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    • 6. 发明申请
    • ANALYSIS METHOD
    • 分析方法
    • WO2008122805A1
    • 2008-10-16
    • PCT/GB2008/001250
    • 2008-04-10
    • SURESCREEN DIAGNOSTICS LIMITEDTRIMEGA LABORATORIES LIMITEDCAMPBELL, James, GordonSILKE, SuesseAVROM, Boris, Lasarow
    • CAMPBELL, James, GordonSILKE, SuesseAVROM, Boris, Lasarow
    • G01N33/92
    • G01N33/92G01N30/72
    • An analysis method consisting of the accurate determination of human fatty acid ethyl esters in hair, skin secretions and/or skin patches, toenails and fingernails by extraction and determination by gas chromatography/mass spectrometry or liquid chromatography/mass spectrometry to determine fatty acid ethyl esters (FAEE's) amongst others the concentrations of ethyl myristate, ethyl palmitate, ethyl oleate compared with deuterised internal standards which allow accurate quantification of these species, in conjunction with the determination of ethyl glucuronide (EtG) to show that the alcohol has been metabolized and is not from contamination with alcohol and comparison of individual levels of FAEE's with real-life data from alcohol consumers, and comparison of the cumulative sum of FAEE's with real-life data from alcohol consumers to give a reliable comparison to the amount of alcohol that has been consumed, whether overall or month by month or such other historical period as may be required from the sample.
    • 一种分析方法,包括通过提取和气相色谱/质谱或液相色谱/质谱法确定毛发,皮肤分泌物和/或皮肤贴片,脚趾甲和指甲中的人脂肪酸乙酯的精确测定,以测定脂肪酸乙酯 (FAEE)除了确定葡萄糖醛酸乙酯(EtG)以显示酒精已经被代谢并且是代谢之外,还有其他浓度的肉豆蔻酸乙酯,棕榈酸乙酯,油酸乙酯与氘代内标相比,可以准确定量这些物质 不受酒精污染,将FAEE的个人水平与酒精消费者的现实生活数据进行比较,并将FAEE与酒精消费者的现实生活数据的累积总和进行比较,以与酒精饮料的数量进行可靠的比较 无论是整体还是逐月消耗,或可能需要的其他历史时期 从样品中汲取。