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1. 发明申请

WO2014143826A3 INTERIOR ENERGY-ACTIVATION OF PHOTO-REACTIVE SPECIES INSIDE A MEDIUM OR BODY 审中-公开
标题翻译：中等或体内光敏物质的内部能量激活
公开(公告)号：WO2014143826A3
公开(公告)日：2014-11-06
申请号：PCT/US2014027965
申请日：2014-03-14
申请人： BOURKE FREDERIC AVERY , FATHI ZAKARYAE , WALDER HAROLD , BEYER WAYNE F
发明人： BOURKE FREDERIC AVERY , FATHI ZAKARYAE , WALDER HAROLD , BEYER WAYNE F
IPC分类号： C08J3/28
CPC分类号： A23L3/28 , A23L3/263 , A23V2002/00 , A61L2/0041 , A61L2/0047 , A61L2/08 , A61L2/082 , A61L2202/24 , A61M1/3681 , A61M1/3683 , A61N5/062 , A61N5/0624 , A61N2005/0661 , A61N2005/0662 , C02F1/307 , C02F1/32 , C02F1/325 , C02F2201/32 , C02F2305/10 , C23C16/458 , G03F7/20 , Y02W10/37
摘要： A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.
摘要翻译：一种用于产生介质变化的方法和系统。该方法在介质附近放置能量调节剂。该方法对介质施加引发能量。引发能与能量调节剂相互作用直接或间接产生介质中的变化。能量调节剂具有在已知产生变化的第二波长范围（WR2）之外的第一波长范围内的辐射的正常主要发射，但是在暴露于所施加的引发能量的同时产生变化。该系统包括引发能量源，其被配置为向介质施加引发能量以激活能量调节剂。

2. 发明申请

WO2008011335A2 METAL BINDING COMPOUNDS, METAL BINDING COMPOSITIONS, AND THEIR USES 审中-公开
标题翻译：金属结合化合物，金属结合组合物及其用途
公开(公告)号：WO2008011335A2
公开(公告)日：2008-01-24
申请号：PCT/US2007073418
申请日：2007-07-13
申请人： AFFINERGY INC , HAMILTON PAUL , BEYER WAYNE F
发明人： HAMILTON PAUL , BEYER WAYNE F
IPC分类号： A61K38/00 , C07H19/04 , C07K2/00 , C07K4/00
CPC分类号： C07K14/001 , A61K38/00 , C07K7/08 , Y10T428/31681
摘要： Compositions are provided comprising a family of peptides having binding specificity for metal, and their use to produce coating compositions. The coating compositions are used to deliver a pharmaceutically active agent to metal, and are used in methods related to metal implants, metal repair, and metal-related diseases.
摘要翻译：提供了包含对金属具有结合特异性的肽家族及其用于生产涂料组合物的组合物。涂料组合物用于将药物活性剂递送到金属中，并且用于与金属植入物，金属修复和金属相关疾病相关的方法。

3. 发明申请

WO2006010047A3 METHODS AND COMPOSITIONS FOR THE DETECTION OF OVARIAN CANCER 审中-公开
公开(公告)号：WO2006010047A3
公开(公告)日：2006-01-26
申请号：PCT/US2005/024359
申请日：2005-07-08
申请人： TRIPATH IMAGING, INC. , BEYER, Wayne, F., Jr , VENETTA, Thomas, Michael , GROELKE, John, W. , BLAESIUS, Rainer, H
发明人： BEYER, Wayne, F., Jr , VENETTA, Thomas, Michael , GROELKE, John, W. , BLAESIUS, Rainer, H
IPC分类号： G01N33/574 , G01N33/68
摘要： Methods and compositions for identifying ovarian cancer in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in ovarian cancer. In preferred embodiments, the body sample is a serum sample. The biomarkers of the invention include any genes or proteins that are selectively overexpressed in ovarian cancer, including, for example, acute phase reactants, lipoproteins, proteins involved in the regulation of the complement system, regulators of apoptosis, proteins that bind hemoglobin, heme, or iron, cytostructural proteins, enzymes that detoxify metabolic byproducts, growth factors, and hormone transporters. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.

4. 发明申请

WO2015112850A3 USE OF PSORALEN DERIVATIVES AND COMBINATION THERAPY FOR TREATMENT OF CELL PROLIFERATION DISORDERS 审中-公开
标题翻译： PSORALEN衍生物的使用和用于治疗细胞增殖障碍的组合治疗
公开(公告)号：WO2015112850A3
公开(公告)日：2015-11-12
申请号：PCT/US2015012669
申请日：2015-01-23
申请人： IMMUNOLIGHT LLC , UNIV DUKE , XIA WENLE , GOODEN DAVID , SODERBLOM ERIK J , TOONE ERIC J , SPECTOR NEIL L , BEYER WAYNE F , WALDER HAROLD
发明人： XIA WENLE , GOODEN DAVID , SODERBLOM ERIK J , TOONE ERIC J , SPECTOR NEIL L , BEYER WAYNE F , WALDER HAROLD
IPC分类号： C07D493/00
CPC分类号： A61K31/436 , A61K31/37 , A61K31/4709 , A61K31/517 , A61K41/0066 , A61K45/06 , A61K2300/00
摘要： Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.
摘要翻译：用于治疗受试者细胞增殖疾病或病症的方法，包括将缺乏DNA交联基序的补骨脂素衍生物应用于癌细胞，施用补骨脂素或其衍生物和拉帕替尼，或施用补骨脂素或其衍生物和神经胶质细胞，并且进一步施加起始辐射能量形成能量源。

5. 发明申请

WO2006007368A3 BIOFUNCTIONAL COATINGS 审中-公开
标题翻译：生物功能涂层
公开(公告)号：WO2006007368A3
公开(公告)日：2006-05-18
申请号：PCT/US2005021147
申请日：2005-06-15
申请人： AFFINERGY INC , HAMILTON PAUL T , GRINSTAFF MARK W , KENAN DANIEL J , CHRISTENSEN DALE J , BEYER WAYNE F JR , HYDE-DERUYSCHER ROBIN , BENSON RAY EDWARD
发明人： HAMILTON PAUL T , GRINSTAFF MARK W , KENAN DANIEL J , CHRISTENSEN DALE J , BEYER WAYNE F JR , HYDE-DERUYSCHER ROBIN , BENSON RAY EDWARD
IPC分类号： A61L27/22 , A61L27/34 , G01N33/543
CPC分类号： A61L27/227 , A61K38/00 , A61L27/34 , A61L27/54 , A61L2300/404 , A61L2300/606 , C07K7/08 , C07K14/001 , C08L89/00
摘要： The present invention provides compositions and methods for an improved coating for medical devices. The coating is an interfacial biomaterial ("IFBM") which comprises at least one binding module that binds to the surface of a device ("surface-binding module") and at least one binding module that performs another function ("affector module") and which acts to inhibit biofilm formation.
摘要翻译：本发明提供了用于医疗器械的改进涂层的组合物和方法。涂层是界面生物材料（“IFBM”），其包括至少一个结合模块（“表面结合模块”）和至少一个执行另一功能的结合模块（“影响模块”）并且其起到抑制生物膜形成的作用。

6. 发明申请

WO2006010047A2 METHODS AND COMPOSITIONS FOR THE DETECTION OF OVARIAN DISEASE 审中-公开
标题翻译：用于检测卵巢疾病的方法和组合物
公开(公告)号：WO2006010047A2
公开(公告)日：2006-01-26
申请号：PCT/US2005024359
申请日：2005-07-08
申请人： TRIPATH IMAGING INC , BEYER WAYNE F JR , VENETTA THOMAS MICHAEL , GROELKE JOHN W , BLAESIUS RAINER H
发明人： BEYER WAYNE F JR , VENETTA THOMAS MICHAEL , GROELKE JOHN W , BLAESIUS RAINER H
IPC分类号： G01N33/574
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/57488 , G01N2333/4725
摘要： Methods and compositions for identifying ovarian cancer in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in ovarian cancer. In preferred embodiments, the body sample is a serum sample. The biomarkers of the invention include any genes or proteins that are selectively overexpressed in ovarian cancer, including, for example, acute phase reactants, lipoproteins, proteins involved in the regulation of the complement system, regulators of apoptosis, proteins that bind hemoglobin, heme, or iron, cytostructural proteins, enzymes that detoxify metabolic byproducts, growth factors, and hormone transporters. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques. Kits for practicing the methods of the invention are further provided.
摘要翻译：提供了用于鉴定患者样品中卵巢癌的方法和组合物。本发明的方法包括检测身体样品中至少一种生物标志物的过表达，其中生物标志物在卵巢癌中选择性地过量表达。在优选的实施方案中，身体样品是血清样品。本发明的生物标志物包括在卵巢癌中选择性过表达的任何基因或蛋白质，包括例如急性期反应物，脂蛋白，参与补体系统调节的蛋白质，细胞凋亡调节剂，结合血红蛋白的蛋白质，血红素，或铁，细胞结构蛋白，解毒代谢副产物，生长因子和激素转运蛋白的酶。在本发明的一些方面，使用生物标志物特异性抗体或在核酸水平使用核酸杂交技术在蛋白质水平上检测目标生物标志物的过表达。还提供了用于实施本发明的方法的试剂盒。

7. 发明申请

WO2015112850A2 USE OF PSORALEN DERIVATIVES AND COMBINATION THERAPY FOR TREATMENT OF CELL PROLIFERATION DISORDERS 审中-公开
标题翻译： PSORALEN衍生物和联合治疗用于治疗细胞增殖性疾病的用途
公开(公告)号：WO2015112850A2
公开(公告)日：2015-07-30
申请号：PCT/US2015/012669
申请日：2015-01-23
申请人： XIA, Wenle , GOODEN, David , SODERBLOM, Erik, J. , TOONE, Eric, J. , SPECTOR, Neil, L. , BEYER, Wayne, F. , WALDER, Harold
发明人： XIA, Wenle , GOODEN, David , SODERBLOM, Erik, J. , TOONE, Eric, J. , SPECTOR, Neil, L. , BEYER, Wayne, F. , WALDER, Harold
IPC分类号： A61K41/00 , A61K31/436
CPC分类号： A61K31/436 , A61K31/37 , A61K31/4709 , A61K31/517 , A61K41/0066 , A61K45/06 , A61K2300/00
摘要： Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif to cancer cells, applying a psoralen or a derivative thereof and lapatinib, or applying a psoralen or derivative thereof and neratinib, to a subject and further applying initiation radiation energy form an energy source.
摘要翻译：用于治疗受试者的细胞增殖疾病或病症的方法，涉及将缺乏DNA交联基序的补骨脂素衍生物应用于癌细胞，应用补骨脂素或其衍生物和拉帕替尼，或者将补骨脂素或其衍生物和奈拉替尼应用于受试者，并进一步从能量源施加初始辐射能量。

8. 发明申请

WO2014143826A2 INTERIOR ENERGY-ACTIVATION OF PHOTO-REACTIVE SPECIES INSIDE A MEDIUM OR BODY 审中-公开
标题翻译：介质或体内光反应物种的内部能量激活
公开(公告)号：WO2014143826A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/027965
申请日：2014-03-14
申请人： BOURKE, Frederic, Avery , FATHI, Zakaryae , WALDER, Harold , BEYER, Wayne, F.
发明人： BOURKE, Frederic, Avery , FATHI, Zakaryae , WALDER, Harold , BEYER, Wayne, F.
IPC分类号： G21K5/02 , B05D3/06 , A61N5/10 , G03F7/20 , A61L2/08 , C02F1/30 , A61M1/36 , C02F1/32 , A23L3/28 , A23L3/26
CPC分类号： A23L3/28 , A23L3/263 , A23V2002/00 , A61L2/0041 , A61L2/0047 , A61L2/08 , A61L2/082 , A61L2202/24 , A61M1/3681 , A61M1/3683 , A61N5/062 , A61N5/0624 , A61N2005/0661 , A61N2005/0662 , C02F1/307 , C02F1/32 , C02F1/325 , C02F2201/32 , C02F2305/10 , C23C16/458 , G03F7/20 , Y02W10/37
摘要： A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.
摘要翻译：用于在介质中产生变化的方法和系统。该方法在介质附近放置能量调节剂。该方法将介入能量应用于介质。引发能量与能量调节剂相互作用以直接或间接地在介质中产生变化。能量调节剂具有在已知产生变化的第二波长范围（WR2）之外的第一波长范围内的正常主辐射辐射，但是在暴露于所施加的引发能量下产生变化。该系统包括启动能量源，该启动能量源被配置为向介质施加启动能量以启动能量调节剂。

9. 发明申请

WO2008011335A3 METAL BINDING COMPOUNDS, METAL BINDING COMPOSITIONS, AND THEIR USES 审中-公开
公开(公告)号：WO2008011335A3
公开(公告)日：2008-01-24
申请号：PCT/US2007/073418
申请日：2007-07-13
申请人： AFFINERGY, INC. , HAMILTON, Paul , BEYER, Wayne, F.
发明人： HAMILTON, Paul , BEYER, Wayne, F.
IPC分类号： A61K38/08
摘要： Compositions are provided comprising a family of peptides having binding specificity for metal, and their use to produce coating compositions. The coating compositions are used to deliver a pharmaceutically active agent to metal, and are used in methods related to metal implants, metal repair, and metal-related diseases.

10. 发明申请

WO2008153762A3 S-NITROSOTHIOL FORMULATIONS AND STORAGE SYSTEMS 审中-公开
公开(公告)号：WO2008153762A3
公开(公告)日：2008-12-18
申请号：PCT/US2008/006640
申请日：2008-05-23
申请人： N30 PHARMACEUTICALS, LLC , LOOKER, Douglas, L. , BEYER, Wayne, F.
发明人： LOOKER, Douglas, L. , BEYER, Wayne, F.
IPC分类号： A61K9/08 , A61K38/06
摘要： The invention provides stable S-nitrosothiol, such as S-nitrosoglutathione, formulations for long term storage of S-nitrosothiols. The invention provides stable formulations comprising S-nitrosothiol, such as S-nitrosoglutathione, and methods of treating patients in need of S-nitrosothiol, such as S-nitrosoglutathione, and/or nitric oxide treatment.

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