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1. 发明申请

WO2006088771A9 APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES 审中-公开
标题翻译：用于分析身体液体样品的装置和方法
公开(公告)号：WO2006088771A9
公开(公告)日：2007-12-21
申请号：PCT/US2006004928
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORP , HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WESCHLER MARK , RULE PETER , KEENAN RICHARD
发明人： HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WESCHLER MARK , RULE PETER , KEENAN RICHARD
IPC分类号： A61B5/15 , A61B5/00 , A61M5/142 , A61M5/172 , G01N33/487
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid wh
摘要翻译：提供一种用于监测患者体液的预定参数的装置，

2. 发明申请

WO2006088792A3 METHOD AND APPARATUS FOR DETECTION OF MULTIPLE ANALYTES 审中-公开
标题翻译：用于检测多个分析仪的方法和装置
公开(公告)号：WO2006088792A3
公开(公告)日：2007-03-01
申请号：PCT/US2006005027
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORP , STERLING BERNHARD B , HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WECHSLER MARK , ZHENG PENG , RULE PETER , KEENAN RICHARD , KING RICHARD A
发明人： STERLING BERNHARD B , HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WECHSLER MARK , ZHENG PENG , RULE PETER , KEENAN RICHARD , KING RICHARD A
IPC分类号： A61B5/15
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： An apparatus (10) for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end (11) configured to maintain fluid communication with a bodily fluid in a patient and at least one pump (203) intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer (140) positioned to analyze at least a portion of the sample and measure the presence of two or more analytes . Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample. Disclosed are further means for separating plasma and serum and a spectroscopic analyzer.
摘要翻译：一种用于分析体液组成的装置（10）。该装置包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端部（11），以及间歇地可操作以从患者抽取体液样本的至少一个泵（203）。该装置还包括流体分析器（140），其定位成分析样品的至少一部分并测量两种或多种分析物的存在。还公开了一种用于分析患者体液组成的方法。该方法包括通过流体处理网络来绘制患者的体液样本，流体处理网络被配置为保持患者体内与体液的流体连通。该方法还包括在流体分析仪中分析样品的至少一部分以估计样品中两种或多种分析物的浓度。公开了用于分离血浆和血清和光谱分析仪的进一步手段。

3. 发明申请

WO2006091426A2 METHODS AND APPARATUS FOR EXTRACTING AND ANALYZING A BODILY FLUID 审中-公开
标题翻译：提取和分析一种体液的方法和装置
公开(公告)号：WO2006091426A2
公开(公告)日：2006-08-31
申请号：PCT/US2006/005112
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORPORATION , CALLICOAT, David N. , GABLE, Jennifer H. , BRAIG, James R. , LI, Kenneth I. , WITTE, Kenneth G. , WECHSLER, Mark , ZHENG, Peng , RULE, Peter , KEENAN, Richard , KING, Richard A.
发明人： CALLICOAT, David N. , GABLE, Jennifer H. , BRAIG, James R. , LI, Kenneth I. , WITTE, Kenneth G. , WECHSLER, Mark , ZHENG, Peng , RULE, Peter , KEENAN, Richard , KING, Richard A.
IPC分类号： A61B5/15 , A61M5/172
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , G06F19/00 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A method of extracting and analyzing bodily fluids from a patient at the point of care for the patient is provided. The method comprises establishing fluid communication between an analyte detection system 334, 1700 and a bodily fluid in the patient. A portion of the bodily fluid is drawn from the patient. The drawn portion is separated into a first component of the bodily fluid, while the analyte detection system 334, 1700 remains in fluid communication with the patient. The analyte detection system 334, 1700 analyzes the first component to measure a concentration of an analyte.
摘要翻译：提供了在患者护理点从患者提取和分析体液的方法。该方法包括建立分析物检测系统334,1700与患者体液之间的流体连通。体液的一部分从患者身上抽出。被拉伸的部分被分离成体液的第一组分，而分析物检测系统334,1700与患者保持流体连通。分析物检测系统334,1700分析第一组分以测量分析物的浓度。

4. 发明申请

WO2006088771A2 APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES 审中-公开
标题翻译：用于分析身体液体样品的装置和方法
公开(公告)号：WO2006088771A2
公开(公告)日：2006-08-24
申请号：PCT/US2006004928
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORP , HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WESCHLER MARK , RULE PETER , KEENAN RICHARD
发明人： HALL W DALE , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , WITTE KENNETH G , WESCHLER MARK , RULE PETER , KEENAN RICHARD
IPC分类号： A61B5/15 , A61B5/00 , A61M5/172 , G01N33/487
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength ?. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.
摘要翻译：提供了一种用于在将输注液注入患者体内时监测患者体液的预定参数的装置。该装置包括输注管线和构造成用于插入患者血管的导管以及连接在输注液源和输注管线和导管之间的可逆输液泵。该装置还包括体液传感器组件，其安装成与输注管线流体连通并且包括第一传感器和样品池。第一传感器提供指示输注管线中存在的任何流体的预定参数的信号。样品池对于包含波长λ的光是基本上透射的。所述装置还包括控制器，所述控制器被配置为沿向前方向操作所述输注泵，以便将所述输注流体泵送通过所述输注管线和导管以输注到所述患者体内。控制器被配置为间歇地中断其在向前方向上的输液泵的操作，以在向后的方向上操作输注泵，以便通过导管和输注管线从患者抽取体液样品。从患者抽出的体液样品被设置成使得体液样品的第一部分与体液传感器组件的第一传感器感测接触，并且体液样品的第二部分设置在样品池内的体液传感器组件。控制器还被配置为监测由体液传感器组件的第一传感器提供的信号，并且检测指示体液样品到达第一传感器的信号的变化。响应于检测体液样品到达第一传感器，控制器被配置为在向后的方向停止输注泵的操作。当体液样品与第一传感器感测接触时，由第一传感器产生的信号提供患者体液的预定参数的指示。

5. 发明申请

WO2011156522A1 MEASURING ANALYTES IN A FLUID SAMPLE DRAWN FROM A PATIENT 审中-公开
标题翻译：在患者的流体样品中测量分析物
公开(公告)号：WO2011156522A1
公开(公告)日：2011-12-15
申请号：PCT/US2011/039674
申请日：2011-06-08
申请人： OPTISCAN BIOMEDICAL CORPORATION , BRAIG, James, R. , RULE, Peter , KEENAN, Richard , CALLICOAT, David, N.
发明人： BRAIG, James, R. , RULE, Peter , KEENAN, Richard , CALLICOAT, David, N.
IPC分类号： G01N33/49 , G01N21/35 , A61B5/15
CPC分类号： G01N33/491 , A61B5/1427 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1495 , A61B5/150022 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150801 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B5/7275 , A61B2560/0223 , A61B2560/0233 , A61B2560/0437 , A61B2560/0443 , A61B2562/0238 , A61B2562/08 , G01N21/35 , G01N2021/3174 , G01N2201/1215 , G01N2201/1293 , G06F19/00
摘要： A first analyte (e.g. hemoglobin) can be measured in a sample (e.g. whole blood) before the sample is separated into its components (e.g. plasma, red blood cells, etc.), and a second analyte (e.g. glucose) can be measured in a component (e.g. plasma) of the sample after separation.
摘要翻译：在将样品分离成其组分（例如血浆，红细胞等）之前，可以在样品（例如全血）中测量第一分析物（例如血红蛋白），并且可以在第分离后的样品的组分（例如等离子体）。

6. 发明申请

WO2009008892A1 ACCURATE AND TIMELY BODY FLUID ANALYSIS 审中-公开
标题翻译：精确和及时的体液分析
公开(公告)号：WO2009008892A1
公开(公告)日：2009-01-15
申请号：PCT/US2007/076050
申请日：2007-08-15
申请人： OPTISCAN BIOMEDICAL CORPORATION , KEENAN, Richard , CHIOU, Jeff , TONG, Roger , RECKNOR, Michael , LI, Ken, I. , BRAIG, James, R. , CALLICOAT, David, N. , GABLE, Jennifer, H.
发明人： KEENAN, Richard , CHIOU, Jeff , TONG, Roger , RECKNOR, Michael , LI, Ken, I. , BRAIG, James, R. , CALLICOAT, David, N. , GABLE, Jennifer, H.
IPC分类号： G01N21/35 , A61B5/00
CPC分类号： G01N35/1095 , A61B5/14532 , A61B5/14557 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150267 , A61B5/150305 , A61B5/150755 , A61B5/150786 , A61B5/150824 , A61B5/153 , A61B5/157 , A61M1/3621 , A61M5/14 , A61M5/1415 , A61M2005/1404 , A61M2005/1726 , A61M2230/201 , B01L3/502 , B01L3/50273 , B01L3/52 , B01L2200/10 , B01L2300/0816 , B01L2400/0478 , B01L2400/0633 , G01N21/35
摘要： A method of extracting and analyzing bodily fluids from a patient at the point of care for the patient is provided. The method comprises establishing fluid communication between an analyte detection system and a bodily fluid in the patient. A portion of the bodily fluid is drawn from the patient. A first component of the bodily fluid is separated from the drawn portion, while the analyte detection system remains in fluid communication with the patient. The analyte detection system analyzes the first component to measure a concentration of an analyte in an accurate and timely manner.
摘要翻译：提供了在患者护理点从患者提取和分析体液的方法。该方法包括在患者体内建立分析物检测系统和体液之间的流体连通。体液的一部分从患者身上抽出。分析物检测系统与患者保持流体连通，将体液的第一组分与拉出部分分离。分析物检测系统分析第一个成分，以准确和及时的方式测量分析物的浓度。

7. 发明申请

WO2006091426A3 METHODS AND APPARATUS FOR EXTRACTING AND ANALYZING A BODILY FLUID 审中-公开
标题翻译：提取和分析一种体液的方法和装置
公开(公告)号：WO2006091426A3
公开(公告)日：2007-04-19
申请号：PCT/US2006005112
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORP , CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , LI KENNETH I , WITTE KENNETH G , WECHSLER MARK , ZHENG PENG , RULE PETER , KEENAN RICHARD , KING RICHARD A
发明人： CALLICOAT DAVID N , GABLE JENNIFER H , BRAIG JAMES R , LI KENNETH I , WITTE KENNETH G , WECHSLER MARK , ZHENG PENG , RULE PETER , KEENAN RICHARD , KING RICHARD A
IPC分类号： A61B5/15 , A61M5/172
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A method of extracting and analyzing bodily fluids from a patient at the point of care for the patient is provided. The method comprises establishing fluid communication between an analyte detection system 334, 1700 and a bodily fluid in the patient. A portion of the bodily fluid is drawn from the patient. The drawn portion is separated into a first component of the bodily fluid, while the analyte detection system 334, 1700 remains in fluid communication with the patient. The analyte detection system 334, 1700 analyzes the first component to measure a concentration of an analyte.
摘要翻译：提供了在患者护理点从患者提取和分析体液的方法。该方法包括建立分析物检测系统334,1700与患者体液之间的流体连通。体液的一部分从患者身上抽出。被拉伸的部分被分离成体液的第一组分，而分析物检测系统334,1700与患者保持流体连通。分析物检测系统334,1700分析第一组分以测量分析物的浓度。

8. 发明申请

WO2006088792A2 METHOD AND APPARATUS FOR DETECTION OF MULTIPLE ANALYTES 审中-公开
标题翻译：用于检测多个分析仪的方法和装置
公开(公告)号：WO2006088792A2
公开(公告)日：2006-08-24
申请号：PCT/US2006/005027
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORPORATION , STERLING, Bernhard, B. , HALL, W., Dale , CALLICOAT, David, N. , GABLE, Jennifer, H. , BRAIG, James, R. , WITTE, Kenneth, G. , WECHSLER, Mark , ZHENG, Peng , RULE, Peter , KEENAN, Richard , KING, Richard, A.
发明人： STERLING, Bernhard, B. , HALL, W., Dale , CALLICOAT, David, N. , GABLE, Jennifer, H. , BRAIG, James, R. , WITTE, Kenneth, G. , WECHSLER, Mark , ZHENG, Peng , RULE, Peter , KEENAN, Richard , KING, Richard, A.
IPC分类号： A61B5/15
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and at least one pump intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer positioned to analyze at least a portion of the sample and measure the presence of two or more analytes. Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample.
摘要翻译：一种用于分析体液组成的装置。该装置包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端以及间歇地可操作以从患者抽取体液样本的至少一个泵。该装置还包括流体分析器，定位成分析样品的至少一部分并测量两种或多种分析物的存在。还公开了一种用于分析患者体液组成的方法。该方法包括通过流体处理网络来绘制患者的体液样本，流体处理网络被配置为保持患者体内与体液的流体连通。该方法还包括在流体分析仪中分析样品的至少一部分以估计样品中两种或多种分析物的浓度。

9. 发明申请

WO2006088771A3 APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES 审中-公开
公开(公告)号：WO2006088771A3
公开(公告)日：2006-08-24
申请号：PCT/US2006/004928
申请日：2006-02-13
申请人： OPTISCAN BIOMEDICAL CORPORATION , HALL, W., Dale , CALLICOAT, David, N. , GABLE, Jennifer, H. , BRAIG, James, R. , WITTE, Kenneth, G. , WESCHLER, Mark , RULE, Peter , KEENAN, Richard
发明人： HALL, W., Dale , CALLICOAT, David, N. , GABLE, Jennifer, H. , BRAIG, James, R. , WITTE, Kenneth, G. , WESCHLER, Mark , RULE, Peter , KEENAN, Richard
IPC分类号： A61B5/15 , A61M5/172 , A61B5/00 , G01N33/487 , A61M5/142
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient (6011). The apparatus comprises an infusion line (6017) and a catheter (6021) configured for insertion into a blood vessel of the patient (6011) , and a reversible infusion pump (6013) connected between a source (6015) of an infusion fluid and the infusion line (6017) and catheter (6021). The apparatus further comprises a body fluid sensor assembly (6019) mounted in fluid communication with the infusion line (6017) and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line (6017). The apparatus further comprises a controller (6023) that is configured to operate the infusion pump (6013) in a forward direction so as to pump the infusion fluid through the infusion line (6017) and catheter (6021) for infusion into the patient (6011). The controller is figured to intermittently interrupt its operating of the infusion pump (6013) in the forward direction to operate the infusion pump (6013) in a rearward direction to operate the infusion pump (6013) in a rearward direction so as to draw a body fluid sample from the patient (6011) through the catheter (6021) and infusion line (6017). The controller (6023), in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump (6013) in the rearward direction.

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