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1. 发明申请

WO2008147022A1 ANTI-WRINKLE COMPOSITION FOR EXTERNAL APPLICATIONS TO THE SKIN CONTAINING BIFLAVONOID DERIVATIVES 审中-公开
标题翻译：用于外用于含有双歧杆菌衍生物的皮肤的抗皱组合物
公开(公告)号：WO2008147022A1
公开(公告)日：2008-12-04
申请号：PCT/KR2008/001038
申请日：2008-02-22
申请人： AMOREPACIFIC CORPORATION , INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY , LEE, ChanWoo , WOO, EunRhan , KIM, HanSung , LEE, Song Yi , CHOI, Hyunjung , KIM, Ji Yeong , KIM, JinWong , KIM, DuckHee , KIM, Han Kon , CHANG, IhSeop
发明人： LEE, ChanWoo , WOO, EunRhan , KIM, HanSung , LEE, Song Yi , CHOI, Hyunjung , KIM, Ji Yeong , KIM, JinWong , KIM, DuckHee , KIM, Han Kon , CHANG, IhSeop
IPC分类号： A61K8/49 , A61K8/97 , A61Q19/08
CPC分类号： A61Q19/08 , A61K8/498 , A61K8/97 , A61Q17/04
摘要： The present invention relates to a cosmetic composition for improving skin wrinkles, which contains biflavonoid derivatives as an active ingredient. The cosmetic composition containing the biflavonoid derivatives of the present invention not only is safe for application on the skin without side-effects but also improves wrinkles caused by UV through procollagen production and MMP-I inhibition.
摘要翻译：本发明涉及一种用于改善皮肤皱纹的化妆品组合物，其含有双黄酮衍生物作为活性成分。含有本发明的双黄酮衍生物的化妆品组合物不仅可以安全地用于皮肤而不会出现副作用，而且可以改善通过原胶原生成和MMP-1抑制的紫外线引起的皱纹。

2. 发明申请

WO2014152437A3 METHODS OF USE FOR AN ANTIMICROBIAL PEPTIDE 审中-公开
标题翻译：用于抗微生物肽的方法
公开(公告)号：WO2014152437A3
公开(公告)日：2014-11-27
申请号：PCT/US2014027340
申请日：2014-03-14
申请人： UNIV ARKANSAS , CHOSUN UNIVERSITY , SONG PETER I , ARMSTRONG CHERYL , RYU SUNHYO , PARK YOONKYUNG , HAHM KYUNG-SOO
发明人： SONG PETER I , ARMSTRONG CHERYL , RYU SUNHYO , PARK YOONKYUNG , HAHM KYUNG-SOO
IPC分类号： A01N63/02 , A61K38/10 , A61P31/04 , C07K7/08
CPC分类号： A61K38/164
摘要： The present invention encompasses methods for treating an infection and/or treating or reducing inflammation through the administration of a therapeutically effective amount of a peptide to a subject in need thereof. In some aspects, the peptide is a Helicobacter pylori-derived peptide, such as an HPA3NT3 peptide and the infection is a bacterial infection.
摘要翻译：本发明包括通过向有需要的受试者施用治疗有效量的肽来治疗感染和/或治疗或减轻炎症的方法。在一些方面，肽是幽门螺杆菌衍生肽，例如HPA3NT3肽，感染是细菌感染。

3. 发明申请

WO2010061984A1 NOVEL ANTIBIOTIC PEPTIDE DERIVED FROM RIBOSOMAL PROTEIN L 1 OF HELICOBACTER PYLORI AND USE THEREOF 审中-公开
标题翻译：来自抗凝蛋白L 1的新型抗生素肽及其用途
公开(公告)号：WO2010061984A1
公开(公告)日：2010-06-03
申请号：PCT/KR2008/006938
申请日：2008-11-25
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY , HAHM, Kyung-Soo , PARK, Yoonkyung , PARK, Seong-Cheol , LEE, Jong-Kook
发明人： HAHM, Kyung-Soo , PARK, Yoonkyung , PARK, Seong-Cheol , LEE, Jong-Kook
IPC分类号： C07K14/205 , C07K14/195
CPC分类号： C07K14/21 , A61K38/00 , C07K14/195 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/31 , C07K14/32 , Y02A50/473 , Y02A50/481
摘要： The present invention relates to a new antibiotic peptide and a usage thereof, which are derived from ribosomal protein Ll, RPLl of Helicobacter pylori . Specifically, the antibiotic peptide comprising the amino acid sequence of SEQ. ID. NO:1 derived from ribosomal protein Ll, RPLl of Helicobacter pylori is substituted with a Phenylalanine, which is situated at the fist and the eighth position from the antibiotic peptide, or in addition an Asparagine, which is situated at the thirteenth position of the antibiotic peptide, is substituted with lysine, wherein the produced peptides have maintained more decreased cytotoxicity when comparing to the existing antibiotic peptides and can be used as a safe antibiotics by showing more antibacterial activity.
摘要翻译：本发明涉及一种新的抗生素肽及其用途，其衍生自幽门螺杆菌的核糖体蛋白L1，RPL1。具体地，包含SEQ ID NO：1的氨基酸序列的抗生素肽。 ID。来自核糖体蛋白L1的NO：1，幽门螺旋杆菌的RPL1被苯丙氨酸取代，苯丙氨酸位于抗生素肽的第一和第八位，或另外位于抗生素的第十三位的天冬酰胺肽被赖氨酸取代，其中所产生的肽与现有的抗生素肽相比保持更多的细胞毒性，并且可以通过显示更多的抗菌活性而被用作安全的抗生素。

4. 发明申请

WO2008054056A1 MAGNETIC SENSOR ARRAY AND APPARATUS FOR DETECTING DEFECT USING THE MAGNETIC SENSOR ARRAY 审中-公开
标题翻译：磁传感器阵列和用于使用磁传感器阵列检测缺陷的装置
公开(公告)号：WO2008054056A1
公开(公告)日：2008-05-08
申请号：PCT/KR2007/003801
申请日：2007-08-07
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY , LEE, Jin-Yi , JUN, Jong-Woo , HWANG, Ji-Seong
发明人： LEE, Jin-Yi , JUN, Jong-Woo , HWANG, Ji-Seong
IPC分类号： G01N27/82
CPC分类号： G01N27/9006
摘要： If surface defects, near surface defects, or internal defects of a ferromagnetic su bstance object, a paramagnetic substance object, or a mixture object of ferromagnetic a nd paramagnetic substances are not quantitatively analyzed, the detected results can b e differently analyzed depending on the knowledge or skill of an inspector. A defect detection apparatus according to an exemplary embodiment of the pres ent invention includes an induced current applier, a magneto-electric converter, a signal processor, a signal converter, and a data processor. The induced current applier app lies a line or surface current to an object that is to be measured by using an alternating current (AC) having a frequency varying depending on a depth to be measured. The magneto-electric converter senses a magnetic field generated from the object by the Hn e or surface current and generates a magnetic field sensing signal corresponding to a s trength of the sensed magnetic field. The signal processor filters and amplifies the ma gnetic field sensing signal and outputs a signal corresponding to amplitude of the filtere d and amplified signal. The signal converter converts the signal output from the signal processor into a digital signal. The data processor quantitatively converts an intensity of a magnetic field generated from the object into a numerical value based on the digital signal output from the signal converter.
摘要翻译：如果没有定量分析铁磁性物体，顺磁性物质对象或铁磁物质和顺磁性物质的混合物体的表面缺陷，近表面缺陷或内部缺陷，则可以根据知识或督察的技能。根据本发明的示例性实施例的缺陷检测装置包括感应电流施加器，磁电转换器，信号处理器，信号转换器和数据处理器。感应电流施加器应用是通过使用具有根据要测量的深度而变化的频率的交流电（AC）而要被测量的物体的线或表面电流。磁电转换器通过Hn e或表面电流感测从物体产生的磁场，并产生对应于感测磁场的强度的磁场感测信号。信号处理器对场感测信号进行滤波和放大，并输出对应于滤波器d和放大信号振幅的信号。信号转换器将从信号处理器输出的信号转换为数字信号。数据处理器基于从信号转换器输出的数字信号，将从物体产生的磁场的强度定量地转换为数值。

5. 发明申请

WO2008038939A1 PREPARATION AND COMPOSITION OF MELOXICAM TRANSDERMAL DRUG DELIVERY SYSTEM 审中-公开
标题翻译： MELOXICAM TRANSDERMAL药物递送系统的制备和组合
公开(公告)号：WO2008038939A1
公开(公告)日：2008-04-03
申请号：PCT/KR2007/004569
申请日：2007-09-20
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY , GOLDEN PACIFIC BIO LIMITED , CHOI, Hoo-Kyun
发明人： CHOI, Hoo-Kyun
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61K31/5415
摘要： A composition for transdermal permeation and a preparation method are disclosed. The composition including meloxicam as an active ingredient and further including at least one permeation enhancing agent selected from the group consisting of a sorbitan fatty acid derivative, a polyglyceryl fatty acid derivative, a polyethylene glycol vegetable oil ester, a polyethylene glycol corn oil glyceride, and a polyethylene glycol almond oil glyceride and at least one acrylic polymer adhesive having a hydroxyl group or no functional group.
摘要翻译：公开了用于透皮渗透的组合物和制备方法。该组合物包括美洛昔康作为活性成分，并且还包括至少一种渗透促进剂，其选自脱水山梨醇脂肪酸衍生物，聚甘油脂肪酸衍生物，聚乙二醇植物油酯，聚乙二醇玉米油甘油酯和聚乙二醇杏仁油甘油酯和至少一种具有羟基或无官能团的丙烯酸聚合物粘合剂。

6. 发明申请

WO2006080625A1 NOVEL PEPTIDE ISOLATED FROM ASPERGILLUS NIDULANS AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：从西班牙尼泊尔分离的新型肽和含有它们的药物组合物
公开(公告)号：WO2006080625A1
公开(公告)日：2006-08-03
申请号：PCT/KR2005/003120
申请日：2005-09-21
申请人： CHOSUN UNIVERSITY , HAHM, Kyung-Soo , PARK, Yoonkyung , KWAK, Ji-Sun , PARK, Seong-Cheol
发明人： HAHM, Kyung-Soo , PARK, Yoonkyung , KWAK, Ji-Sun , PARK, Seong-Cheol
IPC分类号： C07K14/38
CPC分类号： C07K14/38 , A61K38/00
摘要： This invention relates to a novel peptide of Nidulin having antibiotic and antifungal activities, which is identified and isolated from Aspergillus nidulans , and relates to a pharmaceutical composition comprising the peptide as an effective component. Since the novel peptide of Nidulin has potent antibiotic and antifungal activities and has no toxicity, it can be used as preparations of a pesticide, which is non-toxic to human body, a food preservative, a cosmetics preservative, or preparations of a drug preservative.
摘要翻译：本发明涉及一种具有抗生素和抗真菌活性的新型多肽，其从构巢曲霉中鉴定和分离，涉及包含该肽作为有效成分的药物组合物。由于Nidulin新型肽具有有效的抗生素和抗真菌活性，无毒性，可用作对人体无毒的农药，食品防腐剂，化妆品防腐剂或药物防腐剂的制剂。

7. 发明申请

WO2003018083A3 COVERING COMPOSITION FOR DRUG-RELEASE STENT AND DRUG-RELEASE STENT MANUFACTURED USING SAME 审中-公开
公开(公告)号：WO2003018083A3
公开(公告)日：2003-03-06
申请号：PCT/KR2002/001621
申请日：2002-08-28
申请人： CHOSUN UNIVERSITY , INHA UNIVERSITY FOUNDATION , KOREA UNIVERSITY FOUNDATION , KANG, Sung-Gwon , LEE, Don-Haeng , LEE, Kyoo-Baek
发明人： KANG, Sung-Gwon , LEE, Don-Haeng , LEE, Kyoo-Baek
IPC分类号： A61F2/04
摘要： Disclosed is a covering composition for a drug-release stent, and a drug-release stent manufactured by using the same. The covering composition includes polyurethane, polyethyleneglycol, a drug, and an organic solvent.

8. 发明申请

WO2006054829A1 UBIDINE, PEPTIDE ISOLATED FROM ASPERGILLUS NIDULANS AND ANTIBIOTICS CONTAINING THE SAME 审中-公开
标题翻译： UBIDINE，从ASPERGILLUS NIDULANS分离的肽和含有它的抗生素
公开(公告)号：WO2006054829A1
公开(公告)日：2006-05-26
申请号：PCT/KR2005/003121
申请日：2005-09-21
申请人： CHOSUN UNIVERSITY , HAHM, Kyung-Soo , PARK, Yoonkyung , KWAK, Ji-Sun , PARK, Seong-Cheol
发明人： HAHM, Kyung-Soo , PARK, Yoonkyung , KWAK, Ji-Sun , PARK, Seong-Cheol
IPC分类号： C07K7/08
CPC分类号： C07K7/08
摘要： This invention relates to a novel peptide of Ubidine having antibiotic activity, which is identified and isolated from Aspergillus nidulans , and relates to a pharmaceutical composition comprising the peptide as an effective component . Since the novel peptide of Ubidine has potent antibiotic activity to the anthrax pathogen, it can be used as preparations of a biological pesticide for protecting the crops from biological diseases, such as, anthrax, a food preservative, a cosmetics preservative and as preparations of a drug preservative.
摘要翻译：本发明涉及一种具有抗生素活性的新一种具有抗生素活性的肽，其从构巢曲霉中鉴定和分离，涉及包含该肽作为有效成分的药物组合物。由于Ubidine的新肽对炭疽病菌具有有效的抗生素活性，因此可用作生物农药的制剂，用于保护作物免受生物疾病的影响，如炭疽病，食品防腐剂，化妆品防腐剂，以及作为药物防腐剂

9. 发明申请

WO2011027980A3 TUMOR CELL-KILLING PEPTIDES 审中-公开
公开(公告)号：WO2011027980A3
公开(公告)日：2011-03-10
申请号：PCT/KR2010/005391
申请日：2010-08-16
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY , KIM, Tae-Hyoung
发明人： KIM, Tae-Hyoung
IPC分类号： A61K38/16 , A61K38/10 , A61K38/08 , A61P35/00
摘要： The present invention provides a tumor cell-killing peptide and a pharmaceutical composition for treating a cancer. The tumor cell-killing peptide of the present invention selectively homes into tumor cells so that it can induce the death of tumor cells effectively while minimizing the harming of normal cell.

10. 发明申请

WO2008136636A1 COMPOSITION FOR FAST DISINTEGRATING TABLET CONTAINING HERBAL EXTRACT AND ITS PREPARATION METHOD 审中-公开
标题翻译：用于快速消毒含有草药提取物的片剂的组合物及其制备方法
公开(公告)号：WO2008136636A1
公开(公告)日：2008-11-13
申请号：PCT/KR2008/002555
申请日：2008-05-07
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION CHOSUN UNIVERSITY , CHOI, Hoo-Kyun , KANG, Keon-Wook , CHUN, Myung-Kwan , KIM, Sang-Chan , KIM, Yoon-Gyoon
发明人： CHOI, Hoo-Kyun , KANG, Keon-Wook , CHUN, Myung-Kwan , KIM, Sang-Chan , KIM, Yoon-Gyoon
IPC分类号： A61K9/26 , A61K9/20 , A61K47/26 , A61K47/32
CPC分类号： A61K9/0056 , A61K36/27
摘要： Disclosed is a rapidly disintegrating oral formulation comprising a herbal extract. The oral formulation of the present invention can be rapidly dissolved or disintegrated in the mouth and, therefore, easily applied to patients via oral administration. In particular, the formulation is effectively administered to patients with weak swallowing functions such as pediatric and/or elderly patients, patients with mental illnesses and so on. In addition, unlike other general formulations for oral administration, the formulation of the present invention which is simply taken or swallowed without water is useful for patients who are on a trip or do not have immediate access to water. Accordingly, it is expected that the rapidly disintegrating oral formulation of the present invention will improve patient compliance if applied to manufacture of herbal extract or oriental medicine based formulations.
摘要翻译：公开了包含草药提取物的快速崩解口服制剂。本发明的口服制剂可以在口中快速溶解或崩解，因此通过口服给药容易地应用于患者。特别地，该制剂有效地施用于吞咽功能弱的患者，例如儿科和/或老年患者，患有精神疾病的患者等。此外，与口服给药的其它一般制剂不同，本发明的简单地在没有水的情况下被吞服或吞咽的制剂对于在旅途中或不立即进入水的患者是有用的。因此，如果应用于草药提取物或基于东方药物的制剂的制造，则预期本发明的快速崩解的口服制剂将改善患者依从性。

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