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1. 发明申请

WO2012091523A3 CARRIER FOR NEGATIVELY CHARGED DRUGS COMPRISING A CATIONIC LIPID AND A PREPARATION METHOD THEREOF 审中-公开
标题翻译：携带包含阳离子脂肪的负价药物及其制备方法
公开(公告)号：WO2012091523A3
公开(公告)日：2012-12-06
申请号：PCT/KR2011010398
申请日：2011-12-30
申请人： SAMYANG BIOPHARMACEUTICALS , CHOI SUNG-WON , LA MUHN-HO , SON JI-YEON , SEO MIN-HYO
发明人： CHOI SUNG-WON , LA MUHN-HO , SON JI-YEON , SEO MIN-HYO
IPC分类号： A61K47/18 , A61K9/127 , A61K31/175 , A61K47/08 , A61K47/48
CPC分类号： A61K47/16 , A61K9/107 , A61K9/1075 , A61K9/1272 , A61K31/713 , A61K47/18 , A61K47/34 , A61K47/59 , A61K47/595 , C12N15/88
摘要： Disclosed are a carrier for delivering a negatively charged drug, comprising a cationic lipid represented by formula 1, and a preparation method thereof. Also disclosed is a pharmaceutical composition comprising a negatively charged drug and a cationic lipid represented by formula 1, wherein the negatively charged drug forms a complex with the cationic lipid. The composition can increase the in vivo stability of the negatively charged drug after local or systemic administration and allows the intracellular delivery of the negatively charged drug. Thus, the composition will be useful for improving the therapeutic effect of the negatively charged drug.
摘要翻译：公开了用于递送带负电荷药物的载体，其包含由式1表示的阳离子脂质及其制备方法。还公开了包含带负电荷的药物和由式1表示的阳离子脂质的药物组合物，其中带负电荷的药物与阳离子脂质形成复合物。组合物可以在局部或全身给药后增加带负电荷的药物的体内稳定性，并允许带负电荷的药物的细胞内递送。因此，该组合物可用于改善带负电荷的药物的治疗效果。

2. 发明申请

WO2012091523A8 CARRIER FOR NEGATIVELY CHARGED DRUGS COMPRISING A CATIONIC LIPID AND A PREPARATION METHOD THEREOF 审中-公开
标题翻译：携带包含阳离子脂肪的负价药物及其制备方法
公开(公告)号：WO2012091523A8
公开(公告)日：2013-10-10
申请号：PCT/KR2011010398
申请日：2011-12-30
申请人： SAMYANG BIOPHARMACEUTICALS , CHOI SUNG-WON , LA MUHN-HO , SON JI-YEON , SEO MIN-HYO
发明人： CHOI SUNG-WON , LA MUHN-HO , SON JI-YEON , SEO MIN-HYO
IPC分类号： A61K47/18 , A61K9/127 , A61K31/175 , A61K47/08 , A61K47/48
CPC分类号： A61K47/16 , A61K9/107 , A61K9/1075 , A61K9/1272 , A61K31/713 , A61K47/18 , A61K47/34 , A61K47/59 , A61K47/595 , C12N15/88
摘要： Disclosed are a carrier for delivering a negatively charged drug, comprising a cationic lipid represented by formula 1, and a preparation method thereof. Also disclosed is a pharmaceutical composition comprising a negatively charged drug and a cationic lipid represented by formula 1, wherein the negatively charged drug forms a complex with the cationic lipid. The composition can increase the in vivo stability of the negatively charged drug after local or systemic administration and allows the intracellular delivery of the negatively charged drug. Thus, the composition will be useful for improving the therapeutic effect of the negatively charged drug.
摘要翻译：公开了用于递送带负电荷药物的载体，其包含由式1表示的阳离子脂质及其制备方法。还公开了包含带负电荷的药物和由式1表示的阳离子脂质的药物组合物，其中带负电荷的药物与阳离子脂质形成复合物。组合物可以在局部或全身给药后增加带负电荷的药物的体内稳定性，并允许带负电荷的药物的细胞内递送。因此，该组合物可用于改善带负电荷的药物的治疗效果。

3. 发明申请

WO2012091523A2 CARRIER FOR NEGATIVELY CHARGED DRUGS COMPRISING A CATIONIC LIPID AND A PREPARATION METHOD THEREOF 审中-公开
标题翻译：用于含有阳离子脂质的负电荷药物的载体及其制备方法
公开(公告)号：WO2012091523A2
公开(公告)日：2012-07-05
申请号：PCT/KR2011/010398
申请日：2011-12-30
申请人： SAMYANG BIOPHARMACEUTICALS CORPORATION , CHOI, Sung-Won , LA, Muhn-Ho , SON, Ji-Yeon , SEO, Min-Hyo
发明人： CHOI, Sung-Won , LA, Muhn-Ho , SON, Ji-Yeon , SEO, Min-Hyo
IPC分类号： A61K47/18 , A61K47/08 , A61K31/175 , A61K9/127 , A61K47/48
CPC分类号： A61K47/16 , A61K9/107 , A61K9/1075 , A61K9/1272 , A61K31/713 , A61K47/18 , A61K47/34 , A61K47/59 , A61K47/595 , C12N15/88
摘要： Disclosed are a carrier for delivering a negatively charged drug, comprising a cationic lipid represented by formula 1, and a preparation method thereof. Also disclosed is a pharmaceutical composition comprising a negatively charged drug and a cationic lipid represented by formula 1, wherein the negatively charged drug forms a complex with the cationic lipid. The composition can increase the in vivo stability of the negatively charged drug after local or systemic administration and allows the intracellular delivery of the negatively charged drug. Thus, the composition will be useful for improving the therapeutic effect of the negatively charged drug.
摘要翻译：公开了用于递送带负电荷的药物的载体，其包含由式1表示的阳离子脂质，及其制备方法。还公开了包含带负电的药物和由式1表示的阳离子脂质的药物组合物，其中带负电的药物与阳离子脂质形成络合物。在局部或全身施用后，该组合物可以增加带负电荷的药物的体内稳定性，并允许带负电荷的药物的细胞内递送。因此，该组合物可用于改善带负电的药物的治疗效果。

4. 发明申请

WO2010074540A3 PHARMACEUTICAL COMPOSITION CONTAINING AN ANIONIC DRUG, AND A PRODUCTION METHOD THEREFOR 审中-公开
标题翻译：含有阴离子药物的药物组合物及其生产方法
公开(公告)号：WO2010074540A3
公开(公告)日：2010-11-11
申请号：PCT/KR2009007804
申请日：2009-12-24
申请人： SAMYANG CORP , KIM SE-HO , SON JI-YEON , LA MUHN-HO , CHOI SUNG-WON , SEO MIN-HYO
发明人： KIM SE-HO , SON JI-YEON , LA MUHN-HO , CHOI SUNG-WON , SEO MIN-HYO
IPC分类号： A61K9/127 , A61K31/353 , A61K31/56 , A61K31/70 , A61K31/7105 , A61K31/711 , A61K39/21 , A61K39/235
CPC分类号： A61K9/1075 , A61K9/0019 , A61K31/353 , A61K31/56 , A61K31/70 , A61K31/7105 , A61K31/711
摘要： Disclosed is a pharmaceutical composition containing an anionic drug, characterised in that it comprises: an anionic drug as an active component; a cationic lipid; and an amphiphilic block copolymer, and in that the anionic drug forms a complex with the cationic lipid, and the complex is enclosed within a micelle structure of the amphiphilic block copolymer. Also disclosed is a production method for this pharmaceutical composition. The pharmaceutical composition is advantageous in that it can improve the efficacy of anionic drugs since it allows delivery into cells and it can increase the stability of anionic drugs in the blood or in body fluids.
摘要翻译：公开了含有阴离子药物的药物组合物，其特征在于它包含：阴离子药物作为活性组分; 阳离子脂质; 和两亲嵌段共聚物，并且阴离子药物与阳离子脂质形成络合物，并且该络合物被包封在两亲嵌段共聚物的胶束结构内。还公开了该药物组合物的生产方法。该药物组合物的优点在于它可以改善阴离子药物的功效，因为它允许递送到细胞中，并且它可以增加阴离子药物在血液或体液中的稳定性。

5. 发明申请

WO2008156250A1 SUSTAINED-RELEASE CHITOSAN CAPSULES COMPRISING CHITOSAN AND PHYTIC ACID 审中-公开
标题翻译：持续释放包含壳聚糖和植酸的壳聚糖囊
公开(公告)号：WO2008156250A1
公开(公告)日：2008-12-24
申请号：PCT/KR2008/003015
申请日：2008-05-29
申请人： INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY , PARK, Ji Yong , JEONG, Chan Min , LEE, Min Kyung , CHOI, Sung Won , CHO, Young Hee , JEONG, Hoon Ok
发明人： PARK, Ji Yong , JEONG, Chan Min , LEE, Min Kyung , CHOI, Sung Won , CHO, Young Hee , JEONG, Hoon Ok
IPC分类号： A61K9/48
CPC分类号： A61K31/70 , A61K9/0053 , A61K9/5036 , A61K31/7088
摘要： The present invention relates to a chitosan capsule in which a soluble active ingredient is encapsulated in a matrix containing chitosan and phytic acid; a cross-linking method and materials capable of being used in preparing the capsule! and pharmaceutical, food and cosmetic compositions comprising the capsule. The chitosan capsule according to the present invention is prepared via ionic gelation of chitosan as a biodegradable polymer with phytic acid capable of rapidly and effectively forming a cross-linking reaction with the chitosan polymer. The capsule of the present invention shows high encapsulation efficiency for a soluble active ingredient and protects the soluble active ingredient from being damaged in a digestive tract, resulting in improving an in vivo delivery efficiency of a physiologically active material. Further, since the capsule of the present invention has a pH-dependent sustained-release mechanism which can minimize the release of a soluble active ingredient in the stomach and gradually release in the intestine, it is possible to regulate sustained-release of a soluble active ingredient.
摘要翻译：本发明涉及壳聚糖胶囊，其中将可溶性活性成分包封在含有壳聚糖和植酸的基质中; 交联方法和能够用于制备胶囊的材料！以及包含胶囊的药物，食品和化妆品组合物。根据本发明的壳聚糖胶囊通过壳聚糖作为可生物降解聚合物的离子凝胶化制备，其中植酸能够快速且有效地与壳聚糖聚合物形成交联反应。本发明的胶囊对可溶性活性成分显示出高的包封效率，并保护可溶性活性成分在消化道中的损伤，从而提高生理活性物质的体内递送效率。此外，由于本发明的胶囊具有pH依赖性缓释机制，其可以使可溶性活性成分在胃中的释放最小化并在肠中逐渐释放，因此可以调节可溶性活性物质的缓释成分。

6. 发明申请

WO2013085224A1 BITTER TASTE MASKED ORAL THIN FILM FORMULATION OF SILDENAFIL CITRATE 审中-公开
标题翻译： BITTER TASTE MASKED OAL THIN FILM配方的SILDENAFIL CITRATE
公开(公告)号：WO2013085224A1
公开(公告)日：2013-06-13
申请号：PCT/KR2012/010223
申请日：2012-11-29
申请人： KWANG DONG PHARM. CO., LTD. , C. L. PHARM , SONG, Dae-Kun , WON, Yong-Hoon , KIM, Hoi-Sung , KIM, Hye-Mi , CHOI, Sung-Won
发明人： SONG, Dae-Kun , WON, Yong-Hoon , KIM, Hoi-Sung , KIM, Hye-Mi , CHOI, Sung-Won
IPC分类号： A61K9/40 , A61K31/519
CPC分类号： A61K31/519 , A61K9/0056 , A61K9/7007
摘要： Bitter taste masked oral thin film formulations of sildenafil citrate that rapidly dissolve in the oral cavity, are disclosed. By preparing the fast-dissolving oral thin film of compositions, comprising bitter tasting sildenafil citrate and the bitter taste masking agent of sodium hydroxide, sodium bicarbonate or the mixtures thereof, this invention provides a formulation of an excellent fast-dissolving oral thin film which can mask the bitter taste of sildenafil citrate and thus mitigating an unpleasant feelings at time of drug administration.
摘要翻译：公开了苦味西蒙地非酯柠檬酸盐口服薄膜制剂，其快速溶解于口腔中。通过制备组合物的快速溶解口腔薄膜，其包括苦味西地那非柠檬酸盐和氢氧化钠，碳酸氢钠或其混合物的苦味掩蔽剂，本发明提供了优异的快速溶解口腔薄膜的制剂，其可以掩盖柠檬酸西地那非的苦味，从而减轻药物给药时的不适感。

7. 发明申请

WO2013015545A1 COMPOSITION FOR EDIBLE FILM AND PHARMACEUTICAL PREPARATION FOR EDIBLE FILM CONTAINING DRUGS 审中-公开
标题翻译：用于食用薄膜的组合物和含有可食用药物的药物制剂
公开(公告)号：WO2013015545A1
公开(公告)日：2013-01-31
申请号：PCT/KR2012/005447
申请日：2012-07-10
申请人： KWANG DONG PHARM. CO., LTD. , C. L. PHARM , SONG, Dae-Kun , KIM, Hye-Mi , KIM, Hoi-Sung , WON, Yong-Hoon , CHOI, Sung-Won
发明人： SONG, Dae-Kun , KIM, Hye-Mi , KIM, Hoi-Sung , WON, Yong-Hoon , CHOI, Sung-Won
IPC分类号： A61K9/70 , A61K47/38
CPC分类号： A61K9/0056 , A61K9/7007
摘要： This invention relates to composition for film with improved physical properties of edible film and its pharmaceutical preparation for film. This invention provides us with composition for edible film, which consists of hyroxypropyl methylcellulose(HPMC) and polyvinyl alcohol-polyethylene glycol copolymer(PVA-PEG copolymer) and pharmaceutical preparation for edible film containing drugs. Composition for edible film according to this invention enables us to manufacture intended edible film regardless of adding excipients in order to improve physical properties of film. Also, it has high performance on its physical properties, and enables us to manufacture edible film with high dissolution rate in the oral cavity. Furthermore, pharmaceutical preparation for edible film inhibits limitation on contents of drugs due to excipients, and enables us to manufacture pharmaceutical preparation for edible film containing various drugs without improving physical properties by using other excipients, and improves dosage compliance and convenience for various drugs.
摘要翻译：本发明涉及可食用薄膜物理性质改善的薄膜组合物及其药物制剂。本发明提供了由羟丙基甲基纤维素（HPMC）和聚乙烯醇 - 聚乙二醇共聚物（PVA-PEG共聚物）和含有药物的可食用膜的药物制剂组成的食用膜组合物。根据本发明的可食用膜的组合物使得我们能够制造预期的可食用膜，而不管添加赋形剂以改善膜的物理性质。此外，它具有高性能的物理性能，使我们能够在口腔中制造具有高溶解速率的食用膜。此外，可食用膜的药物制剂抑制由赋形剂引起的药物含量的限制，能够制造含有各种药物的食用膜的药物制剂，而通过使用其它赋形剂不改善物理性能，并提高各种药物的剂量依从性和便利性。

8. 发明申请

WO2006025639A1 APPARATUS FOR CLEANING A SUBSTRATE AND METHOD THEREOF 审中-公开
标题翻译：用于清洁基板的装置及其方法
公开(公告)号：WO2006025639A1
公开(公告)日：2006-03-09
申请号：PCT/KR2005/001196
申请日：2005-04-26
申请人： SFA ENGINEERING CORP. , KWAK, Il-Soon , CHOI, Yoo-Chan , CHOI, Sung-Won , SEO, In-Yong
发明人： KWAK, Il-Soon , CHOI, Yoo-Chan , CHOI, Sung-Won , SEO, In-Yong
IPC分类号： H01L21/304
CPC分类号： H01L21/67028 , B08B1/02 , B08B3/022 , B08B3/123 , B08B2203/005 , C11D11/0047 , H01L21/67051
摘要： Disclosed herein are a method and an apparatus for cleaning a substrate using a mixture of electrolyzed water and ozone water during fabrication of a display device. The apparatus comprises a loading section, a cleaning section and an unloading section wherein the cleaning section includes electrolyzed water/ozone water cleaning means arranged adjacent to the loading section to spray electrolyzed water/ozone water on a substrate so as to clean the substrate, rinsing means arranged adjacent to the electrolyzed water/ozone water cleaning means to rinse the cleaned substrate using deionized water, drying means arranged adjacent to the rinsing means to dry the rinsed substrate, and substrate conveying means for passing the substrate through the loading section, the cleaning section and unloading section in this order.
摘要翻译：本文公开了一种在显示装置的制造期间使用电解水和臭氧水的混合物来清洗基板的方法和装置。该装置包括装载部分，清洁部分和卸载部分，其中清洁部分包括邻近装载部分设置的电解水/臭氧水清洁装置，以将电解水/臭氧水喷射到基板上，以清洁基板，冲洗与电解水/臭氧水清洁装置相邻的装置，用去离子水漂洗清洗过的基材，干燥装置邻近冲洗装置设置以干燥漂洗过的基材;以及基板输送装置，用于使基板通过装载部分，清洗部分和卸载部分。

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