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1. 发明申请

WO2010012987A2 GLOW DISCHARGE ION SOURCE 审中-公开
标题翻译： GLOW放射源
公开(公告)号：WO2010012987A2
公开(公告)日：2010-02-04
申请号：PCT/GB2009/001842
申请日：2009-07-27
申请人： MICROMAS UK LIMITED , BROWN, Jeffrey, Mark , GREEN, Martin, Raymond , PRINGLE, Steven, Derek
发明人： BROWN, Jeffrey, Mark , GREEN, Martin, Raymond , PRINGLE, Steven, Derek
IPC分类号： H01J49/00
CPC分类号： H01J49/12 , G01N24/00 , H01J49/0009 , H01J49/0072 , H01J49/0495 , H01J49/107 , H01J49/165 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode (14) which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
摘要翻译：公开了质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。辉光放电装置可以包括设置在真空室中的隔离阀（15）内的管状电极（14）。可以通过管状电极（14）提供试剂蒸气，然后其随后通过辉光放电电离。所得的试剂离子可用于由大气压离子源产生的分析物离子的电子转移离解。考虑其他实施例，其中由辉光放电装置产生的离子可用于通过质子转移反应来减少分析物离子的电荷状态，或者可以作为锁定质量或参考离子。

2. 发明申请

WO2006061625A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006061625A3
公开(公告)日：2007-06-14
申请号：PCT/GB2005004724
申请日：2005-12-08
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , GILES KEVIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE , BROWN JEFFREY MARK
发明人： BATEMAN ROBERT HAROLD , GILES KEVIN , PRINGLE STEVEN DEREK , WILDGOOSE JASON LEE , BROWN JEFFREY MARK
IPC分类号： H01J49/04 , H01J49/42
CPC分类号： H01J49/062 , H01J49/004
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyser (4) arranged upstream of an ion guide (6). Ions are scanned out of the mass selective ion trap or mass analyser (4) and are received in one or more axial potential wells created or formed within the ion guide (6). One or more transient DC voltages or potentials are preferably applied to the ion guide (6) in order to create a plurality of axial potential wells which are translated along the length of the ion guide (6). Ions are released in packets from the exit of the ion guide (6) and are orthogonally accelerated into a drift or flight region of an orthogonal acceleration Time of Flight mass analyser (13) with a relatively high duty cycle.
摘要翻译：公开了一种质谱仪，其包括布置在离子导向器（6）上游的质量选择性离子阱或质量分析器（4）。从质量选择性离子阱或质量分析器（4）中扫描离子，并将其接收在离子导向器（6）内产生或形成的一个或多个轴向势阱中。优选地将一个或多个瞬态DC电压或电位施加到离子导向器（6），以便产生沿离子导向件（6）的长度平移的多个轴向势阱。从离子导向器（6）的出口以分组的形式释放离子，并以相对较高的占空比正交加速到正交加速时间飞行质量分析器（13）的漂移或飞行区域。

3. 发明申请

WO2009127808A3 ELECTRON TRANSFER DISSOCIATION DEVICE 审中-公开
标题翻译：电子传输解调装置
公开(公告)号：WO2009127808A3
公开(公告)日：2010-05-27
申请号：PCT/GB2009000902
申请日：2009-04-03
申请人： MICROMASS LTD , BROWN JEFFREY MARK , GREEN MARTIN RAYMOND
发明人： BROWN JEFFREY MARK , GREEN MARTIN RAYMOND
IPC分类号： H01J49/06 , H01J49/00
CPC分类号： H01J49/28 , H01J49/0072 , H01J49/065
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.
摘要翻译：公开了一种质谱仪，其包括电子转移离解装置，其包括离子导向器。控制系统确定离子导向器内的前体离子的碎裂和电荷减少的程度，并且改变离子通过离子导向器传输的速度，以便优化碎裂和电荷还原过程。

4. 发明申请

WO2009147411A3 METHOD OF CHARGE REDUCTION OF ELECTRON TRANSFER DISSOCIATION PRODUCT IONS 审中-公开
公开(公告)号：WO2009147411A3
公开(公告)日：2009-12-10
申请号：PCT/GB2009/001421
申请日：2009-06-05
申请人： MICROMASS UK LIMITED , CHEN, Weibin , CHAKRABORTY, Asish, B. , GEBLER, John, Charles , BROWN, Jeffrey, Mark
发明人： CHEN, Weibin , CHAKRABORTY, Asish, B. , GEBLER, John, Charles , BROWN, Jeffrey, Mark
IPC分类号： H01J49/06
摘要： A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell 35 by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.

5. 发明申请

WO2009127808A2 ELECTRON TRANSFER DISSOCIATION DEVICE 审中-公开
标题翻译：电子传输解调装置
公开(公告)号：WO2009127808A2
公开(公告)日：2009-10-22
申请号：PCT/GB2009/000902
申请日：2009-04-03
申请人： MICROMASS UK LIMITED , BROWN, Jeffrey, Mark , GREEN, Martin, Raymond
发明人： BROWN, Jeffrey, Mark , GREEN, Martin, Raymond
IPC分类号： H01J49/06 , H01J49/00
CPC分类号： H01J49/28 , H01J49/0072 , H01J49/065
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.
摘要翻译：公开了一种质谱仪，其包括电子转移离解装置，其包括离子导向器。控制系统确定离子导向器内的前体离子的碎裂和电荷减少的程度，并且改变离子通过离子导向器传输的速度，以便优化碎裂和电荷还原过程。

6. 发明申请

WO2006064280A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006064280A3
公开(公告)日：2007-05-31
申请号：PCT/GB2005004911
申请日：2005-12-19
申请人： MICROMASS LTD , BROWN JEFFREY MARK
发明人： BROWN JEFFREY MARK
IPC分类号： H01J49/40 , H01J49/16
CPC分类号： H01J49/004 , H01J49/0031 , H01J49/401
摘要： A mass spectrometer is disclosed comprising a MALDI ion source coupled to an orthogonal acceleration Time of Flight mass analyser (13). The mass spectrometer is operated at a first instrument setting wherein specific parent ions are selected by a mass filter and are accelerated to a first axial energy. The fragment ions are then orthogonally accelerated after a first delay time and first mass spectral data is obtained. The mass spectrometer is then operated at a second instrument setting wherein the axial energy of the parent ions is increased and the resulting fragment ions are orthogonally accelerated after a reduced delay time. Second mass spectral data is then obtained. The first and second mass spectral data are then combined to provided a final composite mass spectrum.
摘要翻译：公开了一种质谱仪，其包括耦合到正交加速时间飞行质量分析仪（13）的MALDI离子源。质谱仪在第一仪器设置下操作，其中通过质量过滤器选择特定的母体离子并加速至第一轴向能量。然后，在获得第一延迟时间和第一质谱数据之后，片段离子被正交加速。然后质谱仪在第二仪器设置下操作，其中母离子的轴向能量增加，并且所产生的碎片离子在减小的延迟时间之后被正交加速。然后获得第二质谱数据。然后组合第一和第二质谱数据以提供最终的复合质谱。

7. 发明申请

WO2006064280A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006064280A2
公开(公告)日：2006-06-22
申请号：PCT/GB2005/004911
申请日：2005-12-19
申请人： MICROMASS UK LIMITED , BROWN, Jeffrey, Mark
发明人： BROWN, Jeffrey, Mark
IPC分类号： H01J49/40
CPC分类号： H01J49/004 , H01J49/0031 , H01J49/401
摘要： A mass spectrometer is disclosed comprising a MALDI ion source coupled to an orthogonal acceleration Time of Flight mass analyser (13). The mass spectrometer is operated at a first instrument setting wherein specific parent ions are selected by a mass filter and are accelerated to a first axial energy. The fragment ions are then orthogonally accelerated after a first delay time and first mass spectral data is obtained. The mass spectrometer is then operated at a second instrument setting wherein the axial energy of the parent ions is increased and the resulting fragment ions are orthogonally accelerated after a reduced delay time. Second mass spectral data is then obtained. The first and second mass spectral data are then combined to provided a final composite mass spectrum.
摘要翻译：公开了一种质谱仪，其包括耦合到正交加速时间飞行质量分析仪（13）的MALDI离子源。质谱仪在第一仪器设置下操作，其中通过质量过滤器选择特定的母体离子并加速至第一轴向能量。然后，在获得第一延迟时间和第一质谱数据之后，片段离子被正交加速。然后质谱仪在第二仪器设置下操作，其中母离子的轴向能量增加，并且所产生的碎片离子在减小的延迟时间之后被正交加速。然后获得第二质谱数据。然后组合第一和第二质谱数据以提供最终的复合质谱。

8. 发明申请

WO2010012987A3 GLOW DISCHARGE ION SOURCE 审中-公开
标题翻译：辉光放电离子源
公开(公告)号：WO2010012987A3
公开(公告)日：2010-07-01
申请号：PCT/GB2009001842
申请日：2009-07-27
申请人： MICROMAS UK LTD , BROWN JEFFREY MARK , GREEN MARTIN RAYMOND , PRINGLE STEVEN DEREK
发明人： BROWN JEFFREY MARK , GREEN MARTIN RAYMOND , PRINGLE STEVEN DEREK
IPC分类号： H01J49/00 , H01J49/10 , H01J49/16
CPC分类号： H01J49/12 , G01N24/00 , H01J49/0009 , H01J49/0072 , H01J49/0495 , H01J49/107 , H01J49/165 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode (14) which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
摘要翻译：公开了一种质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。辉光放电装置可以包括位于设置在真空室中的隔离阀（15）内的管状电极（14）。可以通过管状电极（14）提供试剂蒸气，然后通过辉光放电电离该管状电极（14）。所得到的试剂离子可用于由大气压力离子源产生的分析物离子的电子转移解离。考虑其他实施例，其中由辉光放电装置产生的离子可以用于通过质子转移反应来减少分析物离子的电荷状态，或者可以充当锁定质量或参考离子。

9. 发明申请

WO2009147411A2 METHOD OF CHARGE REDUCTION OF ELECTRON TRANSFER DISSOCIATION PRODUCT IONS 审中-公开
标题翻译：电子转移分离产物离子的电荷减少方法
公开(公告)号：WO2009147411A2
公开(公告)日：2009-12-10
申请号：PCT/GB2009001421
申请日：2009-06-05
申请人： MICROMASS LTD , CHEN WEIBIN , CHAKRABORTY ASISH B , GEBLER JOHN CHARLES , BROWN JEFFREY MARK
发明人： CHEN WEIBIN , CHAKRABORTY ASISH B , GEBLER JOHN CHARLES , BROWN JEFFREY MARK
IPC分类号： H01J49/00
CPC分类号： H01J49/0095 , H01J49/0072 , H01J49/062 , H01J49/165 , H01J49/26 , H01J49/36
摘要： A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell 35 by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.
摘要翻译：公开了一种质谱仪，其中通过使碎片离子与诸如八氢嘧啶并氮杂吖庚因之类的中性超碱原料气体反应，在离子质子转移反应池35内通过母体离子的电子转移离解断裂产生的高电荷碎片离子在电荷状态下被还原。

10. 发明申请

WO2006061625A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006061625A2
公开(公告)日：2006-06-15
申请号：PCT/GB2005/004724
申请日：2005-12-08
申请人： MICROMASS UK LIMITED , BATEMAN, Robert, Harold , GILES, Kevin , PRINGLE, Steven, Derek , WILDGOOSE, Jason, Lee , BROWN, Jeffrey, Mark
发明人： BATEMAN, Robert, Harold , GILES, Kevin , PRINGLE, Steven, Derek , WILDGOOSE, Jason, Lee , BROWN, Jeffrey, Mark
IPC分类号： H01J49/04
CPC分类号： H01J49/062 , H01J49/004
摘要： A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyser (4) arranged upstream of an ion guide (6). Ions are scanned out of the mass selective ion trap or mass analyser (4) and are received in one or more axial potential wells created or formed within the ion guide (6). One or more transient DC voltages or potentials are preferably applied to the ion guide (6) in order to create a plurality of axial potential wells which are translated along the length of the ion guide (6). Ions are released in packets from the exit of the ion guide (6) and are orthogonally accelerated into a drift or flight region of an orthogonal acceleration Time of Flight mass analyser (13) with a relatively high duty cycle.
摘要翻译：公开了一种质谱仪，其包括布置在离子导向器（6）上游的质量选择性离子阱或质量分析器（4）。从质量选择性离子阱或质量分析器（4）中扫描离子，并将其接收在离子导向器（6）内产生或形成的一个或多个轴向势阱中。优选地将一个或多个瞬态DC电压或电位施加到离子导向器（6），以便产生沿离子导向件（6）的长度平移的多个轴向势阱。从离子导向器（6）的出口以分组的形式释放离子，并以相对较高的占空比正交加速到正交加速时间飞行质量分析器（13）的漂移或飞行区域。

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