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1. 发明申请

WO2012047813A1 MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE 审中-公开
标题翻译： MACROCYCLIC LACTONE化合物及其使用方法
公开(公告)号：WO2012047813A1
公开(公告)日：2012-04-12
申请号：PCT/US2011/054637
申请日：2011-10-03
申请人： ELIXIR MEDICAL CORPORATION , YAN, John , ZHENG, Xiaoxia , BHAT, Vinayak, D.
发明人： YAN, John , ZHENG, Xiaoxia , BHAT, Vinayak, D.
IPC分类号： A61K31/44 , A61F2/00
CPC分类号： A61L31/16 , A61K31/436 , A61K45/06 , A61L29/06 , A61L29/148 , A61L29/16 , A61L31/06 , A61L31/08 , A61L31/148 , C08L67/04 , A61K2300/00
摘要： The present disclosure provides a device for intracorporeal use which comprises an implant or a temporary device and at least one source of myolimus or a derivative thereof. The present disclosure also provides a method of inhibiting cell proliferation, inflammation or cytokine production by systemic or local administration of a therapeutically effective amount of myolimus or a derivative thereof. Further included in the present disclosure is a method of treating an ophthalmic condition or disease by administering a therapeutically effective amount of myolimus or a derivative thereof.
摘要翻译：本公开提供了一种用于体内使用的装置，其包括植入物或临时装置和至少一种肌醇来源或其衍生物。本公开还提供了通过全身或局部施用治疗有效量的肌醇酰胺或其衍生物来抑制细胞增殖，炎症或细胞因子产生的方法。本公开内容中还包括通过施用治疗有效量的肌醇酰胺或其衍生物来治疗眼科疾病或疾病的方法。

2. 发明申请

WO2008033956A3 MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE 审中-公开
标题翻译： MACROCYCLIC LACTONE化合物及其使用方法
公开(公告)号：WO2008033956A3
公开(公告)日：2008-11-27
申请号：PCT/US2007078317
申请日：2007-09-12
申请人： ELIXIR MEDICAL CORP , YAN JOHN , ZHENG XIAOXIA , BHAT VINAYAK D
发明人： YAN JOHN , ZHENG XIAOXIA , BHAT VINAYAK D
IPC分类号： A61K31/787
CPC分类号： A61K31/787 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61K2300/00
摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula (I) wherein R1, R2, R3, R5, R6 and R8 are each independently a member selected from the group consisting of H, C1-6 alkyl and OH; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, -OH, -OP(O)Me2, (II) -O-(CH2)n-OH and -O-(CH2)m-O-(CH2)o- CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: (III) each of L and L3 are independently selected from the group consisting of: (IV) salts, hydrates, isomers, metabolites and prodrugs thereof.
摘要翻译：本发明提供包含药学上可接受的赋形剂和式（I）化合物的药物组合物，其中R 1，R 2，R 3，R 5，R 6和R 8各自独立地选自H，C 1-6烷基和OH; R 4，R 7和R 9各自独立地选自C 1-6烷氧基和OH; R 10是选自H，-OH，-OP（O）Me 2，（II）-O-（CH 2）n -OH和-O-（CH 2）m O-（CH 2）o -CH 3，其中下标n和m各自独立地为2至8，下标o为1至6; L1和L4中的每一个独立地选自：（III）L和L3各自独立地选自：（IV）其盐，水合物，异构体，代谢物和前药。

3. 发明申请

WO2008033956A2 MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE 审中-公开
标题翻译： MACROCYCLIC LACTONE化合物及其使用方法
公开(公告)号：WO2008033956A2
公开(公告)日：2008-03-20
申请号：PCT/US2007/078317
申请日：2007-09-12
申请人： ELIXIR MEDICAL CORPORATION , YAN, John , ZHENG, Xiaoxia , BHAT, Vinayak D.
发明人： YAN, John , ZHENG, Xiaoxia , BHAT, Vinayak D.
IPC分类号： A61K31/787
CPC分类号： A61K31/787 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61K2300/00
摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula (I) wherein R 1 , R 2 , R 3 , R 5 , R 6 and R 8 are each independently a member selected from the group consisting of H, C 1-6 alkyl and OH; R 4 , R 7 and R 9 are each independently selected from the group consisting of C 1-6 alkoxy and OH; R 10 is a member selected from the group consisting of H, -OH, -OP(O)Me 2 , (II) -O-(CH 2 ) n -OH and -O-(CH 2 ) m -O-(CH 2 ) o - CH 3 , wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L 1 and L 4 are independently selected from the group consisting of: (III) each of L and L3 are independently selected from the group consisting of: (IV) salts, hydrates, isomers, metabolites and prodrugs thereof.
摘要翻译：本发明提供药物组合物，其包含药学上可接受的赋形剂和式（I）化合物，其中R 1，R 2，R 3， >，R 5，R 6和R 8各自独立地是选自H，C 1〜 6烷基和OH; R 4，R 7和R 9各自独立地选自C 1-6 - 烷氧基和OH; R 10是选自H，-OH，-OP（O）Me 2 2，（II）-O-（CH 2） -OH和-O-（CH 2）2 - （CH 2）n - （CH 2）n - 其中下标n和m各自独立地为2至8，下标o为1至6; L 1和L 4各自独立地选自：（III）L和L3各自独立地选自：（IV）盐，水合物，异构体，代谢物和前药。

4. 发明申请

WO2006108065A3 DEGRADABLE IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可降解植入式医疗器械
公开(公告)号：WO2006108065A3
公开(公告)日：2007-06-28
申请号：PCT/US2006012725
申请日：2006-04-04
申请人： ELIXIR MEDICAL CORP , CRYER BRETT , BHAT VINAYAK D , YAN JOHN , SIRHAN MOTASIM
发明人： YAN JOHN , SIRHAN MOTASIM
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61F2/82 , A61F2/02 , A61F2/06 , A61F2/07 , A61F2/90 , A61F2210/0004 , A61F2220/0058 , A61F2250/003 , A61F2250/0067 , B23K26/0006 , B23K26/0084 , B23K26/0624 , B23K26/382 , B23K26/40 , B23K2201/06 , B23K2203/02 , B23K2203/12 , B23K2203/50
摘要： Devices and methods are provided for an implantable medical device which is degradable over a clinically relevant period of time. The medical devices may have the form of implants, graft implants, vascular implants, non vascular implants, wound closure implants, sutures, drug delivery implants, biologic delivery implants, urinary tract implants, inter-uterine implants, organ implants, bone implants including bone plates, bone screws, dental implants, spinal disks, or the like. In preferred embodiments, the implantable medical device comprises an implantable luminal prosthesis, such as vascular and non-vascular stents and stents grafts.
摘要翻译：提供了用于可临床相关时间段可降解的可植入医疗装置的装置和方法。医疗装置可以具有植入物，移植物植入物，血管植入物，非血管植入物，伤口闭合植入物，缝线，药物递送植入物，生物递送植入物，尿道植入物，子宫内植入物，器官植入物，包括骨骼的骨植入物板，骨螺钉，牙植入物，脊椎盘等。在优选实施例中，可植入医疗装置包括可植入腔内假体，例如血管和非血管支架和支架移植物。

5. 发明申请

WO2008051867A3 LUMINAL PROSTHESES AND METHODS FOR COATING THEREOF 审中-公开
标题翻译：发光材料及其涂层方法
公开(公告)号：WO2008051867A3
公开(公告)日：2008-08-07
申请号：PCT/US2007081996
申请日：2007-10-19
申请人： ELIXIR MEDICAL CORP , YAN JOHN , HUANG HOWARD , BHAT VINAYAK D
发明人： YAN JOHN , HUANG HOWARD , BHAT VINAYAK D
IPC分类号： A61F2/02
CPC分类号： A61L27/34 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2230/0054 , A61F2250/0067 , A61L27/54 , A61L29/085 , A61L29/16 , A61L2300/606 , A61L2430/16
摘要： Luminal prostheses comprise scaffolds having coatings adhered to at least a portion of their outer surfaces. The surfaces are modified to enhance binding of the coatings. For example, the surfaces may be microblasted, laser treated, chemically etched, exposed to plasma, or exposed to a corona discharge, allowing a polymeric coating to adhere to the scaffold more tightly than in the absence of the surface modification. The coatings can be used to deliver therapeutic or other agents dispersed therein.
摘要翻译：假体假体包括具有粘附在其外表面的至少一部分上的涂层的支架。修饰表面以增强涂层的粘结。例如，表面可以被微粉碎，激光处理，化学蚀刻，暴露于等离子体或暴露于电晕放电，使得聚合物涂层比没有表面改性更紧密地粘附到支架上。涂层可用于递送分散在其中的治疗剂或其它药剂。

6. 发明申请

WO2008033956A9 MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE 审中-公开
标题翻译：大环内酯化合物及其使用方法
公开(公告)号：WO2008033956A9
公开(公告)日：2008-09-18
申请号：PCT/US2007078317
申请日：2007-09-12
申请人： ELIXIR MEDICAL CORP , YAN JOHN , ZHENG XIAOXIA , BHAT VINAYAK D
发明人： YAN JOHN , ZHENG XIAOXIA , BHAT VINAYAK D
IPC分类号： A61K31/787
CPC分类号： A61K31/787 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/416 , A61K2300/00
摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula (I) wherein R 1 , R 2 , R 3 , R 5 , R 6 and R 8 are each independently a member selected from the group consisting of H, C 1-6 alkyl and OH; R 4 , R 7 and R 9 are each independently selected from the group consisting of C 1-6 alkoxy and OH; R 10 is a member selected from the group consisting of H, -OH, -OP(O)Me 2 , (II) -O-(CH 2 ) n -OH and -O-(CH 2 ) m -O-(CH 2 ) o - CH 3 , wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L 1 and L 4 are independently selected from the group consisting of: (III) each of L and L3 are independently selected from the group consisting of: (IV) salts, hydrates, isomers, metabolites and prodrugs thereof.
摘要翻译：本发明提供了包含药学上可接受的赋形剂和式（I）化合物的药物组合物，其中R 1，R 2，R 3，SUP， R 5，R 6和R 8各自独立地为选自下组的成员：H，C 1 -C 4烷基， 6烷基和OH; R 4，R 7和R 9各自独立地选自C 1-6烷氧基，C 1-6烷氧基，和OH; R 10选自H，-OH，-OP（O）Me 2，（II）-O-（CH 2 SUB 2）（CH _{）< - > - < - > _{n -OH和-O-（CH _{2 ）< - > 其中下标n和m各自独立地为2至8且下标o为1至6; L和L各自独立地选自：（III）L和L3中的每一个独立地选自由以下各项组成的组：（IV）盐，水合物，异构体，代谢物和前药。}}}

7. 发明申请

WO2006108065A2 DEGRADABLE IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可降解植入式医疗器械
公开(公告)号：WO2006108065A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/012725
申请日：2006-04-04
申请人： ELIXIR MEDICAL CORPORATION , CRYER, Brett , BHAT, Vinayak, D. , YAN, John , SIRHAN, Motasim
发明人： YAN, John , SIRHAN, Motasim
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/02 , A61F2/06 , A61F2/07 , A61F2/90 , A61F2210/0004 , A61F2220/0058 , A61F2250/003 , A61F2250/0067 , B23K26/0006 , B23K26/0084 , B23K26/0624 , B23K26/382 , B23K26/40 , B23K2201/06 , B23K2203/02 , B23K2203/12 , B23K2203/50
摘要： Devices and methods are provided for an implantable medical device which is degradable over a clinically relevant period of time. The medical devices may have the form of implants, graft implants, vascular implants, non vascular implants, wound closure implants, sutures, drug delivery implants, biologic delivery implants, urinary tract implants, inter-uterine implants, organ implants, bone implants including bone plates, bone screws, dental implants, spinal disks, or the like. In preferred embodiments, the implantable medical device comprises an implantable luminal prosthesis, such as vascular and non-vascular stents and stents grafts.
摘要翻译：提供了用于可临床相关时间段可降解的可植入医疗装置的装置和方法。医疗装置可以具有植入物，移植物植入物，血管植入物，非血管植入物，伤口闭合植入物，缝线，药物递送植入物，生物递送植入物，尿道植入物，子宫内植入物，器官植入物，包括骨骼的骨植入物板，骨螺钉，牙植入物，脊椎盘等。在优选实施例中，可植入医疗装置包括可植入腔内假体，例如血管和非血管支架和支架移植物。

8. 发明申请

WO2005051229A2 DEVICES DELIVERING THERAPEUTIC AGENTS AND METHODS REGARDING THE SAME 审中-公开
标题翻译：递送治疗药物的装置及其相关方法
公开(公告)号：WO2005051229A2
公开(公告)日：2005-06-09
申请号：PCT/US2004/039062
申请日：2004-11-19
申请人： AVANTEC VASCULAR CORPORATION , BHAT, Vinayak D. , YAN, John
发明人： BHAT, Vinayak D. , YAN, John
IPC分类号： A61F
CPC分类号： A61L31/16 , A61F2250/0067 , A61L27/54 , A61L2300/414 , A61L2300/416
摘要： Devices and methods for reducing, inhibiting, or treating restenosis and hyperplasia after intravascular intervention are provided. In particular, the present invention provides luminal prostheses which allow for sustained or controlled release of at least one therapeutic capable agent with increased efficacy to selected locations within a patient's vasculature to reduce restenosis. An intraluminal prosthesis may comprise an expandable structure and a source adjacent the expandable structure for releasing the therapeutic capable agent into a body lumen to reduce smooth muscle cell proliferation.
摘要翻译：提供了用于减少，抑制或治疗血管内干预后再狭窄和增生的装置和方法。特别地，本发明提供了腔内假体，其允许至少一种具有治疗能力的药剂的持续或受控释放，其对患者脉管系统内的选定位置具有增加的功效以减少再狭窄。腔内假体可以包括可扩张结构和邻近可扩张结构的源，用于将可治疗能力的药剂释放到体腔中以减少平滑肌细胞增殖。

9. 发明申请

WO2009114010A1 MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE 审中-公开
标题翻译： MACROCYCLIC LACTONE化合物及其使用方法
公开(公告)号：WO2009114010A1
公开(公告)日：2009-09-17
申请号：PCT/US2008/056501
申请日：2008-03-11
申请人： ELIXIR MEDICAL CORPORATION , YAN, John , ZHENG, Xiaoxia , BHAT, Vinayak D.
发明人： YAN, John , ZHENG, Xiaoxia , BHAT, Vinayak D.
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： A61K31/70 , A61K31/436
摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula (I) wherein R 1 , R 2 , R 3 , R 5 , R 6 , R 8 , M 1 , M 2 , M 3 , M 4 , M 5 , M 6 and M 7 are each independently a member selected from the group consisting of H, C 1-6 alkyl, OH and C 1-6 hydroxyalkyl; R 4 , R 7 and R 9 are each independently selected from the group consisting of C 1-6 alkoxy and OH; R 10 is a member selected from the group consisting of H, -OH, -OP(O)Me 2 , (II), (III), -O-(CH 2 ) n -OH and -O-(CH 2 ) m -O-(CH 2 ) o -CH 3 , wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L 1 and L 4 are independently selected from the group consisting of (IV) and (V) wherein each M 8 is independently a member selected from the group consisting Of C 1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L 2 and L 3 are independently selected from the group consisting of (VI), (VII) and (VIII); and salts, hydrates, isomers, metabolites, N-oxides and prodrugs thereof.
摘要翻译：本发明提供包含药学上可接受的赋形剂和式（I）化合物的药物组合物，其中R 1，R 2，R 3，R 5，R 6，R 8，M 1，M 2，M 3，M 5，M 6和M 7各自独立选自H，C 1-6烷基，OH和C 1-6羟基烷基的成员; R 4，R 7和R 9各自独立地选自C 1-6烷氧基和OH; R 10是选自H，-OH，-OP（O）Me 2，（II），（III），-O-（CH 2）n -OH和-O-（CH 2）m O-（CH 2））o-CH3，其中下标n和m各自独立地为2至8，下标o为1至6; L1和L4各自独立地选自（IV）和（V），其中每个M8独立地是选自C1-6烷基，OH和C1-6羟基烷基的成员; L2和L3各自独立地选自由（VI），（VII）和（VIII）组成的组。及其盐，水合物，异构体，代谢物，N-氧化物和前药。

10. 发明申请

WO2008051867A2 LUMINAL PROSTHESES AND METHODS FOR COATING THEREOF 审中-公开
标题翻译： LUMINAL修复体及其涂层方法
公开(公告)号：WO2008051867A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/081996
申请日：2007-10-19
申请人： ELIXIR MEDICAL CORPORATION , YAN, John , HUANG, Howard , BHAT, Vinayak, D.
发明人： YAN, John , HUANG, Howard , BHAT, Vinayak, D.
IPC分类号： A61F2/02
CPC分类号： A61L27/34 , A61F2/91 , A61F2/915 , A61F2002/91558 , A61F2230/0054 , A61F2250/0067 , A61L27/54 , A61L29/085 , A61L29/16 , A61L2300/606 , A61L2430/16
摘要： Luminal prostheses comprise scaffolds having coatings adhered to at least a portion of their outer surfaces. The surfaces are modified to enhance binding of the coatings. For example, the surfaces may be microblasted, laser treated, chemically etched, exposed to plasma, or exposed to a corona discharge, allowing a polymeric coating to adhere to the scaffold more tightly than in the absence of the surface modification. The coatings can be used to deliver therapeutic or other agents dispersed therein.
摘要翻译：管状假体包括具有涂层的支架，所述涂层粘附到其外表面的至少一部分上。对表面进行改性以增强涂层的结合。例如，可以对表面进行微裂纹，激光处理，化学蚀刻，暴露于等离子体或暴露于电晕放电，从而允许聚合物涂层比不存在表面改性时更紧密地粘附到支架。这些涂层可用于输送分散在其中的治疗剂或其他药剂。

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