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1. 发明申请

WO2011157291A1 METHOD AND DEVICE FOR SINR ESTIMATION 审中-公开
标题翻译： SINR估计的方法和装置
公开(公告)号：WO2011157291A1
公开(公告)日：2011-12-22
申请号：PCT/EP2010/058452
申请日：2010-06-16
申请人： TELEFONAKTIEBOLAGET LM ERICSSON (PUBL) , SAHLIN, Henrik , CARLSSON, Roland , MÄLLO, Aare
发明人： SAHLIN, Henrik , CARLSSON, Roland , MÄLLO, Aare
IPC分类号： H04B17/00
CPC分类号： H04W24/06 , H04B17/336 , H04B17/373 , H04B17/382
摘要： A method (200) for a transceiver in a mobile system for determining the SINR for signals from at least two User Equipments during a future time interval, comprising arranging the transceiver to receive (205) transmissions from User Equipments in the mobile system on one radio channel per User Equipment, choosing (210) the at least two User Equipments from User Equipments which have data to transmit to the transceiver. The method comprises determining (220) the radio channel characteristics during the future time interval for the at least two User Equipments,emulating (230) at least one receiver type available to the transceiver during said future time interval in order to determine a post demodulation channel for the at least two User Equipments, in which emulation the determined radio channel characteristics,and determining (235) an SINR in the transceiver for the at least two User Equipments using the post demodulation channel.
摘要翻译：一种用于在未来时间间隔期间用于确定来自至少两个用户设备的信号的SINR的用于移动系统中的收发器的方法（200），包括：设置所述收发器以在一个无线电中接收（205）来自所述移动系统中的用户设备的传输每个用户设备的通道，从用户设备中选择（210）至少两个用户设备，其中具有要发送到收发器的数据。该方法包括确定（220）在至少两个用户设备的未来时间间隔期间的无线电信道特性，在所述未来时间间隔期间模拟（230）可用于收发器的至少一个接收机类型，以便确定后解调信道对于至少两个用户设备，其中仿真确定的无线电信道特性，以及使用后解调信道确定（235）用于至少两个用户设备的收发器中的SINR。

2. 发明申请

WO2011025978A2 METHODS OF TREATMENT USING ANTI-OXIDIZED LDL ANTIBODIES 审中-公开
标题翻译：使用抗氧化低密度脂蛋白抗体的治疗方法
公开(公告)号：WO2011025978A2
公开(公告)日：2011-03-03
申请号：PCT/US2010/047030
申请日：2010-08-27
申请人： BUNTING, Stuart , BULLENS, Sherron , CARLSSON, Roland , FRENDEUS, Björn , GLAZER, Steven , GROVE, Kevin , VAN BRUGGEN, Nick
发明人： BUNTING, Stuart , BULLENS, Sherron , CARLSSON, Roland , FRENDEUS, Björn , GLAZER, Steven , GROVE, Kevin , VAN BRUGGEN, Nick
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/94
摘要： The present invention relates to methods and compositions for increasing insulin sensitivity comprising the administration of anti-oxidized LDL antibodies.
摘要翻译：本发明涉及用于增加胰岛素敏感性的方法和组合物，其包括施用抗氧化的LDL抗体。

3. 发明申请

WO2010091737A1 MOBILE NODE ENTRY AT RADIO ACCESS ARRANGEMENT RESTART 审中-公开
标题翻译：移动节点进入无线接入安排重启
公开(公告)号：WO2010091737A1
公开(公告)日：2010-08-19
申请号：PCT/EP2009/051797
申请日：2009-02-16
申请人： TELEFONAKTIEBOLAGET L M ERICSSON (PUBL) , JOHANSSON, Magnus , CARLSSON, Roland
发明人： JOHANSSON, Magnus , CARLSSON, Roland
IPC分类号： H04W74/08
CPC分类号： H04W48/06 , H04W28/08 , H04W74/006 , H04W74/0833
摘要： The invention relates to communication between mobile nodes and/or node arrangements in wireless communication networks. In particular, the invention relates to a method in a radio access arrangement for improving the balance between the capacity allocated to initial access for network entry and the capacity allocated to payloads in the radio access arrangement. The radio access arrangement is configured to operatively communicate with a plurality of mobile nodes via an air interface. First, an initial access capacity is set to a value (S2), and then a current initial access load is obtained (S3). The next step is to increase (S7) the initial access capacity provided by the radio access arrangement (212, 312) if the current initial access load exceeds a predetermined upper limit (S4).
摘要翻译：本发明涉及无线通信网络中的移动节点和/或节点布置之间的通信。具体地说，本发明涉及无线电接入装置中的方法，用于改善分配给网络入口的初始接入的容量与在无线电接入装置中分配给有效载荷的容量之间的平衡。无线电接入装置被配置为经由空中接口与多个移动节点可操作地通信。首先，初始访问容量被设定为值（S2），然后获得当前的初始访问负载（S3）。如果当前的初始访问负载超过预定的上限（S4），则下一步是增加（S7）由无线电接入装置（212,312）提供的初始接入容量（S7）。

4. 发明申请

WO2008104194A1 OXIDIZED LDL AND ANTIBODIES THERETO FOR THE TREATMENT OF ATHEROSCLEROTI C PLAQUES 审中-公开
标题翻译：氧化低密度脂蛋白和治疗甲状腺功能亢进症的抗体
公开(公告)号：WO2008104194A1
公开(公告)日：2008-09-04
申请号：PCT/EP2007/001723
申请日：2007-02-28
申请人： BIOINVENT INTERNATIONAL AB , NILSSON, Jan , CARLSSON, Roland
发明人： NILSSON, Jan , CARLSSON, Roland
IPC分类号： A61K39/395 , C07K16/18 , A61P9/10
CPC分类号： A61K39/0012 , C07K14/775 , C07K16/18 , C07K2317/565 , C07K2317/622
摘要： The use of immunotherapy against oxidised LDL to induce regression of pre-existing atherosclerotic lesions in an individual. The immunotherapy can be passive immunotherapy utilising antibodies that bind to epitopes present on oxidised LDL, or active immunotherapy utilising a vaccine composition for induction of an immune response against epitopes present on oxidised LDL.
摘要翻译：使用针对氧化LDL的免疫治疗来诱导个体中先前存在的动脉粥样硬化病变的消退。免疫治疗可以是使用与氧化的LDL上存在的表位结合的抗体的免疫治疗，或使用疫苗组合物的活性免疫治疗来诱导针对氧化的LDL上存在的表位的免疫应答。

5. 发明申请

WO2006089678A3 ANTIBODIES AND PEPTIDES BINDING TO HIV TAT, AND USES THEREOF 审中-公开
标题翻译：抗体和肽与HIV TAT的结合及其用途
公开(公告)号：WO2006089678A3
公开(公告)日：2007-04-26
申请号：PCT/EP2006001404
申请日：2006-02-13
申请人： BIOINVENT INT AB , CARLSSON ROLAND , STENBERG YVONNE , SONESSON ELISABETH , GOLDSTEIN GIDEON
发明人： CARLSSON ROLAND , STENBERG YVONNE , SONESSON ELISABETH , GOLDSTEIN GIDEON
IPC分类号： C07K16/10 , A61K39/12
CPC分类号： C07K16/1072 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/92
摘要： The present invention relates to an immunoglobulin variable domain comprising all or a fragment or variant of each of peptide sequences SEQ ID No 2,3 and 4. Generally the invention relates to compositions useful for assaying or treating human immunodeficiency virus- 1(HIV-I) infection. There is also provided antibodies and polypeptides comprising immunoglobulin variable domains, polynucleotides, vectors, host cells encoding immunoglobulin variable domains, pharmaceutical compositions comprising and uses of immunoglobulin variable domains.
摘要翻译：本发明涉及包含肽序列SEQ ID No.2,2和4的全部或片段或变体的免疫球蛋白可变结构域。本发明一般涉及用于测定或治疗人类免疫缺陷病毒-1（HIV-1 ）感染。还提供了包含免疫球蛋白可变结构域，多核苷酸，载体，编码免疫球蛋白可变结构域的宿主细胞，包含免疫球蛋白可变结构域和用途的药物组合物的抗体和多肽。

6. 发明申请

WO2006089678A2 PEPTIDES AND USES THEREOF 审中-公开
标题翻译：肽及其用途
公开(公告)号：WO2006089678A2
公开(公告)日：2006-08-31
申请号：PCT/EP2006/001404
申请日：2006-02-13
申请人： BIOINVENT INTERNATIONAL AB , CARLSSON, Roland , STENBERG, Yvonne , SONESSON, Elisabeth , GOLDSTEIN, Gideon
发明人： CARLSSON, Roland , STENBERG, Yvonne , SONESSON, Elisabeth , GOLDSTEIN, Gideon
CPC分类号： C07K16/1072 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/92
摘要： The present invention relates to an immunoglobulin variable domain comprising all or a fragment or variant of each of peptide sequences SEQ ID No 2,3 and 4. Generally the invention relates to compositions useful for assaying or treating human immunodeficiency virus- 1(HIV-I) infection. There is also provided antibodies and polypeptides comprising immunoglobulin variable domains, polynucleotides, vectors, host cells encoding immunoglobulin variable domains, pharmaceutical compositions comprising and uses of immunoglobulin variable domains.
摘要翻译：本发明涉及包含肽序列SEQ ID No.2,2和4的全部或片段或变体的免疫球蛋白可变结构域。本发明一般涉及用于测定或治疗人类免疫缺陷病毒-1（HIV-1 ）感染。还提供了包含免疫球蛋白可变结构域，多核苷酸，载体，编码免疫球蛋白可变结构域的宿主细胞，包含免疫球蛋白可变结构域和用途的药物组合物的抗体和多肽。

7. 发明申请

WO03097834A2 A METHOD FOR IN VITRO MOLECULAR EVOLUTION OF PROTEIN FUNCTION 审中-公开
标题翻译：一种用于蛋白质功能的体细胞分子进化的方法
公开(公告)号：WO03097834A2
公开(公告)日：2003-11-27
申请号：PCT/GB0302102
申请日：2003-05-16
申请人： ALLIGATOR BIOSCIENCE AB , THOMAS PHILIP JOHN DUVAL , FUREBRING CHRISTINA , CARLSSON ROLAND , BORREBAECK CARL ARNE KRISTER , MALMBORG HAGER ANN-CHRISTIN
发明人： FUREBRING CHRISTINA , CARLSSON ROLAND , BORREBAECK CARL ARNE KRISTER , MALMBORG HAGER ANN-CHRISTIN
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , C07K14/00 , C12N15/10 , C12P21/02 , C12Q1/68
CPC分类号： C12P19/04 , C12N15/1027 , C12N15/1058
摘要： A method for in vitro molecular evolution of protein function The invention provides a method for generating a polynucleotide sequence or population of sequences from parent single-stranded polynucleotide sequences encoding one or more protein motifs, comprising the steps of (a) providing a first population of single-stranded polynucleotide molecules and a second population of single-stranded polynucleotide molecules, the first and second populations together constituting plus and minus strands of parent polynucleotide sequences, (b) carrying out a reaction for digesting the first and second populations of single-stranded polynucleotide molecules with an exonuclease to generate corresponding populations of single-stranded polynucleotide fragments, (c) contacting said fragments generated from the plus strands with fragments generated from the minus strands and optionally, adding primer sequences that anneal to the 3'and 5'ends of at least one of the parent polynucleotides under annealing conditions, and (d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having altered characteristics as compared to the one or more protein motifs encoded by said parent polynucleotides, wherein, in step (b), at least one parameter of the reaction used for digestion of the first population of single-stranded polynucleotide molecules is different from the equivalent parameter(s) used in the reaction for digestion of the second population of single-stranded polynucleotide molecules. Preferably, the reaction parameter is selected from exonuclease type, exonuclease concentration, reaction volume, duration of the digestion reaction, temperature of the reaction mixture, pH of the reaction mixture, length of parent single-stranded polynucleotide sequences, amount of single-stranded polynucleotide molecules and buffer composition of the reaction mixture.
摘要翻译：蛋白质功能的体外分子进化的方法本发明提供了从编码一种或多种蛋白质基序的母体单链多核苷酸序列产生多核苷酸序列或序列群的方法，包括以下步骤：（a）提供第单链多核苷酸分子和第二群单链多核苷酸分子，第一和第二群体一起构成母体多核苷酸序列的正负链，（b）进行用于消化第一和第二群单链的反应多核苷酸分子与外切核酸酶产生相应的单链多核苷酸片段群体，（c）将由正链产生的所述片段与由负链产生的片段接触，并任选加入与3'和5'端退火的引物序列的至少一种母体多核苷酸 g条件，和（d）扩增与所述亲本多核苷酸编码的一种或多种蛋白质基序相比，其彼此退火以产生至少一个编码具有改变的特征的蛋白质基序的多核苷酸序列的多核苷酸序列，其中在步骤（b）中，用于消化第一群单链多核苷酸分子的反应的至少一个参数与用于消化第二群单链多核苷酸分子的反应中使用的等效参数不同。优选地，反应参数选自外切核酸酶类型，核酸外切酶浓度，反应体积，消化反应持续时间，反应混合物的温度，反应混合物的pH，亲本单链多核苷酸序列的长度，单链多核苷酸的量分子和缓冲液组成的反应混合物。

8. 发明申请

WO0169247A3 METHODS OF MAKING AND USING MICROARRAYS OF ANTI-LIGANDS FOR THE ANALYSIS OF PROTEIN EXPRESSION IN CELLS 审中-公开
标题翻译：制备和使用抗体微阵列分析细胞中蛋白质表达的方法
公开(公告)号：WO0169247A3
公开(公告)日：2002-03-28
申请号：PCT/EP0102520
申请日：2001-03-06
申请人： BIOINVENT INT AB , CARLSSON ROLAND , BORREBAECK CARL ARNE KRISTER
发明人： CARLSSON ROLAND , BORREBAECK CARL ARNE KRISTER
IPC分类号： G01N21/64 , B01D57/02 , B03C5/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , G01N21/78 , G01N27/447 , G01N33/53 , G01N33/543 , G01N33/58 , G01N33/68 , G01N37/00 , C07K16/18
CPC分类号： G01N33/6842 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01J2219/00743 , C40B40/06 , C40B40/10 , G01N33/582 , G01N33/6803
摘要： The invention relates to methods of making arrays of anti-ligands for use in the analysis of ligands. Preferred ligands are proteins and preferred anti-ligands are antibodies, or antigen-binding variants or derivatives thereof. The microarrays of the invention provide a convenient means for analysing differential protein expression in cells.
摘要翻译：本发明涉及制备用于分析配体的抗配体阵列的方法。优选的配体是蛋白质，优选的抗配体是抗体或其抗原结合变体或衍生物。本发明的微阵列提供用于分析细胞中差异蛋白表达的便利手段。

9. 发明申请

WO2008075038A1 BINDING AGENTS TO THE INTEGRIN ALPHA-11 SUBUNIT 审中-公开
标题翻译：绑定代理到集成ALPHA-11子
公开(公告)号：WO2008075038A1
公开(公告)日：2008-06-26
申请号：PCT/GB2007/004875
申请日：2007-12-18
申请人： BIOINVENT INTERNATIONAL AB , FRENDÉUS, Björn , CARLSSON, Roland , JANSSON, Bo
发明人： FRENDÉUS, Björn , CARLSSON, Roland , JANSSON, Bo
IPC分类号： C07K16/28 , A61K39/395 , A61K47/48 , A61K51/10 , A61P19/02 , A61P37/00
CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622
摘要： The present invention relates to an antibody, or antigen-binding fragment thereof, with binding specificity for an integrin α11 subunit, or a heterodimer thereof, or a variant, fusion, derivative or polypeptide chain thereof, or a fusion of a said variant or derivative thereof, which retains the binding specificity of the parent antibody wherein the antibody or antigen-binding fragment, or variant, fusion, derivative or polypeptide chain thereof, comprises the following amino acid sequences of SEQ ID NOS: 1 to 6. In particular, the invention relates to antibodies or antigen-binding fragments, or variants, fusions or derivatives thereof, with efficacy in the treatment of inflammatory disorders such as arthritic diseases ( e.g. RA and OA). The invention further provides pharmaceutical compositions and kits comprising the same.
摘要翻译：本发明涉及对整联蛋白a11亚基或其异源二聚体或其变体，融合，衍生物或多肽链或所述变体或衍生物的融合物具有结合特异性的抗体或其抗原结合片段其保留亲本抗体的结合特异性，其中抗体或抗原结合片段或其变体，融合物，衍生物或多肽链包含SEQ ID NO：1至6的以下氨基酸序列。特别地，本发明涉及在治疗诸如关节炎疾病（例如RA和OA）的炎症性疾病中有效的抗体或抗原结合片段或变体，融合物或其衍生物。本发明还提供药物组合物和包含该组合物的试剂盒。

10. 发明申请

WO2007039789A1 THROUGHPUT OPTIMIZED CARRIER ALLOCATION 审中-公开
标题翻译：通过优化的运营商分配
公开(公告)号：WO2007039789A1
公开(公告)日：2007-04-12
申请号：PCT/IB2005/053243
申请日：2005-10-03
申请人： TELEFONAKTIEBOLAGET LM ERICSSON (PUBL) , CARLSSON, Roland
发明人： CARLSSON, Roland
IPC分类号： H04Q7/36 , H04Q7/38
CPC分类号： H04W72/082 , H04W16/08 , H04W72/048
摘要： A cell plan operation, a Routine and a base station are disclosed wherein user entities are allocated to at least two carriers (Cl; C2) in at least one cell (A; B) of a system (node B), the first carrier (Cl) having at least a first channel (DPCH), the second carrier (C2) having at least a second channel (DPCH), the at least two carriers not causing interference to one another, wherein user entities (UE) may be selectively assigned to either first channel and / or the second channel. Information is gathered on respective measures relating to the noise enduring capability (MAX ROT(UEn)) of respective prevalent users within the at least one cell. Prevalent user entities are ordered according to their respective noise enduring capabilities (MAX _ROT(UEn)_UE). User entities with low noise enduring capabilities are allocated to a channel on the first carrier (Cl), while user entities with high noise enduring capabilities (MAX_ROT(UEn)) are allocated to a channel on the second carrier (C2).
摘要翻译：公开了一种小区计划操作，例程和基站，其中用户实体被分配给系统（节点B）的至少一个小区（A; B）中的至少两个载波（C1; C2），第一载波 C1）具有至少第一信道（DPCH），所述第二载波（C2）具有至少第二信道（DPCH），所述至少两个载波不引起彼此的干扰，其中可以选择性地分配用户实体到第一通道和/或第二通道。收集关于至少一个小区内各个流行用户的噪声持久能力（MAX_ROT（UEn））的相关措施的信息。流行的用户实体根据其相应的噪声持续能力（MAX _ROT（UEn）_UE）进行排序。具有低噪声持久能力的用户实体被分配给第一载波（C1）上的信道，而具有高噪声持久能力（MAX_ROT（UEn））的用户实体被分配给第二载波（C2）上的信道。

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