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1. 发明申请

WO2007120644A2 DIAGNOSTIC DEVICE FOR DETERMINING PARTICLE PRODUCTION 审中-公开
标题翻译：用于确定颗粒生产的诊断装置
公开(公告)号：WO2007120644A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/008815
申请日：2007-04-11
申请人： PULMATRIX, INC. , CLARKE, Robert, William , DEHAAN, Wesley, H. , BRANDE, Matthew, Frederick
发明人： CLARKE, Robert, William , DEHAAN, Wesley, H. , BRANDE, Matthew, Frederick
IPC分类号： G01N1/00
CPC分类号： G01N15/06 , G01N33/497
摘要： Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device (10) contains a mouthpiece (12), a filter (14), a low resistance one-way valve (16), a particle counter (20) and a computer (30). Optionally, the device also contains a gas flow meter (22). The data obtained using the device can be used to determine if a formulation for reducing particle exhalation is needed. This device is particularly useful prior to and/or following entry in a cleanroom to ensure that the cleanroom standards are maintained. The device can also be used to identify animals and humans who have an enhanced propensity to exhale aerosols (referred to herein as "over producers", "super-producers", or "superspreaders").
摘要翻译：本文描述了确定颗粒产生速率的方法和装置以及针对个体生产的颗粒的尺寸范围。装置（10）包括一个接口（12），一个过滤器（14），一个低阻力单向阀（16），一个粒子计数器（20）和一个计算机（30）。可选地，该装置还包含气体流量计（22）。使用该装置获得的数据可用于确定是否需要用于减少颗粒呼气的配方。该设备在进入洁净室之前和/或之后特别有用，以确保洁净室标准得到维护。该装置还可以用于鉴定具有更高呼吸气溶胶倾向的动物和人（在本文中称为“超过生产者”，“超级生产者”或“超级扩张者”）。

2. 发明申请

WO2006076265A3 METHOD AND DEVICE FOR DECREASING CONTAMINATION 审中-公开
标题翻译：减少污染的方法和装置
公开(公告)号：WO2006076265A3
公开(公告)日：2006-12-14
申请号：PCT/US2006000618
申请日：2006-01-10
申请人： PULMATRIX INC , EDWARDS DAVID A , GABRIELSON MARK J , CLARKE ROBERT WILLIAM , DEHAAN WESLEY HUGH , BRANDE MATTHEW FREDERICK , MAN JONATHAN CHUN-WAH
发明人： EDWARDS DAVID A , GABRIELSON MARK J , CLARKE ROBERT WILLIAM , DEHAAN WESLEY HUGH , BRANDE MATTHEW FREDERICK , MAN JONATHAN CHUN-WAH
IPC分类号： A61B5/097 , G01N15/02 , G01N33/497
CPC分类号： G01N33/497 , A61B5/0816 , A61B5/0878 , A61B5/097 , G01N15/0205
摘要： Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device (10) contains a mouthpiece (12) , a filter (14) , a low resistance one-way valve (16) , a particle counter (20) and a computer (30) . Optionally, the device also contains a gas flow meter (22) . The data obtained using the device can be used to determine if a formulation for reducing particle exhalation should be administered to an individual. This device is particularly useful prior to and/or following entry in a cleanroom to ensure that the cleanroom standards are maintained.
摘要翻译：本文描述了确定颗粒产生速率的方法和装置以及针对个体生产的颗粒的尺寸范围。装置（10）包括一个接口（12），一个过滤器（14），一个低阻力单向阀（16），一个粒子计数器（20）和一个计算机（30）。可选地，该装置还包含气体流量计（22）。使用该装置获得的数据可用于确定是否应向个体施用用于减少颗粒呼气的制剂。该设备在进入洁净室之前和/或之后特别有用，以确保洁净室标准得到维护。

3. 发明申请

WO2016091694A1 PROCESS FOR PRODUCING A SUPPORTED, PARTIALLY REDUCTIVELY ACTIVATED FISCHER-TROPSCH SYNTHESIS CATALYST, AND PROCESS FOR PRODUCING HYDROCARBONS USING THE SAME 审中-公开
标题翻译：用于生产支持的部分减少活化的螯合物合成催化剂的方法，以及使用该方法生产烃类的方法
公开(公告)号：WO2016091694A1
公开(公告)日：2016-06-16
申请号：PCT/EP2015/078418
申请日：2015-12-02
申请人： BP P.L.C. , JOHNSON MATTHEY DAVY TECHNOLOGIES LIMITED , CLARK, Thomas Edward , CLARKE, Robert William , COUVES, John , FERGUSON, Ewen , GAEMERS, Sander , KRAWIEC, Piotr , SHARMA, Bhushan , WELLS, Matthew James , NAY, Barry
发明人： CLARK, Thomas Edward , CLARKE, Robert William , COUVES, John , FERGUSON, Ewen , GAEMERS, Sander , KRAWIEC, Piotr , SHARMA, Bhushan , WELLS, Matthew James , NAY, Barry
IPC分类号： B01J37/18 , B01J23/06 , B01J23/75 , C10G2/00 , B01J23/94 , C07C1/04 , B01J38/18 , B01J23/89 , B01J37/02
CPC分类号： C10G2/331 , B01J23/80 , B01J23/825 , B01J23/83 , B01J23/85 , B01J23/8892 , B01J23/8913 , B01J23/94 , B01J35/023 , B01J37/0009 , B01J37/0201 , B01J37/16 , B01J37/18 , B01J38/04 , B01J38/10 , B01J38/18 , C07C1/0435 , C07C1/0445 , C07C2523/06 , C07C2523/75 , C10G2300/703 , Y02P20/584 , C07C9/14
摘要： A process for the production of a reductively activated cobalt-containing Fischer- Tropsch catalyst supported on a support material comprising zinc oxide, said process comprising a carbon monoxide reduction step comprising contacting a cobalt-containing Fischer-Tropsch catalyst with a gaseous stream comprising carbon monoxide and less than 10 vol.% hydrogen based on the volume of carbon monoxide; followed by a hydrogen reduction step comprising contacting the product of the carbon monoxide reduction step with a gaseous stream comprising hydrogen and less than 10 vol.% carbon monoxide based on the volume of hydrogen, such that the reductively activated cobalt-containing Fisher- Tropsch catalyst comprises from 20% to 95% metallic cobalt by weight of cobalt.
摘要翻译：一种负载在包含氧化锌的载体材料上的还原活化的含钴费 - 托催化剂的方法，所述方法包括一氧化碳还原步骤，包括使含钴费 - 托催化剂与包含一氧化碳和基于一氧化碳体积的小于10体积％的氢; 随后是氢还原步骤，包括一氧化碳还原步骤的产物与基于氢气体积的包含氢气和小于10体积％一氧化碳的气流接触，使得还原活化的含钴的费 - 托催化剂包含20重量％至95重量％的钴的金属钴。

4. 发明申请

WO2013052844A1 METHODS FOR TREATING AND DIAGNOSING RESPIRATORY TRACT INFECTIONS 审中-公开
标题翻译：用于治疗和诊断呼吸道感染的方法
公开(公告)号：WO2013052844A1
公开(公告)日：2013-04-11
申请号：PCT/US2012/059022
申请日：2012-10-05
申请人： PULMATRIX, INC. , CLARKE, Robert William , HAVA, David L. , HANRAHAN, John P. , DEHAAN, Wesley Hugh , ANDREOTTA, Paulette Wright , AROLD, Stephen P. , KENYON, Jennifer
发明人： CLARKE, Robert William , HAVA, David L. , HANRAHAN, John P. , DEHAAN, Wesley Hugh , ANDREOTTA, Paulette Wright , AROLD, Stephen P. , KENYON, Jennifer
IPC分类号： A61K33/06 , A61K33/14 , A61K9/00 , A61P11/06 , A61P11/12
CPC分类号： A61K31/19 , A61K9/0075 , A61K9/0078 , A61K31/56 , A61K33/06 , A61K33/10 , A61K33/14 , A61K45/06 , G01N33/6884 , G01N2500/10 , G01N2800/12 , G01N2800/52 , G01N2800/60
摘要： Described are methods of preventing, treating and diagnosing of a subject having a condition, such as, an inflammation or infection of the respiratory tract. Methods of treatment and prevention include administration of effective amounts of calcium salt formulations to a subject. Methods of diagnosing include the use of biomarkers and optionally the use of kits that can detect biomarkers. Further described are methods for modulating an immune response that include the modulation of Toll-like receptors.
摘要翻译：描述了预防，治疗和诊断具有诸如呼吸道炎症或感染等病症的对象的方法。治疗和预防方法包括向受试者施用有效量的钙盐制剂。诊断方法包括使用生物标志物和任选地使用可检测生物标志物的试剂盒。还描述了用于调节包括Toll样受体调节的免疫应答的方法。

5. 发明申请

WO2007120644A3 DIAGNOSTIC DEVICE FOR DETERMINING PARTICLE PRODUCTION 审中-公开
标题翻译：用于确定颗粒生产的诊断装置
公开(公告)号：WO2007120644A3
公开(公告)日：2008-11-13
申请号：PCT/US2007008815
申请日：2007-04-11
申请人： PULMATRIX INC , CLARKE ROBERT WILLIAM , DEHAAN WESLEY H , BRANDE MATTHEW FREDERICK
发明人： CLARKE ROBERT WILLIAM , DEHAAN WESLEY H , BRANDE MATTHEW FREDERICK
IPC分类号： A62B7/10 , A62B23/02
CPC分类号： G01N15/06 , G01N33/497
摘要： Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device (10) contains a mouthpiece (12), a filter (14), a low resistance one-way valve (16), a particle counter (20) and a computer (30). Optionally, the device also contains a gas flow meter (22). The data obtained using the device can be used to determine if a formulation for reducing particle exhalation is needed. This device is particularly useful prior to and/or following entry in a cleanroom to ensure that the cleanroom standards are maintained. The device can also be used to identify animals and humans who have an enhanced propensity to exhale aerosols (referred to herein as "over producers", "super-producers", or "superspreaders").
摘要翻译：本文描述了确定颗粒产生速率的方法和装置以及针对个体生产的颗粒的尺寸范围。装置（10）包括一个接口（12），一个过滤器（14），一个低阻力单向阀（16），一个粒子计数器（20）和一个计算机（30）。可选地，该装置还包含气体流量计（22）。使用该装置获得的数据可用于确定是否需要用于减少颗粒呼气的配方。该设备在进入洁净室之前和/或之后特别有用，以确保洁净室标准得到维护。该装置还可以用于鉴定具有更高呼吸气溶胶倾向的动物和人（在本文中称为“超过生产者”，“超级生产者”或“超级扩张者”）。

6. 发明申请

WO2003074465A1 PROCESS FOR THE PRODUCTION OF AN ALKENYL CARBOXYLATE OR AN ALKYL CARBOXYLATE 审中-公开
标题翻译：制备羧酸亚烷基酯或羧酸烷基酯的方法
公开(公告)号：WO2003074465A1
公开(公告)日：2003-09-12
申请号：PCT/GB2003/000619
申请日：2003-02-12
申请人： BP CHEMICALS LIMITED , CLARKE, Robert, William , CROLL, Robert , LUCY, Andrew, Richard , WILLIAMS, Bruce, Leo
发明人： CLARKE, Robert, William , CROLL, Robert , LUCY, Andrew, Richard , WILLIAMS, Bruce, Leo
IPC分类号： C07C67/04
CPC分类号： C07C67/04 , C07C67/055 , Y02P20/125 , Y02P20/582 , C07C69/14 , C07C69/01 , C07C69/15
摘要： Integrated processes for the production of alkenyl carboxylate and alkyl carboxylate comprising oxidation of a C 2 to C 4 alkane to produce the corresponding alkene and carboxylic acid, separation of the product stream to give a gaseous stream comprising the alkene and unreacted alkane, subsequent separation of the alkene and the alkane into respective streams rich in alkene and alkane, and use of the alkene rich stream in the production of either alkenyl carboxylate or alkyl carboxylate.
摘要翻译：用于生产烯基羧酸酯和羧酸烷基酯的整合方法包括将C2至C4烷烃氧化以产生相应的烯烃和羧酸，分离产物流以产生包含烯烃和未反应的烷烃的气流，随后分离烯烃并将烷烃分离成富含烯烃和烷烃的相应物流，以及使用富链烯烃生产链烯基羧酸酯或羧酸烷基酯。

7. 发明申请

WO2006076265A2 METHOD AND DEVICE FOR DECREASING CONTAMINATION 审中-公开
标题翻译：减少污染的方法和装置
公开(公告)号：WO2006076265A2
公开(公告)日：2006-07-20
申请号：PCT/US2006/000618
申请日：2006-01-10
申请人： PULMATRIX, INC. , EDWARDS, David, A. , GABRIELSON, Mark, J. , CLARKE, Robert, William , DEHAAN, Wesley, Hugh , BRANDE, Matthew, Frederick , MAN, Jonathan, Chun-Wah
发明人： EDWARDS, David, A. , GABRIELSON, Mark, J. , CLARKE, Robert, William , DEHAAN, Wesley, Hugh , BRANDE, Matthew, Frederick , MAN, Jonathan, Chun-Wah
CPC分类号： G01N33/497 , A61B5/0816 , A61B5/0878 , A61B5/097 , G01N15/0205
摘要： Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device (10) contains a mouthpiece (12), a filter (14), a low resistance one-way valve (16), a particle counter (20) and a computer (30). Optionally, the device also contains a gas flow meter (22). The data obtained using the device can be used to determine if a formulation for reducing particle exhalation should be administered to an individual. This device is particularly useful prior to and/or following entry in a cleanroom to ensure that the cleanroom standards are maintained. The device can also be used to identify animals and humans who have an enhanced propensity to exhale aerosols (referred to herein as "over producers", "super-producers", or "superspreaders"). Formulations to reduce particle production are also described herein. The formulation is administered in an amount sufficient to alter biophysical properties in the mucosal linings of the body. When applied to mucosal lining fluids, the formulation alters the physical properties such as the gel characteristics at the air/liquid interface, surface elasticity, surface viscosity, surface tension and bulk viscoelasticity of the mucosal lining. The formulation is administered in an effective amount to minimize ambient contamination due to particle formation during breathing, coughing, sneezing, or talking, which is particularly important in cleanroom applications. In one embodiment, the formulation for administration is a non-surfactant solution. In one embodiment, the formulations are conductiv formulations containing conductive agents, such as salts, ionic surfactants, o other substances that are in an ionized state or easily ionized in an aqueous o organic solvent environment. Preferably the formulation is administered in the form of an aerosol.
摘要翻译：本文描述了确定颗粒产生速率的方法和装置以及针对个体生产的颗粒的尺寸范围。装置（10）包括一个接口（12），一个过滤器（14），一个低阻力单向阀（16），一个粒子计数器（20）和一个计算机（30）。可选地，该装置还包含气体流量计（22）。使用该装置获得的数据可用于确定是否应向个体施用用于减少颗粒呼气的制剂。该设备在进入洁净室之前和/或之后特别有用，以确保洁净室标准得到维护。该装置还可以用于鉴定具有更高呼吸气溶胶倾向的动物和人（在本文中称为“超过生产者”，“超级生产者”或“超级扩张者”）。本文还描述了减少颗粒生产的制剂。该制剂的施用量足以改变身体粘膜内衬的生物物理性质。当施用于粘膜衬里液时，制剂改变物理性质，例如在空气/液体界面处的凝胶特性，表面弹性，表面粘度，表面张力和粘膜衬里的体粘弹性。该制剂以有效的量施用以最小化由于在呼吸，咳嗽，打喷嚏或说话期间形成颗粒而造成的环境污染，这在洁净室应用中特别重要。在一个实施方案中，用于给药的制剂是非表面活性剂溶液。在一个实施方案中，制剂是含有导电剂，例如盐，离子表面活性剂，或其它物质，其处于离子化状态或容易在有机溶剂水溶液环境中电离的导电配方。优选地，制剂以气溶胶的形式施用。

8. 发明申请

WO03055838A8 INTEGRATED PROCESS FOR THE MANUFACTURE OF ALKENYL CARBOXYLATES 审中-公开
标题翻译：用于制备羧酸亚烷基酯的综合方法
公开(公告)号：WO03055838A8
公开(公告)日：2003-09-18
申请号：PCT/GB0205455
申请日：2002-12-04
申请人： BP CHEM INT LTD , CLARKE ROBERT WILLIAM , ROBERTS MARK STEPHEN
发明人： CLARKE ROBERT WILLIAM , ROBERTS MARK STEPHEN
IPC分类号： C07C67/05 , C07B61/00 , C07C51/215 , C07C53/08 , C07C67/00 , C07C67/54 , C07C69/01 , C07C69/15
CPC分类号： C07C67/54 , C07C5/48 , C07C51/215 , C07C51/46 , C07C67/055 , Y02P20/125 , Y02P20/582 , C07C69/15 , C07C53/08 , C07C11/04
摘要： An integrated process for the production of an alkenyl carboxylate, such as vinyl acetate which process comprises the steps of (a) contacting in an oxidation reaction zone a C2 to C4 alkane, such as ethane, a molecular oxygen-containing gas, optionally the corresponding alkene and optionally water, in the presence of a catalyst to produce a stream comprising alkene, carboxylic acid and water; (b) separating at least a portion of the stream from step (a) into a fraction comprising the alkene and a fraction comprising the carboxylic acid and water; (c) contacting in a second reaction zone at least a portion of said alkene fraction produced in step (b), a carboxylic acid and a molecular oxygen-containing gas, in the presence of a catalyst to produce a product stream comprising an alkenyl carboxylate, water and carboxylic acid; (d) separating at least a portion of the product stream from step (c) and at least a portion of the carboxylic acid and water fraction produced in step (b) by azeotropic distillation into an overhead fraction comprising the alkenyl carboxylate and a base fraction comprising the carboxylic acid; (e) recovering the alkenyl carboxylate from the overhead fraction separated in step (d).
摘要翻译：一种用于生产烯基羧酸酯如乙酸乙烯酯的整合方法，其方法包括以下步骤：（a）在氧化反应区中使C2至C4烷烃如乙烷，含分子氧的气体，任选相应的烯烃和任选的水，在催化剂的存在下，产生包含烯烃，羧酸和水的流; （b）将来自步骤（a）的物流的至少一部分分离成包含烯烃的馏分和包含羧酸和水的级分; （c）在第二反应区中在催化剂存在下使步骤（b）中产生的所述烯烃馏分的至少一部分与羧酸和含分子氧的气体接触以产生包含链烯基羧酸酯的产物流，水和羧酸; （d）通过共沸蒸馏将步骤（c）中的产物流的至少一部分和步骤（b）中产生的羧酸和水部分的至少一部分分离成包含烯基羧酸酯和碱部分的塔顶馏分包含羧酸; （e）从步骤（d）中分离的塔顶馏分回收烯基羧酸酯。

9. 发明申请

WO2003055838A1 INTEGRATED PROCESS FOR THE MANUFACTURE OF ALKENYL CARBOXYLATES 审中-公开
标题翻译：生产烯基羧酸盐的综合方法
公开(公告)号：WO2003055838A1
公开(公告)日：2003-07-10
申请号：PCT/GB2002/005455
申请日：2002-12-04
申请人： BP CHEMICALS LIMITED , CLARKE, Robert, William , ROBERTS, Mark, Stephen
发明人： CLARKE, Robert, William , ROBERTS, Mark, Stephen
IPC分类号： C07C67/05
CPC分类号： C07C67/54 , C07C5/48 , C07C51/215 , C07C51/46 , C07C67/055 , Y02P20/125 , Y02P20/582 , C07C69/15 , C07C53/08 , C07C11/04
摘要： An integrated process for the production of an alkenyl carboxylate, such as vinyl acetate which process comprises the steps of (a) contacting in an oxidation reaction zone a C 2 to C 4 alkane, such as ethane, a molecular oxygen-containing gas, optionally the corresponding alkene and optionally water, in the presence of a catalyst to produce a stream comprising alkene, carboxylic acid and water; (b) separating at least a portion of the stream from step (a) into a fraction comprising the alkene and a fraction comprising the carboxylic acid and water; (c) contacting in a second reaction zone at least a portion of said alkene fraction produced in step (b), a carboxylic acid and a molecular oxygen-containing gas, in the presence of a catalyst to produce a product stream comprising an alkenyl carboxylate, water and carboxylic acid; (d) separating at least a portion of the product stream from step (c) and at least a portion of the carboxylic acid and water fraction produced in step (b) by azeotropic distillation into an overhead fraction comprising the alkenyl carboxylate and a base fraction comprising the carboxylic acid; (e) recovering the alkenyl carboxylate from the overhead fraction separated in step (d).
摘要翻译：一种用于生产链烯基羧酸盐如乙酸乙烯酯的整合方法，该方法包括以下步骤：（a）在氧化反应区中使C 2 C与C 例如乙烷，含分子氧的气体，任选相应的烯烃和任选的水，在催化剂存在下反应以产生包含烯烃，羧酸和水的物流; （b）将来自步骤（a）的至少一部分物流分离成包含烯烃和包含羧酸和水的馏分的馏分; （c）在第二反应区中，在催化剂存在下，将步骤（b）中产生的所述烯烃馏分的至少一部分，羧酸和含分子氧的气体在催化剂存在下接触以产生包含羧酸烯基酯，水和羧酸; （d）通过共沸蒸馏将至少一部分来自步骤（c）的产物流和至少一部分步骤（b）中产生的羧酸和水馏分分离成包含烯基羧酸盐和碱馏分的塔顶馏分包含羧酸; （e）从步骤（d）中分离的塔顶馏分中回收链烯基羧酸酯。

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