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1. 发明申请

WO2008156331A3 NOVEL USE OF LIGNAN COMPOUNDS 审中-公开
标题翻译：使用LIGNAN化合物的新用途
公开(公告)号：WO2008156331A3
公开(公告)日：2009-02-26
申请号：PCT/KR2008003525
申请日：2008-06-20
申请人： BIOCARE CO LTD , HWANG JAE-KWAN , LEE JAE YOUNG , KIM JEONG HWAN , SHIM JAE-SEOK , LEE HAE JI
发明人： HWANG JAE-KWAN , LEE JAE YOUNG , KIM JEONG HWAN , SHIM JAE-SEOK , LEE HAE JI
IPC分类号： A61K31/075 , A61K36/18 , A61K36/53 , A61P3/04
CPC分类号： A61K31/075 , A61K36/185
摘要： The present invention relates to novel use of lignan compounds, and more particularly, the present invention relates to novel use of an extract of the aril of nutmeg, 2- (4-allyl-2, 6-dimethoxyphenoxy) -1- (4-hydroxy- 3 -methoxyphenyl) -propane, austrobailignan 7 or licarin E, for preventing or treating diabetes or PPAR?-mediated diseases. The said compound and extract of the aril of nutmeg act as ligands for PPARy, and they may be used for preventing or treating PPAR?-mediated diseases, not limited thereto, such as diabetes and diabetic complication. Accordingly, 2- (4-allyl-2, 6- dimethoxyphenoxy) -1- (4 -hydroxy-3 -methoxyphenyl) -propane, austrobailignan 7 or licarin E and extract of the aril of nutmeg may be useful as preventing or treating agent for PPAR?-mediated diseases, not limited thereto, such as diabetes and diabetic complication.
摘要翻译：本发明涉及木脂素化合物的新用途，更具体地说，本发明涉及肉豆蔻酸的提取物2-（4-烯丙基-2,6-二甲氧基苯氧基）-1-（4- 羟基-3-甲氧基苯基） - 丙烷，奥司他林7或赖氨酸E，用于预防或治疗糖尿病或PPARα介导的疾病。所述的肉豆蔻的化合物和提取物作为PPARγ的配体，它们可以用于预防或治疗PPARα介导的疾病，不限于糖尿病和糖尿病并发症。因此，可以使用2-（4-烯丙基-2,6-二甲氧基苯氧基）-1-（4-羟基-3-甲氧基苯基） - 丙烷，奥罗韦利奈恩7或赖氨酸E和肉豆蔻的提取物作为预防或处理剂对于PPARβ介导的疾病，不限于糖尿病和糖尿病并发症。

2. 发明申请

WO2008156331A2 NOVEL USE OF LIGNAN COMPOUNDS 审中-公开
标题翻译：使用LIGNAN化合物的新用途
公开(公告)号：WO2008156331A2
公开(公告)日：2008-12-24
申请号：PCT/KR2008/003525
申请日：2008-06-20
申请人： BIOCARE CO., LTD. , HWANG, Jae-Kwan , LEE, Jae Young , KIM, Jeong Hwan , SHIM, Jae-Seok , LEE, Hae Ji
发明人： HWANG, Jae-Kwan , LEE, Jae Young , KIM, Jeong Hwan , SHIM, Jae-Seok , LEE, Hae Ji
IPC分类号： A61K31/075
CPC分类号： A61K31/075 , A61K36/185
摘要： The present invention relates to novel use of lignan compounds, and more particularly, the present invention relates to novel use of an extract of the aril of nutmeg, 2- (4-allyl-2, 6-dimethoxyphenoxy) -1- (4-hydroxy- 3 -methoxyphenyl) -propane, austrobailignan 7 or licarin E, for preventing or treating diabetes or PPARγ-mediated diseases. The said compound and extract of the aril of nutmeg act as ligands for PPARy, and they may be used for preventing or treating PPARγ-mediated diseases, not limited thereto, such as diabetes and diabetic complication. Accordingly, 2- (4-allyl-2, 6- dimethoxyphenoxy) -1- (4 -hydroxy-3 -methoxyphenyl) -propane, austrobailignan 7 or licarin E and extract of the aril of nutmeg may be useful as preventing or treating agent for PPARγ-mediated diseases, not limited thereto, such as diabetes and diabetic complication.
摘要翻译：本发明涉及木脂素化合物的新用途，更具体地说，本发明涉及肉豆蔻酸的提取物2-（4-烯丙基-2,6-二甲氧基苯氧基）-1-（4- 羟基-3-甲氧基苯基） - 丙烷，奥司他林7或赖氨酸E，用于预防或治疗糖尿病或PPARα介导的疾病。所述的肉豆蔻的化合物和提取物作为PPARγ的配体，它们可以用于预防或治疗PPARα介导的疾病，不限于糖尿病和糖尿病并发症。因此，可以使用2-（4-烯丙基-2,6-二甲氧基苯氧基）-1-（4-羟基-3-甲氧基苯基） - 丙烷，奥罗韦利奈恩7或赖氨酸E和肉豆蔻的提取物作为预防或处理剂对于PPARβ介导的疾病，不限于糖尿病和糖尿病并发症。

3. 发明申请

WO2005023214A1 COMPOSITION FOR SKIN WHITENING 审中-公开
标题翻译：皮肤白化成分
公开(公告)号：WO2005023214A1
公开(公告)日：2005-03-17
申请号：PCT/KR2004/002254
申请日：2004-09-06
申请人： BIOCARE CO., LTD. , HWANG, Jae-Kwan , KIM, Ji-Eun
发明人： HWANG, Jae-Kwan , KIM, Ji-Eun
IPC分类号： A61K7/48
CPC分类号： A61K8/35 , A61K8/498 , A61K8/97 , A61Q19/02
摘要： The present invention relates to a composition for skin whitening, which contains phloroglucinol compound having inhibitory activity for melanin formation as an effective component. The composition for skin whitening containing phloroglucinol compound according to the present invention may be used safely since it shows no side effects on skin. In addition, the composition according to the present invention shows a superior effect to inhibit pigmentation on skin by restraining melanin generation, so it is very effective in skin whitening, e.g., to improve chloasma and freckles.
摘要翻译：本发明涉及一种皮肤美白用组合物，其含有对黑色素形成具有抑制活性的间苯三酚化合物作为有效成分。根据本发明的含有间苯三酚化合物的皮肤美白组合物可以安全使用，因为它对皮肤没有副作用。此外，根据本发明的组合物通过抑制黑色素产生显示出抑制皮肤色素沉着的优异效果，因此在皮肤美白方面非常有效，例如改善黄褐斑和雀斑。

4. 发明申请

WO2004112764A1 SUPPRESSANT OF TOXICITY INDUCED BY CANCER CHEMOTHERAPEUTIC AGENT AND COMPOSITION OF CANCER CHEMOTHERAPEUTIC AGENT CONTAINING THE SAME 审中-公开
标题翻译：癌症化疗药物引起的毒性抑制剂和含有其的癌症化学治疗剂的组合物
公开(公告)号：WO2004112764A1
公开(公告)日：2004-12-29
申请号：PCT/KR2004/001526
申请日：2004-06-24
申请人： BIOCARE CO., LTD. , PARK, Kwang-Kyun , CHUNG, Won-Yoon , HONG, Gyoung-Ok , HWANG, Jae-Kwan
发明人： PARK, Kwang-Kyun , CHUNG, Won-Yoon , HONG, Gyoung-Ok , HWANG, Jae-Kwan
IPC分类号： A61K31/045
CPC分类号： A61K31/045 , A61K31/05 , A61K31/28 , A61K31/555 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Disclosed are a suppressant of toxicity such as hepatotoxicity and nephrotoxicity, induced by cancer chemotherapeutic agent, and a composition of cancer chemotherapeutic agent containing the suppressant. The suppressant of toxicity induced by a cancer chemotherapeutic agent contains xanthorrhizol as an active ingredient. Xanthorrhizol shows an excellent ability in suppressing ill effects generated by dosage of cancer chemotherapeutic agent, such as hepatotoxicity and nephrotoxicity.
摘要翻译：公开了由癌症化学治疗剂诱导的毒性抑制剂如肝毒性和肾毒性，以及含有抑制剂的癌症化学治疗剂的组合物。癌症化学治疗剂诱导的毒性抑制剂含有作为活性成分的黄嘌呤。 Xanthorrhizol具有优异的抑制癌症化疗药物剂量引起的不良反应的能力，如肝毒性和肾毒性。

5. 发明申请

WO2009051434A1 NOVEL USE OF PANDURATIN DERIVATIVES OR EXTRACT OF KAEMPFERIA PANDURATA COMPRISING THE SAME 审中-公开
标题翻译：使用潘多拉汀衍生物或提取其包含其的卡潘普兰
公开(公告)号：WO2009051434A1
公开(公告)日：2009-04-23
申请号：PCT/KR2008/006137
申请日：2008-10-17
申请人： BIOCARE CO., LTD. , WHANG, Jae-Kwan , SHIM, Jae-Seok , GWON, Song Hui , KWON, Yi Young , OH, Hyun In , HAN, Young Sun , CHOI, Eun Jung
发明人： WHANG, Jae-Kwan , SHIM, Jae-Seok , GWON, Song Hui , KWON, Yi Young , OH, Hyun In , HAN, Young Sun , CHOI, Eun Jung
IPC分类号： A61K8/35
CPC分类号： A61K8/35 , A61K8/97 , A61K2800/91 , A61Q19/08
摘要： The present invention relates to a new use of panduratin derivatives or a Kaempferia pandurata extract comprising the same. More particularly, the present invention relates to a composition for improving wrinkles and/or preventing aging, which comprises a panduratin derivative or a Kaempferia pandurata extract comprising the same. The said the panduratin derivative or the Kaempferia pandurata extract comprising the same induces cell proliferation, inhibits degradation of collagen, and promotes synthesis of collagen, therefore, it shows excellent activity in prevention of aging, particularly preventing, improving or treating wrinkle and it 'can be used as an effective ingredient in a cosmetic, food or pharmaceutical composition.
摘要翻译：本发明涉及潘多汀衍生物的新用途或包含其的白头翁提取物。更具体地说，本发明涉及一种用于改善皱纹和/或防止衰老的组合物，其包含潘杜林衍生物或包含其的白芍提取物。所述包含其的潘多汀衍生物或山梨提取物诱导细胞增殖，抑制胶原蛋白的降解，促进胶原蛋白的合成，因此在防止老化，特别是防止，改善或治疗皱纹方面表现出优异的活性，并且可以用作化妆品，食品或药物组合物中的有效成分。

6. 发明申请

WO2008156345A2 USE OF LIGNAN COMPOUND FOR ANTI-WRINKLE TREATMENT 审中-公开
标题翻译： LIGNAN化合物用于抗皱治疗的用途
公开(公告)号：WO2008156345A2
公开(公告)日：2008-12-24
申请号：PCT/KR2008/003547
申请日：2008-06-20
申请人： BIOCARE CO., LTD. , HWANG, Jae-Kwan , LEE, Hae Ji , LEE, Jae Young , SHIM, Jae-Seok , KIM, Jeong Hwan
发明人： HWANG, Jae-Kwan , LEE, Hae Ji , LEE, Jae Young , SHIM, Jae-Seok , KIM, Jeong Hwan
IPC分类号： A61K8/34
CPC分类号： A61K8/97 , A61K8/347 , A61K8/498 , A61Q19/08
摘要： The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme- 1(MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.
摘要翻译：本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠道中分离和纯化用于抗皱，更具体地，本发明涉及用于抗皱的提取物的抗皱纹的新用途肉豆蔻或肉豆蔻，fragrin A，奥维菌素7，licarin E和肉豆蔻衣木脂的提取物。本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的作用，从而具有抑制由光老化。因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。

7. 发明申请

WO2009051437A3 NOVEL USE OF LIGNAN-TYPE COMPOUNDS OR EXTRACT OF NUTMEG OR ARIL OF NUTMEG COMPRISING THE SAME 审中-公开
标题翻译：新型使用LIGNAN型化合物或提取NUTMEG或包含其的NUTMEG
公开(公告)号：WO2009051437A3
公开(公告)日：2009-07-16
申请号：PCT/KR2008006143
申请日：2008-10-17
申请人： BIOCARE CO LTD , HWANG JAE-KWAN , CHO YU-MI , KIM GYU HOI , KIM JEONG HWAN , LEE HAE JI , OH HYUN IN
发明人： HWANG JAE-KWAN , CHO YU-MI , KIM GYU HOI , KIM JEONG HWAN , LEE HAE JI , OH HYUN IN
IPC分类号： A61K8/49
CPC分类号： A61Q19/02 , A61K8/4973 , A61K8/97 , A61K31/357 , A61K36/185
摘要： The present invention relates to a new use of lignan-type compounds or an extract of nutmeg or aril of nutmeg comprising the same. More particularly, the present invention relates to a composition for skin whitening comprising a lignan-type compound or an extract of nutmeg or aril of nutmeg comprising the same. Because the lignan compound represented by Chemical Formulas 1 to 3 or the extract of nutmeg or aril of nutmeg has superior skin whitening activity by inhibiting melanin production and tyrosinase activity, it can be used for the preparation of a cosmetic composition, food composition or pharmaceutical composition for skin whitening.
摘要翻译：本发明涉及木素素型化合物或含有该木素素类化合物的肉豆蔻或肉豆蔻酸提取物的新用途。更具体地，本发明涉及一种皮肤美白组合物，其包含木素素型化合物或包含该组合物的肉豆蔻或肉豆蔻酸的提取物。由于化学式1〜3所示的木酚素化合物或肉豆蔻肉豆蔻酸提取物通过抑制黑色素生成和酪氨酸酶活性而具有优异的皮肤美白活性，因此可用于制备化妆品组合物，食品组合物或药物组合物用于皮肤美白。

8. 发明申请

WO2009051437A2 NOVEL USE OF LIGNAN-TYPE COMPOUNDS OR EXTRACT OF NUTMEG OR ARIL OF NUTMEG COMPRISING THE SAME 审中-公开
标题翻译：木脂素类化合物的新用途或包含该化合物的肉豆蔻或肉豆蔻的提取物的新用途
公开(公告)号：WO2009051437A2
公开(公告)日：2009-04-23
申请号：PCT/KR2008/006143
申请日：2008-10-17
申请人： BIOCARE CO., LTD. , HWANG, Jae-Kwan , CHO, Yu-Mi , KIM, Gyu Hoi , KIM, Jeong Hwan , LEE, Hae Ji , OH, Hyun In
发明人： HWANG, Jae-Kwan , CHO, Yu-Mi , KIM, Gyu Hoi , KIM, Jeong Hwan , LEE, Hae Ji , OH, Hyun In
IPC分类号： A61K8/49
CPC分类号： A61Q19/02 , A61K8/4973 , A61K8/97 , A61K31/357 , A61K36/185
摘要： The present invention relates to a new use of lignan-type compounds or an extract of nutmeg or aril of nutmeg comprising the same. More particularly, the present invention relates to a composition for skin whitening comprising a lignan-type compound or an extract of nutmeg or aril of nutmeg comprising the same. Because the lignan compound represented by Chemical Formulas 1 to 3 or the extract of nutmeg or aril of nutmeg has superior skin whitening activity by inhibiting melanin production and tyrosinase activity, it can be used for the preparation of a cosmetic composition, food composition or pharmaceutical composition for skin whitening.
摘要翻译：本发明涉及木脂素类化合物或包含其的肉豆蔻或肉豆蔻提取物的新用途。更具体地说，本发明涉及用于皮肤增白的组合物，其包含木脂素类化合物或包含其的肉豆蔻或肉豆蔻提取物。由于化学式1至3所示的木脂素化合物或肉豆蔻或肉豆蔻提取物通过抑制黑色素生成和酪氨酸酶活性而具有优异的皮肤增白活性，因此其可用于制备化妆品组合物，食品组合物或药物组合物皮肤美白。

9. 发明申请

WO2008156330A1 USE OF XANTHORRHIZOL FOR ANTI-WRINKLE TREATMENT 审中-公开
标题翻译：使用XANTHORRHIZOL进行抗皱治疗
公开(公告)号：WO2008156330A1
公开(公告)日：2008-12-24
申请号：PCT/KR2008/003522
申请日：2008-06-20
申请人： BIOCARE CO., LTD. , HWANG, Jae-Kwan , SHIM, Jae-Seok , LEE, Hae Ji , CHO, Yu-Mi , GWON, Song Hui
发明人： HWANG, Jae-Kwan , SHIM, Jae-Seok , LEE, Hae Ji , CHO, Yu-Mi , GWON, Song Hui
IPC分类号： A61K8/34
CPC分类号： A61Q19/08 , A61K8/347 , A61K8/97
摘要： The present invention relates to novel use of an extract of Curcuma xanthorrhiza or xanthorrhizol isolated from the extract and represented by Formula 1. The extract of Curcuma xanthorrhiza and xanthorrhizol of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-I, matrix metalloproteinase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibiting wrinkle. Accordingly, an extract of Curcuma xanthorrhiza or xanthorrhizol of the present -invention may be useful for preventing or treating wrinkle caused by photoaging.
摘要翻译：本发明涉及从提取物中分离出的由式1表示的姜黄黄嘌呤或黄嘌呤提取物的新用途。本发明的姜黄黄嘌呤和黄嘌呤的提取物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新胶原（1型前胶原）的形成，从而具有抑制皱纹的作用。因此，本发明的姜黄黄嘌呤或黄嘌呤的提取物可用于预防或治疗由光老化引起的皱纹。

10. 发明申请

WO2002083114A1 PHARMACEUTICAL COMPOSITIONG OR PREVENTING AND TREATING CANCER AND TREATING AN INFLAMMATION 审中-公开
标题翻译：药物组合物或预防和治疗癌症并治疗炎症
公开(公告)号：WO2002083114A1
公开(公告)日：2002-10-24
申请号：PCT/KR2002/000496
申请日：2002-03-22
申请人： BIOCARE CO., LTD. , PARK, Kwang-Kyun , HWANG, Jae-Kwan , LEE, Sang-Kook , CHUNG, Won-Yoon
发明人： PARK, Kwang-Kyun , HWANG, Jae-Kwan , LEE, Sang-Kook , CHUNG, Won-Yoon
IPC分类号： A61K31/045
CPC分类号： A61K31/045
摘要： The present invention realtes to a pharmaceutical composition preventing cancer and treating cancer and inflammation, which is characterized in that including xanthorrhizol as an active principle. Xanthorrhizol not only inhibits mutagenesis and tumor formation, and enhances the activity of detoxification enzame of carcinogen, induces apoptosis of cancer cell, and suppresses the activity of COX-2 and iNOS which are related to tumor promotion and inflammatory reaction. Thus, a pharamceutical composition including xanthorrhizol can be utilized for prevention of cancer and treatment of cancer and inflammation.
摘要翻译：本发明涉及预防癌症和治疗癌症和炎症的药物组合物，其特征在于包括作为活性成分的黄嘌呤。 Xanthorrhizol不仅抑制诱变和肿瘤形成，增强致癌物的解毒活性，诱导癌细胞凋亡，抑制与肿瘤促进和炎症反应相关的COX-2和iNOS的活性。因此，可以利用包含黄嘌呤的药用组合物来预防癌症和治疗癌症和炎症。

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