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1. 发明申请

WO2015136548A2 A PROCESS FOR ISOLATION OF ROMIDEPSIN FROM FERMENTATION BROTH AND PREPARATION OF CRYSTALS OF ROMIDEPSIN 审中-公开
标题翻译：从发酵丝中分离ROMIDEPSIN的方法和ROMIDEPSIN晶体的制备
公开(公告)号：WO2015136548A2
公开(公告)日：2015-09-17
申请号：PCT/IN2015/000113
申请日：2015-03-02
申请人： CONCORD BIOTECH LIMITED
发明人： VAID, Ankur Sudhir , DHIMAN, Anand Mahadev , SHARMA, Traunkant Parshuram
IPC分类号： A61K38/07
CPC分类号： C07K11/02 , C07K5/101
摘要： The present invention describes a process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin. The process of the invention includes fewer purification steps and provides romidepsin having purity of greater than 99.5% area by HPLC. The process of the invention involves simple purification steps and hence, does not require multiple chromatographic purification steps to achieve desired quality of romidepsin. The process is advantageous over reported processes in terms of 99.5 % pure yield, fast process, less expensive and less cumbersome as multiple chromatographic purification is not necessary to achieve desired quality. The process for the preparation of crystals of romidepsin provides advantages like simple steps and involves use of single solvent. The process is advantageous in terms of time, cost, and simplicity.
摘要翻译：本发明描述了一种从发酵液中分离罗非西菌素的方法以及罗曲甜蛋白晶体的制备。本发明的方法包括较少的纯化步骤，并通过HPLC提供具有大于99.5％面积的纯度的罗曲非菌素。本发明的方法涉及简单的纯化步骤，因此，不需要多个色谱纯化步骤来达到所需的罗维菌素质量。该方法优于所报道的方法，其纯度为99.5％，快速加工，较便宜且较不麻烦，因为不需要多次色谱纯化来达到所需的质量。制备罗非曲汀晶体的方法提供了简单步骤的优点，并涉及使用单一溶剂。该方法在时间，成本和简单性方面是有利的。

2. 发明申请

WO2014174528A2 AN IMPROVED PROCESS FOR THE PREPARATION OF FIDAXOMICIN 审中-公开
标题翻译：一种改进的制备fidaxomycin的方法
公开(公告)号：WO2014174528A2
公开(公告)日：2014-10-30
申请号：PCT/IN2014/000251
申请日：2014-04-21
申请人： CONCORD BIOTECH LIMITED
发明人： VAID, Ankur Sudhir , PATEL, Mitesh Jagdishkumar , MEHTA, Dhimant Punjalal , DHIMAN, Anand Mahadev , PATEL, Jayesh Chandubhai , SHARMA, Traunkant Parshuram
IPC分类号： C12P1/00
CPC分类号： C12P19/58 , C07D407/14 , C07H17/08 , C12N1/20 , C12P19/62
摘要： The present invention provides an improved process for the preparation of fidaxomicin by culturing Actinoplanes deccanensis in the culture medium of the invention wherein the fidaxomicin is produced in a yield of greater than 500mg/L broth. The present invention also provides a whole broth extraction process for the isolation of fidaxomicin from the fermentation broth. The present invention also provides fidaxomicin having purity of greater than 97% area by HPLC.
摘要翻译：本发明提供了通过在本发明的培养基中培养Actinoplanes deccanensis制备非达霉素的改进方法，其中非达霉素以大于500mg的产率生产 / L肉汤。本发明还提供了用于从发酵液中分离非达霉素的全发酵液提取方法。本发明还通过HPLC提供纯度大于97％面积的非达霉素。

3. 发明申请

WO2008015693A2 PROCESS FOR THE PREPARATION OF MYCOPHENOLATE MOFETIL 审中-公开
标题翻译：制备MYCOPHENOLATE MOFETIL的方法
公开(公告)号：WO2008015693A2
公开(公告)日：2008-02-07
申请号：PCT/IN2007/000192
申请日：2007-05-10
申请人： CONCORD BIOTECH LIMITED , NARULA, Pardeep , PATEL, Bhautik , VAID, Sudhir
发明人： NARULA, Pardeep , PATEL, Bhautik , VAID, Sudhir
IPC分类号： C07D413/02
CPC分类号： C07D307/83
摘要： Invention provides an improved process for the preparation of Mycophenolate mofetil by reacting Mycophenolic acid with morpholino ethanol in presence of Dipyridyl carbonate.
摘要翻译：本发明提供了通过在碳酸二吡啶酯存在下使霉酚酸与吗啉代乙醇反应来制备霉酚酸酯的改进方法。

4. 发明申请

WO2006072963A1 PROCESS FOR PREPARING SIMVASTATIN FROM LOVASTATIN AMINE SALTS IN THREE STEPS 审中-公开
标题翻译：在三步骤中从LOVASTATIN AMINE SALTS制备辛伐他汀的方法
公开(公告)号：WO2006072963A1
公开(公告)日：2006-07-13
申请号：PCT/IN2005/000066
申请日：2005-02-25
申请人： CONCORD BIOTECH LIMITED
发明人： VAID, Sudhir , NARULA, Pradeep, Dr.
IPC分类号： C07D309/30 , C07C235/30
CPC分类号： C07D309/30
摘要： The application describes a new process for preparing Simvastatin from Lovastatin amine salts in three steps. Lovastatin was hydrolysed to acid form and then isolated in the form of amine salt like cyclopropyl or t-octyl amine etc. The salts isolated were methylated directly without any protection and deprotection of hydroxy groups. The Simvastatin ammonium salt was produced directly, converted to Simvastatin by conventional methods & then purified to Simvastatin.
摘要翻译：该申请描述了从洛伐他汀胺盐制备辛伐他汀的三个步骤的新方法。将洛伐他汀水解成酸形式，然后以胺盐形式分离，如环丙基或叔辛基胺等。分离的盐直接甲基化，无任何保护和羟基脱保护。辛伐他汀铵盐直接生产，通过常规方法转化为辛伐他汀，然后纯化至辛伐他汀。

5. 发明申请

WO2008059516A2 PROCESS FOR PURIFICATION OF MACROLIDES 审中-公开
标题翻译： MACROLIDES净化工艺
公开(公告)号：WO2008059516A2
公开(公告)日：2008-05-22
申请号：PCT/IN2007/000352
申请日：2007-08-16
申请人： CONCORD BIOTECH LIMITED , NARULA, Pardeep , PATEL, Jayesh , VAID, Sudhir , PATEL, Pragnesh
发明人： NARULA, Pardeep , PATEL, Jayesh , VAID, Sudhir , PATEL, Pragnesh
IPC分类号： A61K31/4745
CPC分类号： C07D498/08
摘要： The invention is a novel process for purification of macrolides such as Tacrolimus using a new polymer resin and copper salts containing cupric ions. The novel polymer resin contains polyvinyl pyrrolidone, metha acrylate, divinyl benzene based compounds. In the said process manufacturing of new polymer resin and use of cupric salt is very much cost effective. The same metal salts can also be used along with other neutral non-ionic adsorption resins of polyethylene i e HP2O, HP2OSS, Sepabeads SP207 and the like. The concentration of copper ions may be generally 0.20 to 1.5 mol/L, preferably 0.30 to 0.40 mol/L. As an aqueous medium for the copper ion containing aqueous solvent, an aqueous acetone, an aqueous alcohol, an aqueous acetonitrile or the like. The invention covers Tacrolimus having a purity of more than 99.7%.
摘要翻译：本发明是使用新的聚合物树脂和含有铜离子的铜盐来纯化大环内酯如塔克罗莫司的新方法。新型聚合物树脂含有聚乙烯吡咯烷酮，甲基丙烯酸酯，二乙烯基苯基化合物。在所述方法中制造新型聚合物树脂和使用铜盐是非常成本有效的。同样的金属盐也可以与聚乙烯的其它中性非离子吸附树脂一起使用，例如HP2O，HP2OSS，Sepabeads SP207等。铜离子的浓度通常为0.20〜1.5mol / L，优选为0.30〜0.40mol / L。作为含有铜离子的含水溶剂的水性介质，含水丙酮，含水醇，乙腈水溶液等。本发明涵盖具有超过99.7％纯度的他克莫司。

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