUNK, Aaron R.
IPC分类号： A61B18/12 , A61B18/00
CPC分类号： A61B18/14 , A61B18/1206 , A61B18/1492 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2018/00648 , A61B2018/00678 , A61B2018/00702 , A61B2018/00714 , A61B2018/00726 , A61B2018/00779 , A61B2018/00791 , A61B2090/065
摘要： A medical method, device, and system are provided, including advancing an ablation element of a medical device into contact with tissue to be treated, selecting a power level of energy to ablate the tissue, delivering energy at the selected power level to the ablation element, determining whether the ablation element is in continuous contact with the tissue, and reducing the selected power level when the ablation element ceases to be in continuous contact with the tissue.
摘要翻译：提供了一种医疗方法，装置和系统，包括使医疗装置的消融元件与待治疗组织接触，选择能量消耗组织的能量水平，将所选功率水平的能量输送到消融元件确定消融元件是否与组织连续接触，以及当消融元件停止与组织连续接触时降低所选择的功率水平。

5. 发明申请

WO2012057911A1 REACTANCE CHANGES TO IDENTIFY AND EVALUATE CRYO ABLATION LESIONS 审中-公开
标题翻译：确定和评估CRYO ABLATION LESIONS的反应变化
公开(公告)号：WO2012057911A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/049632
申请日：2011-08-30
申请人： MEDTRONIC ABLATION FRONTIERS LLC , CONDIE, Catherine R. , KASISCHKE, Kathryn Elaine , SHERMAN, Marshall L.
发明人： CONDIE, Catherine R. , KASISCHKE, Kathryn Elaine , SHERMAN, Marshall L.
IPC分类号： A61B18/02 , A61B17/00 , A61B5/053
CPC分类号： A61B5/0538 , A61B2017/00026 , A61B2018/00755 , A61B2018/0262 , A61B2018/1407 , A61B2018/1467
摘要： A method of assessing lesion quality of an ablated tissue region comprising ablating at least a portion of the tissue region. The reactance of the ablated tissue region is measured. The lesion quality of the ablated tissue region is determined based on the measured reactance.
摘要翻译：一种评估消融组织区域的损伤质量的方法，包括烧蚀组织区域的至少一部分。测量消融的组织区域的电抗。基于测得的电抗确定烧伤组织区域的损伤质量。

6. 发明申请

WO2012094157A1 MULTIPOLARITY EPI CARDIAL RADIOFREQUENCY ABLATION 审中-公开
标题翻译：多重EPI心脏无线电消除
公开(公告)号：WO2012094157A1
公开(公告)日：2012-07-12
申请号：PCT/US2011/066468
申请日：2011-12-21
申请人： MEDTRONIC ABLATION FRONTIERS LLC , CONDIE, Catherine R. , AHLBERG, Sarah E.
发明人： CONDIE, Catherine R. , AHLBERG, Sarah E.
IPC分类号： A61B18/12 , A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00029 , A61B2018/00267 , A61B2018/00363 , A61B2018/00577 , A61B2018/00821 , A61B2018/1407 , A61B2018/1467 , A61B2218/002
摘要： A method of ablating an epicardial tissue region, including positioning a medical device adjacent the epicardial tissue region, the medical device having a first electrode, a second electrode, and a third electrode located in between the first and second electrodes; delivering an irrigation fluid to the tissue region; and ablating at least a portion of the tissue region by sequentially activating the third electrode in a monopolar radiofrequency delivery mode and activating the first and second electrodes in a bipolar radiofrequency delivery mode.
摘要翻译：一种消融心外膜组织区域的方法，包括定位邻近心外膜组织区域的医疗装置，所述医疗装置具有位于第一和第二电极之间的第一电极，第二电极和第三电极; 向组织区域输送冲洗流体; 以及通过以单极射频递送模式顺序启动所述第三电极并且以双极射频递送模式激活所述第一和第二电极，从而消融所述组织区域的至少一部分。

7. 发明申请

WO2009148429A1 ELECTROGRAM STORAGE FOR SUSPECTED NON-PHYSIOLOGICAL EPISODES 审中-公开
标题翻译：电生物存储用于悬浮的非生理性EPISODES
公开(公告)号：WO2009148429A1
公开(公告)日：2009-12-10
申请号：PCT/US2008/009199
申请日：2008-07-30
申请人： MEDTRONIC, INC. , OUSDIGIAN, Kevin, T. , CONDIE, Catherine, R. , KLECKNER, Karen, J. , GUNDERSON, Bruce, D.
发明人： OUSDIGIAN, Kevin, T. , CONDIE, Catherine, R. , KLECKNER, Karen, J. , GUNDERSON, Bruce, D.
IPC分类号： A61N1/37 , A61B5/0245 , A61N1/08
CPC分类号： A61N1/3702 , A61B5/042 , A61B5/046 , A61B5/0464 , A61B5/053 , A61B5/0538 , A61B5/7264 , A61B2560/0276 , A61N1/3704 , A61N2001/083
摘要： Techniques for storing electrograms (EGMs) that are associated with sensed episodes or events that may be non-physiological and, instead, associated with a sensing integrity condition are described. In some examples, a device or system identifies suspected non-physiological NSTs, and stores an EGM for the suspected non-physiological NSTs within an episode log. In some examples, a device or system determines whether to store an EGM for a suspected non- physiological episode or event based on whether an impedance integrity criterion has been satisfied. For example, a device or system may store an EGM for a detected short interval if the impedance integrity criterion has been met. In some examples, a device or system determines whether to buffer EGM data based on whether an impedance integrity criterion or other sensing integrity criterion has been met.
摘要翻译：描述了用于存储与可能是非生理感知的事件相关联的电描记图（EGM）的技术，并且相反地与感测完整性条件相关联。在一些示例中，设备或系统识别疑似非生理NST，并且在发作日志中存储用于可疑非生理NST的EGM。在一些示例中，设备或系统基于是否已经满足阻抗完整性标准来确定是否存储用于怀疑非生理事件或事件的EGM。例如，如果已经满足了阻抗完整性标准，则设备或系统可以存储用于检测到的短间隔的EGM。在一些示例中，设备或系统基于是否已经满足阻抗完整性标准或其他感测完整性标准来确定是否缓冲EGM数据。

8. 发明申请

WO2012106100A2 MULTI FREQUENCY AND MULTI POLARITY COMPLEX IMPEDANCE MEASUREMENTS TO ASSESS ABLATION LESIONS 审中-公开
标题翻译：多频和多极性复合阻抗测量来评估消除距离
公开(公告)号：WO2012106100A2
公开(公告)日：2012-08-09
申请号：PCT/US2012/021478
申请日：2012-01-17
申请人： MEDTRONIC ABLATION FRONTIERS LLC , SHERMAN, Marshall L. , CONDIE, Catherine R. , STEWART, Mark T.
发明人： SHERMAN, Marshall L. , CONDIE, Catherine R. , STEWART, Mark T.
IPC分类号： A61B18/12
CPC分类号： A61B5/0531 , A61B5/0536 , A61B5/4848 , A61B5/7246 , A61B18/02 , A61B18/12 , A61B18/1492 , A61B2017/00128 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00279 , A61B2018/00285 , A61B2018/00404 , A61B2018/00577 , A61B2018/00642 , A61B2018/00648 , A61B2018/00666 , A61B2018/00869 , A61B2018/00875 , A61B2018/0212
摘要： A method of assessing a tissue ablation treatment, including positioning a medical device adjacent a target tissue; measuring a first impedance magnitude a first frequency with the medical device; measuring a first impedance phase at a second frequency with the medical device; ablating at least a portion of the target tissue with the medical device; measuring at second impedance magnitude at a third frequency with the medical device; measuring a second impedance phase at a fourth frequency with the medical device; comparing at least one of (i) the first and second impedance magnitudes and (ii) the first and second impedance phases; and providing an indication of the efficacy of the ablation treatment based at least in part on the comparison.
摘要翻译：一种评估组织消融治疗的方法，包括定位邻近靶组织的医疗装置; 用所述医疗设备测量第一频率的第一阻抗幅度; 用所述医疗装置测量第二频率的第一阻抗相位; 用医疗装置切除目标组织的至少一部分; 以医疗装置在第三频率的第二阻抗幅度下测量; 用所述医疗装置测量第四频率的第二阻抗相位; 比较（i）第一和第二阻抗幅度和（ii）第一和第二阻抗相位中的至少一个; 以及至少部分地基于比较来提供消融治疗的功效的指示。

9. 发明申请

WO2010014062A1 PRE-QUALIFICATION OF AN ALTERNATE SENSING CONFIGURATION 审中-公开
标题翻译：预备感应配置的预认证
公开(公告)号：WO2010014062A1
公开(公告)日：2010-02-04
申请号：PCT/US2008/009241
申请日：2008-07-31
申请人： MEDTRONIC, INC. , CASAVANT, David , CONDIE, Catherine, R. , SPENCE, Jon, W. , MUNSTERMAN, Nathan
发明人： CASAVANT, David , CONDIE, Catherine, R. , SPENCE, Jon, W. , MUNSTERMAN, Nathan
IPC分类号： A61N1/39
CPC分类号： A61N1/3925 , A61N1/3622 , A61N1/3704 , A61N1/385 , A61N1/3956
摘要： Multiple sensing configurations may be qualified based on one induced tachyarrhythmia, e.g., ventricular fibrillation, or other qualification event during an implantation procedure. Each sensing configuration comprises a different combination of two or more electrodes used for sensing electrical signals of the heart of the patient. In some examples, an implantable medical device or other device generates qualification information for each sensing configuration, which may indicate whether the sensing configuration is qualified for subsequent cardiac event detection based on an accuracy of the cardiac event detection for the sensing configuration during the qualification event. One of the qualified configurations may initially be selected as a primary sensing configuration for subsequent cardiac event detection. Switching to an alternate sensing configuration, e.g., upon identification of any sensing integrity condition of the primary sensing configuration, may be expedited by the previous collection of qualification data for at least one other sensing configuration.
摘要翻译：可以基于一种诱导的快速性心律失常，例如心室颤动或植入手术期间的其他鉴定事件来限定多个感测构造。每个感测配置包括用于感测患者心脏的电信号的两个或更多个电极的不同组合。在一些示例中，可植入医疗装置或其他装置产生用于每个感测配置的鉴定信息，其可以基于在资格事件期间的感测配置的心脏事件检测的精度来指示感测配置是否适合于随后的心脏事件检测。最初可以选择其中一个合格配置作为随后的心脏事件检测的主感测配置。例如在识别主要感测配置的任何感测完整性状况时，切换到备选感测配置可以通过先前收集的至少一个其他感测配置的限定数据来加速。

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