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1. 发明申请

WO2015095462A1 PROCESS FOR EXTRACTING LIPIDS FOR USE IN PRODUCTION OF BIOFUELS 审中-公开
标题翻译：用于生产生物燃料的提取脂肪的方法
公开(公告)号：WO2015095462A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/071055
申请日：2014-12-18
申请人： BP BIOFUELS UK LIMITED , APT, Kirk , BARCLAY, William , BLAZER, Micah , BORDEN, Jacob , BURJA, Adam , DONG, Daniel , DURAZO, Armando , DUMENIL, Jean-charles , EDGE, Arthur , HANSEN, Jon , HOFLER, Alexandra , JEFFERS, David , LYON, Chris , PAI, Vidya , PFEIFER, Joseph, W. III. , SELLERS, Martin, J. , SHANK, Ginger , STEGE, Justin
发明人： APT, Kirk , BARCLAY, William , BLAZER, Micah , BORDEN, Jacob , BURJA, Adam , DONG, Daniel , DURAZO, Armando , DUMENIL, Jean-charles , EDGE, Arthur , HANSEN, Jon , HOFLER, Alexandra , JEFFERS, David , LYON, Chris , PAI, Vidya , PFEIFER, Joseph, W. III. , SELLERS, Martin, J. , SHANK, Ginger , STEGE, Justin
IPC分类号： C11B1/02 , C11B1/10 , C11B1/12 , C12N9/14 , C12N9/24
CPC分类号： C11B1/025 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C11B1/10 , C11B1/12 , C12N1/063 , C12N1/066 , C12N9/2411 , C12N9/2414 , C12N9/2488 , C12P7/6463 , C12Y302/01001 , Y02E50/343
摘要： Methods and systems used to extract lipids suitable in production of biofuels from a fermentation broth may include using heat to pre-treat the fermentation broth in order to more easily extract a product from oleaginous microorganisms in the broth. Additionally or alternatively, a combination of enzymes including amylase, 1-4 mannosidase, and 1-3 mannosidase may be used to break down cell walls of the oleaginous microorganisms. Residual broth water may be recycled and used as imbibition water for washing a process feedstock to extract sugar.
摘要翻译：用于提取适合于从发酵液生产生物燃料的脂质的方法和系统可包括使用热来预处理发酵液，以便更容易地从肉汤中的含油微生物中提取产物。另外或替代地，可以使用包括淀粉酶，1-4甘露糖苷酶和1-3甘露糖苷酶的酶的组合来分解含油微生物的细胞壁。残余肉汤水可以循环使用，并用作洗涤水以洗涤工艺原料以提取糖。

2. 发明申请

WO2011112948A1 YEAST STRAINS AND THEIR USES IN THE PRODUCTION OF LIPIDS 审中-公开
标题翻译： YEAST菌株及其在生产脂肪中的用途
公开(公告)号：WO2011112948A1
公开(公告)日：2011-09-15
申请号：PCT/US2011/028122
申请日：2011-03-11
申请人： MARTEK BIOSCIENCES CORPORATION , APT, Kirk, E. , BARCLAY, William, R. , BEHRENS, Paul, Warren
发明人： APT, Kirk, E. , BARCLAY, William, R. , BEHRENS, Paul, Warren
IPC分类号： C12N1/16 , C12N1/02 , C12P7/64
CPC分类号： C12N1/16 , C12P7/6409 , C12P7/6427 , C12R1/645
摘要： The invention is directed to isolated microorganisms, as well as biomasses, cultures, microbial oils, and compositions thereof. The invention also provides methods of producing the microbial oils and methods of using the isolated microorganisms, biomasses, and microbial oils.
摘要翻译：本发明涉及分离的微生物以及生物量，培养物，微生物油及其组合物。本发明还提供了生产微生物油的方法和使用分离的微生物，生物质和微生物油的方法。

3. 发明申请

WO2006055965A2 OXYLIPINS FROM LONG CHAIN POLYUNSATURATED FATTY ACIDS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：来自长链多脂脂肪酸的氧化锌及其制备和使用方法
公开(公告)号：WO2006055965A2
公开(公告)日：2006-05-26
申请号：PCT/US2005/042462
申请日：2005-11-21
申请人： MARTEK BIOSCIENCES CORPORATION , ARTERBURN, Linda, Mary , BARCLAY, William , DANGI, Bindi , FLATT, James , LEE, Jung , VAN ELSWYK, Mary
发明人： ARTERBURN, Linda, Mary , BARCLAY, William , DANGI, Bindi , FLATT, James , LEE, Jung , VAN ELSWYK, Mary
IPC分类号： C07C57/00
CPC分类号： C12P7/6472 , C07C59/42 , C07D303/38 , C12P7/6427
摘要： Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.
摘要翻译：公开了衍生自C22多不饱和脂肪酸的新型oxylipin，本文称为二十二烷酸，以及制备和使用这种oxylipin的方法。还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6）作为生产新型oxylipins的底物，以及由此产生的oxylipin。还公开了在治疗和营养或化妆品应用中使用DPAn-6，DPAn-3，DTAn-6和/或衍生自其的oxylipin，和/或衍生自C22脂肪酸结构的新型二十二烷酸，特别是作为抗炎或抗神经变性化合物。本发明还涉及生产长链多不饱和酸（LCPUFA）的油和组合物的新方法，其含有增强和有效量的LCPUFA衍生的草甘膦脂类，特别是二十二烷酸。

4. 发明申请

WO2001053508A3 METHODS FOR RAISING RABBITS 审中-公开
公开(公告)号：WO2001053508A3
公开(公告)日：2001-07-26
申请号：PCT/US2001/001720
申请日：2001-01-19
申请人： OMEGATECH, INC. , BARCLAY, William, R. , MORDENTI, Archimede , TASSINARI, Marco , ZOTTI, Alessandro
发明人： BARCLAY, William, R. , MORDENTI, Archimede , TASSINARI, Marco , ZOTTI, Alessandro
IPC分类号： A01K1/02
摘要： The present invention provides a method for raising rabbits, in particular by feeding the rabbit with a feed containing a source of long-chain fatty acid. In this manner, mortality and the feed conversion rates are decreased while average daily weight gain and long-chain fatty acid content of rabbit meat are increased compared to a rabbit raised in the absence of the long-chain fatty acid source.

5. 发明申请

WO2007090162A3 OXYLIPINS FROM STEARIDONIC ACID AND ?-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：来自硬脂酸和α-亚油酸的烯丙酯及其制备和使用方法
公开(公告)号：WO2007090162A3
公开(公告)日：2008-08-21
申请号：PCT/US2007061397
申请日：2007-01-31
申请人： MARTEK BIOSCIENCES CORP , ARTERBURN LINDA MARY , BARCLAY WILLIAM , DANGI BINDI , FLATT JAMES , LEE JUNG , VINJAMOORI DUTT
发明人： ARTERBURN LINDA MARY , BARCLAY WILLIAM , DANGI BINDI , FLATT JAMES , LEE JUNG , VINJAMOORI DUTT
IPC分类号： A61K31/202
CPC分类号： C07C59/42 , C12P7/6427 , C12P7/6472
摘要： Disclosed are novel oxylipins that are derived from ?-linolenic acid (GLA; 18:3n-6) and stearidonic acid (STA or SDA; 18:4n-3), and methods of making and using such oxylipins. Also disclosed is the use of such oxylipins in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. Also disclosed are The invention novel ways of producing long chain polyunsaturated acid (LCPUF A)-rich oils and compositions that contain enhanced and effective amounts of SDA- and/or GLA-derived oxylipins.
摘要翻译：公开了衍生自α-亚麻酸（GLA; 18：3n-6）和十八碳四烯酸（STA或SDA; 18：4n-3）的新型oxylipin，以及制备和使用这些oxylipin的方法。还公开了这种oxylipin在治疗和营养或化妆品应用中的用途，特别是作为抗炎或抗神经变性化合物。还公开了本发明新颖的生产长链多不饱和酸（LCPUF A）的油和组合物的新方法，其含有增强和有效量的SDA和/或GLA衍生的草甘膦。

6. 发明申请

WO2006055965A3 OXYLIPINS FROM LONG CHAIN POLYUNSATURATED FATTY ACIDS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：长链多不饱和脂肪酸中的氧化脂及其制备和使用方法
公开(公告)号：WO2006055965A3
公开(公告)日：2006-11-30
申请号：PCT/US2005042462
申请日：2005-11-21
申请人： MARTEK BIOSCIENCES CORP , ARTERBURN LINDA MARY , BARCLAY WILLIAM , DANGI BINDI , FLATT JAMES , LEE JUNG , VAN ELSWYK MARY
发明人： ARTERBURN LINDA MARY , BARCLAY WILLIAM , DANGI BINDI , FLATT JAMES , LEE JUNG , VAN ELSWYK MARY
IPC分类号： C07C53/00 , A61K31/02 , C07C57/00 , C12P7/64
CPC分类号： C12P7/6472 , C07C59/42 , C07D303/38 , C12P7/6427
摘要： Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.
摘要翻译：公开了衍生自C22多不饱和脂肪酸的本文中称为二十二烷酸的新型氧化喜树碱，以及制备和使用这种氧化喜树碱的方法。还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6）作为生产新的羟基脂质的基质，以及由此生成的羟基脂质。还公开了在治疗和营养或美容应用中DPAn-6，DPAn-3，DTAn-6和/或由其衍生的氧化脂质和/或衍生自C22脂肪酸结构的新型二十二烷酸类的用途，特别是作为抗炎或抗神经退行性化合物。本发明还涉及生产长链多不饱和酸（LCPUFA）的油和组合物的新方法，所述油和组合物含有增强且有效量的LCPUFA衍生的羟基脂，特别是二十二烷酸。

7. 发明申请

WO2001054510A1 ENHANCED PRODUCTION OF LIPIDS CONTAINING POLYENOIC FATTY ACIDS BY HIGH DENSITY CULTURES OF EUKARYOTIC MICROBES IN FERMENTORS 审中-公开
标题翻译：通过高密度培养的文化微生物在发酵中增强含有多烯酸脂肪酸的脂肪的生产
公开(公告)号：WO2001054510A1
公开(公告)日：2001-08-02
申请号：PCT/US2001/002715
申请日：2001-01-26
申请人： OMEGATECH, INC. , REUCKER, Craig, M. , DIMASI, Don , HANSEN, Jon, M. , MIRRASOUL, Peter, J. , BAILEY, Richard, B. , WEEDER, George, T., III , KANEKO, Tatsuo , BARCLAY, William, R.
发明人： REUCKER, Craig, M. , DIMASI, Don , HANSEN, Jon, M. , MIRRASOUL, Peter, J. , BAILEY, Richard, B. , WEEDER, George, T., III , KANEKO, Tatsuo , BARCLAY, William, R.
IPC分类号： A23B7/10
CPC分类号： A23K50/80 , A23D9/00 , A23K20/158 , A23L29/065 , A23V2002/00 , C11B1/10 , C12N1/00 , C12N1/12 , C12P7/6409 , C12P7/6427 , C12P7/6472 , Y10S435/911
摘要： The present invention provides a process for growing eukaryotic microorganisms, which are capable of producing lipids, in particular, lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.
摘要翻译：本发明提供了一种生长真核微生物的方法，其能够产生脂质，特别是含有多烯脂肪酸的脂质。本发明还提供了一种生产真核微生物脂质的方法。

8. 发明申请

WO2008103753A3 OXYLIPINS FROM LONG CHAIN POLYUNSATURATED FATTY ACIDS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：来自长链聚氧乙烯脂肪酸的脂蛋白及其制备和使用方法
公开(公告)号：WO2008103753A3
公开(公告)日：2008-11-27
申请号：PCT/US2008054456
申请日：2008-02-20
申请人： MARTEK BIOSCIENCES CORP , ARTERBURN LINDA , BARCLAY WILLIAM , DANGI BINDI , FLATT JAMES , LEE JUNG , VINJAMOORI DUTT , VAN ELSWYK MARY
发明人： ARTERBURN LINDA , BARCLAY WILLIAM , DANGI BINDI , FLATT JAMES , LEE JUNG , VINJAMOORI DUTT , VAN ELSWYK MARY
IPC分类号： A61K31/22 , C07C53/00
CPC分类号： A61K31/202 , A23L33/12 , A61K8/361 , A61K31/60 , A61K45/06 , A61Q19/00 , C07C59/42 , C07D303/36 , C07D303/48 , A61K2300/00
摘要： Disclosed are novel oxylipins, referred to herein as docosanoids and eicosanoids, that are derived from C22 polyunsaturated fatty acids and from C20 polyunsaturated fatty acids, respectively, and methods of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6), docosatrienoic acid (C22:3n-3) (DTrAn-3), docosadienoic acid (C22:2n-6) (DDAn-6), eicosatrienoic acid (C20:3n-3) (ETrAn-3) eicosapentaenoic acid and arachidonic acid as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUF A)-rich oils and compositions that contain enhanced and effective amounts of LCPUF A-derived oxylipins, and particularly, docosanoids.
摘要翻译：公开了分别衍生自C22多不饱和脂肪酸和C20多不饱和脂肪酸的新型牛脂蛋白，分别是衍生自C22多不饱和脂肪酸的二十二烷酸和类二十烷酸，以及制备和使用这些氧基脂蛋白的方法。还公开了二十二碳五烯酸（C22：5n-6）（DPAn-6），二十二碳五烯酸（C22：5n-3）（DPAn-3）和二十二碳四烯酸（DTAn-6：C22：4n-6），二十二碳三烯酸（C22：3n-3）（DTrAn-3），二十二碳烯酸（C22：2n-6）（DDAn-6），二十碳三烯酸（C20：3n-3）（ETrAn-3）二十碳五烯酸和花生四烯酸作为生产新型oxylipin的底物，以及由此产生的oxylipin。还公开了在治疗和营养或美容应用中使用DPAn-6，DPAn-3，DTAn-6和/或由其衍生的oxylipin，和/或衍生自C22脂肪酸结构的新型二醇多糖，特别是作为抗炎或抗神经变性化合物。本发明还涉及生产长链多不饱和酸（LCPUF A）的油和组合物的新方法，其含有增强和有效量的LCPUF A衍生的草甘膦，特别是二十二烷酸。

9. 发明申请

WO2007090162A2 OXYLIPINS FROM STEARIDONIC ACID AND γ-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：来自硬脂酸和α-亚油酸的烯丙酯及其制备和使用方法
公开(公告)号：WO2007090162A2
公开(公告)日：2007-08-09
申请号：PCT/US2007/061397
申请日：2007-01-31
申请人： MARTEK BIOSCIENCES CORPORATION , ARTERBURN, Linda, Mary , BARCLAY, William , DANGI, Bindi , FLATT, James , LEE, Jung , VINJAMOORI, Dutt
发明人： ARTERBURN, Linda, Mary , BARCLAY, William , DANGI, Bindi , FLATT, James , LEE, Jung , VINJAMOORI, Dutt
IPC分类号： A61K31/22
CPC分类号： C07C59/42 , C12P7/6427 , C12P7/6472
摘要： Disclosed are novel oxylipins that are derived from γ-linolenic acid (GLA; 18:3n-6) and stearidonic acid (STA or SDA; 18:4n-3), and methods of making and using such oxylipins. Also disclosed is the use of such oxylipins in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. Also disclosed are The invention novel ways of producing long chain polyunsaturated acid (LCPUF A)-rich oils and compositions that contain enhanced and effective amounts of SDA- and/or GLA-derived oxylipins.
摘要翻译：公开了衍生自α-亚麻酸（GLA; 18：3n-6）和十八碳四烯酸（STA或SDA; 18：4n-3）的新型oxylipin，以及制备和使用这些oxylipin的方法。还公开了在治疗和营养或化妆品应用中使用这种oxylipin，特别是作为抗炎或抗神经变性化合物。还公开了本发明新颖的生产长链多不饱和酸（LCPUF A）的油和组合物的新方法，其含有增强的和有效量的SDA和/或GLA衍生的氧环磷脂。

10. 发明申请

WO2009035551A1 BIOLOGICAL OILS AND PRODUCTION AND USES THEREOF 审中-公开
标题翻译：生物油及其生产及其用途
公开(公告)号：WO2009035551A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/010454
申请日：2008-09-08
申请人： MARTEK BIOSCIENCES CORPORATION , LIPPMEIER, James, Casey , PFEIFER, Joseph, W. , HANSEN, Jon, Milton , APT, Kirk, E. , BARCLAY, William, Robert , BEHRENS, Paul, Warren , MARTIN, David, Christian
发明人： LIPPMEIER, James, Casey , PFEIFER, Joseph, W. , HANSEN, Jon, Milton , APT, Kirk, E. , BARCLAY, William, Robert , BEHRENS, Paul, Warren , MARTIN, David, Christian
IPC分类号： C12P7/64 , C12P1/04
CPC分类号： C12P7/6472 , C10L1/02 , C10L1/026 , C10L2200/0469 , C10L2270/026 , C10L2270/04 , C10L2290/26 , C12P7/649 , Y02E50/13 , Y02P30/20
摘要： The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.
摘要翻译：本发明提供生物油及其方法和用途。生物油优选通过使用含纤维素原料作为主要碳源的一种或多种微生物的异养发酵产生。本发明还提供了使用生物油制备基于脂质的生物燃料和食品，营养和药物产品的方法。

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