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1. 发明申请

WO2005096996A1 OSTIAL STENT 审中-公开
公开(公告)号：WO2005096996A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/011118
申请日：2005-04-01
申请人： CAPPELLA, INC. , SHMULEWITZ, Ascher
发明人： SHMULEWITZ, Ascher
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2002/821 , A61F2230/005 , A61F2250/0039 , A61F2250/0067
摘要： An intraluminal device (100) for placement in a side-branch vessel associated with a main vessel via an ostial region. The intraluminal device includes a stem portion (102) and a toroidal cap portion (104). The stem portion of the device is placed in the side branch vessel and the toroidal cap portion is placed adjacent to the ostial region.
摘要翻译：一种管腔内装置（100），用于经由口腔区域放置在与主血管相关联的侧支血管中。管腔内装置包括杆部分（102）和环形帽部分（104）。装置的茎部被放置在侧分支容器中，并且环形帽部分被放置成邻近于口部区域。

2. 发明申请

WO2008157830A1 MEDICAL DEVICE DELIVERY SYSTEM WITH SHEATH HAVING BALLOON-RELATIVE POSITION 审中-公开
标题翻译：具有气孔相关位置的医疗装置输送系统
公开(公告)号：WO2008157830A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/067898
申请日：2008-06-23
申请人： CAPPELLA, INC. , SLATTERY, David , KELLY, Damian , O'CONNOR, Therese , KERINS, Joseph , GILMORE, Michael , STECKEL, Mark
发明人： SLATTERY, David , KELLY, Damian , O'CONNOR, Therese , KERINS, Joseph , GILMORE, Michael , STECKEL, Mark
IPC分类号： A61F2/84 , A61M25/10
CPC分类号： A61M25/1038 , A61F2/958 , A61F2/97 , A61F2002/9583
摘要： A delivery system for delivering a self- expanding medical device such as a stent (16) includes the stent mounted on a balloon portion (30) of a catheter. A sheath (18,40) is provided around the stent to hold the device in place in a compressed state. A portion of the sheath (42,44) is positioned at a predetermined location, or within a predetermined range of locations, on the circumference of the sheath. The predetermined location or range of locations are determined with respect to a configuration of the balloon portion. The sheath may be profiled or shaped to reduce instances of interference between a distal edge of the sheath and a vessel or with any lesion or lesions that might be present in the vessel. The sheath is formed by modifying a cylinder of sheath material to include three portions and an initiation slit (602) that controls the rupturing of the sheath to facilitate delivery of the medical device.
摘要翻译：用于递送诸如支架（16）的自扩张医疗装置的递送系统包括安装在导管的球囊部分（30）上的支架。在支架周围设置护套（18,40），以将装置保持在压缩状态。护套（42,44）的一部分位于护套的圆周上的预定位置或位于预定范围内的位置。相对于球囊部分的构造来确定位置的预定位置或范围。护套可以被成形或成形，以减少护套的远侧边缘与血管之间的干涉或与血管中可能存在的任何损伤或病变的干扰。护套通过改变护套材料的圆筒以包括三个部分和起始狭缝（602）形成，起始狭缝（602）控制护套的破裂以促进医疗装置的传送。

3. 发明申请

WO2007011730A1 DELIVERY SYSTEM AND METHOD OF USE FOR DEPLOYMENT OF SELF-EXPANDABLE VASCULAR DEVICE 审中-公开
标题翻译：交付系统和使用自发扩张血管装置的方法
公开(公告)号：WO2007011730A1
公开(公告)日：2007-01-25
申请号：PCT/US2006/027375
申请日：2006-07-14
申请人： CAPPELLA INC. , YACOBY, Menashe , SHMULEWITZ, Ascher , BAR-ON, Raz , NAOR, Gil , KELLY, Damian , GILMORE, Michael , STECKEL, Mark
发明人： YACOBY, Menashe , SHMULEWITZ, Ascher , BAR-ON, Raz , NAOR, Gil , KELLY, Damian , GILMORE, Michael , STECKEL, Mark
IPC分类号： A61F2/84
CPC分类号： A61F2/97 , A61F2/844 , A61F2/88 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2/966 , A61F2002/821 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/9522 , A61F2002/9583 , A61F2230/005 , A61F2230/0054 , A61F2250/0039 , A61M25/10 , A61M25/1034 , A61M2025/1081 , Y10T29/4987
摘要： A delivery system for a self-expandable prosthesis includes a catheter (12) having a distal end and a proximal end, a balloon (22) positioned on the distal end of the catheter, a self-expandable prosthesis (1100) positioned on the balloon, and a sheath (26) at least partially surrounding the self-expandable prosthesis. Upon infation of the balloon, the sheath opens in a controllable manner, allowing the self -expandable prosthesis to be released. The sheath is either removed from the vessel or allowed to remain in the vessel .
摘要翻译：用于自扩张假体的输送系统包括具有远端和近端的导管（12），定位在导管远端的球囊（22），位于球囊上的自扩张假体（1100），以及至少部分地围绕所述自膨胀假体的护套（26）。气囊发生时，鞘以可控制的方式打开，允许释放自发性假体。护套从容器中取出或允许留在容器中。

4. 发明申请

WO2011123852A1 SYSTEMS AND METHODS FOR DELIVERING A STENT TO A BODY LUMEN 审中-公开
标题翻译：将体系输送到身体的体液和方法
公开(公告)号：WO2011123852A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/031085
申请日：2011-04-04
申请人： CAPPELLA, INC. , SLATTERY, David , GILMORE, Michael , CURLEY, Aemon , KELLY, Damian
发明人： SLATTERY, David , GILMORE, Michael , CURLEY, Aemon , KELLY, Damian
IPC分类号： A61F2/84
CPC分类号： A61F2/97 , A61F2/958 , A61F2002/9583
摘要： A stent delivery system configured to deliver a stent to a target region of a body lumen may include a catheter; a stent associated with the catheter, the stent having a first region and a second region; a balloon associated with the catheter, the balloon having a first balloon portion associated with the catheter proximate the first region of the stent and a second balloon portion associated with the catheter proximate the second region of the stent; and a sheath about the stent and the balloon, the sheath maintaining the stent in an undeployed configuration for delivery to a target region of a body lumen. The sheath may comprise a first sheath region configured to split at a first pressure thereby permitting the first region of the stent to assume a deployed configuration, a second sheath region configured to split at a second pressure thereby permitting the second region of the stent to assume a deployed configuration, the second pressure being greater than the first pressure and the first pressure being insufficient to cause the second region of the sheath to split, a split-stopping structure between the first and second sheath regions, the split-stopping structure being configured to prevent a split from propagating from the first sheath region to the second sheath region at the first pressure.
摘要翻译：构造成将支架输送到体腔的目标区域的支架输送系统可以包括导管; 与所述导管相关联的支架，所述支架具有第一区域和第二区域; 与所述导管相关联的球囊，所述球囊具有与所述导管相邻的第一球囊部分，所述第一球囊部分邻近所述支架的第一区域;以及第二球囊部分，其与所述导管相邻，所述第二球囊部分邻近所述支架的第二区域; 以及围绕支架和气囊的护套，护套将支架保持在未部署的构造中，用于输送到体腔的目标区域。护套可以包括构造成以第一压力分裂从而允许支架的第一区域呈现展开构型的第一护套区域，第二护套区域被配置成在第二压力下分裂，从而允许支架的第二区域呈现所述第二压力大于所述第一压力，所述第一压力不足以使所述护套的所述第二区域分裂，所述第一和第二护套区域之间的分离停止结构，所述分离停止结构被构造成以防止在第一压力下从第一护套区域传播到第二护套区域的分裂。

5. 发明申请

WO2009045623A1 DEVICE DELIVERY SYSTEM WITH TWO STAGE WITHDRAWAL 审中-公开
标题翻译：具有两级撤销的设备传送系统
公开(公告)号：WO2009045623A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/071937
申请日：2008-08-01
申请人： CAPPELLA, INC. , O'CONNOR, Therese , GILMORE, Michael , SLATTERY, David , KELLY, Damian
发明人： O'CONNOR, Therese , GILMORE, Michael , SLATTERY, David , KELLY, Damian
IPC分类号： A61F2/84
CPC分类号： A61F2/958 , A61F2002/9665
摘要： A medical device delivery system provides for a two-stage withdrawal of a deflated balloon portion (14) of a catheter (12) and the remains of a ruptured sheath (18). The deflated balloon portion is withdrawn from within an expanded medical device (16) a predetermined distance before the remains of the ruptured sheath begins being removed from between the expanded device and a vessel wall. Initiating removal of the deflated balloon portion before the sheath reduces a total amount of drag that is exerted against a self-expanding medical device that has been deployed in a vessel.
摘要翻译：医疗装置输送系统提供导尿管（12）的放气气球部分（14）和破裂鞘（18）的残留物的两级抽出。在扩张的医疗装置（16）内从放大的装置和血管壁之间开始移除破裂的护套的残余物之前，将预定距离从放大的医疗装置（16）中取出。在护套之前开始去除放气气球部分减少了对已经部署在容器中的自扩张医疗装置施加的总阻力。

6. 发明申请

WO2008089257A3 DRUG ELUTING MEDICAL DEVICE USING POLYMERIC THERAPEUTICS WITH TRANSGLUTAMINASE SUBSTRATES 审中-公开
公开(公告)号：WO2008089257A3
公开(公告)日：2008-07-24
申请号：PCT/US2008/051195
申请日：2008-01-16
申请人： CAPPELLA, INC. , RANADE, Shrirang , STECKEL, Mark , OHRI, Rachit
发明人： RANADE, Shrirang , STECKEL, Mark , OHRI, Rachit
IPC分类号： A61K47/48
摘要： Disclosed herein are coatings for implantable medical device. The coatings comprise a composition, comprising a polymer linked to a chemical moiety through a covalent bond, wherein the chemical moiety forms a pharmaceutically active agent upon degradation (e.g., hydrolysis) of the covalent bond; and transglutaminase substrates.

7. 发明申请

WO2008089256A2 POLYMERIC THERAPEUTICS 审中-公开
标题翻译：聚合物治疗
公开(公告)号：WO2008089256A2
公开(公告)日：2008-07-24
申请号：PCT/US2008/051193
申请日：2008-01-16
申请人： CAPPELLA, INC. , OHRI, Rachit , STECKEL, Mark , RANADE, Shrirang
发明人： OHRI, Rachit , STECKEL, Mark , RANADE, Shrirang
IPC分类号： A61K47/48
CPC分类号： A61K47/6957 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/605 , A61K47/62
摘要： Disclosed herein are polymers comprising a chemical moiety linked through a covalent bond, where the chemical moiety forms a pharmaceutically active agent upon degradation of the covalent bond. The polymers can be chosen from star polymers, dendrimers, and hyperbranched polymers. Also disclosed are coatings for implantable medical device comprising such polymers.
摘要翻译：本文公开了包含通过共价键连接的化学部分的聚合物，其中化学部分在共价键降解时形成药物活性剂。聚合物可以选自星形聚合物，树枝状聚合物和超支化聚合物。还公开了包含这种聚合物的可植入医疗装置的涂层。

8. 发明申请

WO2008089258A3 DRUG ELUTING MEDICAL DEVICE USING POLYMERIC THERAPEUTICS 审中-公开
标题翻译：使用聚合物治疗药物给药医疗器械
公开(公告)号：WO2008089258A3
公开(公告)日：2009-12-30
申请号：PCT/US2008051196
申请日：2008-01-16
申请人： CAPPELLA INC , RANADE SHRIRANG , STECKEL MARK , OHRI RACHIT
发明人： RANADE SHRIRANG , STECKEL MARK , OHRI RACHIT
IPC分类号： A61K47/48
CPC分类号： A61K47/6957 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/605 , A61K47/62
摘要： Disclosed herein are coatings for implantable medical device. The coatings comprise a biodegradable polymer linked to a chemical moiety through a covalent bond, wherein the chemical moiety forms a pharmaceutically active agent upon degradation of the covalent bond.
摘要翻译：本文公开了用于可植入医疗装置的涂层。涂层包含通过共价键与化学部分连接的可生物降解的聚合物，其中化学部分在共价键降解时形成药物活性剂。

9. 发明申请

WO2008089256A3 POLYMERIC THERAPEUTICS 审中-公开
标题翻译：聚合物治疗
公开(公告)号：WO2008089256A3
公开(公告)日：2009-12-30
申请号：PCT/US2008051193
申请日：2008-01-16
申请人： CAPPELLA INC , OHRI RACHIT , STECKEL MARK , RANADE SHRIRANG
发明人： OHRI RACHIT , STECKEL MARK , RANADE SHRIRANG
IPC分类号： A61K47/48
CPC分类号： A61K47/6957 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/605 , A61K47/62
摘要： Disclosed herein are polymers comprising a chemical moiety linked through a covalent bond, where the chemical moiety forms a pharmaceutically active agent upon degradation of the covalent bond. The polymers can be chosen from star polymers, dendrimers, and hyperbranched polymers. Also disclosed are coatings for implantable medical device comprising such polymers.
摘要翻译：本文公开了包含通过共价键连接的化学部分的聚合物，其中化学部分在共价键降解时形成药物活性剂。聚合物可以选自星形聚合物，树枝状聚合物和超支化聚合物。还公开了包含这种聚合物的可植入医疗装置的涂层。

10. 发明申请

WO2009129199A1 SHEATH WITH RADIO-OPAQUE MARKERS FOR IDENTIFYING SPLIT PROPAGATION 审中-公开
标题翻译：用于识别分裂传播的无线电OPAQUE标记
公开(公告)号：WO2009129199A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/040421
申请日：2009-04-14
申请人： CAPPELLA, INC. , STECKEL, Mark , OHRI, Rachit
发明人： STECKEL, Mark , OHRI, Rachit
IPC分类号： A61F2/84
CPC分类号： A61F2/97 , A61F2/958 , A61F2002/821 , A61F2002/9583 , A61F2250/0098
摘要： A medical device delivery system includes a self-expanding medical device mounted on a balloon portion of a catheter. A sheath is provided around the medical device to hold the device in place with the device staying in a compressed state. The balloon portion is inflated to cause the sheath to rupture and release the self-expanding medical device. A number of radio- opaque markers in a pattern that will aid in determining whether or not the sheath has properly ruptured upon inflation of the balloon portion are provided on the sheath. The radio-opaque markers are positioned with respect to an expected sheath rupture propagation path along which the sheath is expected to rupture. The pattern of the markers changes as the sheath ruptures and this change is detected by an operator of the system.
摘要翻译：医疗装置输送系统包括安装在导管的球囊部分上的自扩张医疗装置。在医疗装置周围设置护套，以将装置保持在处于压缩状态的装置的适当位置。气囊部分被充气以使皮肤破裂并释放自膨胀的医疗装置。许多不透射线的标记物将有助于确定在球囊部分膨胀时护套是否已经适当地破裂。射线不透明标记物相对于期望的鞘破裂传播路径定位，预期护套穿过其将破裂。标记的图案随着鞘破裂而变化，并且该变化由系统的操作者检测到。

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