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1. 发明申请

WO2017003909A3 CHIRAL SEPARATION AND ANALYSIS BY MOLECULAR PROPELLER EFFECT 审中-公开
标题翻译： CHIRAL分离和分子分子螺旋桨效应
公开(公告)号：WO2017003909A3
公开(公告)日：2017-02-16
申请号：PCT/US2016039505
申请日：2016-06-27
申请人： CHACHISVILIS MIRIANAS
发明人： CHACHISVILIS MIRIANAS
IPC分类号： C07B57/00 , C07C231/20
CPC分类号： C07B57/00
摘要： A method and a device for separation and analysis of chiral molecules are described. The method relies on using a fluid shear to induce molecular rotation and the molecular propeller effect to transform rotational motion into translation motion of opposite direction for counterpart enantiomers. The direction of motion of each enantiomers is used to determine its absolute configuration by comparing the direction value with theoretically calculated one. The device uses multiple moving surfaces or pressure induced flows to induce shear flow condition in the solution to separate enantiomers.
摘要翻译：描述了用于手性分子分离和分析的方法和装置。该方法依赖于使用流体剪切来诱导分子旋转和分子螺旋桨效应，以将旋转运动转换成对应对映异构体的相反方向的平移运动。每个对映异构体的运动方向用于通过将方向值与理论计算的方向进行比较来确定其绝对构型。该装置使用多个移动表面或压力诱导流以在溶液中诱导剪切流动条件以分离对映异构体。

2. 发明申请

WO2017003909A2 CHIRAL SEPARATION AND ANALYSIS BY MOLECULAR PROPELLER EFFECT 审中-公开
标题翻译：分子螺旋桨作用下的手性分离与分析
公开(公告)号：WO2017003909A2
公开(公告)日：2017-01-05
申请号：PCT/US2016/039505
申请日：2016-06-27
申请人： CHACHISVILIS, Mirianas
发明人： CHACHISVILIS, Mirianas
IPC分类号： B01D15/26
CPC分类号： C07B57/00
摘要： A method and a device for separation and analysis of chiral molecules are described. The method relies on using a fluid shear to induce molecular rotation and the molecular propeller effect to transform rotational motion into translation motion of opposite direction for counterpart enantiomers. The direction of motion of each enantiomers is used to determine its absolute configuration by comparing the direction value with theoretically calculated one. The device uses multiple moving surfaces or pressure induced flows to induce shear flow condition in the solution to separate enantiomers.
摘要翻译：描述了用于分离和分析手性分子的方法和装置。该方法依赖于使用流体剪切力来引起分子旋转和分子螺旋桨效应，以将旋转运动转化为相反对映体的相反方向的平移运动。每个对映体的运动方向用于通过将方向值与理论计算值进行比较来确定其绝对构型。该装置使用多个移动表面或压力诱导流动来引起溶液中的剪切流动条件以分离对映异构体。

3. 发明申请

WO2012006301A1 RENEWABLE ENERGY EXTRACTION 审中-公开
标题翻译：可再生能源提取
公开(公告)号：WO2012006301A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/042998
申请日：2011-07-06
申请人： DYNAMIC CONNECTIONS, LLC , KIBAR, Osman , CHACHISVILIS, Mirianas
发明人： KIBAR, Osman , CHACHISVILIS, Mirianas
IPC分类号： H02N11/00 , H02N1/00
CPC分类号： F03G7/00
摘要： Among other things, renewable energy is extracted from an asymmetric system (or the ability of the system to have renewable energy extracted from it is enhanced, or both) that is characterized by one or more stochastic variables, which exhibit at least one statistical component that is not Gaussian and/or not white.
摘要翻译：除其他之外，可再生能源从不对称系统（或系统提取的可再生能源的能力得到增强或两者提取），其特征在于一个或多个随机变量，其表现出至少一个统计组件，不是高斯和/或不是白色。

4. 发明申请

WO2011050153A1 MOTION OF A CHIRAL OBJECT 审中-公开
标题翻译：运动对象
公开(公告)号：WO2011050153A1
公开(公告)日：2011-04-28
申请号：PCT/US2010/053525
申请日：2010-10-21
申请人： DYNAMIC CONNECTIONS, LLC , CHACHISVILIS, Mirianas , KIBAR, Osman
发明人： CHACHISVILIS, Mirianas , KIBAR, Osman
IPC分类号： G01N33/00
CPC分类号： B01J19/087
摘要： Directional motion of chiral objects in a mixture is caused by rotation of the chiral objects produced by a field that is applied across, and rotates relative to, a chamber; and a computer-implemented step determines or uses, or determines and uses, in an application or process, a feature of a coupling between the rotational and the translational motion of the chiral objects.
摘要翻译：手性物体在混合物中的定向运动是由通过施加在室上并相对于腔室旋转的场产生的手性物体的旋转引起的; 并且计算机实现的步骤在应用或过程中确定或使用或使用，或确定和使用手性对象的旋转和平移运动之间的耦合的特征。

5. 发明申请

WO2009097240A1 ENHANCING PHORETIC SEPARATION 审中-公开
标题翻译：增强动态分离
公开(公告)号：WO2009097240A1
公开(公告)日：2009-08-06
申请号：PCT/US2009/032002
申请日：2009-01-26
申请人： DYNAMIC CONNECTIONS, LLC , CHACHISVILIS, Mirianas , KIBAR, Osman , TU, Eugene
发明人： CHACHISVILIS, Mirianas , KIBAR, Osman , TU, Eugene
IPC分类号： B01D57/02
CPC分类号： G01N27/44773
摘要： Among other things, a force is applied, at a first location in a medium and at a first time, to cause an object to move in a direction along the medium. At a later, second time, a force is applied at a second location, which is farther along the direction in which the object is moving, to cause the object to move an additional distance in the medium, when the force is no longer being applied at the first location. Both the distance traveled by the object and how long the object is subject to the force depend on a property of the object. At least one of the times and locations of applying the force is selected based on the property of the object.
摘要翻译：尤其是在介质中的第一位置和第一时间施加力以使物体沿着介质的方向移动。在稍后的第二时间，在不再施加力的第二位置施加力，该第二位置沿着物体移动的方向进一步移动，以使物体在介质中移动另外的距离在第一个位置。物体行进的距离和物体受力的时间取决于物体的属性。基于对象的属性选择施加力的次数和位置中的至少一个。

6. 发明申请

WO2009155406A1 SEPARATION AND MANIPULATION OF A CHIRAL OBJECT 审中-公开
标题翻译：一个对象的分离和操作
公开(公告)号：WO2009155406A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/047778
申请日：2009-06-18
申请人： DYNAMIC CONNECTIONS, LLC , KIBAR, Osman , CHACHISVILIS, Mirianas , TU, Eugene , MARSILJE, Thomas, H.
发明人： KIBAR, Osman , CHACHISVILIS, Mirianas , TU, Eugene , MARSILJE, Thomas, H.
IPC分类号： G01N33/00 , B01J19/00
CPC分类号： C07C303/44 , B03C1/24 , B03C7/026 , C07B57/00 , C07C201/16 , Y10T436/143333 , Y10T436/25375
摘要： Among other things, for use in directional motion of chiral objects in a mixture, a field is applied across the chamber and is rotating relative to the chamber to cause rotation of the chiral objects. The rotation of the objects causes them to move directionally based on their chirality. The method applies to sugars, proteins, and peptides, among other things, and can be used in a wide variety of applications.
摘要翻译：除其他之外，为了用于手性物体在混合物中的定向运动，场被施加在腔室上并且相对于腔室旋转以引起手性物体的旋转。物体的旋转导致它们基于手性方向移动。该方法适用于糖，蛋白质和肽等，并可用于各种应用。

7. 发明申请

WO2009117573A1 MOVING A SMALL OBJECT IN A DIRECTION 审中-公开
标题翻译：以方向移动一个小对象
公开(公告)号：WO2009117573A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/037661
申请日：2009-03-19
申请人： DYNAMIC CONNECTIONS, LLC , KIBAR, Osman , CHACHISVILIS, Mirianas , TU, Eugene , SENYEI, Andrew
发明人： KIBAR, Osman , CHACHISVILIS, Mirianas , TU, Eugene , SENYEI, Andrew
IPC分类号： C12N13/00
CPC分类号： C12N13/00 , Y10T436/143333
摘要： For directional motion of a small object, a combination of at least two different properties is imparted to the object. At least one of the properties being responsive to an external influence to produce a force or torque acting on the object. At least another of the properties is responsive to the force or torque to cause a directional motion of the object.
摘要翻译：对于小物体的定向运动，赋予物体至少两种不同性质的组合。至少一个属性响应于外部影响以产生作用在物体上的力或扭矩。至少另一个属性响应于力或扭矩以引起物体的定向运动。

8. 发明申请

WO2008130980A3 SEPARATION AND MANIPULATION OF A CHIRAL OBJECT 审中-公开
标题翻译：手套对象的分离和操作
公开(公告)号：WO2008130980A3
公开(公告)日：2008-12-31
申请号：PCT/US2008060444
申请日：2008-04-16
申请人： DYNAMIC CONNECTIONS LLC , KIBAR OSMAN , CHACHISVILIS MIRIANAS , TU EUGENE , MARSILJE THOMAS H
发明人： KIBAR OSMAN , CHACHISVILIS MIRIANAS , TU EUGENE , MARSILJE THOMAS H
IPC分类号： B01F13/08
CPC分类号： B03C1/24 , B03C7/026 , C07B57/00
摘要： Among other things, to cause directional motion of chiral objects in a mixture in a chamber, a field is rotated relative to a chamber to cause rotation of the chiral objects. The rotation of the objects causes them to move directionally based on their chirality.
摘要翻译：其中，为了引起手术室内混合物中手性物体的定向运动，场相对于室旋转以引起手征物体的旋转。物体的旋转使它们根据其手性方向进行定向移动。

9. 发明申请

WO2004033059A3 METHODS AND APPARATUS FOR OPTOPHORETIC DIAGNOSIS OF CELLS AND PARTICLES 审中-公开
标题翻译：细胞和颗粒的OPTOPHORETIC诊断的方法和装置
公开(公告)号：WO2004033059A3
公开(公告)日：2006-01-26
申请号：PCT/US0330975
申请日：2003-09-30
申请人： GENOPTIX INC , ZHANG HAICHUAN , CHUNG THOMAS D Y , HALL JEFF , SOOHOO WILLIAM , KOHRUMEL JOSH , TU EUGENE , WANG MARK , RAYMOND DANIEL EDWARD , MARCHAND PHILIPPE , DIVER JONATHAN , BUTLER WILLIAM F , NGUYEN PHAN , CHACHISVILIS MIRIANAS , KATZ ANDREW , HAGEN NORBERT , LYKSTAD KRIS , PESTANA LUIS
发明人： ZHANG HAICHUAN , CHUNG THOMAS D Y , HALL JEFF , SOOHOO WILLIAM , KOHRUMEL JOSH , TU EUGENE , WANG MARK , RAYMOND DANIEL EDWARD , MARCHAND PHILIPPE , DIVER JONATHAN , BUTLER WILLIAM F , NGUYEN PHAN , CHACHISVILIS MIRIANAS , KATZ ANDREW , HAGEN NORBERT , LYKSTAD KRIS , PESTANA LUIS
IPC分类号： G01N33/48 , G01N33/569 , G21K1/00 , C12Q1/00 , C12M1/00 , G01F23/00 , G01N33/558
CPC分类号： G01N33/56966 , G01N15/147 , G01N15/1484 , G01N2015/1006 , G01N2015/1075 , G01N2015/145
摘要： A device for characterizing a cell or particle includes a channel having an inlet and an outlet, the channel containing a moving fluid therein for carrying the cell or particle from the inlet to the outlet. The device includes detectors for monitorng the position of the cell or particle along the channel. The device further comprises a light source to provide an optical gradient and a control system to receive and process signals from the detector.The device can be used to characterize and sort cells based on a biological property.
摘要翻译：用于表征细胞或颗粒的装置包括具有入口和出口的通道，所述通道在其中包含运动流体，用于将细胞或颗粒从入口运送到出口。该装置包括用于监测细胞或颗粒沿着通道的位置的检测器。该装置还包括提供光学梯度的光源和用于接收和处理来自检测器的信号的控制系统。该装置可用于基于生物特性来表征和分类细胞。

10. 发明申请

WO2011091094A1 ENZYMATIC OR ORGANIC CATALYTIC CHEMICAL REACTIONS 审中-公开
标题翻译：酶或有机催化化学反应
公开(公告)号：WO2011091094A1
公开(公告)日：2011-07-28
申请号：PCT/US2011/021792
申请日：2011-01-20
申请人： DYNAMIC CONNECTIONS, LLC , KIBAR, Osman , CHACHISVILIS, Mirianas , TU, Eugene
发明人： KIBAR, Osman , CHACHISVILIS, Mirianas , TU, Eugene
IPC分类号： G06F7/60
CPC分类号： B01J19/087 , B01J2219/0892
摘要： In an aspect, a perturbation is applied to a system comprising an enzymatic chemical reaction and/or an organic catalytic chemical reaction with the perturbation being non-directional (average of the force applied by the perturbation being zero) with respect to a variable of the system. A directional effect is caused with respect to the said enzymatic or organic catalytic chemical reaction as a result of the perturbation and an asymmetry of the perturbed system. The present invention also embodies an apparatus comprising a site for an enzymatic or organic catalytic chemical reaction and a device controlled to perturb a system that includes the enzymatic or organic catalytic chemical reaction, the average of the force applied by the perturbation being zero, a directional effect being caused with respect to the chemical reaction as a result of the perturbation and an asymmetry of the perturbed system.
摘要翻译：在一个方面，扰动被应用于包括酶化学反应和/或有机催化化学反应的系统，其中扰动是无方向性的（由扰动施加的力的平均值为零）相对于系统。由于扰动和扰动系统的不对称性，相对于所述酶促或有机催化化学反应引起定向效应。本发明还体现了一种装置，其包括用于酶促或有机催化化学反应的位点和被控制以扰乱包括酶促或有机催化化学反应的系统的装置，由扰动施加的力的平均值为零，定向由于扰动和扰动系统的不对称性，对化学反应产生的影响。

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