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1. 发明申请

WO2011153233A1 SYSTEMS AND METHODS FOR TRANSNASAL DILATION OF PASSAGEWAYS IN THE EAR, NOSE OR THROAT 审中-公开
标题翻译： EAR，NOSE或THROAT中PASSAGEWAYS的离散放电系统和方法
公开(公告)号：WO2011153233A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/038751
申请日：2011-06-01
申请人： ACCLARENT, INC. , GOLDFARB, Eric , CHANG, John, Y. , FACTEAU, William, M. , LAM, Sivette , HA, Hung, V. , KIM, Issac, J. , MUNI, Ketan, P.
发明人： GOLDFARB, Eric , CHANG, John, Y. , FACTEAU, William, M. , LAM, Sivette , HA, Hung, V. , KIM, Issac, J. , MUNI, Ketan, P.
IPC分类号： A61M25/01 , A61M29/00 , A61B17/24
CPC分类号： A61M29/02 , A61B1/233 , A61B17/24 , A61M25/0041 , A61M25/0097 , A61M25/0108 , A61M25/1002 , A61M2025/0004 , A61M2025/0008 , A61M2025/0183 , A61M2025/1061 , A61M2025/1079 , A61M2025/1086 , A61M2210/0618 , A61M2210/0681 , A61M2230/005 , A61M2210/005
摘要： A dilation catheter device (120) and system for dilating an opening in a paranasal sinus and/or other passageways within the ear, nose or throat is disclosed. A dilation catheter device and system is constructed in a manner that facilitates ease of use by the operator and, in at least some cases, allows the dilation procedure to be performed by a single operator. Additionally, the dilation catheter device and system may be useable in conjunction with an endoscope and/or a fluoroscope to provide for easy manipulation and positioning of the devices and real time visualization of the entire procedure or selected portions thereof. In some embodiments, shaft markers (118,121,116,114,112) are disposed on a shaft of the dilation catheter and have a light color to contrast with a dark color of the dilation catheter shaft. The high contrast between the markers and catheter shaft allows for easy viewing of the markers in low light and operation conditions.
摘要翻译：公开了一种扩张导管装置（120）和用于扩张鼻窦和/或耳朵，鼻子或喉部内的其它通道中的开口的系统。膨胀导管装置和系统以促进操作者易于使用的方式构造，并且在至少一些情况下允许扩张程序由单个操作者执行。此外，扩张导管装置和系统可以与内窥镜和/或荧光镜结合使用，以提供装置的简单操作和定位以及整个程序或其选定部分的实时可视化。在一些实施例中，轴标记（118,121,116,114,112）设置在扩张导管的轴上并且具有与扩张导管轴的深色对比的浅色。标记和导管轴之间的高对比度允许在低光和操作条件下容易地观察标记。

2. 发明申请

WO2008134288A3 MECHANICAL DILATION OF THE OSTIA OF PARANASAL SINUSES AND OTHER PASSAGEWAYS OF THE EAR, NOSE AND THROAT 审中-公开
标题翻译：肛门手术的机械放大和其他耳蜗，鼻塞和喉咙的通气
公开(公告)号：WO2008134288A3
公开(公告)日：2008-12-24
申请号：PCT/US2008061048
申请日：2008-04-21
申请人： ACCLARENT INC , MORRISS JOHN H , JENKINS THOMAS R , GOLDFARB ERIC , BARON SCOTT J , MUNI KETAN P , CHANG JOHN Y , VRANY JULIA D , HARFE DANIEL T , SWEI SERENA , WOOD ROBERT N , CHAN RANDY S , HA HUNG V
发明人： MORRISS JOHN H , JENKINS THOMAS R , GOLDFARB ERIC , BARON SCOTT J , MUNI KETAN P , CHANG JOHN Y , VRANY JULIA D , HARFE DANIEL T , SWEI SERENA , WOOD ROBERT N , CHAN RANDY S , HA HUNG V
IPC分类号： A61M29/00 , A61B17/24 , A61M1/00
CPC分类号： A61B17/24 , A61B17/0218 , A61M29/02
摘要： Devices and methods for dilating the ostia of paranasal sinuses and other passageways within the ear, nose and throat. A mechanical dilator is inserted through a nostril and used to dilate an ostium or a paranasal sinus or other passageway within the ear, nose or throat (e.g., a Eustachian tube or nasolacrimal duct). The mechanical dilator may be an expandable dilators that comprises one or more non-balloon structures with or without an accompanying balloon or a members of varying diameter or cross dimension (e.g., a tapered member) that may be advanced into the ostium or other passageway to cause dilation of that passageway.
摘要翻译：用于扩张鼻窦口和耳，鼻和咽喉内其他通道的装置和方法。通过鼻孔插入机械扩张器，用于扩大耳朵，鼻子或咽喉（例如咽鼓管或鼻泪管）内的口或鼻旁窦或其他通道。机械扩张器可以是包括一个或多个非球囊结构的可膨胀扩张器，所述非球囊结构具有或不具有伴随的球囊或具有不同直径或横截面尺寸的部件（例如，锥形构件），其可被推进到口或其它通道中导致通道扩张。

3. 发明申请

WO2008131195A2 SYSTEM AND METHOD FOR THE SIMULTANEOUS BILATERAL TREATMENT OF TARGET TISSUES WITHIN THE EARS 审中-公开
标题翻译：耳蜗内靶向组织同时双重治疗的系统与方法
公开(公告)号：WO2008131195A2
公开(公告)日：2008-10-30
申请号：PCT/US2008060779
申请日：2008-04-18
申请人： ACCLARENT INC , CLIFFORD ANTON , LIU GREG , MORRISS JOHN , MAKOWER JOSHUA , FACTEAU WILLIAM , GOLDFARB ERIC , CHANG JOHN Y , SHAHOIAN ERIK JAMES
发明人： CLIFFORD ANTON , LIU GREG , MORRISS JOHN , MAKOWER JOSHUA , FACTEAU WILLIAM , GOLDFARB ERIC , CHANG JOHN Y , SHAHOIAN ERIK JAMES
IPC分类号： A61F11/00
CPC分类号： A61M31/00 , A61B5/0077 , A61B2017/00787 , A61F11/002 , A61M2210/0662 , A61N1/30 , A61N1/306
摘要： A) Systems and methods for bilateral treatment of a patient having a head with a first ear and a second ear function by aligning a first device with a target tissue of the first ear; aligning a second device with a target tissue of the second ear; and therapeutically remodeling, with synchronization, the target tissues of the first and second ear with the first and second aligned devices, respectively. B) Systems and methods for treating a patient having a head with a first ear and a second ear function by mounting a support system to the head of the patient so that the support system is aligned with a target tissue of the first ear; applying a therapeutic agent to the first ear by energizing an iontophoresis electrode supported by the support system; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear. C) Systems and methods for treating a patient having an ear canal and a target tissue function by positioning a fluid or gel in the ear canal, the fluid or gel comprising a therapeutic agent; retaining the fluid or gel with a support structure, the support structure supporting an electrode and a battery; and applying the agent from the fluid or gel to the target tissue by energizing the electrode with an iontophoresis potential from the battery. D) Systems and methods for treating a patient having a head with a first ear and a second ear, function by mounting a support structure to the head of the patient; aligning the support structure with a target tissue in an ear canal of the first ear; stabilizing the support structure relative to the target tissue by injecting a material into the canal and hardening the material; and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear. E) Systems and methods for treating a patient having a head with a first ear and a second ear, function by aligning a first device with a tympanic membrane of the first ear; inputting a command to an input device operatively coupled to the first device to generate a signal; and actuating the first device in response to the signal so as to drive a penetrator of the device through the tympanic membrane.
摘要翻译： A）通过将第一装置与第一耳朵的目标组织对准来双侧治疗具有第一耳朵和第二耳朵功能的患者的系统和方法; 将第二装置与第二耳朵的目标组织对准; 以及分别与第一和第二对准的装置分别对第一和第二耳朵的目标组织进行同步化的治疗重塑。 B）通过将支撑系统安装到患者的头部来治疗具有第一耳朵和第二耳朵功能的头部的患者的系统和方法，使得支撑系统与第一耳朵的目标组织对准; 通过对由所述支撑系统支撑的离子电渗电极通电来将治疗剂施加到所述第一耳朵; 以及当所述装置由所述支撑系统支撑时启动装置，使得所述装置治疗性地改造所述第一耳朵的目标组织。 C）通过将流体或凝胶定位在耳道中来治疗患有耳道和靶组织功能的患者的系统和方法，所述流体或凝胶包含治疗剂; 用支撑结构保持流体或凝胶，支撑结构支撑电极和电池; 以及通过从所述电池离子电渗电位激发所述电极，将所述药剂从所述流体或凝胶施加到所述靶组织。 D）用于治疗患有具有第一耳朵和第二耳朵的头部的患者的系统和方法通过将支撑结构安装到患者的头部而起作用; 将支撑结构与第一耳的耳道中的目标组织对准; 通过将材料注入到管道中并使材料硬化来相对于目标组织稳定支撑结构; 以及当所述装置由所述支撑系统支撑时启动装置，使得所述装置治疗性地改造所述第一耳朵的目标组织。 E）用于治疗患有具有第一耳朵和第二耳朵的头部的患者的系统和方法，其功能是使第一装置与第一耳朵的鼓膜对准; 向可操作地耦合到所述第一设备的输入设备输入命令以产生信号; 以及响应于所述信号致动所述第一装置，以便通过所述鼓膜驱动所述装置的穿透器。

4. 发明申请

WO2008124787A2 ETHMOIDOTOMY SYSTEM AND IMPLANTABLE SPACER DEVICES HAVING THERAPEUTIC SUBSTANCE DELIVERY CAPABILITY FOR TREATMENT OF PARANASAL SINUSITIS 审中-公开
标题翻译： ETHMOIDOTOMY系统和具有治疗物质传递能力的可植入间隔器装置治疗鼻旁窦炎
公开(公告)号：WO2008124787A2
公开(公告)日：2008-10-16
申请号：PCT/US2008059786
申请日：2008-04-09
申请人： ACCLARENT INC , MUNI KETAN P , HA HUNG V , CHANG JOHN Y , CHAN RANDY S , VAN NGA K , MAKOWER JOSHUA , FACTEAU WILLIAM M , LEVINE HOWARD L
发明人： MUNI KETAN P , HA HUNG V , CHANG JOHN Y , CHAN RANDY S , VAN NGA K , MAKOWER JOSHUA , FACTEAU WILLIAM M , LEVINE HOWARD L
IPC分类号： A61M31/00
CPC分类号： A61M25/10 , A61B17/24 , A61B17/3415 , A61B17/3417 , A61B17/3421 , A61B2090/062 , A61F11/004 , A61M25/0075 , A61M25/0084 , A61M25/04 , A61M29/02 , A61M31/00 , A61M2025/0681 , A61M2025/105
摘要： Substance delivering spacer devices may comprise expandable reservoirs that are implantable in paranasal sinuses and other cavities, openings and passageways of the body to maintain patency and to provide sustained local delivery of a therapeutic or diagnostic substance. Also provided are sinus penetrator devices and systems for performing ethmoidotomy procedures or for creating other openings in the walls of paranasal sinuses or other anatomical structures.
摘要翻译：递送间隔物装置的物质可包括可植入副鼻窦和其他腔室，身体的开口和通道以维持开放并提供治疗或诊断物质的持续局部递送的可膨胀储存器。还提供了用于执行筛选手术或用于在副鼻窦或其他解剖结构的壁上创建其他开口的鼻窦穿刺器装置和系统。

5. 发明申请

WO2011082139A1 SYSTEM FOR TREATING TARGET TI S SUE WITHIN THE EUSTACHIAN TUBE 审中-公开
标题翻译：在欧盟管道内处理目标的系统
公开(公告)号：WO2011082139A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/062161
申请日：2010-12-27
申请人： ACCLARENT, INC. , CLIFFORD, Anton, G. , MAKOWER, Joshua , CHANG, John, Y. , MORRISS, John, H. , BRIGHT, Earl, A. , GOLDFARB, Eric , VRANY, Julia, D.
发明人： CLIFFORD, Anton, G. , MAKOWER, Joshua , CHANG, John, Y. , MORRISS, John, H. , BRIGHT, Earl, A. , GOLDFARB, Eric , VRANY, Julia, D.
IPC分类号： A61M25/00 , A61M25/06 , A61M25/10 , A61M29/00 , A61M25/09 , A61B1/00 , A61F2/84 , A61B17/3207 , A61K31/00 , A61L29/00 , A61B18/00
CPC分类号： A61M29/02 , A61B1/227 , A61B1/233 , A61B5/036 , A61B5/415 , A61B8/12 , A61B17/24 , A61B18/08 , A61B18/20 , A61F11/002 , A61F11/004 , A61M25/0041 , A61M25/0054 , A61M25/0068 , A61M25/007 , A61M25/008 , A61M25/0662 , A61M25/09 , A61M25/10 , A61M25/1002 , A61M31/002 , A61M2025/0037 , A61M2025/0039 , A61M2025/09008 , A61M2025/09183 , A61M2025/105 , A61M2025/1054 , A61M2025/1086 , A61N7/02
摘要： Systems for accessing a Eustachian tube (26) of a patient are disclosed. The system includes a guide (1600) configured for passing into a nasal passage of the patient to position a distal tip (1602) of the catheter at or near a Eustachian tube, the guide having a distal tip with a bend having an angle between 30 and 90 degrees; and a guidewire (1604) configured to pass through the guide into the Eustachian tube. A device (1606) for providing therapy to the Eustachian tube is passed through the guide.
摘要翻译：公开了用于访问患者的咽鼓管（26）的系统。该系统包括引导件（1600），其构造成用于进入患者的鼻通道以将导管的远侧末端（1602）定位在咽鼓管处或附近，其具有远侧末端，弯曲部的角度在30度和90度; 以及导丝（1604），其被配置成穿过所述引导件进入咽鼓管。用于向咽鼓管提供治疗的装置（1606）通过引导件。

6. 发明申请

WO2011082074A1 TISSUE REMOVAL IN THE PARANASAL SINUS AND NASAL CAVITY 审中-公开
标题翻译：组合去除在纳西和纳皮尔山脉的组织
公开(公告)号：WO2011082074A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/061850
申请日：2010-12-22
申请人： ACCLARENT, INC. , MAKOWER, Joshua , CHANG, John, Y. , GOLDFARB, Eric , ANDREAS, Bernard, H. , JENKINS, Thomas , SHERMAN, Nick , HEISER, Ronda, M. , HA, Hung, V. , MORRISS, John, H.
发明人： MAKOWER, Joshua , CHANG, John, Y. , GOLDFARB, Eric , ANDREAS, Bernard, H. , JENKINS, Thomas , SHERMAN, Nick , HEISER, Ronda, M. , HA, Hung, V. , MORRISS, John, H.
IPC分类号： A61B17/24 , A61B17/22 , A61B17/32 , A61B17/3205 , A61M29/02
CPC分类号： A61B17/24 , A61B17/320016 , A61B17/32056 , A61B2017/22038 , A61B2017/22079 , A61M25/0105 , A61M25/1011 , A61M29/02 , A61M31/00 , A61M2025/0186 , A61M2025/109
摘要： Sinusitis, tumors, infections, fractures and other disorders of the paranasal sinuses, are diagnosed and/or treated using minimally invasive approaches. Access devices may be used to facilitate insertion of working devices such catheters, balloon catheters, dilation catheters, tissue cutting or remodeling devices, suction or irrigation devices and biopsy devices.
摘要翻译：鼻窦炎，肿瘤，感染，骨折和其他鼻旁窦病变，使用微创方法进行诊断和/或治疗。可以使用进入装置来促进诸如导管，球囊导管，扩张导管，组织切割或重塑装置，抽吸或冲洗装置和活检装置的工作装置的插入。

7. 发明申请

WO2011002854A1 SYSTEMS AND METHODS FOR TRANSNASAL DILATION OF PASSAGEWAYS IN THE EAR, NOSE OR THROAT 审中-公开
标题翻译： EAR，NOSE或THROAT中PASSAGEWAYS的离散放电系统和方法
公开(公告)号：WO2011002854A1
公开(公告)日：2011-01-06
申请号：PCT/US2010/040548
申请日：2010-06-30
申请人： ACCLARENT, INC. , GOLDFARB, Eric , CHANG, John, Y. , FACTEAU, William, M. , LAM, Sivette , HA, Hung, V. , KIM, Isaac, J. , MUNI, Ketan
发明人： GOLDFARB, Eric , CHANG, John, Y. , FACTEAU, William, M. , LAM, Sivette , HA, Hung, V. , KIM, Isaac, J. , MUNI, Ketan
IPC分类号： A61M25/00 , A61M25/01 , A61M25/10 , A61M29/02
CPC分类号： A61B17/24 , A61B6/12 , A61B6/487 , A61B2017/246 , A61M25/0041 , A61M25/09 , A61M25/1002 , A61M29/02 , A61M2025/1079 , A61M2025/1086 , A61M2210/0618 , A61M2210/0681 , A61M2230/005
摘要： A dilation catheter device and system for dilating an opening in a paranasal sinus and/or other passageways within the ear, nose or throat is disclosed. A dilation catheter device and system is constructed in a manner that facilitates ease of use by the operator and, in at least some cases, allows the dilation procedure to be performed by a single operator. Additionally, the dilation catheter device and system may be useable in conjunction with an endoscope and/or a fluoroscope to provide for easy manipulation and positioning of the devices and real time visualization of the entire procedure or selected portions thereof. In some embodiments, shaft markers are disposed on a shaft of the dilation catheter and have a light color to contrast with a dark color of the dilation catheter shaft. The high contrast between the markers and catheter shaft allows for easy viewing of the markers in low light and operation conditions.
摘要翻译：公开了一种扩张导管装置和系统，用于扩张鼻窦和/或耳朵，鼻子或喉部内的其它通道中的开口。膨胀导管装置和系统以促进操作者易于使用的方式构造，并且在至少一些情况下允许扩张程序由单个操作者执行。此外，扩张导管装置和系统可以与内窥镜和/或荧光镜结合使用，以提供装置的简单操作和定位以及整个程序或其选定部分的实时可视化。在一些实施例中，轴标记设置在扩张导管的轴上并且具有与扩张导管轴的深色对比的浅色。标记和导管轴之间的高对比度允许在低光和操作条件下容易地观察标记。

8. 发明申请

WO2008131195A3 SYSTEM AND METHOD FOR THE SIMULTANEOUS BILATERAL TREATMENT OF TARGET TISSUES WITHIN THE EARS 审中-公开
公开(公告)号：WO2008131195A3
公开(公告)日：2008-10-30
申请号：PCT/US2008/060779
申请日：2008-04-18
申请人： ACCLARENT, INC. , CLIFFORD, Anton , LIU, Greg , MORRISS, John , MAKOWER, Joshua , FACTEAU, William , GOLDFARB, Eric , CHANG, John Y. , SHAHOIAN, Erik James
发明人： CLIFFORD, Anton , LIU, Greg , MORRISS, John , MAKOWER, Joshua , FACTEAU, William , GOLDFARB, Eric , CHANG, John Y. , SHAHOIAN, Erik James
IPC分类号： A61F11/00
摘要： Systems and methods for bilateral treatment of a patient having a head with a first ear and a second ear function by aligning a first device with a target tissue of the first ear, aligning a second device with a target tissue of the second ear, and therapeutically remodeling, with synchronization, the target tissues of the first and second ear with the first and second aligned devices, respectively Systems and methods for treating a patient having a head with a first ear and a second ear function by mounting a support system to the head of the patient so that the support system is aligned with a target tissue of the first ear, applying a therapeutic agent to the first ear by energizing an iontophoresis electrode supported by the support system, and actuating a device while the device is supported by the support system.

9. 发明申请

WO2008045242A3 IMPLANTABLE DEVICES AND METHODS FOR TREATING SINUSITIS AND OTHER DISORDERS 审中-公开
公开(公告)号：WO2008045242A3
公开(公告)日：2008-04-17
申请号：PCT/US2007/021170
申请日：2007-10-01
申请人： ACCLARENT, INC. , MUNI, Ketan, P. , HA, Hung, V. , MORRISS, John, H. , BOLGER, William, E. , FACTEAU, William, M. , MAKOWER, Joshua , CHANG, John, Y. , CHAN, Randy, S. , VAN, Nga, K. , CLIFFORD, Anton, G.
发明人： MUNI, Ketan, P. , HA, Hung, V. , MORRISS, John, H. , BOLGER, William, E. , FACTEAU, William, M. , MAKOWER, Joshua , CHANG, John, Y. , CHAN, Randy, S. , VAN, Nga, K. , CLIFFORD, Anton, G.
IPC分类号： A61K9/22
摘要： Devices, systems and methods for stenting, spacing, draining, ventilating and/or delivering drugs and other therapeutic or diagnostic substances to desired locations within the bodies of human or non-human animal subjects, including methods and systems for treating paranasal sinusitis and ethmoid disease.

10. 发明申请

WO2008045242A2 IMPLANTABLE DEVICES AND METHODS FOR TREATING SINUSITIS AND OTHER DISORDERS 审中-公开
标题翻译：可治疗的装置和治疗神经病和其他疾病的方法
公开(公告)号：WO2008045242A2
公开(公告)日：2008-04-17
申请号：PCT/US2007021170
申请日：2007-10-01
申请人： ACCLARENT INC , MUNI KETAN P , HA HUNG V , MORRISS JOHN H , BOLGER WILLIAM E , FACTEAU WILLIAM M , MAKOWER JOSHUA , CHANG JOHN Y , CHAN RANDY S , VAN NGA K , CLIFFORD ANTON G
发明人： MUNI KETAN P , HA HUNG V , MORRISS JOHN H , BOLGER WILLIAM E , FACTEAU WILLIAM M , MAKOWER JOSHUA , CHANG JOHN Y , CHAN RANDY S , VAN NGA K , CLIFFORD ANTON G
IPC分类号： A61M31/00
CPC分类号： A61M29/02 , A61B17/1204 , A61B17/12104 , A61B17/12136 , A61B17/24 , A61B17/3417 , A61B17/3421 , A61B17/3478 , A61F11/004 , A61M25/0075 , A61M25/0084 , A61M25/04 , A61M25/10 , A61M2025/105 , A61M2025/1052 , A61M2025/1086 , A61M2210/0618
摘要： Devices, systems and methods for stenting, spacing, draining, ventilating and/or delivering drugs and other therapeutic or diagnostic substances to desired locations within the bodies of human or non-human animal subjects, including methods and systems for treating paranasal sinusitis and ethmoid disease.
摘要翻译：用于支架，间隔，排水，通气和/或递送药物和其他治疗或诊断物质到人或非人类动物受试者体内所需位置的装置，系统和方法，包括用于治疗鼻旁窦炎和筛窦疾病的方法和系统。

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