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1. 发明申请

WO2009055830A1 READY TO FEED CONTAINER WITH DRINKING DISPENSER AND SEALING MEMBER, AND RELATED METHOD 审中-公开
标题翻译：准备饮用饮料分配器和密封件的进料容器及相关方法
公开(公告)号：WO2009055830A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/081393
申请日：2008-10-27
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , ARKINS, Thomas, Daniel , CHAN, Julian , TULLEY, Bryan , WILLEY, Jeffrey
发明人： PY, Daniel , ARKINS, Thomas, Daniel , CHAN, Julian , TULLEY, Bryan , WILLEY, Jeffrey
IPC分类号： A61J11/00
CPC分类号： B65D47/36 , A61J1/202 , A61J9/00 , A61J9/008 , A61J11/04 , B65B3/04 , B65D47/063 , B65D47/265 , B65D47/32 , B65D51/002
摘要： A container including a body defining an outflow opening and at least one chamber adapted for storing a product, such as a fat containing liquid product, and a container closure including a primary seal for hermetically sealing the product within the chamber during storage. The container closure includes a sealing member forming a substantially fluid-tight seal between the container closure and the body, and a dispensing member in fluid communication with the chamber. The container closure and body move relative to each other between a first position where the primary seal is seated about the outflow port to hermetically seal the product in the chamber during storage, and a second position where the primary seal is displaced from the outflow port to allow product to pass from the chamber through the outflow port and into dispensing member to dispense the product.
摘要翻译：一种容器，其包括限定流出开口的主体和适于储存产品（例如含脂肪的液体产品）的至少一个室，以及容器盖，该容器封闭件包括用于在储存期间气密地密封室内的产品的主密封件。容器封闭件包括在容器封闭件和主体之间形成基本上流体密封的密封件和与腔室流体连通的分配构件的密封构件。容器封闭件和主体在第一位置和第二位置之间移动，第一位置和第二位置之间，第一位置处主要密封件围绕流出端口安置，以便在存储期间将产品气密地密封在腔室中;以及第二位置，其中主密封件从流出端口移位到允许产品从腔室通过流出口并进入分配构件以分配产品。

2. 发明申请

WO2006063360A3 CONTAINER AND VALVE ASSEMBLY FOR STORING AND DISPENSING SUBSTANCES, AND RELATED METHOD 审中-公开
标题翻译：用于储存和分配物质的集装箱和阀组件及相关方法
公开(公告)号：WO2006063360A3
公开(公告)日：2007-04-19
申请号：PCT/US2005045110
申请日：2005-12-12
申请人： MEDICAL INSTILL TECH INC , PY DANIEL C , CHAN JULIAN V
发明人： PY DANIEL , CHAN JULIAN V
IPC分类号： B65D5/72
CPC分类号： B65D35/46 , B65D47/205 , B65D47/2056 , B65D47/2081
摘要： A container and valve assembly for storing and dispensing substances including edible substances. The container is a tubular body that defines a storage chamber for storing the substance and a head portion for supports the valve assembly. The valve assembly includes a valve body and a valve seat surrounded by a flexible outer cover that includes a valve portion. A seem between the valve portion and valve seat form a one-way release valve wherein a portion of the seam remains closed when the substance is dispensed. To dispense the substance, pressure is applied to the body forcing the substance into the valve assembly, which in turn, controls the flow and release of the substance without exposing the remaining substance to the external atmosphere; thus, the sterility of the storage chamber and remaining substance is maintained, and the shelf life of the substance is increased.
摘要翻译：用于储存和分配包括可食用物质的物质的容器和阀组件。容器是限定用于储存物质的储存室和用于支撑阀组件的头部的管状体。阀组件包括阀体和由包括阀部分的柔性外盖包围的阀座。在阀部分和阀座之间似乎形成单向释放阀，其中当物质被分配时，接缝的一部分保持关闭。为了分配物质，将压力施加到身体上，迫使物质进入阀组件，这进而控制物质的流动和释放，而不将剩余物质暴露于外部大气中; 因此，保持储存室和剩余物质的无菌性，物质的保存期限增加。

3. 发明申请

WO2006063000A2 ONE-WAY VALVE, APPARATUS AND METHOD OF USING THE VALVE 审中-公开
标题翻译：单向阀，使用该阀的装置和方法
公开(公告)号：WO2006063000A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/044167
申请日：2005-12-05
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , CHAN, Julian, V. , ADAMO, Benoit
发明人： PY, Daniel , CHAN, Julian, V. , ADAMO, Benoit
IPC分类号： G06Q10/00
CPC分类号： B67D1/0004 , B65B39/004 , B67D1/0007 , B67D1/0009 , B67D1/0082 , B67D1/10 , B67D1/108 , B67D1/1279 , B67D3/04 , B67D2001/0827 , F04B43/1238 , F04B53/1037 , Y10T137/7761
摘要： An apparatus has a valve body defining a first passageway, a valve seat, and a flow aperture extending through the valve body and coupled in fluid communication with the first passageway. A valve cover of the apparatus is formed of an elastic material and includes a cover base mounted on the valve body and fixedly secured against movement relative thereto, and a valve portion overlying the valve seat. The valve portion defines a predetermined radial thickness and forms an interference fit with the valve seat. The valve portion and the valve seat define a normally closed, axially-extending valve opening therebetween. The valve portion is movable between a normally closed position with the valve portion engaging the valve seat, and an open position with at least a segment of the valve portion spaced away from the valve seat to connect the valve opening in fluid communication with the flow aperture to thereby allow the passage of fluid from the flow aperture through the valve opening. A hermetically sealed variable-volume storage chamber stores therein multiple portions of the fluid and is connectible in fluid communication with the one-way valve assembly. A pump is coupled between the variable-volume storage chamber and the one-way valve assembly, and is configured to pump discrete portions of fluid from the variablevolume storage chamber, through the flow aperture, and through the valve opening to dispense the portions of fluid through the valve assembly.
摘要翻译：装置具有限定第一通道，阀座和延伸穿过阀体并与第一通道流体连通地联接的流动孔的阀体。该设备的阀盖由弹性材料形成，并且包括安装在阀体上并且固定地防止相对于其移动的盖基座以及覆盖阀座的阀门部分。阀部分限定预定的径向厚度并与阀座形成过盈配合。阀部分和阀座在它们之间限定了常闭的轴向延伸的阀开口。阀部分可在阀部分与阀座接合的常闭位置和打开位置之间移动，其中阀部分的至少一段与阀座隔开以将阀开口与流动孔口流体连通地连接从而允许流体从流动孔通过阀开口。密封的可变容积存储腔室在其中存储流体的多个部分并且可与单向阀组件流体连通地连接。泵联接在可变容积存储腔室和单向阀组件之间，并且被配置为从可变容积存储腔室抽出离散的部分流体，穿过流动孔并且通过阀门开口以分配部分流体通过阀门组件。

4. 发明申请

WO2005058743A3 CONTAINER AND ONE-WAY VALVE ASSEMBLY FOR STORING AND DISPENSING SUBSTANCES, AND RELATED METHOD 审中-公开
标题翻译：用于储存和分配物质的集装箱和单向阀组件及相关方法
公开(公告)号：WO2005058743A3
公开(公告)日：2006-04-20
申请号：PCT/US2004041369
申请日：2004-12-10
申请人： MEDICAL INSTILL TECH INC , PY DANIEL C , CHAN JULIAN V , RODRIGUEZ GIOVANNI
发明人： PY DANIEL , CHAN JULIAN V , RODRIGUEZ GIOVANNI
IPC分类号： B65D47/20 , B65D51/22 , B67D7/74 , B67D99/00 , B67D5/00
CPC分类号： B65D51/226 , B65D47/2075
摘要： A device for storing and dispensing a substance includes a container having a body defining therein a storage chamber for receiving and storing the substance. The container includes a head located at one end of the body and a first passageway that is in fluid communication with the storage chamber of the body and defines a flow path therebetween. The container also includes a pierceable wall located on an opposite side of the passageway relative to the storage chamber, and a first connecting portion for connecting another component thereto. The device also includes a one-way valve assembly that includes a valve body including a body base defining a second passageway and at least one piercing portion engageable with the pierceable wall of the container. The valve assembly includes a second connecting portion that is connectable to the first connecting portion of the container for fixedly securing the valve assembly to the container.
摘要翻译：用于存储和分配物质的装置包括具有在其中限定有用于接收和存储物质的储存室的主体的容器。容器包括位于主体一端的头部和与主体的储存室流体连通并限定其间的流路的第一通道。容器还包括位于通道相对于储存室的相对侧上的可穿透壁，以及用于将另一部件连接到其上的第一连接部分。该装置还包括单向阀组件，该单向阀组件包括阀体，该阀体包括限定第二通道的主体基座和与容器的可刺穿壁可接合的至少一个穿孔部分。阀组件包括可连接到容器的第一连接部分的第二连接部分，用于将阀组件固定地固定到容器。

5. 发明申请

WO2006039721A2 BISPHOSPHONATE COMPOUNDS AND METHODS FOR BONE RESORPTION DISEASES, CANCER, BONE PAIN, IMMUNE DISORDERS, AND INFECTIOUS DISEASES 审中-公开
标题翻译：双膦酸盐化合物和骨质疏松症，癌症，骨骼疼痛，免疫缺陷病毒和感染性疾病的方法
公开(公告)号：WO2006039721A2
公开(公告)日：2006-04-13
申请号：PCT/US2005/036425
申请日：2005-10-07
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , SANDERS, John M. , SONG, Yongcheng , CHAN, Julian M. W. , OLDFIELD, Eric , ZHANG, Yonghui
发明人： SANDERS, John M. , SONG, Yongcheng , CHAN, Julian M. W. , OLDFIELD, Eric , ZHANG, Yonghui
IPC分类号： H05B33/04 , H05B33/00
CPC分类号： C07F9/3873 , C07F9/581 , C07F9/582 , C07F9/60 , C07F9/62 , C07F9/65061 , C07F9/65583
摘要： Bishosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.
摘要翻译：公开了二膦酸盐化合物及其制备和应用的相关方法，包括吡啶鎓-1-基，喹啉鎓-1-基和相关化合物。在功能测定的上下文中公开了化合物的活性，例如

6. 发明申请

WO2005023270A2 COMPOSITIONS AND METHODS FOR USE OF ANTIVIRAL DRUGS IN THE TREATMENT OF RETROVIRAL DISEASES RESISTANT TO NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS 审中-公开
标题翻译：组合物和方法用于治疗抗核素逆转录酶抑制剂的抗逆转录病毒药物
公开(公告)号：WO2005023270A2
公开(公告)日：2005-03-17
申请号：PCT/US2004/029375
申请日：2004-09-09
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , UNIVERSITY OF ILLINOIS , PARNIAK, Michael , MELLORS, John, W. , OLDFIELD, Eric , TOVIAN, Zev , CHAN, Julian, Mun, Weng
发明人： PARNIAK, Michael , MELLORS, John, W. , OLDFIELD, Eric , TOVIAN, Zev , CHAN, Julian, Mun, Weng
IPC分类号： A61K31/663
CPC分类号： A61K31/663 , A61K31/66 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： The present invention relates to novel compositions comprising an excisioninhibiting bisphosphonate and a nucleoside reverse transcriptase inhibitor. The present invention also relates to methods for preventing or treating retrovirus-related diseases using a composition comprising a bisphosphonate and a nucleoside reverse transcriptase inhibitor. In a specific embodiment, the invention provides methods for preventing or treating AIDS by administering a bisphosphonate-based compound in combination with 3'-azido-3'-deoxythymidine (AZT) to patients infected with AZTresistant HIV to improve the effectiveness of AZT therapy.
摘要翻译：本发明涉及包含切除抑制双膦酸盐和核苷逆转录酶抑制剂的新型组合物。本发明还涉及使用包含双膦酸盐和核苷逆转录酶抑制剂的组合物预防或治疗逆转录病毒相关疾病的方法。在一个具体实施方案中，本发明提供了通过将双膦酸盐类化合物与3'-叠氮基-3'-脱氧胸苷（AZT）组合施用于感染耐AZ抗药性HIV的患者来提高AZT疗法的有效性来预防或治疗AIDS的方法。

7. 发明申请

WO2004101027A2 DISPENSER AND APPARATUS AND METHOD FOR FILLING A DISPENSER 审中-公开
标题翻译：分配器和装置以及填充分配器的方法
公开(公告)号：WO2004101027A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/014823
申请日：2004-05-12
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , CHAN, Julian, V.
发明人： PY, Daniel , CHAN, Julian, V.
IPC分类号： A61M
CPC分类号： B65D83/62 , A61J1/00 , A61J1/1443 , B65B3/30 , B65B31/044 , B65D83/425
摘要： A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.
摘要翻译：用于保持多个剂量的流体或其它物质并用于分配物质的分配器具有小瓶，容纳在小瓶内的柔性囊，以及形成在膀胱和小瓶之间的可变体积存储室。填充阀与储存室流体连通地联接并且限定（1）将储存室与环境大气密封的常闭密封的流体密封位置，和（2）允许流体通过阀门的打开位置两者都抽真空储存室并引入流体通过阀门填充储存室。泵与储存室流体连通地联接，用于将流体泵出储存室。分配阀与泵流体连通地联接并限定（1）常闭的，流体密封的位置，防止流体从分配器通过，以及（2）用于分配泵送的流体通过的打开位置。密封的空分配器被灭菌，例如通过对其施加γ射线。然后，通过使填充阀与排气/分配构件接合以消除储存室，并且通过将来自填充构件的流体通过打开的填充阀引入并进入储存室，灭菌的密封的空分配器充满流体。填充构件从阀中取出，并且弹簧将阀移动到关闭位置以将分配器内的流体气密地密封。

8. 发明申请

WO2003041763A2 INTRADERMAL DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：内部递送装置和方法
公开(公告)号：WO2003041763A2
公开(公告)日：2003-05-22
申请号：PCT/US2002/036617
申请日：2002-11-14
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , CHAN, Julian, V.
发明人： PY, Daniel , CHAN, Julian, V.
IPC分类号： A61M
CPC分类号： A61M5/425 , A61M5/24 , A61M5/3158 , A61M5/31591 , A61M5/3287 , A61M5/46
摘要： The subject intradermal delivery device provides for penetration to a fixed depth without requiring special expertise by the user. The device consists of a syringe nested inside an inner shell and an outer shell. An elongated annular channel is formed between the inner shell and the outer shell. A housing receives the syringe and concentric shells in a sliding engagement. A first seal on the distal end of the housing forms a variable length channel in communication with the elongated annular channel via a port formed in the outer shell. When the device is applied to the skin, the housing and syringe are slid towards the skin, and the variable length channel generates a vacuum which forces the skin to bulge into the elongated annular channel. As a result, the skin is tensioned across the inner shell to form a substantially planar, taut target area of skin. The taut target area of skin in combination with a stop on the housing determines the insertion depth of the syringe.
摘要翻译：受试者皮内递送装置提供穿透至固定深度，而不需要用户的专门知识。该装置由嵌套在内壳和外壳内的注射器组成。在内壳和外壳之间形成细长的环形通道。壳体以滑动接合的方式接收注射器和同心壳体。在壳体的远端上的第一密封件通过形成在外壳中的端口形成与细长环形通道连通的可变长度通道。当将该装置应用于皮肤时，壳体和注射器朝向皮肤滑动，并且可变长度通道产生迫使皮肤凸起进入细长环形通道的真空。结果，皮肤被横跨内壳张紧，以形成基本上平坦的，拉紧的皮肤目标区域。与壳体上的止动件组合的皮肤的拉紧目标区域决定了注射器的插入深度。

9. 发明申请

WO2011137413A1 READY TO FEED CONTAINER AND METHOD 审中-公开
标题翻译：准备进料容器和方法
公开(公告)号：WO2011137413A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/034703
申请日：2011-04-30
申请人： MEDICAL INSTILL TECHNOLOGIES, INC. , PY, Daniel , CHAN, Julian , WILLEY, Jeffrey
发明人： PY, Daniel , CHAN, Julian , WILLEY, Jeffrey
IPC分类号： A61J9/00
CPC分类号： A61J9/00 , A61J1/2093
摘要： A container including a body defining an outflow opening and at least one chamber adapted for storing a product, such as a fat containing liquid product, and a container closure including a primary seal for hermetically sealing the product within the chamber during storage. The container closure includes a sealing member forming a substantially fluid-tight seal between the container closure and the body, and a dispensing member in fluid communication with the chamber. The container closure and body move relative to each other between a first position where the primary seal is seated about the outflow port to hermetically seal the product in the chamber during storage, and a second position where the primary seal is displaced from the outflow port to allow product to pass from the chamber through the outflow port and into dispensing member to dispense the product.
摘要翻译：一种容器，其包括限定流出开口的主体和适于储存产品（例如含脂肪的液体产品）的至少一个室，以及容器盖，该容器封闭件包括用于在储存期间气密地密封室内的产品的主密封件。容器封闭件包括在容器封闭件和主体之间形成基本上流体密封的密封件和与腔室流体连通的分配构件的密封构件。容器封闭件和主体在第一位置和第二位置之间移动，第一位置和第二位置之间，第一位置处主要密封件围绕流出端口安置，以便在存储期间将产品气密地密封在腔室中;以及第二位置，其中主密封件从流出端口移位到允许产品从腔室通过流出口并进入分配构件以分配产品。

10. 发明申请

WO2006039721A3 BISPHOSPHONATE COMPOUNDS AND METHODS FOR BONE RESORPTION DISEASES, CANCER, BONE PAIN, IMMUNE DISORDERS, AND INFECTIOUS DISEASES 审中-公开
标题翻译：双膦酸盐化合物和骨质疏松症，癌症，骨骼疼痛，免疫缺陷病毒和感染性疾病的方法
公开(公告)号：WO2006039721A3
公开(公告)日：2006-06-29
申请号：PCT/US2005036425
申请日：2005-10-07
申请人： UNIV ILLINOIS , SANDERS JOHN M , SONG YONGCHENG , CHAN JULIAN M W , OLDFIELD ERIC , ZHANG YONGHUI
发明人： SANDERS JOHN M , SONG YONGCHENG , CHAN JULIAN M W , OLDFIELD ERIC , ZHANG YONGHUI
IPC分类号： C07F9/38 , A01N43/40 , A61K31/44 , C07F9/58
CPC分类号： C07F9/3873 , C07F9/581 , C07F9/582 , C07F9/60 , C07F9/62 , C07F9/65061 , C07F9/65583
摘要： Bishosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such as Leishmania major farnesyl diphosphate synthase (FPPS) inhibition, Dictyostelium discoideum growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.
摘要翻译：公开了二膦酸盐化合物及其制备和应用的相关方法，包括吡啶鎓-1-基，喹啉鎓-1-基和相关化合物。化合物的活性在诸如利什曼原虫主要法呢基二磷酸合成酶（FPPS）抑制，盘基网柄菌生长抑制，人γδT细胞活化和骨吸收等功能测定的上下文中公开。公开了二膦酸化合物在寄生虫感染（例如针对锥虫）的情况下的适用性。公开了关于治疗一种或多种病症如骨吸收障碍，癌症，骨痛，感染性疾病和免疫治疗的本发明的其它潜在应用。

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