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1. 发明申请

WO2013016094A3 IMPROVED DEVICE AND METHOD FOR DILATING AN AIRWAY STENOSIS 审中-公开
标题翻译：改进的设备和方法，用于泄漏空中航迹
公开(公告)号：WO2013016094A3
公开(公告)日：2013-03-21
申请号：PCT/US2012047148
申请日：2012-07-18
申请人： ACCLARENT INC , MUNI KETAN P , CHAN RANDY S , LAM SIVETTE , RANADE SHRIRANG V
发明人： MUNI KETAN P , CHAN RANDY S , LAM SIVETTE
IPC分类号： A61M16/04 , A61M29/02
CPC分类号： A61B17/24 , A61B6/12 , A61M16/0057 , A61M16/04 , A61M16/0438 , A61M16/044 , A61M16/0445 , A61M16/0463 , A61M16/0486 , A61M16/0488 , A61M16/0816 , A61M25/0026 , A61M25/007 , A61M29/02 , A61M2205/32 , A61M2205/6081
摘要： A medical device (100) and a system for dilating a stenotic airway of a patient are described. The medical device comprises a proximal end (122), a distal end (120), and a shaft system (102) having an inflation lumen (108) and a ventilation lumen (110) the proximal end. The shaft system has a proximal shaft section and a distal shaft section. An inflatable balloon (104) is attached to the distal shaft section in a position that is proximal to the distal end. The ventilating tip (106) is distal to the balloon on the distal shaft section and has one or more radially facing openings (112). A method for treating a stenotic airway includes inserting the medical device into a patient's airway, and dilating and ventilating the airway.
摘要翻译：描述了医疗装置（100）和用于扩张患者的狭窄气道的系统。医疗装置包括近端（122），远端（120）和具有近端的充气腔（108）和通气腔（110）的轴系（102）。轴系具有近轴部分和远侧轴部分。可膨胀气球（104）在远端轴部分附近位于远端的位置。通气尖端（106）在远侧轴部分上远离球囊并且具有一个或多个径向面对的开口（112）。用于治疗狭窄气道的方法包括将医疗装置插入患者的气道中，并使气道扩张和通气。

2. 发明申请

WO2013016094A2 IMPROVED DEVICE AND METHOD FOR DILATING AN AIRWAY STENOSIS 审中-公开
标题翻译：改进的设备和方法，用于使空中航行障碍降低
公开(公告)号：WO2013016094A2
公开(公告)日：2013-01-31
申请号：PCT/US2012/047148
申请日：2012-07-18
申请人： ACCLARENT, INC. , MUNI, Ketan P. , CHAN, Randy S. , LAM, Sivette , RANADE, Shrirang V.
发明人： MUNI, Ketan P. , CHAN, Randy S. , LAM, Sivette
IPC分类号： A61M16/04 , A61M29/02
CPC分类号： A61B17/24 , A61B6/12 , A61M16/0057 , A61M16/04 , A61M16/0438 , A61M16/044 , A61M16/0445 , A61M16/0463 , A61M16/0486 , A61M16/0488 , A61M16/0816 , A61M25/0026 , A61M25/007 , A61M29/02 , A61M2205/32 , A61M2205/6081
摘要： A medical device and a system and for dilating a stenotic airway of a patient are described. The medical device comprises a proximal end, a distal end, and a shaft system having an inflation lumen and a ventilation lumen the proximal end. The shaft system has a proximal shaft section and a distal shaft section. An inflatable balloon is attached to the distal shaft section in a position that is proximal to the distal end. The ventilating tip is distal to the balloon on the distal shaft section and has one or more radially facing openings. A method for treating a stenotic airway includes inserting the medical device into a patient's airway, and dilating and ventilating the airway.
摘要翻译：描述了医疗装置和系统，并且用于扩张患者的狭窄气道。医疗装置包括近端，远端以及具有充气腔和远端的通气腔的轴系。轴系具有近轴部分和远侧轴部分。可膨胀的气球在远端轴部分附近位于远端的位置。通气尖端在远侧轴部分上的球囊的远侧，并且具有一个或多个径向面对的开口。用于治疗狭窄性气道的方法包括将医疗装置插入患者的气道中，并使气道扩张和通气。

3. 发明申请

WO2008024511A3 MEDICAL DEVICES FOR THE RELEASE OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于释放治疗药物的医疗器械
公开(公告)号：WO2008024511A3
公开(公告)日：2009-02-05
申请号：PCT/US2007018841
申请日：2007-08-24
申请人： BOSTON SCIENT SCIMED INC , RANADE SHRIRANG V , STECKEL MARK , SIKES COURTNEY
发明人： RANADE SHRIRANG V , STECKEL MARK , SIKES COURTNEY
IPC分类号： A61L27/54 , A61L27/58 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L27/58 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/148 , A61L29/16 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/604
摘要： According to one aspect of the invention, medical devices are provided which contain the following: (a) an interior region that contains at least one degradation promoting agent and (b) an exterior region disposed over the interior region that contains at least one biodegradable polymer and at least one therapeutic agent.
摘要翻译：根据本发明的一个方面，提供了包含以下物质的医疗装置：（a）含有至少一种降解促进剂的内部区域和（b）设置在内部区域上的外部区域，其包含至少一种可生物降解的聚合物和至少一种治疗剂。

4. 发明申请

WO2006083698A3 IMPLANTABLE OR INSERTABLE MEDICAL DEVICES HAVING OPTIMAL SURFACE ENERGY 审中-公开
标题翻译：具有最佳表面能量的可植入或插入式医疗器械
公开(公告)号：WO2006083698A3
公开(公告)日：2007-05-10
申请号：PCT/US2006002853
申请日：2006-01-26
申请人： BOSTON SCIENT SCIMED INC , HELMUS MICHAEL N , VALINT PAUL JR , RANADE SHRIRANG V
发明人： HELMUS MICHAEL N , VALINT PAUL JR , RANADE SHRIRANG V
IPC分类号： A61L27/34 , A61L27/26 , A61L27/50 , A61L31/10
CPC分类号： A61L27/26 , A61L27/50
摘要： An implantable or insertable medical device is provided that contains at least one polymeric region which comes into contact with a subject upon implantation or insertion of the device into the subject. The polymeric region(s) contain at least one bulk polymer moiety and at least one surface-active polymer moiety that (a) is covalently attached to the bulk polymer moiety/moieties or admixed with the bulk polymer moiety/moieties and (b) is provided in an amount that is effective in providing the polymeric region(s) with a critical surface energy that is between 20 dynes/cm and 30 dynes/cm upon implantation or insertion of the device into the subject.
摘要翻译：提供了可植入或可插入的医疗装置，其包含至少一个聚合物区域，所述至少一个聚合物区域在将装置植入或插入受试者时与受试者接触。聚合物区域包含至少一个本体聚合物部分和至少一个表面活性聚合物部分，（a）共价连接到本体聚合物部分/部分或与本体聚合物部分/部分混合，（b）提供的量可以有效地提供聚合物区域在植入或插入该受试者时在20达因/厘米至30达因/厘米之间的临界表面能。

5. 发明申请

WO2005107828A3 IMPLANTABLE OR INSERTABLE MEDICAL ARTICLES HAVING COVALENTLY MODIFIED, BIOCOMPATIBLE SURFACES 审中-公开
标题翻译：具有共同修饰，生物化学表面的可植入或不可剥离的医疗用品
公开(公告)号：WO2005107828A3
公开(公告)日：2006-01-12
申请号：PCT/US2005013212
申请日：2005-04-20
申请人： BOSTON SCIENT SCIMED INC , HELMUS MICHAEL N , RANADE SHRIRANG V
发明人： HELMUS MICHAEL N , RANADE SHRIRANG V
IPC分类号： A61F2/00 , A61L27/00 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L27/28 , A61L31/08
CPC分类号： A61L29/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2400/18
摘要： Implantable or insertable medical devices comprising a surface region that is modified by covalently coupling a molecular species (or a combination of molecular species) to the same. The molecular species are selected such that the resulting modified surface region has critical surface energy between (20) and (30) dynes/cm. In certain embodiments, the covalently coupled molecular species comprise one or more methyl groups. An advantage of the present invention is that novel medical devices are provided, which have a surface with a critical surface energy value that has been shown to display enhanced biocompatibility, including enhanced throboresistance, relative to other surfaces.
摘要翻译：可植入或可插入的医疗装置包括通过共价地将分子种类（或分子种类的组合）共价连接到其上的表面区域。选择分子种类使得所得到的改性表面区域具有在（20）和（30）达因/厘米之间的临界表面能。在某些实施方案中，共价偶联的分子种类包含一个或多个甲基。本发明的一个优点是提供了新的医疗装置，其具有表面具有临界表面能值，该表面已被证明显示出增强的生物相容性，包括相对于其它表面增强的阻抗。

6. 发明申请

WO2007143159A3 MEDICAL DEVICES HAVING IMPROVED PERFORMANCE 审中-公开
公开(公告)号：WO2007143159A3
公开(公告)日：2007-12-13
申请号：PCT/US2007/013051
申请日：2007-06-01
申请人： BOSTON SCIENTIFIC SCIMED, INC. , STRICKLER, Frederick , RANADE, Shrirang, V.
发明人： STRICKLER, Frederick , RANADE, Shrirang, V.
IPC分类号： A61L27/16 , A61L29/04 , A61L31/04 , A61L27/34 , A61L29/08 , A61L31/10 , A61L27/54
摘要： According to an aspect of the present invention, medical devices are provided that contain at least one polymeric region which contains (a) at least one block copolymer that contains at least at least three polymer blocks that differ from one another and (b) at least one therapeutic agent.

7. 发明申请

WO2006062975A3 ORIENTING POLYMER DOMAINS FOR CONTROLLED DRUG DELIVERY 审中-公开
标题翻译：定向聚合物领域用于控制药物递送
公开(公告)号：WO2006062975A3
公开(公告)日：2007-01-11
申请号：PCT/US2005044128
申请日：2005-12-07
申请人： BOSTON SCIENT SCIMED INC , RANADE SHRIRANG V , RICHARD ROBERT E , DAO KINH-LUAN LENNY , GIDO SAMUEL P , ISAACS-SODEYE AKINBODE IDOWU
发明人： RANADE SHRIRANG V , RICHARD ROBERT E , DAO KINH-LUAN LENNY , GIDO SAMUEL P , ISAACS-SODEYE AKINBODE IDOWU
IPC分类号： A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/60 , A61L2300/602
摘要： The present invention provides a method for the formation of a medical device that comprises a therapeutic agent and a release region, which regulates the rate at which the therapeutic agent is released from the medical device. The method comprises providing a precursor region that comprises a polymer composition comprising two or more microphage separated polymer domains that are immiscible with one another, and forming said release region by a process that comprises applying an orienting field comprising an electric field, a magnetic field, a mechanical shear field, or a solvent gradient field, or a combination of two or more fields to said precursor region, wherein said field or combination of fields changes the spatial orientation of the microphase separated polymer domains within the release region. The electric, magnetic, mechanical shear or solvent gradient field is of sufficient strength to change the spatial orientation of the microphase separated domains. Moreover, the spatial orientation of the immiscible microphase separated polymer domains affects the rate of release of the therapeutic agent from the medical device. Hence, the present invention is further directed to methods of modulating the rate of release of a therapeutic agent from a medical device. Other aspects of the invention are directed to medical devices fromed from the above techniques.
摘要翻译：本发明提供一种形成医疗装置的方法，其包括治疗剂和释放区域，其调节治疗剂从医疗装置释放的速率。该方法包括提供包含聚合物组合物的前体区域，该聚合物组合物包含彼此不混溶的两个或更多个微小间隔分离的聚合物区域，以及通过包括施加包括电场，磁场的取向场的方法形成所述释放区域，机械剪切场或溶剂梯度场，或两个或更多个场的组合与所述前体区域，其中所述场或场的组合改变了微相分离的聚合物区域在释放区域内的空间取向。电，磁，机械剪切或溶剂梯度场具有足够的强度来改变微相分离域的空间取向。此外，不混溶的微相分离的聚合物区域的空间取向影响治疗剂从医疗装置释放的速率。因此，本发明进一步涉及从医疗装置调节治疗剂释放速率的方法。本发明的其它方面涉及来自上述技术的医疗装置。

8. 发明申请

WO2006062975A2 ORIENTING POLYMER DOMAINS FOR CONTROLLED DRUG DELIVERY 审中-公开
标题翻译：定向聚合物领域用于控制药物递送
公开(公告)号：WO2006062975A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/044128
申请日：2005-12-07
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RANADE, Shrirang, V. , RICHARD, Robert, E. , DAO, Kinh-Luan (Lenny) , GIDO, Samuel, P. , ISAACS-SODEYE, Akinbode, Idowu
发明人： RANADE, Shrirang, V. , RICHARD, Robert, E. , DAO, Kinh-Luan (Lenny) , GIDO, Samuel, P. , ISAACS-SODEYE, Akinbode, Idowu
CPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/60 , A61L2300/602
摘要： The present invention provides a method for the formation of a medical device that comprises a therapeutic agent and a release region, which regulates the rate at which the therapeutic agent is released from the medical device. The method comprises providing a precursor region that comprises a polymer composition comprising two or more microphage separated polymer domains that are immiscible with one another, and forming said release region by a process that comprises applying an orienting field comprising an electric field, a magnetic field, a mechanical shear field, or a solvent gradient field, or a combination of two or more fields to said precursor region, wherein said field or combination of fields changes the spatial orientation of the microphase separated polymer domains within the release region. The electric, magnetic, mechanical shear or solvent gradient field is of sufficient strength to change the spatial orientation of the microphase separated domains. Moreover, the spatial orientation of the immiscible microphase separated polymer domains affects the rate of release of the therapeutic agent from the medical device. Hence, the present invention is further directed to methods of modulating the rate of release of a therapeutic agent from a medical device. Other aspects of the invention are directed to medical devices fromed from the above techniques.
摘要翻译：本发明提供一种形成医疗装置的方法，其包括治疗剂和释放区域，其调节治疗剂从医疗装置释放的速率。该方法包括提供包含聚合物组合物的前体区域，该聚合物组合物包含彼此不混溶的两个或更多个微小间隔分离的聚合物区域，以及通过包括施加包括电场，磁场的取向场的方法形成所述释放区域，机械剪切场或溶剂梯度场，或两个或更多个场的组合与所述前体区域，其中所述场或场的组合改变了微相分离的聚合物区域在释放区域内的空间取向。电，磁，机械剪切或溶剂梯度场具有足够的强度来改变微相分离域的空间取向。此外，不混溶的微相分离的聚合物区域的空间取向影响治疗剂从医疗装置释放的速率。因此，本发明进一步涉及从医疗装置调节治疗剂的释放速率的方法。本发明的其它方面涉及来自上述技术的医疗装置。

9. 发明申请

WO2006052538A3 METHOD OF INCORPORATING CARBON NANOTUBES IN A MEDICAL APPLIANCE, A CARBON NANOTUBE MEDICAL APPLIANCE, AND A MEDICAL APPLIANCE COATED USING CARBON NANOTUBE TECHNOLOGY 审中-公开
公开(公告)号：WO2006052538A3
公开(公告)日：2006-05-18
申请号：PCT/US2005/039460
申请日：2005-11-01
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RANADE, Shrirang V.
发明人： RANADE, Shrirang V.
IPC分类号： A61L31/16 , A61L27/30 , A61L29/10 , A61L27/54 , A61L29/16
摘要： A method of caoting an article is provided. The method includes: preparing a solution including a bioactive agent and a carbon nanotube precursor; treating the solution to form carbon nanotubes; and applying the solution to the article. A method of producing a medical device is provided. The method includes: forming a core of the medical device with a pattern on a surface of the core and assembling a multi-walled carbon nanotube array on the pattern on the surface. The pattern on the surface may determine an orientation of the multi-walled carbon nanotube array. A method of manufacturing a medical appliance is provided. The method includes creating a mixture of a carbon nanotube precursor and a polymer and injecting the mixture into a mold. The mold forms the mixture into a shape of the medical appliance. A method of forming a nanotube tissue scaffold is provided. The method includes forming a nanotube precursor and treating the nanotube precursor to form the nanotube tissue scaffold. The nanotube tissue scaffold is electrically conductive.

10. 发明申请

WO2005107828A2 IMPLANTABLE OR INSERTABLE MEDICAL ARTICLES HAVING COVALENTLY MODIFIED, BIOCOMPATIBLE SURFACES 审中-公开
标题翻译：具有共同修饰，生物化学表面的可植入或不可剥离的医疗用品
公开(公告)号：WO2005107828A2
公开(公告)日：2005-11-17
申请号：PCT/US2005/013212
申请日：2005-04-20
申请人： BOSTON SCIENTIFIC SCIMED, INC. , HELMUS, Michael, N. , RANADE, Shrirang, V.
发明人： HELMUS, Michael, N. , RANADE, Shrirang, V.
IPC分类号： A61L27/00
CPC分类号： A61L29/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2400/18
摘要： Implantable or insertable medical devices comprising a surface region that is modified by covalently coupling a molecular species (or a combination of molecular species) to the same. The molecular species are selected such that the resulting modified surface region has critical surface energy between (20) and (30) dynes/cm. In certain embodiments, the covalently coupled molecular species comprise one or more methyl groups. An advantage of the present invention is that novel medical devices are provided, which have a surface with a critical surface energy value that has been shown to display enhanced biocompatibility, including enhanced throboresistance, relative to other surfaces.
摘要翻译：可植入或可插入的医疗装置包括通过共价偶联分子种类（或分子种类的组合）而被修饰的表面区域。选择分子种类使得得到的改性表面区域具有在（20）和（30）达因/厘米之间的临界表面能。在某些实施方案中，共价偶联的分子种类包含一个或多个甲基。本发明的一个优点是提供了新的医疗装置，其具有表面具有临界表面能值，该表面已显示出相对于其它表面显示增强的生物相容性，包括增强的阻抗。

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