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1. 发明申请

WO2007055735A3 HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：水解物，核酸编码方法及其使用方法
公开(公告)号：WO2007055735A3
公开(公告)日：2008-10-02
申请号：PCT/US2006020169
申请日：2006-05-23
申请人： VERENIUM CORP , MATHUR ERIC , CALLEN WALTER , FIELDING RODERICK
发明人： MATHUR ERIC , CALLEN WALTER , FIELDING RODERICK
IPC分类号： C12P21/06 , C07H21/04 , C12N9/20
CPC分类号： C12N9/14
摘要： The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phospholipase A, B, C and/or D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds). The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts, including the manufacture of cosmetics and nutraceuticals. In another aspect, the polypeptides of the invention are used to synthesize enantiomerically pure chiral products.
摘要翻译：本发明提供水解酶，编码它们的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明涉及具有水解酶活性的多肽，例如酯酶，酰基转移酶，脂肪酶，磷脂酶（例如，磷脂酶A，B，C和/或D活性，patatin活性，脂质酰基水解酶（LAH）活性）或蛋白酶活性，包括热稳定和耐热水解酶活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的多肽和肽的水解酶活性包括酯酶活性，脂肪酶活性（脂质水解），酸解反应（用游离脂肪酸代替酯化脂肪酸），酯交换反应（甘油三酸酯之间的脂肪酸交换），酯合成，酯交换反应，磷脂酶活性和蛋白酶活性（肽键的水解）。本发明的多肽可用于各种药物，农业和工业环境中，包括制造化妆品和营养品。另一方面，本发明的多肽用于合成对映体纯的手性产物。

2. 发明申请

WO2003106654A3 XYLANASES, NUCLEIC ADICS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
公开(公告)号：WO2003106654A3
公开(公告)日：2003-12-24
申请号：PCT/US2003/019153
申请日：2003-06-16
申请人： DIVERSA CORPORATION , STEER, Brian , CALLEN, Walter , HEALEY, Shaun , HAZLEWOOD, Geoff , WU, Di , BLUM, David , ESTEGHLALIAN, Alireza
发明人： STEER, Brian , CALLEN, Walter , HEALEY, Shaun , HAZLEWOOD, Geoff , WU, Di , BLUM, David , ESTEGHLALIAN, Alireza
IPC分类号： C12N15/56
摘要： The invention relates to xylanases and to polynucleotides encoding the xylanases. In addition, methods of designing new xylanases and methods of use thereof are also provided. The xylanases have increased activity and stability at increased pH and temperature.

3. 发明申请

WO2003083054A2 AMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：氨基酸，编码它们的核酸及其制备和使用它们的方法
公开(公告)号：WO2003083054A2
公开(公告)日：2003-10-09
申请号：PCT/US2003/008906
申请日：2003-03-24
申请人： DIVERSA CORPORATION , CALLEN, Walter , RICHARDSON, Toby , FREY, Gerhard , MILLER, Carl, A. , KAZAOKA, Martin , MATHUR, Eric , SHORT, Jay, M.
发明人： CALLEN, Walter , RICHARDSON, Toby , FREY, Gerhard , MILLER, Carl, A. , KAZAOKA, Martin , MATHUR, Eric , SHORT, Jay, M.
IPC分类号： C12N
CPC分类号： C12N9/2417 , C12P19/14
摘要： In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of starch into 10 sugars.
摘要翻译：一方面，本发明涉及具有淀粉酶活性的多肽，编码多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明的多肽可用作淀粉酶，例如α-淀粉酶，以催化淀粉水解成10个糖。

4. 发明申请

WO2005003319A3 GLUCANASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：葡萄糖，编码它们的核酸及其制备和使用它们的方法
公开(公告)号：WO2005003319A3
公开(公告)日：2008-10-16
申请号：PCT/US2004021492
申请日：2004-07-02
申请人： DIVERSA CORP , STEER BRIAN , CALLEN WALTER , HEALEY SHAUN , PULLIAM DERRICK
发明人： STEER BRIAN , CALLEN WALTER , HEALEY SHAUN , PULLIAM DERRICK
IPC分类号： C07H21/04 , A23K1/00 , A23K1/165 , A23K1/18 , C12N20060101 , C12N9/24 , C12N9/42 , C12P21/06
CPC分类号： C12N9/2405 , A23C9/1322 , A23C19/04 , A23K10/14 , A23K20/189 , A23K40/10 , A23K50/10 , A23L2/52 , A23L29/10 , A23L33/18 , A23V2002/00 , A61K9/0056 , A61K38/47 , C09K8/62 , C11D3/38636 , C12N9/2437 , C12N11/02 , C12N11/14 , C12N11/16 , C12P7/10 , C12P19/02 , C12P19/18 , C12Y302/01004 , D21C1/00 , D21C5/005 , G01N33/53 , G01N33/573 , G01N2333/924 , G01N2500/00 , Y02E50/16 , Y02E50/17
摘要： The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e.g., endo-1,4-beta-D-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-D-glycosidic linkages in cellulose, cellulose derivatives (e.g., carboxy methyl cellulose and hydroxy ethyl cellulose) lichenin, beta-1,4 bonds in mixed beta-1,3 glucans, such as cereal beta-D-glucans or xyloglucans and other plant material containing cellulosic parts. In addition, methods of designing new enzymes and methods of use thereof are also provided. In alternative aspects, the new glucanases e.g., endoglucanases, mannanases, xylanases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及具有葡聚糖酶的多肽，例如内切葡聚糖酶，甘露聚糖酶，木聚糖酶活性或这些活性的组合，以及编码它们的多核苷酸。一方面，葡聚糖酶活性是内切葡聚糖酶活性（例如内切-1,4-β-D-葡聚糖4-葡聚糖水解酶活性），并且包括在纤维素，纤维素衍生物中水解1,4-β-D-糖苷键（例如，羧甲基纤维素和羟乙基纤维素）地衣淀粉，混合的β-1,3葡聚糖中的β-1,4键，例如谷类β-D-葡聚糖或木葡聚糖和含有纤维素部分的其它植物材料。此外，还提供了设计新酶的方法及其使用方法。在替代方面，新葡聚糖酶例如内切葡聚糖酶，甘露聚糖酶，木聚糖酶在增加的pH和温度下具有增加的活性和稳定性。

5. 发明申请

WO2004044129A3 XYLOSE ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： XYLOSE异构体，编码它们的核酸及其制备和使用它们的方法
公开(公告)号：WO2004044129A3
公开(公告)日：2007-09-13
申请号：PCT/US0334008
申请日：2003-10-23
申请人： DIVERSA CORP , CALLEN WALTER
发明人： CALLEN WALTER
IPC分类号： C12N9/92 , C12P19/02
CPC分类号： C12P19/02 , A01K2217/05 , C12N9/92
摘要： In one aspect, the invention provides xylose isomerase enzymes, polynucleotides encoding the enzymes, methods of making and using these polynucleotidesand polypeptides. The polypeptides of the invention can be used in a variety of agricultural and industrial contexts. For example, the polypeptides of the invention can be used for converting glucose to fructose or for manufacturing high content fructose syrups in large quantities. Other examples include use of the polypetides of the invention in confectionary, brewing, alcohol and soft drinks production, and in diabetic foods and sweetners.
摘要翻译：一方面，本发明提供木糖异构酶，编码酶的多核苷酸，制备和使用这些多核苷酸和多肽的方法。本发明的多肽可用于各种农业和工业环境。例如，本发明的多肽可用于将葡萄糖转化为果糖或大量制造高含量果糖糖浆。其他实例包括在糖果，酿造，酒精和软饮料生产中使用本发明的多肽，以及在糖尿病食品和甜味剂中的使用。

6. 发明申请

WO2007092314A2 ESTERASES AND RELATED NUCLEIC ACIDS AND METHODS 审中-公开
标题翻译：酯和相关核酸和方法
公开(公告)号：WO2007092314A2
公开(公告)日：2007-08-16
申请号：PCT/US2007/002904
申请日：2007-02-02
申请人： DIVERSA CORPORATION , MATHUR, Eric, J. , CALLEN, Walter , FIELDING, Roderick
发明人： MATHUR, Eric, J. , CALLEN, Walter , FIELDING, Roderick
CPC分类号： C12N9/14 , Y02E50/16
摘要： The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phosphplipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds). The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts, including the manufacture of cosmetics and nutraceuticals. In another aspect, the polypeptides of the invention are used to synthesize enantiomerically pure chiral products.
摘要翻译：本发明提供水解酶，编码它们的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明涉及具有水解酶活性的多肽，例如酯酶，酰基转移酶，脂肪酶，磷脂酶（例如磷脂酰酶A，B，C和D活性，patatin活性，脂质酰基水解酶（ LAH）活性）或蛋白酶活性，包括耐热和耐热水解酶活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的多肽和肽的水解酶活性包括酯酶活性，脂肪酶活性（脂质水解），酸解反应（用游离脂肪酸代替酯化脂肪酸），酯交换反应（甘油三酸酯之间的脂肪酸交换），酯合成，酯交换反应，磷脂酶活性和蛋白酶活性（肽键的水解）。本发明的多肽可用于各种药物，农业和工业环境中，包括制造化妆品和营养品。另一方面，本发明的多肽用于合成对映体纯的手性产物。

7. 发明申请

WO2002068597A2 ENZYMES HAVING ALPHA AMYLASE ACTIVITY AND METHODS OF USE THEREOF 审中-公开
标题翻译：具有ALPHA AMYLASE活性的酶及其使用方法
公开(公告)号：WO2002068597A2
公开(公告)日：2002-09-06
申请号：PCT/US2002/005538
申请日：2002-02-21
申请人： DIVERSA CORPORATION , CALLEN, Walter , RICHARDSON, Toby , FREY, Gerhard , MILLER, Carl , KAZAOKA, Martin , MATHUR, Eric, J. , SHORT, Jay, M.
发明人： CALLEN, Walter , RICHARDSON, Toby , FREY, Gerhard , MILLER, Carl , KAZAOKA, Martin , MATHUR, Eric, J. , SHORT, Jay, M.
IPC分类号： C12N
CPC分类号： C12N9/2417 , A21D8/042 , C12N9/2414 , C12P19/04 , C12P19/14 , C12Y302/01001 , Y02E50/16 , Y02E50/17
摘要： The invention relates to alpha amylates and to polynucleotides encoding the alpha amylases. In addition methods of designing new alpha amylases and methods of use thereof are also provided. The alpha amylases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及α-淀粉酶和编码α-淀粉酶的多核苷酸。另外还提供了设计新的α-淀粉酶的方法及其使用方法。 α淀粉酶在增加的pH和温度下具有增加的活性和稳定性。

8. 发明申请

WO2004091544A9 AMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：氨基酸，编码它们的核酸及其制备和使用它们的方法
公开(公告)号：WO2004091544A9
公开(公告)日：2009-08-13
申请号：PCT/US2004007096
申请日：2004-03-08
申请人： DIVERSA CORP , CALLEN WALTER , RICHARDSON TOBY , FREY GERHARD , GRAY KEVIN , KEROVUO JANNE S , SLUPSKA MATGORZATA , BARTON NELSON , O'DONOGHUE EILEEN , MILLER CARL
发明人： CALLEN WALTER , RICHARDSON TOBY , FREY GERHARD , GRAY KEVIN , KEROVUO JANNE S , SLUPSKA MATGORZATA , BARTON NELSON , O'DONOGHUE EILEEN , MILLER CARL
IPC分类号： C12N15/56 , C12N1/15 , C12N1/21 , C12N5/10 , C12N9/26 , C12N9/28 , C12N15/11 , C12N15/63 , C12Q1/68
CPC分类号： A21D8/042 , A61K38/00 , C12C5/004 , C12N9/2411 , C12N9/2414 , C12N9/2428 , C12P19/14 , C12P19/16 , C12P19/20 , Y02E50/17
摘要： In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of starch into sugars. In one aspect, the invention provides delayed release compositions comprising an desired ingredient coated by a latex polymer coating.
摘要翻译：一方面，本发明涉及具有淀粉酶活性的多肽，编码多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一个方面，本发明的多肽可用作淀粉酶，例如α-淀粉酶，以催化淀粉水解成糖。一方面，本发明提供包含通过胶乳聚合物涂层涂覆的所需成分的延迟释放组合物。

9. 发明申请

WO2007055735A2 HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：水解物，核酸编码方法及其使用方法
公开(公告)号：WO2007055735A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/020169
申请日：2006-05-23
申请人： DIVERSA CORPORATION , MATHUR, Eric , CALLEN, Walter , FIELDING, Roderick
发明人： MATHUR, Eric , CALLEN, Walter , FIELDING, Roderick
IPC分类号： C12N9/14
CPC分类号： C12N9/14
摘要： The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phospholipase A, B, C and/or D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds). The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts, including the manufacture of cosmetics and nutraceuticals. In another aspect, the polypeptides of the invention are used to synthesize enantiomerically pure chiral products.
摘要翻译：本发明提供水解酶，编码它们的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。一方面，本发明涉及具有水解酶活性的多肽，例如酯酶，酰基转移酶，脂肪酶，磷脂酶（例如，磷脂酶A，B，C和/或D活性，patatin活性，脂质酰基水解酶（LAH）活性）或蛋白酶活性，包括热稳定和耐热水解酶活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。本发明的多肽和肽的水解酶活性包括酯酶活性，脂肪酶活性（脂质水解），酸解反应（用游离脂肪酸代替酯化脂肪酸），酯交换反应（甘油三酸酯之间的脂肪酸交换），酯合成，酯交换反应，磷脂酶活性和蛋白酶活性（肽键的水解）。本发明的多肽可用于各种药物，农业和工业环境中，包括制造化妆品和营养品。另一方面，本发明的多肽用于合成对映体纯的手性产物。

10. 发明申请

WO2005003319A2 GLUCANASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：葡萄糖，编码它们的核酸及其制备和使用它们的方法
公开(公告)号：WO2005003319A2
公开(公告)日：2005-01-13
申请号：PCT/US2004/021492
申请日：2004-07-02
申请人： DIVERSA CORPORATION , STEER, Brian , CALLEN, Walter , HEALEY, Shaun , PULLIAM, Derrick
发明人： STEER, Brian , CALLEN, Walter , HEALEY, Shaun , PULLIAM, Derrick
IPC分类号： C12N
CPC分类号： C12N9/2405 , A23C9/1322 , A23C19/04 , A23K10/14 , A23K20/189 , A23K40/10 , A23K50/10 , A23L2/52 , A23L29/10 , A23L33/18 , A23V2002/00 , A61K9/0056 , A61K38/47 , C09K8/62 , C11D3/38636 , C12N9/2437 , C12N11/02 , C12N11/14 , C12N11/16 , C12P7/10 , C12P19/02 , C12P19/18 , C12Y302/01004 , D21C1/00 , D21C5/005 , G01N33/53 , G01N33/573 , G01N2333/924 , G01N2500/00 , Y02E50/16 , Y02E50/17
摘要： The invention relates to polypeptides having glucanase, e.g., endoglucanase, mannanase, xylanase activity or a combination of these activities, and polynucleotides encoding them. In one aspect, the glucanase activity is an endoglucanase activity (e.g., endo-1,4-beta-D-glucan 4-glucano hydrolase activity) and comprises hydrolysis of 1,4-beta-D-glycosidic linkages in cellulose, cellulose derivatives (e.g., carboxy methyl cellulose and hydroxy ethyl cellulose) lichenin, beta-1,4 bonds in mixed beta-1,3 glucans, such as cereal beta-D-glucans or xyloglucans and other plant material containing cellulosic parts. In addition, methods of designing new enzymes and methods of use thereof are also provided. In alternative aspects, the new glucanases e.g., endoglucanases, mannanases, xylanases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及具有葡聚糖酶的多肽，例如内切葡聚糖酶，甘露聚糖酶，木聚糖酶活性或这些活性的组合，以及编码它们的多核苷酸。一方面，葡聚糖酶活性是内切葡聚糖酶活性（例如内切-1,4-β-D-葡聚糖4-葡聚糖水解酶活性），并且包括在纤维素，纤维素衍生物中水解1,4-β-D-糖苷键（例如，羧甲基纤维素和羟乙基纤维素）地衣淀粉，混合的β-1,3葡聚糖中的β-1,4键，例如谷类β-D-葡聚糖或木葡聚糖和含有纤维素部分的其它植物材料。此外，还提供了设计新酶的方法及其使用方法。在替代方面，新葡聚糖酶例如内切葡聚糖酶，甘露聚糖酶，木聚糖酶在增加的pH和温度下具有增加的活性和稳定性。

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