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1. 发明申请

WO2008063857A3 ANTIOXIDANT DIETARY SUPPLEMENT COMPOSITIONS AND METHODS FOR MAINTAINING HEALTHY SKIN 审中-公开
公开(公告)号：WO2008063857A3
公开(公告)日：2008-05-29
申请号：PCT/US2007/083696
申请日：2007-11-06
申请人： MOLECULAR RESEARCH CENTER INC. , CHOMCZYNSKI, Piotr
发明人： CHOMCZYNSKI, Piotr
IPC分类号： A23L1/212 , A23L1/30 , A23L2/58 , A61K31/047 , A61K36/81 , A61K36/22
摘要： Compositions and methods for maintaining healthy skin and alleviating skin conditions such as redness, inflammation, irritation and skin aging, as well as for maintaining healthy scalp and hair are disclosed. The oral compositions disclosed comprise antioxidants including lycopene, gallic acid and ascorbic acid. Preferably lycopene containing tomato compositions has been water-extracted, more preferably under acid conditions. In the method of treatment aspect of the invention, an oral composition containing antioxidant(s) is administered to a person concurrently with a topical treatment for said skin conditions. Preferred topical compositions comprise cyclohexane polyols, such as cyclohexanediol or cyclohexanetriol.

2. 发明申请

WO2006060470A1 ANTIOXIDANT DIETARY SUPPLEMENT COMPOSITIONS AND METHODS FOR MAINTAINING HEALTHY SKIN 审中-公开
标题翻译：抗氧化剂补充剂组合物和维持健康皮肤的方法
公开(公告)号：WO2006060470A1
公开(公告)日：2006-06-08
申请号：PCT/US2005/043301
申请日：2005-11-29
申请人： CHOMCZYNSKI, Piotr
发明人： CHOMCZYNSKI, Piotr
IPC分类号： A61K36/81 , A61K31/045 , A61K31/047 , A61P17/10 , A61K131/00
CPC分类号： A61K31/01 , A23L33/105 , A23V2002/00 , A61K9/0095 , A61K31/045 , A61K31/047 , A61K36/185 , A61K36/42 , A61K36/61 , A61K36/752 , A61K36/81 , A61K36/9068 , A61K45/06 , A61K2236/331 , A61K2300/00
摘要： Compositions and methods for maintaining healthy skin and alleviating skin conditions such as redness, inflammation, irritation and skin aging, as well as for maintaining healthy scalp and hair are disclosed. The oral compositions disclosed comprise antioxidants including lycopene, gallic acid and ascorbic acid. Preferably lycopene has been water-extracted, more preferably under acid conditions. In the method of treatment aspect of the invention, an oral composition containing antioxidant(s) is administered to a person concurrently with a topical treatment for said skin conditions. Preferred topical compositions comprise cyclohexane polyols, such as cyclohexanediol or cyclohexanetriol.
摘要翻译：公开了用于维持健康皮肤和减轻皮肤状况如红发炎，刺激和皮肤老化以及维持健康的头皮和头发的组合物和方法。所公开的口腔组合物包括抗氧化剂，包括番茄红素，没食子酸和抗坏血酸。优选番茄红素已经被水提取，更优选在酸性条件下。在本发明的治疗方法中，将含有抗氧化剂的口服组合物与所述皮肤状况的局部治疗同时施用于人。优选的局部组合物包含环己烷多元醇，例如环己二醇或环己烷三醇。

3. 发明申请

WO2022115450A2 RAPID PROCESSING OF BIOLOGICAL SAMPLES USING GLYCOLS AND ALKALINE PH FOR SARS-COV-2-RNA DETECTION 审中-公开
公开(公告)号：WO2022115450A2
公开(公告)日：2022-06-02
申请号：PCT/US2021/060557
申请日：2021-11-23
申请人： CHOMCZYNSKI, Piotr
发明人： CHOMCZYNSKI, Piotr
IPC分类号： C12Q1/6806
摘要： Viral RNA detection in biological samples based on the use of a composition for processing the sample, wherein the composition comprises a glycol, e.g. polyethylene gylcol (PEG), polypropylene glycol, propylene glycol and polyglycol, preferably PEG-200, at a concentration between 10 and 25 %, preferably between 20 and 23%, and an alkaline pH higher than 11.5, preferably between 12.2 and 12.8. The composition is preferably used in a RT-PCR based method which also employs heat and a non-ionic detergent, e.g. Tween-20, for detection of SARS-CoV-2. Claimed is also the said composition and a kit for use in such viral detection processes.

4. 发明申请

WO2005103252A1 REAGENTS AND METHODS FOR ISOLATION OF PURIFIED RNA 审中-公开
标题翻译：用于分离纯化RNA的试剂和方法
公开(公告)号：WO2005103252A1
公开(公告)日：2005-11-03
申请号：PCT/US2005/012814
申请日：2005-04-14
申请人： CHOMCZYNSKI, Piotr
发明人： CHOMCZYNSKI, Piotr
IPC分类号： C12N15/10
CPC分类号： C12N15/1003
摘要： Compositions and methods to isolate intact RNA that is substantially free of DNA, termed purified RNA. RNA from any source (e.g., human, other animals, plants, viruses, etc.) may be isolated. In one embodiment, the sample is treated with phenol at a pH less than 4.0 and purified RNA is recovered from the aqueous phase. In another embodiment, RNA is precipitated from an acidified sample containing a low volume of an organic solvent. Other embodiments are disclosed. The same inventive composition may be used for several embodiments with pH adjustment. Purified RNA obtained by the inventive method may be used in assays where DNA contamination is undesirable, such as the polymerase chain reaction.
摘要翻译：分离基本上不含DNA的完整RNA的组合物和方法，称为纯化的RNA。可以分离来自任何来源（例如人，其他动物，植物，病毒等）的RNA。在一个实施方案中，样品用pH小于4.0的酚处理，并从水相中回收纯化的RNA。在另一个实施方案中，从含有少量有机溶剂的酸化样品中沉淀出RNA。公开了其他实施例。相同的本发明组合物可以用于具有pH调节的几个实施方案。通过本发明方法获得的纯化RNA可用于不期望DNA污染的测定中，例如聚合酶链式反应。

5. 发明申请

WO9705248A2 SOLUTION CONTAINING CHAOTROPIC AGENT AND PROCESS USING IT FOR ISOLATION OF DNA, RNA AND PROTEINS 审中-公开
标题翻译：含有液体代谢物的方法和使用其分离DNA，RNA和蛋白质的方法
公开(公告)号：WO9705248A2
公开(公告)日：1997-02-13
申请号：PCT/US9611875
申请日：1996-07-18
申请人： CHOMCZYNSKI PIOTR
发明人： CHOMCZYNSKI PIOTR
IPC分类号： C07K1/30 , C12N15/10 , C07K1/14
CPC分类号： C07K1/30 , C12N15/1003
摘要： Solutions and methods are disclosed for the effective, simple isolation/extraction of DNA, RNA and proteins from a single biological material sample, such as cells, tissues and biological fluids. The preferred solutions include effective amounts of a chaotropic agent(s), buffer, reducing agent, and may or may not include an organic solvent. Genomic DNA and total RNA can be isolated utilizing the solutions and methods of the invention in as little as 20 minutes, and proteins in as little as 30 minutes.
摘要翻译：公开了解决方案和方法，用于从单个生物材料样品例如细胞，组织和生物流体中有效，简单地分离/提取DNA，RNA和蛋白质。优选的溶液包括有效量的离液剂，缓冲剂，还原剂，并且可以包括或可以不包括有机溶剂。基因组DNA和总RNA可以在短短20分钟内利用本发明的溶液和方法分离，蛋白质可在短至30分钟内分离。

6. 发明申请

WO2008063857A2 ANTIOXIDANT DIETARY SUPPLEMENT COMPOSITIONS AND METHODS FOR MAINTAINING HEALTHY SKIN 审中-公开
标题翻译：抗氧化剂补充组合物和维持健康皮肤的方法
公开(公告)号：WO2008063857A2
公开(公告)日：2008-05-29
申请号：PCT/US2007083696
申请日：2007-11-06
申请人： MOLECULAR RES CT INC , CHOMCZYNSKI PIOTR
发明人： CHOMCZYNSKI PIOTR
IPC分类号： A23L1/212 , A23L1/30 , A23L2/58 , A61K31/047 , A61K36/22 , A61K36/81
CPC分类号： A61K8/31 , A23L2/02 , A23L2/52 , A23L2/58 , A23L19/09 , A23L33/105 , A23L33/15 , A23V2002/00 , A61K8/97 , A61K31/045 , A61K31/047 , A61K36/185 , A61K36/42 , A61K36/61 , A61K36/752 , A61K36/81 , A61K36/9068 , A61K2800/92 , A61Q19/00 , A61Q19/08 , A61K2300/00 , A23V2250/213 , A23V2250/21 , A23V2200/30 , A23V2200/318
摘要： Compositions and methods for maintaining healthy skin and alleviating skin conditions such as redness, inflammation, irritation and skin aging, as well as for maintaining healthy scalp and hair are disclosed. The oral compositions disclosed comprise antioxidants including lycopene, gallic acid and ascorbic acid. Preferably lycopene containing tomato compositions has been water-extracted, more preferably under acid conditions. In the method of treatment aspect of the invention, an oral composition containing antioxidant(s) is administered to a person concurrently with a topical treatment for said skin conditions. Preferred topical compositions comprise cyclohexane polyols, such as cyclohexanediol or cyclohexanetriol.
摘要翻译：公开了用于维持健康皮肤和缓解皮肤状况（例如发红，炎症，刺激和皮肤老化）以及用于维持健康的头皮和头发的组合物和方法。所公开的口服组合物包含抗氧化剂，包括番茄红素，没食子酸和抗坏血酸。优选含番茄红素的番茄组合物已被水提取，更优选在酸性条件下。在本发明的治疗方法中，将含有抗氧化剂的口腔组合物与所述皮肤病症的局部治疗同时施用于人。优选的局部组合物包含环己烷多元醇，如环己二醇或环己三醇。

7. 发明申请

WO2003105816A1 METHOD OF TREATING ROSACEA BY TOPICAL APPLICATION OF A CYCLOHEXANE DERIVATIVE 审中-公开
标题翻译：通过环孢菌素衍生物的局部应用治疗罗非鱼的方法
公开(公告)号：WO2003105816A1
公开(公告)日：2003-12-24
申请号：PCT/US2003/017999
申请日：2003-06-09
申请人： CHOMCZYNSKI, Piotr
发明人： CHOMCZYNSKI, Piotr
IPC分类号： A61K31/045
CPC分类号： A61K31/047 , A61K31/045
摘要： A method for topically treating rosacea is disclosed. In this method, an active material having the formula given below is applied to the patient at the site of said rosacea: wherein R 1 is selected from -OH and C 1 -C 3 alkyl OH; and R 2 , R 3 , R 4 , R 5 and R 6 are independently selected from -H, -OH, C 1 -C 6 alkyl, and C 3 -C 6 cycloalkyl. Preferred active materials include 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, and mixtures of those materials. Methods for treating acne vulgaris, as well as colds, flu, sinusitis, and ear infections, using these actives are also disclosed.
摘要翻译：公开了一种局部治疗酒渣鼻的方法。在该方法中，在所述红斑痤疮的部位将具有下式的活性物质施用于患者：其中R 1选自-OH和C 1 -C 3烷基OH; R 2，R 3，R 4，R 5和R 6独立地选自-H，-OH，C 1 -C 6烷基和C 3 -C 6环烷基。优选的活性物质包括1,2-环己二醇，1,3-环己二醇，1,4-环己二醇以及这些物质的混合物。还公开了使用这些活性物质治疗寻常型痤疮以及感冒，流感，鼻窦炎和耳朵感染的方法。

8. 发明申请

WO1997005248A3 SOLUTION CONTAINING CHAOTROPIC AGENT AND PROCESS USING IT FOR ISOLATION OF DNA, RNA AND PROTEINS 审中-公开
公开(公告)号：WO1997005248A3
公开(公告)日：1997-02-13
申请号：PCT/US1996011875
申请日：1996-07-18
申请人： CHOMCZYNSKI, Piotr
IPC分类号： C12N15/10

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