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1. 发明申请

WO2008090517A2 ENRICHED PLANT EXTRACT, COMPOUND, AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开
标题翻译：增强植物提取物，化合物和治疗增殖性疾病的方法
公开(公告)号：WO2008090517A2
公开(公告)日：2008-07-31
申请号：PCT/IB2008/050227
申请日：2008-01-23
申请人： PIRAMAL LIFE SCIENCES LIMITED , PERIYASAMY, Giridharan , SUTHAR, Ashish , BALAKRISHNAN, Arun , VISHWAKARMA, Ram , MANOHAR, Venkat , PARI, Koteppa , CHAUHAN, Vijay, Singh , KULANTHAIVELU, Pathmanathan
发明人： PERIYASAMY, Giridharan , SUTHAR, Ashish , BALAKRISHNAN, Arun , VISHWAKARMA, Ram , MANOHAR, Venkat , PARI, Koteppa , CHAUHAN, Vijay, Singh , KULANTHAIVELU, Pathmanathan
IPC分类号： A61K31/56
CPC分类号： C07J1/00
摘要： The present invention relates to an enriched plant extract containing a mixture of two compounds, obtained from the leaves of the plant Vitex negundo , used for the treatment of proliferative disorders such as cancer. The invention also relates to a compound of formula (1) : The compound of formula (1) can be isolated from the enriched extract and has antiproliferative activity. The present invention further relates to a herbal composition including enriched extract of leaves of Vitex negundo containing the mixture of two compounds as main ingredient for the treatment of proliferative disorders such as cancer. The invention also relates to a pharmaceutical composition including the compound of formula (1), for the treatment of proliferative disorders such as cancer. The invention further relates to the method of treatment of proliferative disorders such as cancer, by adapting the compositions in mammals, in need thereof.
摘要翻译：本发明涉及富含植物提取物，其含有从植物Vitex negundo的叶子获得的两种化合物的混合物，其用于治疗增殖性疾病如癌症。本发明还涉及式（1）化合物：式（1）化合物可以从富集的提取物中分离并具有抗增殖活性。本发明还涉及包含Vitex negundo的叶的富集提取物的草药组合物，其含有两种化合物的混合物作为用于治疗增殖性疾病如癌症的主要成分。本发明还涉及包含用于治疗增殖性疾病如癌症的式（1）化合物的药物组合物。本发明还涉及通过使需要的哺乳动物中的组合物适应而治疗增殖性疾病例如癌症的方法。

2. 发明申请

WO2007036900A2 HERBAL COMPOSITION FOR INFLAMMATORY DISORDERS 审中-公开
标题翻译：用于炎症性疾病的草本组合物
公开(公告)号：WO2007036900A2
公开(公告)日：2007-04-05
申请号：PCT/IB2006/053540
申请日：2006-09-28
申请人： NICHOLAS PIRAMAL INDIA LTD , CHAUHAN, Vijay , SUTHAR, Ashish , SAPRE, Dhananjay , BAL-TEMBE, Swati , GANGOPADHYAY, Ashok Kumar , KULKARNI-ALMEIDA, Asha , PARIKH, Sapna Hasit
发明人： CHAUHAN, Vijay , SUTHAR, Ashish , SAPRE, Dhananjay , BAL-TEMBE, Swati , GANGOPADHYAY, Ashok Kumar , KULKARNI-ALMEIDA, Asha , PARIKH, Sapna Hasit
CPC分类号： A61K36/28
摘要： This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3- methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1 ,2-b]furan-2-one (7- Hydroxy-4,1 1 (13)-eudesmadien-12,6-olide) (compound 1 ), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl- 3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1 ,2-b]furan-2-one (compound 1 ) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor-α (TNF- α) and interleukin (IL-1 , IL-6, IL-8) inhibitory activity of the said compositions. The invention relates to inhibition of the expression of intercellular adhesion molecule 1 (ICAM-1 ), vascular-cell adhesion molecule 1 (VCAM-1 ), and E-Selectin by the said compositions. The said compositions may optionally contain at least one anti- inflammatory agent or can be used in combination with at least one anti- inflammatory agent.
摘要翻译：本发明涉及一种新颖的草药组合物，其包含植物的开花和果实头的提取物，Sphaeranthus indicus。所述所述Sphaeranthus indicus提取物含有一种化合物，3a-羟基-5a，9-二甲基-3-亚甲基-3a，4,5,5a，6,7,8,9b-八氢-3H-萘并[1,2- b]呋喃-2-酮（7-羟基-4,1 1（13） - 去马来麦地 - 12,6-二醇）（化合物1）作为生物活性标记物。本发明还涉及包含3a-羟基-5a，9-二甲基-3-亚甲基-3a，4,5,5a，6,7,8,9b-八氢-3H-萘并[1,2-b] 呋喃-2-酮（化合物1）作为活性成分。本发明还涉及制备所述组合物的方法。本发明还涉及将所述组合物给予需要治疗炎症性疾病的受试者的方法。本发明还涉及所述组合物的肿瘤坏死因子-α（TNF-α）和白介素（IL-1，IL-6，IL-8）抑制活性。本发明涉及通过所述组合物抑制细胞间粘附分子1（ICAM-1），血管细胞粘附分子1（VCAM-1）和E-选择蛋白的表达。所述组合物可任选地含有至少一种抗炎剂或可与至少一种抗炎剂组合使用。

3. 发明申请

WO2006082481A1 HERBAL COMPOSITION FOR TINEA INFECTION 审中-公开
标题翻译：用于感染TINEA的草本组合物
公开(公告)号：WO2006082481A1
公开(公告)日：2006-08-10
申请号：PCT/IB2005/051997
申请日：2005-06-17
申请人： NICHOLAS PIRAMAL INDIA LIMITED , CHAUHAN, Vijay Singh , SATYAN, Kalkunte S. , KADAM, Kavita P.
发明人： CHAUHAN, Vijay Singh , SATYAN, Kalkunte S. , KADAM, Kavita P.
IPC分类号： A01N65/00 , A61K36/00
CPC分类号： A61K36/9068 , A01N65/00 , A01N65/08 , A01N65/10 , A01N65/12 , A01N65/28 , A01N65/32 , A01N65/42 , A01N65/48 , A01N2300/00
摘要： Compositions containing extract of hedychium spicatum are useful for treating Tinea infections by topical application. Extracts from rhizomes of hedychium spicatum are particularly useful.
摘要翻译：含有枸杞提取物的组合物可用于通过局部施用治疗癣感染。枸杞根茎提取物特别有用。

4. 发明申请

WO2009156962A1 ORAL HERBAL COMPOSITION FOR THE TREATMENT OF ORAL CANDIDIASIS 审中-公开
标题翻译：用于治疗口腔糖尿病的口服组合物
公开(公告)号：WO2009156962A1
公开(公告)日：2009-12-30
申请号：PCT/IB2009/052741
申请日：2009-06-25
申请人： PIRAMAL LIFE SCIENCES LIMITED , CHAUHAN, Vijay Singh , SALKAR, Kavita Sujeet
发明人： CHAUHAN, Vijay Singh , SALKAR, Kavita Sujeet
IPC分类号： A61K36/67 , A61P31/10 , A61K8/97
CPC分类号： A61K36/67
摘要： An oral herbal composition comprising a therapeutically effective amount of an extract derived from the berries of a plant, Piper cubeba, wherein the composition is provided for use in the treatment of oral candidiasis (oral thrush). The oral herbal composition can be formulated in the form of a candy, a chewable tablet and an oral gel. The herbal composition exhibits antifungal activity against azole resistant strains of Candida albicans. The herbal composition is safe to administer and has improved patient compliance.
摘要翻译：一种口服草药组合物，其包含治疗有效量的源自植物浆果（Piper cubeba）的提取物，其中所述组合物用于治疗口腔念珠菌病（口服鹅口疮）。口服草药组合物可以以糖，咀嚼片和口服凝胶的形式配制。草药组合物对白色念珠菌的抗唑菌株表现出抗真菌活性。草药组合物可安全施用，并改善了患者的依从性。

5. 发明申请

WO2007080525A3 HERBAL COMPOSITION 审中-公开
标题翻译：草本成分
公开(公告)号：WO2007080525A3
公开(公告)日：2007-12-06
申请号：PCT/IB2007050031
申请日：2007-01-05
申请人： NICHOLAS PIRAMAL INDIA LTD , CHAUHAN VIJAY , SHANMUGANATHAN MUTHUSAMY VELUC
发明人： CHAUHAN VIJAY , SHANMUGANATHAN MUTHUSAMY VELUC
IPC分类号： A61K36/00
CPC分类号： A61K36/185
摘要： The present invention relates to a novel herbal composition comprising extract of leaves of Polyalthia longifolia and method of manufacture of said composition. The present invention relates to a herbal extract selectively comprising a compound 16- hydroxycleroda-3,13(14)-dien-15, 16-olide (compound 1), as a bioactive marker and optionally other active(s). The invention also discloses methods of administration of the said herbal composition for the treatment of various inflammatory disorders. Optionally the said extract may be combined with other bioactive substances to obtain a synergistic effect.
摘要翻译：本发明涉及一种新颖的草药组合物，其包含长叶茯苓叶提取物和所述组合物的制造方法。本发明涉及一种草药提取物，其选择性地包含作为生物活性标记物和任选的其它活性物质的化合物16-羟基胆固醇-3,13（14） - 二烯-15,16-二醇（化合物1）。本发明还公开了用于治疗各种炎性疾病的所述草药组合物的施用方法。任选地，所述提取物可与其它生物活性物质组合以获得协同效应。

6. 发明申请

WO2011001451A1 METHOD AND APPRATUS FOR GROUPING DISCRETE LAMINAR ARTICLES INTO BATHES OF PREDETERMINED COUNT 审中-公开
标题翻译：将离散层状文章分类到预计数据的方法和装置
公开(公告)号：WO2011001451A1
公开(公告)日：2011-01-06
申请号：PCT/IN2010/000445
申请日：2010-06-29
申请人： CHAUHAN, Vijay
发明人： CHAUHAN, Vijay
IPC分类号： B65B23/14
CPC分类号： B65B23/14 , B65B57/20 , B65G47/082 , B65G59/108 , B65G2201/0205
摘要： An apparatus for grouping discrete laminar articles (30) into batches of predetermined count includes a feed conveyor (12), a left-hand screw (18) and a right-hand screw (16) combination, a means (24) for synchronizing and automating starting and stopping rotation of the screws (16,18) and a platform assembly (26). The platform assembly (26) is connected to the feed conveyor (12) and includes a hatch (28) and a pusher mechanism (14). The feed conveyor (12) supports articles disposed thereon. The screws (16,18) are disposed along edges of and at either side of the feed conveyor and are adapted to rotate to facilitate counting and pushing of the articles. The screws (16,18) stop rotating and thereby stop further pushing of the articles, when a predetermined count of articles has been pushed. The pusher mechanism (14) receives the predetermined count of articles pushed by screws and moves them to the hatch from where they are dropped into a delivery line (34).
摘要翻译：用于将离散层状制品（30）分组成预定计数的装置包括进料输送机（12），左旋螺杆（18）和右旋螺杆（16）组合，用于同步和自动启动和停止螺钉（16,18）和平台组件（26）的旋转。平台组件（26）连接到进料输送机（12）并且包括舱口（28）和推动机构（14）。进料输送机（12）支撑设置在其上的物品。螺钉（16,18）沿着进料输送机的边缘并且在进料输送机的任一侧设置并且适于旋转以便于物品的计数和推动。螺钉（16,18）停止旋转，从而停止进一步推动物品，当预定的物品数量被推动时。推动器机构（14）接收由螺钉推动的物品的预定计数，并将它们移动到舱口，从那里它们落入输送管线（34）。

7. 发明申请

WO2011001451A9 METHOD AND APPARATUS FOR GROUPING DISCRETE LAMINAR ARTICLES INTO BATHES OF PREDETERMINED COUNT 审中-公开
标题翻译：将离散层状物品分类到预计数据的方法和装置
公开(公告)号：WO2011001451A9
公开(公告)日：2011-03-17
申请号：PCT/IN2010000445
申请日：2010-06-29
申请人： CHAUHAN VIJAY
发明人： CHAUHAN VIJAY
IPC分类号： B65B23/14
CPC分类号： B65B23/14 , B65B57/20 , B65G47/082 , B65G59/108 , B65G2201/0205
摘要： An apparatus for grouping discrete laminar articles (30) into batches of predetermined count includes a feed conveyor (12), a left-hand screw (18) and a right-hand screw (16) combination, a means (24) for synchronizing and automating starting and stopping rotation of the screws (16,18) and a platform assembly (26). The platform assembly (26) is connected to the feed conveyor (12) and includes a hatch (28) and a pusher mechanism (14). The feed conveyor (12) supports articles disposed thereon. The screws (16,18) are disposed along edges of and at either side of the feed conveyor and are adapted to rotate to facilitate counting and pushing of the articles. The screws (16,18) stop rotating and thereby stop further pushing of the articles, when a predetermined count of articles has been pushed. The pusher mechanism (14) receives the predetermined count of articles pushed by screws and moves them to the hatch from where they are dropped into a delivery line (34).
摘要翻译：用于将离散层状制品（30）分组成预定计数的装置包括进料输送机（12），左旋螺杆（18）和右旋螺杆（16）组合，用于同步和自动启动和停止螺钉（16,18）和平台组件（26）的旋转。平台组件（26）连接到进料输送机（12）并且包括舱口（28）和推动机构（14）。进料输送机（12）支撑设置在其上的物品。螺钉（16,18）沿着进料输送机的边缘并在其两侧设置并且适于旋转以便于物品的计数和推动。螺钉（16,18）停止旋转，从而停止进一步推动物品，当预定的物品数量被推动时。推动器机构（14）接收由螺钉推动的物品的预定计数，并将它们移动到舱口，从那里它们落入输送管线（34）。

8. 发明申请

WO2008090517A3 ENRICHED PLANT EXTRACT, COMPOUND, AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开
标题翻译：增强植物提取物，化合物和治疗增殖性疾病的方法
公开(公告)号：WO2008090517A3
公开(公告)日：2009-12-30
申请号：PCT/IB2008050227
申请日：2008-01-23
申请人： PIRAMAL LIFE SCIENCES LTD , PERIYASAMY GIRIDHARAN , SUTHAR ASHISH , BALAKRISHNAN ARUN , VISHWAKARMA RAM , MANOHAR VENKAT , PARI KOTEPPA , CHAUHAN VIJAY SINGH , KULANTHAIVELU PATHMANATHAN
发明人： PERIYASAMY GIRIDHARAN , SUTHAR ASHISH , BALAKRISHNAN ARUN , VISHWAKARMA RAM , MANOHAR VENKAT , PARI KOTEPPA , CHAUHAN VIJAY SINGH , KULANTHAIVELU PATHMANATHAN
IPC分类号： A61K31/56 , C07D215/00
CPC分类号： C07J1/00
摘要： The present invention relates to an enriched plant extract containing a mixture of two compounds, obtained from the leaves of the plant Vitex negundo, used for the treatment of proliferative disorders such as cancer. The invention also relates to a compound of formula (1) : The compound of formula (1) can be isolated from the enriched extract and has antiproliferative activity. The present invention further relates to a herbal composition including enriched extract of leaves of Vitex negundo containing the mixture of two compounds as main ingredient for the treatment of proliferative disorders such as cancer. The invention also relates to a pharmaceutical composition including the compound of formula (1), for the treatment of proliferative disorders such as cancer. The invention further relates to the method of treatment of proliferative disorders such as cancer, by adapting the compositions in mammals, in need thereof.
摘要翻译：本发明涉及富含植物提取物，其含有从植物Vitex negundo的叶子获得的两种化合物的混合物，其用于治疗增殖性疾病如癌症。本发明还涉及式（1）化合物：式（1）化合物可以从富集的提取物中分离并具有抗增殖活性。本发明还涉及包含Vitex negundo的叶的富集提取物的草药组合物，其含有两种化合物的混合物作为用于治疗增殖性疾病如癌症的主要成分。本发明还涉及包含用于治疗增殖性疾病如癌症的式（1）化合物的药物组合物。本发明还涉及通过使需要的哺乳动物中的组合物适应而治疗增殖性疾病例如癌症的方法。

9. 发明申请

WO2007036900A3 HERBAL COMPOSITION FOR INFLAMMATORY DISORDERS 审中-公开
标题翻译：炎症性疾病的草药组合物
公开(公告)号：WO2007036900A3
公开(公告)日：2007-08-02
申请号：PCT/IB2006053540
申请日：2006-09-28
申请人： NICHOLAS PIRAMAL INDIA LTD , CHAUHAN VIJAY , SUTHAR ASHISH , SAPRE DHANANJAY , BAL-TEMBE SWATI , GANGOPADHYAY ASHOK KUMAR , KULKARNI-ALMEIDA ASHA , PARIKH SAPNA HASIT
发明人： CHAUHAN VIJAY , SUTHAR ASHISH , SAPRE DHANANJAY , BAL-TEMBE SWATI , GANGOPADHYAY ASHOK KUMAR , KULKARNI-ALMEIDA ASHA , PARIKH SAPNA HASIT
IPC分类号： A61K36/28 , A61K133/00 , A61P29/00
CPC分类号： A61K36/28
摘要： This invention relates to a novel herbal composition comprising an extract of flowering and fruiting heads of the plant, Sphaeranthus indicus. The said extract of Sphaeranthus indicus contains a compound, 3a-hydroxy-5a,9-dimethyl-3- methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1 ,2-b]furan-2-one (7- Hydroxy-4,1 1 (13)-eudesmadien-12,6-olide) (compound 1 ), as a bioactive marker. The invention also relates to a composition comprising 3a-hydroxy-5a,9-dimethyl- 3-methylene-3a,4,5,5a,6,7,8,9b-octahydro-3H-naphtho[1 ,2-b]furan-2-one (compound 1 ) as an active ingredient. The invention also relates to methods of manufacture of the said compositions. The invention also relates to methods of administration of the said compositions to a subject in need of treatment for an inflammatory disorder. The invention also relates to tumor necrosis factor-a (TNF- a) and interleukin (IL-1 , IL-6, IL-8) inhibitory activity of the said compositions. The invention relates to inhibition of the expression of intercellular adhesion molecule 1 (ICAM-1 ), vascular-cell adhesion molecule 1 (VCAM-1 ), and E-Selectin by the said compositions. The said compositions may optionally contain at least one anti- inflammatory agent or can be used in combination with at least one anti- inflammatory agent.
摘要翻译：本发明涉及一种新型草药组合物，该组合物包含植物开花和结果头的提取物，Sphaeranthus indicus。所述绒毛菊提取物含有化合物3α-羟基-5,9-二甲基-3-亚甲基-3a，4,5,5a，6,7,8,9b-八氢-3H-萘并[1,2- b]呋喃-2-酮（7-羟基-4,11-（13） - 月癸二烯-12,6-内酯）（化合物1）作为生物活性标记。本发明还涉及包含3α-羟基-5α，9-二甲基-3-亚甲基-3a，4,5,5a，6,7,8,9b-八氢-3H-萘并[1,2-b] 呋喃-2-酮（化合物1）作为活性成分。本发明还涉及制造所述组合物的方法。本发明还涉及将所述组合物给予需要治疗炎性疾病的对象的方法。本发明还涉及所述组合物的肿瘤坏死因子-α（TNF-α）和白细胞介素（IL-1，IL-6，IL-8）抑制活性。本发明涉及通过所述组合物抑制细胞间粘附分子1（ICAM-1），血管细胞粘附分子1（VCAM-1）和E-选择蛋白的表达。所述组合物可以任选地包含至少一种抗炎剂或可以与至少一种抗炎剂组合使用。

10. 发明申请

WO2007080525A2 HERBAL COMPOSITION 审中-公开
标题翻译：草药组合物
公开(公告)号：WO2007080525A2
公开(公告)日：2007-07-19
申请号：PCT/IB2007/050031
申请日：2007-01-05
申请人： NICHOLAS PIRAMAL INDIA LTD , CHAUHAN, Vijay , SHANMUGANATHAN, Muthusamy, Veluchamy
发明人： CHAUHAN, Vijay , SHANMUGANATHAN, Muthusamy, Veluchamy
IPC分类号： A61K36/185
CPC分类号： A61K36/185
摘要： The present invention relates to a novel herbal composition comprising extract of leaves of Polyalthia longifolia and method of manufacture of said composition. The present invention relates to a herbal extract selectively comprising a compound 16- hydroxycleroda-3,13(14)-dien-15, 16-olide (compound 1), as a bioactive marker and optionally other active(s). The invention also discloses methods of administration of the said herbal composition for the treatment of various inflammatory disorders. Optionally the said extract may be combined with other bioactive substances to obtain a synergistic effect.
摘要翻译：本发明涉及一种包含长叶鬼伞叶提取物的新型草药组合物及其制造方法。本发明涉及选择性地包含作为生物活性标记物的化合物16-羟基妥可-3,13（14） - 二烯-15,16-内酯（化合物1）和任选的其他活性物质的草药提取物。本发明还公开了所述草药组合物用于治疗各种炎症的方法。任选地，所述提取物可以与其他生物活性物质组合以获得协同作用。

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