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1. 发明申请

WO2021229104A1 ANTI-CD38 SINGLE-DOMAIN ANTIBODIES IN DISEASE MONITORING AND TREATMENT 审中-公开
公开(公告)号：WO2021229104A1
公开(公告)日：2021-11-18
申请号：PCT/EP2021/063021
申请日：2021-05-17
申请人： UNIVERSITÉ DE LIÈGE , CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE , VRIJE UNIVERSITEIT BRUSSEL
发明人： CAERS, Jo , DURAY, Elodie , DUMOULIN, Mireille , D’HUYVETTER, Matthias
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28
摘要： The present invention relates to medical imaging, disease monitoring and theranostic approaches in neoplastic diseases of certain anti-CD38 single-domain antibodies (sdAb).

2. 发明申请

WO2012168484A1 TARGETS AND AGENTS FOR THE TREATMENT OF IMPAIRED BONE FRACTURE HEALING 审中-公开
标题翻译：治疗有骨折骨折治疗的目标和药剂
公开(公告)号：WO2012168484A1
公开(公告)日：2012-12-13
申请号：PCT/EP2012/061036
申请日：2012-06-11
申请人： UNIVERSITÉ LIBRE DE BRUXELLES , BONE THERAPEUTICS SA , UNIVERSITÉ DE LIÈGE , CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE , GANGJI, Valérie , HAUZEUR, Jean-Philippe , DE SENY, Dominique , MATHIEU, Myrielle , INGELS, Aude , RIGUTTO, Sabrina , SPRUYT, Delphine , BASTIANELLI, Enrico , ALBARANI, Valentina , PESESSE, Xavier , MAILAISE, Michel
发明人： GANGJI, Valérie , HAUZEUR, Jean-Philippe , DE SENY, Dominique , MATHIEU, Myrielle , INGELS, Aude , RIGUTTO, Sabrina , SPRUYT, Delphine , BASTIANELLI, Enrico , ALBARANI, Valentina , PESESSE, Xavier , MAILAISE, Michel
IPC分类号： G01N33/68 , A61K38/19
CPC分类号： C07K14/5421 , A61K38/2053 , G01N33/6863 , G01N33/6869 , G01N2333/522 , G01N2333/5412 , G01N2333/5421
摘要： The application teaches a composition comprising one or more pharmaceutical active ingredients selected from the group consisting of interleukin-8 (IL-8 or CXCL8), a functional fragment of IL-8, a functional variant of IL-8, andan agonist of IL-8 receptor,for therapeutic and/orprophylactic interventions in impaired bone fracture healing, such as but not limited to non-union fractures, mal-union fractures,or delayed union fractures.
摘要翻译：本申请教导了包含一种或多种选自白细胞介素-8（IL-8或CXCL8），IL-8的功能片段，IL-8的功能性变体和IL-8的激动剂的药物活性成分的组合物， 8受体，用于骨折愈合受损的治疗和/或预防性干预，例如但不限于非联合骨折，非联合骨折或延迟联合骨折。

3. 发明申请

WO2021009317A1 EXTRACELLULAR VESICLES CONTAINING MIR-142-3P TO TREAT FIBROSING DISEASES 审中-公开
公开(公告)号：WO2021009317A1
公开(公告)日：2021-01-21
申请号：PCT/EP2020/070215
申请日：2020-07-16
申请人： UNIVERSITÉ DE LIÈGE , CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE
发明人： GUIOT, Julien , STRUMAN, Ingrid , NJOCK, Makon-Sébastien
IPC分类号： C12Q1/6883
摘要： The present invention relates to pharmaceutical formulations comprising extracellular vesicles wherein the content of the vesicles comprises microRNA miR-142-3p, methods for producing the pharmaceutical formulations, and uses of the formulations to treat fibro-inflammatory diseases in a subject.

4. 发明申请

WO2012168482A1 MARKERS FOR IMPAIRED BONE FRACTURE HEALING 审中-公开
标题翻译：骨折骨折治疗标记
公开(公告)号：WO2012168482A1
公开(公告)日：2012-12-13
申请号：PCT/EP2012/061034
申请日：2012-06-11
申请人： UNIVERSITÉ LIBRE DE BRUXELLES , BONE THERAPEUTICS SA , UNIVERSITÉ DE LIÈGE , CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE , GANGJI, Valérie , HAUZEUR, Jean-Philippe , DE SENY, Dominique , MATHIEU, Myrielle , INGELS, Aude , RIGUTTO, Sabrina , SPRUYT, Delphine , BASTIANELLI, Enrico , ALBARANI, Valentina , PESESSE, Xavier , MALAISE, Michel
发明人： GANGJI, Valérie , HAUZEUR, Jean-Philippe , DE SENY, Dominique , MATHIEU, Myrielle , INGELS, Aude , RIGUTTO, Sabrina , SPRUYT, Delphine , BASTIANELLI, Enrico , ALBARANI, Valentina , PESESSE, Xavier , MALAISE, Michel
IPC分类号： G01N33/50
CPC分类号： C12Q1/6881 , G01N33/6869 , G01N33/6887 , G01N2333/5421 , G01N2800/10 , G01N2800/52
摘要： The present application discloses particularly interleukin-8 (IL-8)as a novel biomarker for the prediction, diagnosis, prognosis and/or monitoring of impaired bone fracture healing; and related methods, uses and kits.
摘要翻译：本申请特别公开了白细胞介素-8（IL-8）作为骨折愈合受损的预测，诊断，预后和/或监测的新型生物标志物; 及相关方法，用途和试剂盒。

5. 发明申请

WO2022180235A1 NEW ANTIMICROBIAL AND ANTITHROMBOGENIC MEDICAL DEVICE 审中-公开
公开(公告)号：WO2022180235A1
公开(公告)日：2022-09-01
申请号：PCT/EP2022/054854
申请日：2022-02-25
申请人： UNIVERSITÉ DE LIÈGE , CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE
发明人： LANCELLOTTI, Patrizio , OURY, Cécile , JEROME, Christine , DETREMBLEUR, Christophe , AQIL, Abdelhafid , MELO, Sofia , PIERRARD, Anna
IPC分类号： C08G71/04 , C08G18/75 , C08G18/48 , C08G18/24 , C09D175/04
摘要： A medical device comprising one or more polyhydroxyurethane (PHU) and a method of manufacturing thereof.Use of the medical device to load and release or graft bioactive molecules, particularly antimicrobial,anti-thrombotic and anticalcification molecules

6. 发明申请

WO2016077620A1 TREATMENT OF HORMONAL DISORDERS OF GROWTH 审中-公开
标题翻译：治疗生长异常的疾病
公开(公告)号：WO2016077620A1
公开(公告)日：2016-05-19
申请号：PCT/US2015/060442
申请日：2015-11-12
申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , UNIVERSITÉ DE LIÈGE , CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE
发明人： BECKERS, Albert , DALY, Adrian Francis , FAUCZ, Fabio Rueda , STRATAKIS, Constantine A. , TRIVELLIN, Giampaolo
IPC分类号： C07K14/705 , A61P5/06
CPC分类号： A61K38/31 , A61K31/352 , A61K31/437 , A61K31/473 , A61K31/48 , A61K31/713 , A61K38/12 , A61K38/1709 , A61K38/27 , A61K47/60 , C07K14/705 , C07K16/28 , C12N15/1138 , C12N2310/11 , C12N2310/14
摘要： The present invention refers to a GPR101 inhibitor, antagonist or inverse agonist or inverse agonist for use in preventive and/or therapeutic treatment of diseases selected from the group consisting of acromegaly and gigantism and to methods for preventive and/or therapeutic treatment of diseases selected from the group consisting of acromegaly and gigantism wherein to a subject GPR101 inhibitor, antagonist or inverse agonist is administered. Further, the present invention provides a GPR101 agonist for use in preventive and/or therapeutic treatment of disorders selected from the group consisting of dwarfism, short stature, hypopituitarism and a disease of low levels of pituitary hormone secretion and to methods for preventive and/or therapeutic treatment of diseases selected from the group consisting of dwarfism, short stature, hypopituitarism and a disease of low levels of pituitary hormone secretion wherein to a subject GPR101 agonist is administered. The present invention also provides GHRH inhibitors, antagonists or inverse agonists and GH antagonists for use in the therapeutic treatment of X-linked acrogigantism (X-LAG syndrome). In addition, the present invention refers to a method of increasing body mass and/or body size of lifestock comprising administering to livestock an effective amount of GPR101 agonist. Further, the present invention is directed to a non-human transgenic animal, comprising as expressed transgene a gene encoding GPR101 or overexpressing endogenous GPR101 gen.
摘要翻译：本发明涉及一种GPR101抑制剂，拮抗剂或反向激动剂或反向激动剂，其用于预防和/或治疗治疗选自由肢端肥大症和巨人症组成的群体的疾病，以及预防和/或治疗治疗疾病的方法，所述疾病选自其中给予受试者GPR101抑制剂，拮抗剂或反向激动剂的肢端肥大症和巨人症组成的组。此外，本发明提供了用于预防和/或治疗治疗选自侏儒症，身材矮小，垂体下垂症和低垂体激素分泌水平的疾病的GPR101激动剂，以及用于预防和/ 选自侏儒症，身材矮小，垂体功能减退和低垂体激素分泌水平的疾病的治疗性治疗，其中给予受试者GPR101激动剂。本发明还提供了用于治疗X连锁急性发作（X-LAG综合征）的GHRH抑制剂，拮抗剂或反向激动剂和GH拮抗剂。此外，本发明涉及一种增加寿命的体重和/或体型的方法，其包括向家畜施用有效量的GPR101激动剂。此外，本发明涉及非人转基因动物，其包含编码GPR101的基因或过表达内源性GPR101基因的转录基因。

7. 发明申请

WO2018224605A1 PORTABLE URINATION WEIGHT MEASUREMENT DEVICE 审中-公开
公开(公告)号：WO2018224605A1
公开(公告)日：2018-12-13
申请号：PCT/EP2018/065065
申请日：2018-06-07
申请人： CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE , WSL
发明人： JOURET, François , BIHR, Damien , NICLAES, Christophe
IPC分类号： A61B5/20 , G01G23/00 , G01G17/04 , G01G21/22 , G01G3/14 , G01G19/56 , A61B10/00
摘要： A portable urination weight measurement device comprising: - a holding unit for releasably holding a container, and - a handle comprising a weight measurement unit coupled to the holding unit so as to allow the measure of a weight exerted on the holding unit; and a toilet flushable container having: • a rim having a fold at a front side of the opening and a fold at a back side of the opening, each fold forming at rest an angle of less than 20°, and • a collar secured to the rim and comprising at least one fold at the front side of the opening forming at rest an angle of less than 20°, the collar being of a rigidity such that increasing the angle of the collar fold to 180° increases the angle of the rim fold at the back of the opening to from 50 to 90°.

8. 发明申请

WO2022242892A1 ANTI-CD38 SINGLE-DOMAIN ANTIBODIES IN DISEASE MONITORING AND TREATMENT 审中-公开
公开(公告)号：WO2022242892A1
公开(公告)日：2022-11-24
申请号：PCT/EP2021/082025
申请日：2021-11-17
申请人： UNIVERSITÉ DE LIÈGE , CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE , VRIJE UNIVERSITEIT BRUSSEL , KTH HOLDING AB
发明人： CAERS, Jo , DURAY, Elodie , DUMOULIN, Mireille , D’HUYVETTER, Matthias , ERIKSSON KARLSTRÖM, Amelie
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28 , A61K51/10 , G01N33/574 , A61K2039/505 , A61K51/1027 , A61K51/1069 , C07K16/2896 , C07K2317/569 , C07K2317/73 , C07K2317/77 , G01N33/57426 , G01N33/57492
摘要： The present invention relates to medical imaging, disease monitoring and theranostic approaches in neoplastic diseases of certain anti-CD38 single-domain antibodies (sdAb).

9. 发明申请

WO2021191386A1 METHODS AND TOOLS FOR ANALYSING THE DUCHENNE MUSCULAR DYSTROPHY (DMD) GENE 审中-公开
公开(公告)号：WO2021191386A1
公开(公告)日：2021-09-30
申请号：PCT/EP2021/057825
申请日：2021-03-25
申请人： CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE , UNIVERSITÉ DE LIÈGE
发明人： BECKERS, Pablo , BOEMER, François , SERVAIS, Laurent , BOURS, Vincent
IPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/16
摘要： An aspect of the invention provides a method for analysing the Duchenne Muscular Dystrophy (DMD) gene in a sample containing genetic material of a subject, wherein the method detects the presence or absence of at least exons 7, 43, 44, 45, 46, 49, 50, 51, 52 and 54 of the DMD gene in the genetic material of the subject, wherein the detection of the presence or absence of the exons comprises multiplex polymerase-based nucleic acid amplification. Another aspect of the invention provides a method for analysing the DMD gene in a sample containing genetic material of a subject, wherein the method detects the presence or absence of at least exons 7, 43, 44, 45, 46, 49, 50, 51, 52 and 54 of the DMD gene in the genetic material of the subject, and wherein the sample is blood. Additional aspects of the invention provide tools applicable in the disclosed methods, such as primers, primer pairs, primer pair sets, oligonucleotide probes and probe sets, as well as compositions and kits containing the same.

10. 发明申请

WO2021165230A1 FAT TISSUE REMOVAL DEVICE 审中-公开
公开(公告)号：WO2021165230A1
公开(公告)日：2021-08-26
申请号：PCT/EP2021/053717
申请日：2021-02-16
申请人： UNIVERSITÉ DE LIÈGE , CENTRE HOSPITALIER UNIVERSITAIRE DE LIÈGE
发明人： NIKKELS, Arjen
IPC分类号： A61M1/00 , A61B17/32
摘要： Fat tissue removal device comprising a cannula (100) comprising an evacuation tube (150) for connecting an evacuation system, a blunt cap (110) provided at a distal end of the cannula (100), and a rotatable shaft (130) comprising a cutting element (120) attached to the rotatable shaft, said rotatable shaft further being configured to be connectable to a driving device, the blunt cap (110) comprising a grinding chamber (160) for grinding fat tissue with the cutting element (120), an assembly comprising such device, a kit of parts for the removal of fat tissue, and a method for the removal of fat tissue with such device.

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