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1. 发明申请

WO2009127808A3 ELECTRON TRANSFER DISSOCIATION DEVICE 审中-公开
标题翻译：电子传输解调装置
公开(公告)号：WO2009127808A3
公开(公告)日：2010-05-27
申请号：PCT/GB2009000902
申请日：2009-04-03
申请人： MICROMASS LTD , BROWN JEFFREY MARK , GREEN MARTIN RAYMOND
发明人： BROWN JEFFREY MARK , GREEN MARTIN RAYMOND
IPC分类号： H01J49/06 , H01J49/00
CPC分类号： H01J49/28 , H01J49/0072 , H01J49/065
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.
摘要翻译：公开了一种质谱仪，其包括电子转移离解装置，其包括离子导向器。控制系统确定离子导向器内的前体离子的碎裂和电荷减少的程度，并且改变离子通过离子导向器传输的速度，以便优化碎裂和电荷还原过程。

2. 发明申请

WO2010012987A3 GLOW DISCHARGE ION SOURCE 审中-公开
标题翻译：辉光放电离子源
公开(公告)号：WO2010012987A3
公开(公告)日：2010-07-01
申请号：PCT/GB2009001842
申请日：2009-07-27
申请人： MICROMAS UK LTD , BROWN JEFFREY MARK , GREEN MARTIN RAYMOND , PRINGLE STEVEN DEREK
发明人： BROWN JEFFREY MARK , GREEN MARTIN RAYMOND , PRINGLE STEVEN DEREK
IPC分类号： H01J49/00 , H01J49/10 , H01J49/16
CPC分类号： H01J49/12 , G01N24/00 , H01J49/0009 , H01J49/0072 , H01J49/0495 , H01J49/107 , H01J49/165 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode (14) which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
摘要翻译：公开了一种质谱仪，其包括在质谱仪的初始真空室内的辉光放电装置。辉光放电装置可以包括位于设置在真空室中的隔离阀（15）内的管状电极（14）。可以通过管状电极（14）提供试剂蒸气，然后通过辉光放电电离该管状电极（14）。所得到的试剂离子可用于由大气压力离子源产生的分析物离子的电子转移解离。考虑其他实施例，其中由辉光放电装置产生的离子可以用于通过质子转移反应来减少分析物离子的电荷状态，或者可以充当锁定质量或参考离子。

3. 发明申请

WO2009066087A3 ION- ION REACTION DEVICE 审中-公开
标题翻译：离子反应装置
公开(公告)号：WO2009066087A3
公开(公告)日：2009-11-26
申请号：PCT/GB2008003916
申请日：2008-11-24
申请人： MICROMASS LTD , BROWN JEFFERY MARK , GREEN MARTIN RAYMOND
发明人： BROWN JEFFERY MARK , GREEN MARTIN RAYMOND
IPC分类号： H01J49/00
CPC分类号： H01J49/065 , H01J49/0072
摘要： An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide ()2. A transient DC voltage wave is applied to the electrodes (2) in order to load reagent anions into the ion guide (2). Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave.
摘要翻译：提供了包括形成离子导向器（）2的多个电极（1）的离子 - 离子反应池。将瞬态直流电压波施加到电极（2）上以将试剂阴离子加载到离子导向器（2）中。随后分析物阳离子通过随后的瞬态DC电压波传输通过离子 - 离子反应池。离子布置成在反应池内进行离子 - 离子反应，然后通过瞬态直流电压波将在反应池内形成的碎片离子随后转移出反应池。

4. 发明申请

WO2009150410A3 METHOD OF AVOIDING SPACE CHARGE SATURATION EFFECTS IN AN ION TRAP 审中-公开
标题翻译：避免空穴电荷饱和效应在离子阱中的方法
公开(公告)号：WO2009150410A3
公开(公告)日：2010-02-18
申请号：PCT/GB2009001434
申请日：2009-06-08
申请人： MICROMASS LTD , GREEN MARTIN RAYMOND , WILDGOOSE JASON LEE
发明人： GREEN MARTIN RAYMOND , WILDGOOSE JASON LEE
IPC分类号： H01J49/42
CPC分类号： H01J49/02 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/4265
摘要： A mass spectrometer is provided comprising a first ion trap (2) arranged upstream of an analytical second ion trap (5). The charge capacity of the first ion trap (2) is set at a value such that if all the ions stored within the first ion trap (2) up to the charge capacity limit of the first ion trap (2) are then transferred to the second ion trap (5), then the analytical performance of the second ion trap (5) is not substantially degraded due to space charge effects.
摘要翻译：提供质谱仪，其包括布置在分析性第二离子阱（5）上游的第一离子阱（2）。将第一离子阱（2）的充电容量设定为使得如果存储在第一离子阱（2）内的所有离子直到第一离子阱（2）的充电容量极限，则转移到第二离子阱（5），则由于空间电荷效应，第二离子阱（5）的分析性能基本上不劣化。

5. 发明申请

WO2009087402A3 LINEAR ION TRAP 审中-公开
标题翻译：线性离子阱
公开(公告)号：WO2009087402A3
公开(公告)日：2010-02-18
申请号：PCT/GB2009000071
申请日：2009-01-12
申请人： MICROMASS LTD , GREEN MARTIN RAYMOND , KENNY DANIEL JAMES , LANGRIDGE DAVID , WILDGOOSE JASON LEE
发明人： GREEN MARTIN RAYMOND , KENNY DANIEL JAMES , LANGRIDGE DAVID , WILDGOOSE JASON LEE
IPC分类号： H01J49/42
CPC分类号： H01J49/4225 , H01J49/4285
摘要： A linear ion trap (6,7,8) is disclosed comprising a central quadrupole rod set (6) and a post-filter quadrupole rod set (8). A 180° phase difference is maintained between axially adjacent rod electrodes of the central quadrupole rod set (6) and the post-filter quadrupole (8) so that an axial pseudo-potential barrier is created between the central quadrupole rod set (6) and the post-filter quadrupole (8). A supplementary AC voltage is applied to the rods of the central quadrupole (6) in order to radially excite ions which are desired to be ejected from the ion trap. The ions are ejected from the ion trap (6,7,8) non-adiabatically in an axial direction.
摘要翻译：公开了一种线性离子阱（6,7,8），其包括中心四极杆组（6）和后过滤四极杆组（8）。在中心四极杆组（6）和后过滤器四极（8）的轴向相邻杆电极之间保持180°相位差，使得在中心四极杆组（6）和后滤器四极杆（8）。补充的交流电压施加到中心四极杆（6）的杆上，以便径向地激发希望从离子阱排出的离子。离子从离子阱（6,7,8）沿轴向非绝热地排出。

6. 发明申请

WO2012123730A3 ION MOBILITY SPECTROMETER WITH VARIABLE EFFECTIVE DRIFT LENGTH 审中-公开
标题翻译：离子移动光谱仪具有可变的有效载流子长度
公开(公告)号：WO2012123730A3
公开(公告)日：2012-12-06
申请号：PCT/GB2012050545
申请日：2012-03-13
申请人： MICROMASS LTD , GREEN MARTIN RAYMOND , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
发明人： GREEN MARTIN RAYMOND , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
IPC分类号： H01J49/40 , G01N27/62 , H01J49/42
CPC分类号： H01J49/36 , G01N27/624 , H01J49/06 , H01J49/42 , H01J49/426
摘要： An ion mobility separator or spectrometer is disclosed comprising an inner cylinder (2) and an outer cylinder (1). The inner cylinder (2) and the outer cylinder (1) define an annular volume (3) through which ions are transmitted. One or more spiral electrodes a-f are arranged on a surface of the inner cylinder (2) and/or on a surface of the outer cylinder (1). A first device is arranged and adapted to maintain a DC electric field and/or a pseudo- potential force which acts to urge ions from a first end of the ion mobility separator or spectrometer to a second end of the ion mobility separator or spectrometer. A second device is arranged and adapted to apply one or more transient DC voltages to the one or more spiral electrodes in order to urge ions towards the first end of the ion mobility separator or spectrometer. The net effect is to extend the effective path length of the ion mobility separator.
摘要翻译：公开了一种离子迁移率分离器或光谱仪，其包括内筒（2）和外筒（1）。内筒（2）和外筒（1）限定了一个环形体积（3），离子通过该环体积传递。一个或多个螺旋形电极a-f布置在内筒（2）的表面和/或外筒（1）的表面上。第一装置被布置并适于维持DC电场和/或伪电势力，其作用是将离子从离子迁移率分离器或光谱仪的第一端促进到离子迁移率分离器或光谱仪的第二端。第二装置被布置并适于将一个或多个瞬态DC电压施加到所述一个或多个螺旋电极，以促使离子朝向离子迁移率分离器或光谱仪的第一端。净效应是延长离子迁移率分离器的有效路径长度。

7. 发明申请

WO2012085595A2 FAST PUSHING TIME OF FLIGHT MASS SPECTROMETER COMBINED WITH RESTRICTED MASS TO CHARGE RATIO RANGE DELIVERY 审中-公开
标题翻译：与限制质量组合的飞行质谱仪的快速推送时间以充电比例范围传送
公开(公告)号：WO2012085595A2
公开(公告)日：2012-06-28
申请号：PCT/GB2011052577
申请日：2011-12-22
申请人： MICROMASS LTD , GREEN MARTIN RAYMOND , KENNY DANIEL JAMES , WILDGOOSE JASON LEE
发明人： GREEN MARTIN RAYMOND , KENNY DANIEL JAMES , WILDGOOSE JASON LEE
IPC分类号： H01J49/40
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0086
摘要： Ions having a restricted range of mass to charge ratios are transmitted to the acceleration region of a Time of Flight mass analyser. A control system applies a first extraction pulse to an acceleration electrode in order to accelerate a first group of ions into the time of flight region at a first time T1, wherein tons having the lowest mass to charge ratio in the first group of ions have a time of flight ?T1min through the time of flight region and ions having the highest mass to charge ratio in the first group of ions have a time of flight ?T1max through the time of flight region. The control system applies a second extraction pulse to the acceleration electrode at a subsequent second time T2, wherein ?T1max- ?T1min = T2-T1 max.
摘要翻译：具有有限范围的质荷比的离子被传送到飞行时间质量分析器的加速区域。控制系统将第一提取脉冲施加到加速电极，以便在第一时间T1将第一组离子加速到飞行时间区域，其中在第一组离子中具有最低质荷比的吨具有飞行时间T1min通过飞行时间段，第一组离子中质荷比最高的离子在飞行时间段内具有飞行时间T1max。控制系统在随后的第二时间T2向加速电极施加第二提取脉冲，其中ΔT1max-ΔT1min= T2-T1max。

8. 发明申请

WO2013027054A2 ION TRAP WITH SPATIALLY EXTENDED ION TRAPPING REGION 审中-公开
标题翻译：离子阱与空间扩展的离子俘获区域
公开(公告)号：WO2013027054A2
公开(公告)日：2013-02-28
申请号：PCT/GB2012052053
申请日：2012-08-22
申请人： MICROMASS LTD , GILES KEVIN , GREEN MARTIN RAYMOND , KENNY DANIEL JAMES , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
发明人： GILES KEVIN , GREEN MARTIN RAYMOND , KENNY DANIEL JAMES , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
IPC分类号： H01J49/42
CPC分类号： H01J49/424 , H01J49/421 , H01J49/422 , H01J49/4285
摘要： A mass or mass to charge ratio selective ion trap is disclosed having an increased charge storage capacity. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC voltage and/or an RF voltage acts to confine ions in a second (x) direction within the ion trap. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. Ions are excited in the third (z) direction and are caused to be mass or mass to charge ratio selectively ejected in the third (z) direction.
摘要翻译：公开的具有增加的电荷存储容量的质量或质荷比选择离子阱。 RF电压用于在离子阱内的第一（y）方向上限制离子。直流电压和/或RF电压用于在离子阱内的第二（x）方向上限制离子。二次直流势阱用于在离子阱内的第三（z）方向上限制离子。离子在第三（z）方向上被激发，并且导致质量或质荷比选择性地在第三（z）方向上喷射。

9. 发明申请

WO2012123729A2 ION GUIDE WITH ORTHOGONAL SAMPLING 审中-公开
标题翻译：离子指南与正交采样
公开(公告)号：WO2012123729A2
公开(公告)日：2012-09-20
申请号：PCT/GB2012050544
申请日：2012-03-13
申请人： MICROMASS LTD , GREEN MARTIN RAYMOND , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
发明人： GREEN MARTIN RAYMOND , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
IPC分类号： H01J49/06 , G01N27/62
CPC分类号： H01J49/065 , G01N27/622 , H01J49/0031 , H01J49/022 , H01J49/062 , H01J49/063 , H01J49/36
摘要： A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the RF ion guide. The ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001 -0.001 mbar; (ii) 0.001 -0.01 mbar; (iii) 0.01 -0.1 mbar; (iv) 0.1 -1 mbar; (v) 1 -10 mbar; (vi) 10-100 mbar; and (vii) > 100 mbar.
摘要翻译：公开了一种质谱仪，其包括RF离子导向器，其中在操作模式中，连续的，准连续的或脉冲的离子束从离子导向器正交地采样，并且其中连续的，准连续的或脉冲的离子束不轴向被捕获或以其它方式轴向限制在RF离子导向器内。离子导向器在使用中以选自以下的压力保持：（i）0.0001 -0.001毫巴; （ii）0.001 -0.01毫巴; （iii）0.01 -0.1毫巴; （iv）0.1-1毫巴; （v）1 -10 mbar; （vi）10-100毫巴; 和（vii）> 100mbar。

10. 发明申请

WO2009127808A8 ELECTRON TRANSFER DISSOCIATION DEVICE 审中-公开
标题翻译：电子传输解调装置
公开(公告)号：WO2009127808A8
公开(公告)日：2011-04-28
申请号：PCT/GB2009000902
申请日：2009-04-03
申请人： MICROMASS LTD , BROWN JEFFERY MARK , GREEN MARTIN RAYMOND
发明人： BROWN JEFFERY MARK , GREEN MARTIN RAYMOND
IPC分类号： H01J49/06 , H01J49/00
CPC分类号： H01J49/28 , H01J49/0072 , H01J49/065
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.
摘要翻译：公开了一种质谱仪，其包括电子转移离解装置，其包括离子导向器。控制系统确定离子导向器内的前体离子的碎裂和电荷减少的程度，并且改变离子通过离子导向器传输的速度，以便优化碎裂和电荷还原过程。

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