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1. 发明申请

WO2004099107A3 DNA-BASED MEMORY DEVICE AND METHOD OF READING AND WRITING SAME 审中-公开
标题翻译：基于DNA的存储器件及其读取和写入方法
公开(公告)号：WO2004099107A3
公开(公告)日：2005-04-14
申请号：PCT/US2004001683
申请日：2004-01-22
申请人： UNIV CLEMSON , BOLAND THOMAS , WAGNER THOMAS
发明人： BOLAND THOMAS , WAGNER THOMAS
IPC分类号： G01Q60/00 , C12Q1/68 , G06N3/12 , G11C11/54 , G11C13/02 , H01L27/10 , H01L35/24 , H01L49/00 , H01L51/30
CPC分类号： G06N3/123 , B82Y10/00 , G11C13/0014 , G11C13/0019 , H01L51/0093 , H01L51/0595 , Y10S977/946
摘要： The present invention is directed to a memory device (120) having very high storage density capability. In general, the memory device (120) includes an array of individual memory cells (114) which store information that is assigned a value based on the molecular contents of the memory cell. In a preferred embodiment, the molecules utilized for storing information in the memory cells may be single-strand polynucleotides, for instance single-strand oligonucleotides (112) of between about 5 and about 20 monomer units. The present invention is also directed to methods and systems useful for writing and reading the molecular-based memory devices. In particular, the devices may be written and read via modified atomic force microscopy processes.
摘要翻译：本发明涉及具有非常高的存储密度能力的存储器件（120）。通常，存储器件（120）包括存储基于存储器单元的分子内容分配值的信息的单独存储器单元（114）的阵列。在优选的实施方案中，用于将信息存储在记忆细胞中的分子可以是单链多核苷酸，例如约5至约20个单体单元的单链寡核苷酸（112）。本发明还涉及用于写入和读取基于分子的存储器件的方法和系统。特别地，可以通过经修改的原子力显微镜方法书写和读取装置。

2. 发明申请

WO2004099107A2 DNA-BASED MEMORY DEVICE AND METHOD OF READING AND WRITING SAME 审中-公开
标题翻译：基于DNA的存储器件及其读取和写入方法
公开(公告)号：WO2004099107A2
公开(公告)日：2004-11-18
申请号：PCT/US2004/001683
申请日：2004-01-22
申请人： CLEMSON UNIVERSITY , BOLAND, Thomas , WAGNER, Thomas
发明人： BOLAND, Thomas , WAGNER, Thomas
IPC分类号： C07C
CPC分类号： G06N3/123 , B82Y10/00 , G11C13/0014 , G11C13/0019 , H01L51/0093 , H01L51/0595 , Y10S977/946
摘要： The present invention is directed to a memory device having very high storage density capability. In general, the memory device includes an array of individual memory cells which store information that is assigned a value based on the molecular contents of the memory cell. In a preferred embodiment, the molecules utilized for storing information in the memory cells may be single-strand polynucleotides, for instance single-strand oligonucleotides of between about 5 and about 20 monomer units. The present invention is also directed to methods and systems useful for writing and reading the molecular-based memory devices. In particular, the devices may be written and read via modified atomic force microscopy processes.
摘要翻译：本发明涉及具有非常高的存储密度能力的存储器件。通常，存储器件包括存储基于存储器单元的分子内容分配值的信息的各个存储器单元阵列。在优选的实施方案中，用于在记忆细胞中存储信息的分子可以是单链多核苷酸，例如约5至约20个单体单元的单链寡核苷酸。本发明还涉及用于写入和读取基于分子的存储器件的方法和系统。特别地，可以通过经修改的原子力显微镜方法书写和读取装置。

3. 发明申请

WO2015061800A3 TISSUE ENGINEERED DEVICES AND METHODS FOR MAKING SAME 审中-公开
标题翻译：组织工程设备及其制造方法
公开(公告)号：WO2015061800A3
公开(公告)日：2015-06-18
申请号：PCT/US2014062469
申请日：2014-10-27
申请人： COLLINS SCOTT FORREST , BOLAND THOMAS , YANEZ MARIA
发明人： COLLINS SCOTT FORREST , BOLAND THOMAS , YANEZ MARIA
IPC分类号： A01N63/00 , A01N65/00 , A61K35/12
CPC分类号： A61L27/3839 , A61F2/12 , A61F2210/0076 , A61F2220/005 , A61F2240/004 , A61F2310/00371 , A61F2310/00377 , A61F2310/00383 , A61K35/28 , A61K35/33 , A61K35/35 , A61K35/44 , A61L27/225 , A61L27/227 , A61L27/3804 , A61L27/3808 , A61L27/3834 , A61L27/3886 , A61L27/52 , A61L2430/04 , C12N5/0653 , C12N5/0697 , C12N2502/1352 , C12N2502/28 , C12N2533/56 , C12N2533/76 , C12N2535/10 , A61K2300/00
摘要： Tissue engineered constructs and methods for fabricating the disclosed constructs are provided. Some of the disclosed tissue engineered constructs are designed to fill a void in the body due to surgical resection, for example from mastectomy or lumpectomy, wounds and the like. Some disclosed constructs comprise one or more projections designed to mimic the appearance of a structural feature when implanted into a host.
摘要翻译：提供了用于制造所公开的构建体的组织工程构建体和方法。所公开的组织工程构建体中的一些被设计成由于手术切除，例如乳房切除术或乳房切除术，伤口等而填充身体中的空隙。一些公开的结构包括一个或多个突出物，其被设计为当植入宿主时模拟结构特征的外观。

4. 发明申请

WO2013123049A1 TISSUE ENGINEERING DEVICE AND CONSTRUCTION OF VASCULARIZED DERMIS 审中-公开
标题翻译：组织工程设备和血管造影的构建
公开(公告)号：WO2013123049A1
公开(公告)日：2013-08-22
申请号：PCT/US2013/025938
申请日：2013-02-13
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , BOLAND, Thomas
发明人： BOLAND, Thomas
IPC分类号： A61L27/56 , A61L27/38 , A61L27/60 , A61L27/54
CPC分类号： A61L27/38 , A61L27/225 , A61L27/54 , A61L27/56 , A61L27/60 , B29C64/112 , B33Y10/00 , B33Y80/00
摘要： An Inkjet printing method, system, and computer-usable tangible storage device to print cells and biomaterials for three-dimensional cellular scaffolds and engineered skin grafts are disclosed. The process simultaneously deposits living cells, nutrients, growth factors, therapeutic drugs along with biomaterial scaffolds at the right time and location. This technology can also be used for the microvasculature fabrication using appropriate human microvascular endothelial cells and fibrin to form the microvasculature. When printing human microvascular endothelial cells in conjunction with the fibrin, the cells aligned themselves inside the channels and proliferated to form confluent linings. The 3D tubular structure was also found in the printed patterns. Simultaneously printing biological materials to form a three-dimensional cellular scaffold promotes human microvascular endothelial cell proliferation and microvasculature formation.
摘要翻译：公开了一种用于打印三维细胞支架和工程皮肤移植物的细胞和生物材料的喷墨打印方法，系统和计算机可用的有形存储装置。该过程在正确的时间和位置同时沉积活细胞，营养物质，生长因子，治疗药物以及生物材料支架。该技术也可用于使用合适的人微血管内皮细胞和纤维蛋白的微血管制造以形成微血管。当与纤维蛋白结合印刷人类微血管内皮细胞时，细胞将其自身排列在通道内并增殖以形成汇合衬里。 3D管状结构也在印刷图案中找到。同时打印生物材料以形成三维细胞支架，促进人微血管内皮细胞增殖和微血管形成。

5. 发明申请

WO2015021145A1 MOLECULAR IMPRINTED COLORED SILICA BEADS 审中-公开
标题翻译：分子印花彩色硅胶珠
公开(公告)号：WO2015021145A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/049929
申请日：2014-08-06
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , BOLAND, Thomas
发明人： BOLAND, Thomas
IPC分类号： G01N33/50 , C12Q1/68 , C12M1/34
CPC分类号： G01N33/552 , G01N33/54313 , G01N33/551 , G01N2600/00
摘要： Macromolecular imprinted silica particles ("MIP") in the presence of polymer grafted carbon black are disclosed. The disclosed molecular imprinted beads can detect disease in body fluids. For the silica gel matrix, tetraethyl orthosilicate (TEOS) was used as the backbone monomer and 3-aminopropy/triethoxysilane (APS) as a functional monomer. Carbon black was added to the sol-gel process, yielding black silica particles. Furthermore, sodium dodecyl sulfate (SDS) was used as a structure-directing agent to increase network diffusion of the template. A total of 16 M!Ps were synthetized in parallel with variables that evaluate the role of key reactants in the synthesis procedure. Agglomeration tests were performed with ail 16 M!Ps in the presence of their template, alongside their respective controls using only phosphate buffered saline ("PBS"). Each of the MIPs was evaluated using a novel device capable of simultaneously measuring up to four samples for near infrared transmission.
摘要翻译：公开了在聚合物接枝炭黑存在下的大分子印迹二氧化硅颗粒（“MIP”）。所公开的分子印迹珠可以检测体液中的疾病。对于硅胶基质，使用原硅酸四乙酯（TEOS）作为主链单体和3-氨基丙基/三乙氧基硅烷（APS）作为官能单体。将炭黑加入到溶胶 - 凝胶法中，得到黑色二氧化硅颗粒。此外，使用十二烷基硫酸钠（SDS）作为结构导向剂以增加模板的网络扩散。共计16 M！Ps与评估关键反应物在合成过程中的作用的变量并行合成。在其模板存在的情况下，使用只有磷酸盐缓冲盐水（“PBS”）的各自的对照进行聚集测试。使用能够同时测量多达四个用于近红外透射的样品的新型装置来评估每个MIP。

6. 发明申请

WO2015061800A2 TISSUE ENGINEERED DEVICES AND METHODS FOR MAKING SAME 审中-公开
标题翻译：组织工程装置及其制造方法
公开(公告)号：WO2015061800A2
公开(公告)日：2015-04-30
申请号：PCT/US2014/062469
申请日：2014-10-27
申请人： COLLINS, Scott Forrest , BOLAND, Thomas , YANEZ, Maria
发明人： COLLINS, Scott Forrest , BOLAND, Thomas , YANEZ, Maria
IPC分类号： A61K35/12
CPC分类号： A61L27/3839 , A61F2/12 , A61F2210/0076 , A61F2220/005 , A61F2240/004 , A61F2310/00371 , A61F2310/00377 , A61F2310/00383 , A61K35/28 , A61K35/33 , A61K35/35 , A61K35/44 , A61L27/225 , A61L27/227 , A61L27/3804 , A61L27/3808 , A61L27/3834 , A61L27/3886 , A61L27/52 , A61L2430/04 , C12N5/0653 , C12N5/0697 , C12N2502/1352 , C12N2502/28 , C12N2533/56 , C12N2533/76 , C12N2535/10 , A61K2300/00
摘要： Tissue engineered constructs and methods for fabricating the disclosed constructs are provided. Some of the disclosed tissue engineered constructs are designed to fill a void in the body due to surgical resection, for example from mastectomy or lumpectomy, wounds and the like. Some disclosed constructs comprise one or more projections designed to mimic the appearance of a structural feature when implanted into a host.
摘要翻译：提供了用于制造所公开的构建体的组织工程构建体和方法。一些公开的组织工程构建体被设计成填充由于例如来自乳房切除术或乳房肿瘤切除术，伤口等的手术切除而引起的体内空隙。一些公开的构建体包含一个或多个突出物，其被设计成当植入宿主中时模仿结构特征的外观。

7. 发明申请

WO2004108418A1 INK-JET PRINTING OF VIABLE CELLS 审中-公开
标题翻译： INK-JET打印可变电池
公开(公告)号：WO2004108418A1
公开(公告)日：2004-12-16
申请号：PCT/US2004/011276
申请日：2004-04-13
申请人： CLEMSON UNIVERSITY , BOLAND, Thomas , WILSON, JR., W., Chris , XU, Tao
发明人： BOLAND, Thomas , WILSON, JR., W., Chris , XU, Tao
IPC分类号： B41J2/17
CPC分类号： B01L3/0268 , B01L2300/0819 , B01L2400/0439 , B01L2400/0442 , B33Y70/00 , B33Y80/00 , G01N2035/00158 , G01N2035/00168 , G01N2035/1041
摘要： A method for forming an array of viable cells is provided. In one embodiment, the method comprises ink-jet printing a cellular composition containing cells onto a substrate. Upon printing, at least about 25% of the cells remain viable after incubation for 24 hours at 37°C in a 5% CO2 / 95% O2 environment.
摘要翻译：提供了形成活细胞阵列的方法。在一个实施方案中，该方法包括将含有细胞的细胞组合物喷墨印刷到基底上。在印刷时，在5％CO 2/95％O 2环境中，37℃下孵育24小时后，至少约25％的细胞保持活性。

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