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1. 发明申请

WO2010104577A3 METHODS AND KITS FOR TREATING JOINTS AND SOFT TISSUES 审中-公开
标题翻译：治疗关节和软组织的方法和工具
公开(公告)号：WO2010104577A3
公开(公告)日：2010-12-23
申请号：PCT/US2010000726
申请日：2010-03-11
申请人： SPINAL RESTORATION INC , THORNE KEVIN , BURKINSHAW BRIAN
发明人： THORNE KEVIN , BURKINSHAW BRIAN
IPC分类号： A61P19/00 , A61K38/36 , A61L27/22
CPC分类号： A61L24/106 , A61K35/58 , A61K38/363 , A61K45/06 , A61L2400/06 , A61K2300/00
摘要： Methods to treat and provide pain relief for damaged and degenerated tissues of a musculoskeletal joint are disclosed. These methods include introducing into, around and/or on the musculoskeletal joint an effective amount of biocompatible matrix or biocompatible polymeric compound to reduce pain associated with the damaged and degenerated tissues of a musculoskeletal joint, wherein at least a portion of it is activated and polymerized in situ. Examples of the musculoskeletal joints include intervertebral joints and synovial joints.
摘要翻译：公开了治疗和提供肌肉骨骼关节损伤和退化的组织的疼痛缓解的方法。这些方法包括向肌肉骨骼关节内，周围和/或上方引入有效量的生物相容性基质或生物相容性聚合物，以减少与肌肉骨骼关节的受损和退化的组织相关的疼痛，其中至少一部分活化和聚合在原地。肌肉骨骼关节的例子包括椎间关节和滑膜关节。

2. 发明申请

WO2010104578A1 METHODS FOR TREATING SOFT TISSUE DAMAGE ASSOCIATED WITH A SURGICAL PROCEDURE 审中-公开
标题翻译：治疗与手术相关的软组织损伤的方法
公开(公告)号：WO2010104578A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/000727
申请日：2010-03-11
申请人： SPINAL RESTORATION, INC. , THORNE, Kevin , BURKINSHAW, Brian
发明人： THORNE, Kevin , BURKINSHAW, Brian
IPC分类号： A61L24/10 , A61L27/22 , A61L27/58
CPC分类号： A61L24/106 , A61K35/58 , A61K38/363 , A61K45/06 , A61K2300/00
摘要： Methods for treating soft tissue damage associated with a surgical procedure and enhancing pain relief by accelerating the repair of painful disruptions associated with damaged and/or degenerated synovial joints and spinal discs are disclosed. The methods include injecting an effective amount of a biocompatible matrix or biocompatible polymeric compound into a soft tissue that is damaged or at the risk of being damaged during a surgical procedure.
摘要翻译：公开了用于治疗与外科手术相关的软组织损伤并通过加速与损伤和/或退化的滑膜关节和脊椎盘相关的疼痛中断的修复来增强疼痛缓解的方法。所述方法包括将有效量的生物相容性基质或生物相容性聚合物注射到被损坏或在外科手术过程中被损坏的风险中的软组织中。

3. 发明申请

WO2007089942A2 FIBRIN SEALANT DELIVERY DEVICE INCLUDING PRESSURE MONITORING, AND METHODS AND KITS THEREOF 审中-公开
标题翻译：包括压力监测的FIBRIN密封剂输送装置及其方法和工具
公开(公告)号：WO2007089942A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/002998
申请日：2007-02-01
申请人： SPINAL RESTORATION, INC. , RICHARDS, Mark, I. , BURKINSHAW, Brian, D. , PAUZA, Kevin, B. , ROGAN, James, B.
发明人： RICHARDS, Mark, I. , BURKINSHAW, Brian, D. , PAUZA, Kevin, B. , ROGAN, James, B.
IPC分类号： A61M5/19
CPC分类号： A61B17/00491 , A61B2017/00495 , A61B2090/064 , A61M5/19 , A61M5/2425 , A61M5/31575 , A61M5/3158 , A61M5/31581 , A61M5/31585 , A61M5/31593 , A61M5/31596 , A61M5/486 , A61M25/0032 , A61M2005/3114 , A61M2005/3152 , A61M2005/3201
摘要： Apparatus for delivering biologic sealant device that includes a pressure monitor coupled to the delivery device to measure pressure within the device. A method of treating a disc using the device as well as a kit including the device is described.
摘要翻译：用于输送生物密封剂装置的装置，其包括耦合到输送装置的压力监测器，以测量装置内的压力。描述使用该装置处理盘的方法以及包括该装置的套件。

4. 发明申请

WO2014124453A3 UNITARY SPINAL DISC IMPLANT 审中-公开
标题翻译：单位脊椎椎间盘植入物
公开(公告)号：WO2014124453A3
公开(公告)日：2014-11-20
申请号：PCT/US2014015850
申请日：2014-02-11
申请人： BURKINSHAW BRIAN , STUPKA JONATHAN
发明人： BURKINSHAW BRIAN , STUPKA JONATHAN
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61F2/442 , A61F2/4465 , A61F2002/30205 , A61F2002/3021 , A61F2002/30217 , A61F2002/30224 , A61F2002/30227 , A61F2002/30235 , A61F2002/30448 , A61F2002/30563 , A61F2002/30604 , A61F2002/30616 , A61F2002/30769 , A61F2002/30772 , A61F2002/30795 , A61F2002/30841 , A61F2002/30906 , A61F2002/3093
摘要： A unitary intervertebral device, having no moving components is provided for non-fusion articulation applications. The interbody articulating device allows for limited flexion and rotation between adjacent vertebrae, helping to preserve or restore near-normal motion between adjacent vertebrae. Rotational motion is achieved through one or more protrusions incorporated into the spinal interbody device. In one articulating form, a first protrusion extends perpendicularly from the superior aspect of the disc-shaped interbody device to form a spike or rotational protrusion, while a second protrusion extends axially from the inferior aspect of the interbody device to form a second spike or rotational protrusion. Protrusions preferably extend perpendicular from the apex of both the first and second arcuate articulating surfaces.
摘要翻译：为非融合关节应用提供了没有移动部件的单一椎间装置。椎间关节运动装置允许相邻椎骨之间有限的弯曲和旋转，有助于保持或恢复相邻椎骨之间的近正常运动。通过结合到脊椎体间装置中的一个或多个突起实现旋转运动。在一个铰接形式中，第一突起从盘形体间装置的上部垂直方向延伸以形成尖头或旋转突起，而第二突起从该体间装置的下部方向轴向延伸以形成第二尖峰或旋转突出。突起优选地从第一和第二弓形铰接表面的顶点垂直延伸。

5. 发明申请

WO2010151281A1 METHODS AND KITS FOR TREATING JOINTS AND SOFT TISSUES 审中-公开
标题翻译：治疗关节和软组织的方法和工具
公开(公告)号：WO2010151281A1
公开(公告)日：2010-12-29
申请号：PCT/US2010/000724
申请日：2010-03-11
申请人： SPINAL RESTORATION, INC. , THORNE, Kevin , BURKINSHAW, Brian
发明人： THORNE, Kevin , BURKINSHAW, Brian
IPC分类号： A61K31/573 , A61L24/10 , A61K9/00 , A61P29/00 , A61P23/02 , A61P5/44
CPC分类号： A61K31/573 , A61K9/0019 , A61K9/0024 , A61K9/1641 , A61K9/1658 , A61K9/19 , A61K31/00 , A61K31/56 , A61K35/58 , A61K38/363 , A61K45/06 , A61L24/106 , A61L27/18 , A61L27/225 , A61L27/54 , A61L2300/222 , A61L2300/402 , A61L2300/45 , A61L2300/604 , A61L2300/622 , A61L2300/802 , A61L2400/06 , A61L2430/24 , C08L73/02 , A61K2300/00
摘要： Methods to treat and provide pain relief for damaged and degenerated tissues of a musculoskeletal joint are disclosed. These methods include introducing into, around and/or on the musculoskeletal joint an effective amount of a pharmaceutical composition containing a biocompatible matrix or biocompatible polymeric compound, a pain reliever, and a corticosteroid formulated for extended-release, wherein at least a portion of the biocompatible matrix or biocompatible polymeric compound is activated and polymerized in situ . Also disclosed is a composition for treating a damaged or degenerated joint or soft tissue. The composition contains a polymerizable material capable of forming a biocompatible and biodegradable matrix in situ at a treatment site, a pain reliever; and a corticosteroid formulated for extended-release.
摘要翻译：公开了治疗和提供肌肉骨骼关节损伤和退化的组织的疼痛缓解的方法。这些方法包括向肌肉骨骼关节内，周围和/或上部引入有效量的含有生物相容性基质或生物相容性聚合物的药物组合物，止痛药和配制用于延长释放的皮质类固醇，其中至少一部分生物相容性基质或生物相容性聚合物被原位活化和聚合。还公开了用于治疗损伤或退化的关节或软组织的组合物。该组合物含有能够在治疗部位就地形成生物相容性和可生物降解的基质的可聚合材料，即止痛剂; 和配制用于延长释放的皮质类固醇。

6. 发明申请

WO2010104576A1 METHODS FOR TREATING JOINTS AND DISCS WITH A CARRIER MATRIX AND CELLS 审中-公开
标题翻译：用载体矩阵和细胞处理接头和圆盘的方法
公开(公告)号：WO2010104576A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/000725
申请日：2010-03-11
申请人： SPINAL RESTORATION, INC. , THORNE, Kevin , BURKINSHAW, Brian
发明人： THORNE, Kevin , BURKINSHAW, Brian
IPC分类号： A61P19/00 , A61K38/36 , A61L27/22
CPC分类号： A61L27/3856 , A61K35/58 , A61K38/363 , A61K45/06 , A61L24/106 , A61L27/14 , A61L27/3804 , A61L27/3852 , A61L27/58 , A61L2400/06 , A61K2300/00
摘要： Methods for enhancing pain relief and accelerating repair of painful disruptions associated with damaged and/or degenerated synovial joints and spinal discs are disclosed. These methods include injecting an effective amount of a biocompatible matrix or biocompatible polymeric compound, as well as a plurality of cells, into and/or around the damaged and/or degenerated synovial joints or spinal discs. The plurality of cells may include fibroblast cells, chondrocytes, genetically altered cells, stem cells such as mesenchymal stem cells, or combinations thereof.
摘要翻译：公开了用于增强疼痛缓解和加速与受损和/或退化的滑膜关节和脊椎盘相关的疼痛中断的修复的方法。这些方法包括将有效量的生物相容性基质或生物相容性聚合物以及多个细胞注射入损伤和/或退化的滑膜关节或脊椎盘内和/或周围。多个细胞可以包括成纤维细胞，软骨细胞，遗传改变的细胞，干细胞例如间充质干细胞或其组合。

7. 发明申请

WO2008153664A2 METHOD FOR TREATING HERNIATED DISCS 审中-公开
标题翻译：治疗神经病变的方法
公开(公告)号：WO2008153664A2
公开(公告)日：2008-12-18
申请号：PCT/US2008006242
申请日：2008-05-15
申请人： SPINAL RESTORATION INC , PAUZA KEVIN , BURKINSHAW BRIAN , ROGAN JAMES
发明人： PAUZA KEVIN , BURKINSHAW BRIAN , ROGAN JAMES
IPC分类号： A61L27/22 , A61L27/50
CPC分类号： A61L27/58 , A61L27/225 , A61L2430/38
摘要： A method is effective for treating herniated discs. The method includes (a) surgically remove a herniated portion of disc annulus from a herniated disc, or surgically depressing and holding a herniated portion of disc annulus within original boundaries of the herniated disc, and (b) re-enforcing the surgically treated disc with an effective amount of a biocompatible degradable polymeric compound, such as a fibrin sealant.
摘要翻译：一种治疗椎间盘突出症的方法是有效的。该方法包括（a）从突出的椎间盘外科手术移除椎间盘环的突出部分，或在椎间盘突出的原始边界内手术压迫并保持椎间盘突出的部分，以及（b）重新执行手术治疗的椎间盘，有效量的生物相容性可降解聚合物，例如纤维蛋白密封剂。

8. 发明申请

WO2008150354A1 METHOD, COMPOSITION AND KIT FOR TREATING DEGENERATED DISC DISEASE AND DISCOGENIC PAIN 审中-公开
标题翻译：用于治疗退化性疾病和感染性疼痛的方法，组合物和药盒
公开(公告)号：WO2008150354A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/006241
申请日：2008-05-15
申请人： SPINAL RESTORATION, INC. , BURKINSHAW, Brian
发明人： BURKINSHAW, Brian
IPC分类号： A61K47/30 , A61P19/00
CPC分类号： A61K9/0024 , A61K9/0085 , A61K31/5415 , A61K38/363 , A61K38/4833
摘要： A method, and a corresponding kit and a pharmaceutical composition, is effective for treating discogenic pain caused by a degenerated disc. The method includes injecting a neurotropic agent and polymeric carrier, such as a fibrin sealant, into the degenerated disc. The fibrin sealant injected into the disc includes fibrinogen and an activating compound. The neurotropic agent may be injected before, simultaneously with, or after the injection of the fibrin sealant.
摘要翻译：方法和相应的试剂盒和药物组合物对于治疗由退化的椎间盘引起的椎间性疼痛是有效的。该方法包括将神经营养因子和聚合物载体如纤维蛋白密封剂注射入退化的椎间盘中。注射到椎间盘中的纤维蛋白密封剂包括纤维蛋白原和激活化合物。神经营养剂可以在注射纤维蛋白密封剂之前，同时或之后注射。

9. 发明申请

WO2014124453A2 UNITARY SPINAL DISC IMPLANT 审中-公开
标题翻译：单位脊椎椎间盘植入物
公开(公告)号：WO2014124453A2
公开(公告)日：2014-08-14
申请号：PCT/US2014/015850
申请日：2014-02-11
申请人： BURKINSHAW, Brian , STUPKA, Jonathan
发明人： BURKINSHAW, Brian , STUPKA, Jonathan
CPC分类号： A61F2/4455 , A61F2/442 , A61F2/4465 , A61F2002/30205 , A61F2002/3021 , A61F2002/30217 , A61F2002/30224 , A61F2002/30227 , A61F2002/30235 , A61F2002/30448 , A61F2002/30563 , A61F2002/30604 , A61F2002/30616 , A61F2002/30769 , A61F2002/30772 , A61F2002/30795 , A61F2002/30841 , A61F2002/30906 , A61F2002/3093
摘要： A unitary intervertebral device, having no moving components is provided for non-fusion articulation applications. The interbody articulating device allows for limited flexion and rotation between adjacent vertebrae, helping to preserve or restore near-normal motion between adjacent vertebrae. Rotational motion is achieved through one or more protrusions incorporated into the spinal interbody device. In one articulating form, a first protrusion extends perpendicularly from the superior aspect of the disc-shaped interbody device to form a spike or rotational protrusion, while a second protrusion extends axially from the inferior aspect of the interbody device to form a second spike or rotational protrusion. Protrusions preferably extend perpendicular from the apex of both the first and second arcuate articulating surfaces. In another form, a single protrusion extends axially from the superior aspect of a circular-shape of the interbody device to form a spike or anchoring protrusion, while the inferior surface may be slightly rounded and/or comprising a bone-ingrowth promoting surface. In another form, one or both of the first and / or second arcuate surfaces may be highly polished. Numerous planar geometries are described to define various profiles of the disc replacement implant which may be utilized, including irregular Reuleaux polygons. Numerous variations of the disc replacement and methods of use are described. Similarly configured fusion salvage devices are also described.
摘要翻译：为非融合关节应用提供了没有移动部件的单一椎间装置。椎间关节运动装置允许相邻椎骨之间有限的弯曲和旋转，有助于保持或恢复相邻椎骨之间的近正常运动。通过结合到脊椎体间装置中的一个或多个突起实现旋转运动。在一个铰接形式中，第一突起从盘形体间装置的上部垂直方向延伸以形成尖头或旋转突起，而第二突起从该体间装置的下部方向轴向延伸以形成第二尖峰或旋转突出。突起优选地从第一和第二弓形铰接表面的顶点垂直延伸。在另一种形式中，单个突起从中间体装置的圆形的上部方向轴向延伸以形成钉或锚定突起，而下表面可以稍微圆化和/或包括骨内生长促进表面。在另一种形式中，第一和/或第二弧形表面中的一个或两个可以被高度抛光。描述了许多平面几何形状以限定可以使用的盘替换植入物的各种轮廓，包括不规则的Reuleaux多边形。描述了盘替换和使用方法的许多变化。还描述了类似配置的融合救助装置。

10. 发明申请

WO2012047289A1 INTERBODY FUSION DEVICE AND ASSOCIATED METHODS 审中-公开
公开(公告)号：WO2012047289A1
公开(公告)日：2012-04-12
申请号：PCT/US2011/001716
申请日：2011-10-04
申请人： SPINESMITH PARTNERS L.P. , KANA, Richard, J. , BURKINSHAW, Brian , ROSSMAN, John, B. , DUNWORTH, Kevin
发明人： KANA, Richard, J. , BURKINSHAW, Brian , ROSSMAN, John, B. , DUNWORTH, Kevin
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61B17/064 , A61F2/30744 , A61F2/4465 , A61F2002/2835 , A61F2002/30092 , A61F2002/30131 , A61F2002/302 , A61F2002/30352 , A61F2002/30383 , A61F2002/30428 , A61F2002/30482 , A61F2002/30484 , A61F2002/30492 , A61F2002/30523 , A61F2002/30525 , A61F2002/30579 , A61F2002/30604 , A61F2002/30691 , A61F2002/30785 , A61F2002/30904 , A61F2002/4475 , A61F2220/0025 , A61F2220/0033 , A61F2230/0013 , A61F2230/0065
摘要： A medical device comprising a non-enclosed housing configured to fit between two adjacent vertebrae; one or more housing fasteners extending at least partially through the housing, one or more driving mechanisms operationally positioned in relationship to at least one housing fastener, such that activation of at least one driving mechanism engages and drives at least one housing fastener to compress into at least one adjacent vertebrae and one or more plates removably coupled to the housing.
摘要翻译：一种医疗装置，包括被构造成装配在两个相邻椎骨之间的非封闭壳体; 一个或多个外壳紧固件，其至少部分地延伸穿过所述壳体，一个或多个驱动机构可操作地定位成与至少一个壳体紧固件相关联，使得至少一个驱动机构的致动接合并驱动至少一个壳体紧固件以压缩成至少一个相邻的椎骨和一个或多个可拆卸地联接到所述外壳的板。

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