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1. 发明申请

WO2004042023B1 STEM CELL LIBRARIES 审中-公开
公开(公告)号：WO2004042023B1
公开(公告)日：2004-10-21
申请号：PCT/US0334811
申请日：2003-10-31
申请人： FIVE PRIME THERAPEUTICS INC , ZHANG HONGBING , WILLIAMS LEWIS T , CHU KETTING , COHEN FRED
发明人： ZHANG HONGBING , WILLIAMS LEWIS T , CHU KETTING , COHEN FRED
IPC分类号： A01K67/00 , A01K67/033 , C12N20060101 , C12N5/00 , C12N5/02 , C12N5/0735 , C12N15/85 , G01N33/00
CPC分类号： C12N5/0606
摘要： A stem cell library is created by genetically modifying stem cells with nucleic acids encoding polypeptides which can promote stem cell differentiation into specific cell types. Alternatively, the stem cell library is exposed to an externally added factor that promotes stem cell differentiation into a desired cell line, e.g., neuronal or muscle. The library is used to determine the effect of the encoded protein on the differentiation process. The library is also used to produce nucleic acids for insertion into embryonic stem cells to produce transfected embryonic stem cells. The nucleic acids are inserted into a locus that permits widespread expression of the encoded polypeptide in animals produced from blastocysts that incorporate the transfected cells. Non-human chimeric animals produced by combining blastocysts derived from animal models of human disease and embryonic stem cells transfected with molecules from the library provide an in vivo system for therapeutic design.
摘要翻译：通过用能够促进干细胞分化成特定细胞类型的多肽的核酸对遗传修饰干细胞产生干细胞文库。或者，将干细胞文库暴露于外部添加的因子，其促进干细胞分化成期望的细胞系，例如神经元或肌肉。该文库用于确定编码的蛋白质对分化过程的影响。该文库还用于生产用于插入胚胎干细胞以产生转染的胚胎干细胞的核酸。将核酸插入到允许编码的多肽在掺入转染细胞的囊胚产生的动物中广泛表达的基因座。通过将源自人类疾病的动物模型的胚泡和来自文库的分子转染的胚胎干细胞组合产生的非人类嵌合动物提供用于治疗设计的体内系统。

2. 发明申请

WO2004042023A3 STEM CELL LIBRARIES 审中-公开
公开(公告)号：WO2004042023A3
公开(公告)日：2004-05-21
申请号：PCT/US2003/034811
申请日：2003-10-31
申请人： FIVE PRIME THERAPEUTICS, INC. , ZHANG, Hongbing , WILLIAMS, Lewis, T. , CHU, Ketting , COHEN, Fred
发明人： ZHANG, Hongbing , WILLIAMS, Lewis, T. , CHU, Ketting , COHEN, Fred
IPC分类号： G01N33/00
摘要： A stem cell library is created by genetically modifying stem cells with nucleic acids encoding polypeptides which can promote stem cell differentiation into specific cell types. Alternatively, the stem cell library is exposed to an externally added factor that promotes stem cell differentiation into a desired cell line, e.g., neuronal or muscle. The library is used to determine the effect of the encoded protein on the differentiation process. The library is also used to produce nucleic acids for insertion into embryonic stem cells to produce transfected embryonic stem cells. The nucleic acids are inserted into a locus that permits widespread expression of the encoded polypeptide in animals produced from blastocysts that incorporate the transfected cells. Non-human chimeric animals produced by combining blastocysts derived from animal models of human disease and embryonic stem cells transfected with molecules from the library provide an in vivo system for therapeutic design.

3. 发明申请

WO2004042023A2 STEM CELL LIBRARIES 审中-公开
公开(公告)号：WO2004042023A2
公开(公告)日：2004-05-21
申请号：PCT/US0334811
申请日：2003-10-31
申请人： FIVE PRIME THERAPEUTICS INC , ZHANG HONGBING , WILLIAMS LEWIS T , CHU KETTING , COHEN FRED
发明人： ZHANG HONGBING , WILLIAMS LEWIS T , CHU KETTING , COHEN FRED
IPC分类号： A01K67/00 , A01K67/033 , C12N20060101 , C12N5/00 , C12N5/02 , C12N5/0735 , C12N15/85 , G01N33/00 , C12N
CPC分类号： C12N5/0606
摘要： A stem cell library is created by genetically modifying stem cells with nucleic acids encoding polypeptides which can promote stem cell differentiation into specific cell types. Alternatively, the stem cell library is exposed to an externally added factor that promotes stem cell differentiation into a desired cell line, e.g., neuronal or muscle. The library is used to determine the effect of the encoded protein on the differentiation process. The library is also used to produce nucleic acids for insertion into embryonic stem cells to produce transfected embryonic stem cells. The nucleic acids are inserted into a locus that permits widespread expression of the encoded polypeptide in animals produced from blastocysts that incorporate the transfected cells. Non-human chimeric animals produced by combining blastocysts derived from animal models of human disease and embryonic stem cells transfected with molecules from the library provide an in vivo system for therapeutic design.

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