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1. 发明申请

WO2020264112A1 REACTIVE ELECTROCHEMICAL MEMBRANE FOR WASTEWATER TREATMENT 审中-公开
公开(公告)号：WO2020264112A1
公开(公告)日：2020-12-30
申请号：PCT/US2020/039553
申请日：2020-06-25
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , CLARKSON UNIVERSITY
发明人： YANG, Yang , HOFFMANN, Michael R.
IPC分类号： B01D67/00 , B01D69/10 , B01D69/12 , B01D71/02 , C02F1/467 , C02F1/461
摘要： Aspects of the invention include a porous and water-permeable electrode for electrocatalysis comprising: a porous and water-permeable reactive electrochemical membrane ("REM") comprising: a porous and water-permeable support membrane; wherein the support membrane comprises a titanium metal; and an electrocatalytic coating on at least a portion of the metal support membrane, the electrocatalytic coating being a tin oxide bilayer comprising: a first layer adjacent to and directly contacting the metal support membrane; wherein the first layer comprises tin oxide doped with antimony; and a second layer adjacent to and directly contacting the first layer; wherein the second layer forms a surface of the REM such that the second layer is in direct contact with an aqueous solution when the REM is in contact with the aqueous solution; wherein the second layer comprises tin oxide doped with antimony and nickel or cerium. Preferably, the support membrane is formed of a titanium metal.

2. 发明申请

WO2016112081A1 SILVER COATED COPPER FLAKES AND METHODS OF THEIR MANUFACTURE 审中-公开
标题翻译：镀银铜箔及其制造方法
公开(公告)号：WO2016112081A1
公开(公告)日：2016-07-14
申请号：PCT/US2016/012299
申请日：2016-01-06
申请人： CLARKSON UNIVERSITY
发明人： GOIA, Dan V. , GOIA, Corina , NJAGI, John I.
IPC分类号： C23C18/16 , B22F1/00 , B22F1/02 , C23C18/44 , C23C18/54
CPC分类号： C23C18/1635 , B22F1/0055 , B22F1/025 , B22F2999/00 , C23C18/1651 , C23C18/1692 , C23C18/44 , C23C18/54 , H01B1/026 , B22F1/0062 , B22F1/0088
摘要： Compositions having copper flakes coated with silver, where the silver is present as a hermetically closed metal shell around the copper, are described. The hermetically closed metal shell can limit oxidation of copper for at least 365 days at a temperature of less than 100 °C. The composition can also contain palladium in an amount of about 1 % or less by weight of silver in the shell. Palladium limits the migration of copper from the core flakes to the silver shell at temperatures below 250 °C. Methods of manufacturing copper flakes coated can include the steps of treating copper flakes with an acid to form acid treated copper flakes, treating the acid treated copper flakes with a polyamine to form polyamine treated copper flakes, depositing silver on the polyamine treated copper flakes to form copper flakes comprising silver deposits, and depositing silver onto the copper flakes comprising silver deposits.
摘要翻译：描述了具有涂覆有银的铜片的组合物，其中银作为围绕铜的气密封闭的金属壳存在。密封的金属外壳可以在低于100℃的温度下限制铜的氧化至少365天。该组合物还可以含有壳中约1％或更少量的银的钯。钯在低于250℃的温度下限制铜从芯片迁移到银壳。制造铜薄片的方法可以包括用酸处理铜薄片以形成酸处理的铜薄片的步骤，用多胺处理酸处理的铜薄片以形成多胺处理的铜薄片，在多胺处理的铜薄片上沉积银以形成包括银沉积物的铜片，并将银沉积在包含银沉积物的铜片上。

3. 发明申请

WO2018030984A1 ENHANCED CONTACT ELECTRICAL DISCHARGE PLASMA REACTOR FOR LIQUID AND GAS PROCESSING 审中-公开
标题翻译：用于液体和气体处理的增强接触式放电等离子体反应器
公开(公告)号：WO2018030984A1
公开(公告)日：2018-02-15
申请号：PCT/US2016/046013
申请日：2016-08-08
申请人： CLARKSON UNIVERSITY
发明人： MEDEDOVIC, Selma , STRATTON, Gunnar , HOLSEN, Thomas , BELLONA, Christopher
IPC分类号： B01J19/08 , C02F1/46
CPC分类号： C02F1/4608 , B01J19/088 , B01J2219/0811 , B01J2219/0815 , B01J2219/0828 , B01J2219/083 , B01J2219/0835 , B01J2219/0839 , B01J2219/0841 , B01J2219/0869 , B01J2219/0884 , C02F2201/4611 , C02F2201/4619 , C02F2301/028
摘要： An electrical discharge plasma reactor system for treating a liquid, a gas, and/or a suspension. The reactor system includes a reactor chamber configured to hold the liquid and a gas, a discharge electrode disposed within the gas of the reactor chamber, a non-discharge electrode disposed within the liquid, a gas diffuser disposed within the liquid and configured to induce the generation of a layer of foam on the surface of the liquid in a plasma-contact region, and a power supply connected to the discharge electrode and configured to induce the discharge electrode to generate plasma in the plasma-contact region.
摘要翻译：用于处理液体，气体和/或悬浮液的放电等离子体反应器系统。该反应器系统包括被配置为保持液体和气体的反应器室，布置在反应器室的气体内的放电电极，布置在液体内的非放电电极，布置在液体内并配置成引发在等离子体接触区域中的液体表面上产生泡沫层;以及电源，其连接到放电电极并且被配置为引起放电电极在等离子体接触区域中产生等离子体。

4. 发明申请

WO1988005337A1 PROCESS FOR PREPARATION OF MONODISPERSED BARIUM CONTAINING FERRITES 审中-公开
标题翻译：用于制备含有黑麦糖的单体混合物的方法
公开(公告)号：WO1988005337A1
公开(公告)日：1988-07-28
申请号：PCT/US1988000083
申请日：1988-01-14
申请人： CLARKSON UNIVERSITY
发明人： CLARKSON UNIVERSITY , MATIJEVIC, Egon
IPC分类号： B01J13/00
CPC分类号： B03C1/01 , A61K9/5094 , C01G49/0036 , C01P2004/38 , C01P2004/52 , C01P2004/62 , C01P2006/42 , C01P2006/60 , C04B35/2683 , H01F1/445
摘要： An improved process for preparation of well-defined monodispersed colloidal particles of barium containing ferrites. This process involves the formation of colloidal barium ferrite particles in aqueous media by phase transformation of a ferrous hydroxide gel in the presence of barium ions. In this process, a magnetite is initially formed in aqueous solution and barium substituted into the resultant particle by displacement of Fe . This procedure is performed in a nonoxidizing atmosphere and under mildly caustic conditions. As the reaction proceeds to completion (aging) the system becomes decidedly more acidic. The colloidal particles produced in accordance with this invention are easily dispersible in aqueous media and, unlike magnetite, are superparamagnetic in response to a magnetic field. This procedure is in sharp contrast to more traditional methods of solid state transformations of the magnetite to ferrite at temperatures typically in excess of 1000 DEG C.
摘要翻译：用于制备含钡铁氧体的明确定义的单分散胶体颗粒的改进方法。该方法包括在钡离子存在下通过氢氧化亚铁凝胶的相转化在水介质中形成胶态钡铁氧体颗粒。在这个过程中，最初在水溶液中形成磁铁矿，并通过置换Fe 2+将钡取代成所得颗粒。该方法在非氧化气氛和弱苛性条件下进行。当反应进行到完成（老化）时，系统变得更加酸性。根据本发明生产的胶体颗粒易于分散在水性介质中，并且与磁铁矿不同，响应于磁场而具有超顺磁性。该过程与在通常超过1000℃的温度下磁铁矿固体转化为铁素体的传统方法形成鲜明对照。

5. 发明申请

WO2013181659A1 ADJUSTABLE LENGTH ORTHOPEDIC DEVICE 审中-公开
标题翻译：可调节长度正交装置
公开(公告)号：WO2013181659A1
公开(公告)日：2013-12-05
申请号：PCT/US2013/043900
申请日：2013-06-03
申请人： CLARKSON UNIVERSITY , CLARK, Alexander Martin
发明人： CLARK, Alexander Martin , KUXHAUS, Laurel
IPC分类号： A61B17/56 , A61B17/70 , A61B17/86
CPC分类号： A61B17/7216 , A61B17/7233 , A61B17/725 , A61B17/744 , A61B17/8685
摘要： An adjustable length orthopedic device and system. According to one embodiment, the adjustable length orthopedic device or system comprises an elongated shaft with a longitudinal axis, and an adjustable portion extending from a proximal end of the elongated shaft along the longitudinal axis. The adjustable length orthopedic device further comprises at least one hole in a distal end portion of the device, where the hole is adapted for insertion of a pin through the device and into the bone in order to anchor the device to the bone. According to another embodiment is a lag screw extending from a proximal end of the elongated shaft at an angle oblique to the longitudinal axis, the lag screw comprising a lag screw shaft segment, and an adjustable segment that extends from the proximal end of the shaft segment. According to another embodiment is an adjustable length locking screw.
摘要翻译：可调长度的矫形装置和系统。根据一个实施例，可调整长度的矫形装置或系统包括具有纵向轴线的细长轴和从长轴的纵向轴线延伸的可调节部分。所述可调整长度的矫形装置还包括在所述装置的远端部分中的至少一个孔，其中所述孔适于将销插入穿过所述装置并进入所述骨中，以将所述装置锚固到所述骨上。根据另一个实施例，拉杆螺钉从细长轴的近端以与纵向轴线倾斜的角度延伸，拉力螺钉包括拉力螺杆轴段，以及从轴段的近端延伸的可调段。根据另一实施例是可调节长度的锁定螺钉。

6. 发明申请

WO2013159096A1 METHODS FOR WATER-BORNE THIOL-ENE POLYMERIZATION 审中-公开
标题翻译：水硼氢化聚合方法
公开(公告)号：WO2013159096A1
公开(公告)日：2013-10-24
申请号：PCT/US2013/037601
申请日：2013-04-22
申请人： CLARKSON UNIVERSITY , DURHAM, Olivia, Z. , SHIPP, Devon, Andrew , KRISHNAN, Sitaraman
发明人： DURHAM, Olivia, Z. , SHIPP, Devon, Andrew , KRISHNAN, Sitaraman
IPC分类号： C08G75/02 , C08G73/06 , C08L81/02 , C08F28/04 , C08F2/18
CPC分类号： C08J3/28 , C08G75/04 , C08G75/045
摘要： A method for suspension polymerization of thiol-ene particles comprising combining a plurality of thiol-ene precursor monomers with or without a solvent to create a first mixture, combining an emulsifier and water to create a second mixture, adding an initiator to either the first or second mixture, adding the first mixture and the second mixture to create a third mixture, agitating the third mixture to create a heterogeneous dispersion, and initiating polymerization of thiol-ene particles from the thiol-ene precursor monomers in the third mixture which is simultaneously agitated.
摘要翻译：包括硫醇 - 烯体的悬浮聚合方法，包括将多种硫醇 - 前体单体与或不与溶剂组合以产生第一混合物，组合乳化剂和水以产生第二混合物，将引发剂加入到第一或第二混合物，加入第一混合物和第二混合物以产生第三混合物，搅拌第三混合物以产生非均相分散体，并引发硫醇 - 烯体颗粒从同时搅拌的第三混合物中的硫醇 - 前体单体的聚合。

7. 发明申请

WO2020014708A1 NANOFLUIDIC ANALYTICAL DEVICES AND METHODS OF USING THEREOF 审中-公开
公开(公告)号：WO2020014708A1
公开(公告)日：2020-01-16
申请号：PCT/US2019/041872
申请日：2019-07-15
申请人： UNIVERSITY OF KANSAS , THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE , NORTHEASTERN UNIVERSITY , CLARKSON UNIVERSITY
发明人： SOPER, Steven A. , MCKINNEY, Collin J. , PODLAHA-MURPHY, Elizabeth , PARK, Sunggook
IPC分类号： G01N33/487 , C12Q1/68
摘要： Disclosed are nanofluidic analytical devices. The devices employ a sample processing region that includes a plurality of fluidically connected sample handling elements that, in combination, affect a physical change on a sample introduced into the sample processing region. This physical change can include, for example, purification of an analyte of interest present in the sample, concentration of an analyte of interest present in the sample, chemical modification (e.g., cleavage and/or chemical derivatization) of an analyte of interest present in the sample, or a combination thereof. The analytical devices further include a nanochannel comprising a plurality of in-plane nanopores in series fluidically coupled to the sample processing region. The in-plane nanopores can be used to detect and/or analyze analyte(s) present in the sample following processing by the sample processing region. These analytical devices can advantageously provide for the label-free detection of single molecules.

8. 发明申请

WO2018226834A1 ADJUSTABLE LENGTH ORTHOPEDIC DEVICE 审中-公开
公开(公告)号：WO2018226834A1
公开(公告)日：2018-12-13
申请号：PCT/US2018/036262
申请日：2018-06-06
申请人： CLARKSON UNIVERSITY
发明人： KUXHAUS, Laurel , CLARK, Alexander, Martin , PALIN, Stephen, C. , HEDGELAND, Mark , ROBINSON, Deja
IPC分类号： A61B17/72
CPC分类号： A61B17/742 , A61B17/72 , A61B90/03 , A61B90/08 , A61B2017/00477 , A61B2017/00991 , A61B2090/035 , A61B2090/0811 , A61F2/38 , A61F2002/30504 , A61F2002/30507 , A61F2002/30512 , A61F2002/3055 , A61F2002/30601 , A61F2002/30617
摘要： An adjustable length orthopedic device comprising: (i) a shaft having a longitudinal axis extending from a proximal end of the shaft to a distal end of the shaft, comprising an exterior having a diameter smaller than the medullary cavity of a bone within which at least a portion of the shaft is configured to reside, wherein the shaft comprises at least a portion of an adjustability mechanism located at said proximal end; (ii) a rod comprising a proximal end having at least a portion of an adjustability mechanism complementary to the adjustability mechanism of the shaft, wherein the adjustability mechanism of the shaft and the adjustability mechanism of the rod are configured to engage with one another in an adjustable manner; and (iii) a locking mechanism positioned at the intersection of the shaft and the rod configured to prevent rotation of at least one of the shaft and the rod.

9. 发明申请

WO2012170851A2 REAGENTLESS CERIA-BASED COLORIMETRIC SENSOR 审中-公开
标题翻译：无基于CERIA的彩色传感器
公开(公告)号：WO2012170851A2
公开(公告)日：2012-12-13
申请号：PCT/US2012/041608
申请日：2012-06-08
申请人： CLARKSON UNIVERSITY , ANDREESEU, Emanuela, Silvana , ORNATSKA, Maryna , ISPAS, Cristina R. , ANDREESCU, Daniel
发明人： ANDREESEU, Emanuela, Silvana , ORNATSKA, Maryna , ISPAS, Cristina R. , ANDREESCU, Daniel
IPC分类号： G01N31/22 , G01N21/77 , G01N21/78
CPC分类号： C12Q1/60 , C12Q1/26 , C12Q1/54 , G01N21/78 , G01N21/8483 , G01N31/228 , G01N33/587 , Y10T436/206664
摘要： A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex. The rate of color change and the intensity of the color are proportional to the amount of analyte present in the sample. Also described is the use of ceria and doped ceria nanoparticles as an oxygen storage/delivery vehicle for oxidase enzymes and applications in biocatalytic processes in anaerobic conditions of interest in biomedicine and bioanalysis. Further described are a variety of related applications of the disclosed technology including clinical diagnosis, in vivo implantable devices, food safety, and fermentation control.
摘要翻译：纳米颗粒，复合纳米颗粒和纳米颗粒涂层形式的比色试剂，包括使用方法，制备方法，相关设备的沉积和组装以及具体应用。比色试剂包括氧化铈纳米颗粒，其用于溶液中或固定在固体支持物上，单独或与氧化酶结合，形成与分析物反应形成有色复合物的活性比色组分。颜色变化率和颜色强度与样品中存在的分析物的量成比例。还描述了二氧化铈和掺杂的二氧化铈纳米颗粒作为用于氧化酶的氧气储存/递送载体的用途以及在生物医药和生物分析中感兴趣的厌氧条件下的生物催化过程中的应用。进一步描述了所公开技术的各种相关应用，包括临床诊断，体内可植入装置，食品安全和发酵控制。

10. 发明申请

WO2011116151A2 ENZYME-LOGIC BIOSENSING 审中-公开
标题翻译： ENZYME-LOGIC生物传感
公开(公告)号：WO2011116151A2
公开(公告)日：2011-09-22
申请号：PCT/US2011/028747
申请日：2011-03-16
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CLARKSON UNIVERSITY , WANG, Joseph , WINDMILLER, Joshua, Ray , SANTHOSH, Padmanabhan , CHUANG, Min-Chieh , KATZ, Evgeny , HALÁMEK, Jan , BOCHAROVA, Vera , PITA, Marcos , PRIVMAN, Vladimir
发明人： WANG, Joseph , WINDMILLER, Joshua, Ray , SANTHOSH, Padmanabhan , CHUANG, Min-Chieh , KATZ, Evgeny , HALÁMEK, Jan , BOCHAROVA, Vera , PITA, Marcos , PRIVMAN, Vladimir
IPC分类号： C12Q1/26 , C12Q1/48 , G01N33/15 , G01N33/50
CPC分类号： G01N27/327 , C12Q1/001 , C12Q1/005 , C12Q1/006 , G01N21/31 , G01N27/27 , G01N2333/902 , G01N2333/90241 , G01N2333/904 , G01N2333/908 , G01N2333/91188 , G01N2333/91205 , G01N2333/988 , G06N3/002
摘要： Techniques, apparatus and systems are disclosed for implementing enzyme-logic based diagnosis that uses patterns of multiple markers and biochemical processing of the signal information for reliably identifying cardiac abnormalities and providing a final digital binary answer. In one aspect, a biochemical logic sensing system includes a network of enzyme- biocatalyzed logic gates adapted to receive biomarker input signals and perform an enzyme- biocatalyzed reaction resembling a Boolean logic operation using the received biomarker input signals to generate an output signal of the enzyme-biocatalyzed reaction. A signal processing unit is connected to the network of enzyme-biocatalyzed logic gates. The signal processing unit processes the generated output signal of the enzyme-biocatalyzed reaction and generates a digital binary output having a value of zero or one. The generated digital binary output indicates a type of an injury.
摘要翻译：公开了技术，装置和系统，用于实现基于酶 - 逻辑的诊断，其使用多个标记的模式和用于可靠地识别心脏异常并提供最终数字二进制答案的信号信息的生化处理。一方面，生物化学逻辑感测系统包括适于接收生物标志物输入信号的酶 - 生物催化逻辑门网络，并且使用所接收的生物标志物输入信号进行类似于布尔逻辑运算的酶 - 生物催化反应以产生酶的输出信号 - 催化反应。信号处理单元连接到酶 - 生物催化逻辑门的网络。信号处理单元处理所生成的酶 - 生物催化反应的输出信号，并生成值为零或1的数字二进制输出。生成的数字二进制输出表示伤害类型。

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