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1. 发明申请

WO2008045534A3 NOVEL CURCUMIN AND TETRAHYDROCURCUMIN DERIVATIVES 审中-公开
标题翻译：新型光泽和四氯化铬衍生物
公开(公告)号：WO2008045534A3
公开(公告)日：2008-06-12
申请号：PCT/US2007021805
申请日：2007-10-12
申请人： UNIV CITY , RAJA KRISHNASWAMI , BANERJEE PROBAL , AUERBACH ANDREW , SHI WEI , L AMOREAUX WILLIAM
发明人： RAJA KRISHNASWAMI , BANERJEE PROBAL , AUERBACH ANDREW , SHI WEI , L AMOREAUX WILLIAM
IPC分类号： A01N43/20 , A01N43/24 , A61K31/335
CPC分类号： C07C229/12 , A61K8/37 , A61K8/39 , A61K8/496 , A61K8/8147 , A61K2800/522 , A61K2800/56 , A61Q19/02 , C07C49/248 , C07C49/255 , C07C69/52 , C07C69/602 , C07C247/04 , C07D249/04
摘要： The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.
摘要翻译：本发明涉及新的姜黄素和四氢姜黄素衍生物，它们已经在一个酚基团被修饰以引入更多的反应性基团。姜黄素和四氢姜黄素衍生物是单体，二聚体和聚合物的形式。

2. 发明申请

WO2008045534A2 NOVEL CURCUMIN AND TETRAHYDROCURCUMIN DERIVATIVES 审中-公开
标题翻译：新型莪术和四氢姜黄素衍生物
公开(公告)号：WO2008045534A2
公开(公告)日：2008-04-17
申请号：PCT/US2007/021805
申请日：2007-10-12
申请人： RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK , RAJA, Krishnaswami , BANERJEE, Probal , AUERBACH, Andrew , SHI, Wei , L'AMOREAUX, William
发明人： RAJA, Krishnaswami , BANERJEE, Probal , AUERBACH, Andrew , SHI, Wei , L'AMOREAUX, William
IPC分类号： A01N43/20
CPC分类号： C07C229/12 , A61K8/37 , A61K8/39 , A61K8/496 , A61K8/8147 , A61K2800/522 , A61K2800/56 , A61Q19/02 , C07C49/248 , C07C49/255 , C07C69/52 , C07C69/602 , C07C247/04 , C07D249/04
摘要： The invention relates to novel curcumin and tetrahydrocurcumin derivatives, which have been modified at one phenolic group to incorporate more-reactive groups. The curcumin and tetrahydrocurcumin derivatives are in the form of monomers, dimmers, and polymers.
摘要翻译：本发明涉及新的姜黄素和四氢姜黄素衍生物，其在一个酚基上被修饰以引入更多反应性基团。姜黄素和四氢姜黄素衍生物以单体，二聚体和聚合物的形式存在。

3. 发明申请

WO2011106691A2 CURCUMIN DERIVATIVES 审中-公开
标题翻译： CURCUMIN衍生物
公开(公告)号：WO2011106691A2
公开(公告)日：2011-09-01
申请号：PCT/US2011026308
申请日：2011-02-25
申请人： UNIV CITY NEW YORK RES FOUND , RAJA KRISHNASWAMI , ALONSO ALEJANDRA , BANERJEE PROBAL , DOLAI SUKANTA , CORBO CHRISTOPHER , AVERICK SAADYAH , MOGHA AMIT , DEBNATH SHAWON
发明人： RAJA KRISHNASWAMI , ALONSO ALEJANDRA , BANERJEE PROBAL , DOLAI SUKANTA , CORBO CHRISTOPHER , AVERICK SAADYAH , MOGHA AMIT , DEBNATH SHAWON
IPC分类号： C07C49/223 , A61K31/12 , A61P25/28 , C07C49/255 , C07D249/04
CPC分类号： C07H13/04 , A61K31/4192 , A61K31/7056 , C07C49/255 , C07C69/42 , C07C69/716 , C07C233/18 , C07D249/04 , C07H7/06 , C07H15/08 , C07H15/26
摘要： The invention relates to novel curcumin derivatives in which one or two of the phenolic groups have been modified.
摘要翻译：本发明涉及其中一个或两个酚基已被改性的新型姜黄素衍生物。

4. 发明申请

WO2011068894A3 NOVEL CURCUMIN-ANTIBODY CONJUGATES AS ANTI-CANCER AGENTS 审中-公开
公开(公告)号：WO2011068894A3
公开(公告)日：2011-06-09
申请号：PCT/US2010/058588
申请日：2010-12-01
申请人： RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK , BANERJEE, Probal , KRISHNASWAMI, Raja
发明人： BANERJEE, Probal , KRISHNASWAMI, Raja
IPC分类号： A61K39/395 , A61K39/44 , A61K47/48 , C07D207/40 , A61P35/00
摘要： The invention relates to curcumin derivatives having the formula I: wherein: Z represents: H 3 CO A represents -CH 2 -CH 2 - or -CH=CH-;L represents-C(O)-(NH) n1 -R-(NH) n2 -C(O)-; R represents a saturated or unsaturated, branched or unbranched hydrocarbyl chain having a minimum of 3 carbon atoms in the chain; wherein the maximum number of carbon atoms in the chain is 24; and wherein the carbon atoms of the chain can be replaced by at least one heteroatom, wherein the heteroatoms are independently -O- or - NH 2 -, with the proviso that each heteroatom is separated from each other heteroatom by at least two carbon atoms;n1 and n2 independently represent 0 or 1; and Y represents an antibody that binds specifically to a target antigen of a tumor cell. The invention further relates to methods of method of inhibiting the growth of tumors in a human by administering an effective amount of the curcumin derivative, and to methods of producing the curcumin derivative.

5. 发明申请

WO2009140683A1 LIVING COPOLYMER PROTEIN/PEPTIDE HYBRIDS FOR BIOMEDICAL APPLICATIONS 审中-公开
标题翻译：生物医学应用生物共聚蛋白/肽复合物
公开(公告)号：WO2009140683A1
公开(公告)日：2009-11-19
申请号：PCT/US2009/044371
申请日：2009-05-18
申请人： RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK , RAJA, Krishnaswami , SHI, Wei , DOLAI, Sukanta , AVERICK, Saadyah , L'AMOREAUX, William , BANERJEE, Probal
发明人： RAJA, Krishnaswami , SHI, Wei , DOLAI, Sukanta , AVERICK, Saadyah , L'AMOREAUX, William , BANERJEE, Probal
IPC分类号： C08G64/00
CPC分类号： A61K47/4823 , A61K47/4813 , A61K47/48215 , A61K47/48246 , A61K47/555 , A61K47/60 , A61K47/61 , A61K47/64 , A61K49/0032 , A61K49/0054 , A61K49/0056 , A61K49/085 , A61K49/12
摘要： Water soluble polymers having formula I: Y-(L 1 ) ni -(C(O)) n2 -(R 1 )n 3 -R 2 are claimed. The polymers may contain multiple water soluble, immunogenicity reducing moieties and multiple active moieties. The polymers may be linked to a protein, or a peptide having up to twelve amino acids.
摘要翻译：具有式I：Y-（L1）ni-（C（O））n2-（R1）n3-R2的水溶性聚合物。聚合物可以含有多个水溶性，免疫原性降低部分和多个活性部分。聚合物可以连接到蛋白质或具有至多12个氨基酸的肽。

6. 发明申请

WO2011068894A2 NOVEL CURCUMIN-ANTIBODY CONJUGATES AS ANTI-CANCER AGENTS 审中-公开
标题翻译：作为抗癌剂的新型CURCUMIN-ANTIBODY缀合物
公开(公告)号：WO2011068894A2
公开(公告)日：2011-06-09
申请号：PCT/US2010058588
申请日：2010-12-01
申请人： UNIV CITY NEW YORK RES FOUND , BANERJEE PROBAL , KRISHNASWAMI RAJA
发明人： BANERJEE PROBAL , KRISHNASWAMI RAJA
IPC分类号： A61K39/395 , A61K39/44 , A61K47/48 , A61P35/00 , C07D207/40
CPC分类号： A61K47/48384 , A61K47/50 , A61K47/6803 , A61K47/6849 , A61K47/6865
摘要： The invention relates to curcumin derivatives having the formula I: wherein: Z represents: H3CO A represents -CH2-CH2- or -CH=CH-;L represents-C(O)-(NH)n1-R-(NH)n2-C(O)-; R represents a saturated or unsaturated, branched or unbranched hydrocarbyl chain having a minimum of 3 carbon atoms in the chain; wherein the maximum number of carbon atoms in the chain is 24; and wherein the carbon atoms of the chain can be replaced by at least one heteroatom, wherein the heteroatoms are independently -O- or - NH2-, with the proviso that each heteroatom is separated from each other heteroatom by at least two carbon atoms;n1 and n2 independently represent 0 or 1; and Y represents an antibody that binds specifically to a target antigen of a tumor cell. The invention further relates to methods of method of inhibiting the growth of tumors in a human by administering an effective amount of the curcumin derivative, and to methods of producing the curcumin derivative.
摘要翻译：本发明涉及具有式I的姜黄素衍生物：其中：Z表示：H 3 CO A表示-CH 2 -CH 2 - 或-CH = CH-; L表示-C（O） - （NH）n1-R-（NH）n2 -C（O） - ; R代表在链中具有最少3个碳原子的饱和或不饱和的支链或非支链烃基链; 其中链中碳原子的最大数目是24; 并且其中所述链的碳原子可以被至少一个杂原子替代，其中所述杂原子独立地为-O-或-NH 2 - ，条件是每个杂原子彼此隔开至少两个碳原子; n 1 和n2独立地表示0或1; Y代表特异性结合肿瘤细胞的靶抗原的抗体。本发明还涉及通过施用有效量的姜黄素衍生物来抑制人类肿瘤生长的方法，以及生产姜黄素衍生物的方法。

7. 发明申请

WO2009073050A2 USE OF CURCUMIN TO BLOCK BRAIN TUMOR FORMATION IN VIVO 审中-公开
标题翻译：莪术素在体内阻断脑肿瘤形成的研究
公开(公告)号：WO2009073050A2
公开(公告)日：2009-06-11
申请号：PCT/US2008009053
申请日：2008-07-25
申请人： RES FOUNDATION OF CITY UNIVERS , BANERJEE PROBAL , RAJA KRISHNASWAMI SAMBASIVAN
发明人： BANERJEE PROBAL , RAJA KRISHNASWAMI SAMBASIVAN
IPC分类号： A61K31/12
CPC分类号： A61K36/9066
摘要： The présent invention provides compositions and methods of using curcumin or curcumin derivatives or analogs to activate the pro-apoptotic enzymes caspase-3/7 in cancer cells. The présent invention also provides formulations of curcumin or derivatives or analogs with increased solubility or improved bioavailability. The formulations may be administered to a subject such that high concentrations of therapeutically effective curcumin compounds resuit in the subject' s bloodstream. The invention thus involves the use of curcumin or curcumin derivatives or analogs to diminish cancer cell growth, decrease tumor size, prevent tumor formation, and to reduce or prevent cancer or tumor cell invasion or metastasis into a tissue, e.g., into the nervous System and especially the brain, of a subject. The instant invention may be used prophylactically to prevent tumor formation or metastasis, as a monotherapy to treat existing tumors, after surgery to prevent récurrence of tumors or in conjunction with conventional cancer thérapies to improve patient prognosis and reduce side-effects.
摘要翻译：本发明提供了使用姜黄素或姜黄素衍生物或类似物来激活癌细胞中的促凋亡酶胱天蛋白酶-3/7的组合物和方法。本发明还提供具有增加的溶解度或改善的生物利用度的姜黄素或衍生物或类似物的制剂。该制剂可以施用于受试者，使得高浓度的治疗有效的姜黄素化合物在受试者的血流中结果。因此，本发明涉及使用姜黄素或姜黄素衍生物或类似物来减少癌细胞生长，减小肿瘤尺寸，防止肿瘤形成，以及减少或预防癌症或肿瘤细胞侵入或转移到组织中，例如进入神经系统和特别是大脑，一个主题。本发明可以预防性地用于预防肿瘤形成或转移，作为治疗现有肿瘤的单一疗法，手术后预防肿瘤发生或与常规癌症疗法结合以改善患者预后并减少副作用。

8. 发明申请

WO2011106691A3 CURCUMIN DERIVATIVES 审中-公开
标题翻译： CURCUMIN衍生物
公开(公告)号：WO2011106691A3
公开(公告)日：2011-09-01
申请号：PCT/US2011/026308
申请日：2011-02-25
申请人： RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK , RAJA, Krishnaswami , ALONSO, Alejandra , BANERJEE, Probal , DOLAI, Sukanta , CORBO, Christopher , AVERICK, Saadyah , MOGHA, Amit , DEBNATH, Shawon
发明人： RAJA, Krishnaswami , ALONSO, Alejandra , BANERJEE, Probal , DOLAI, Sukanta , CORBO, Christopher , AVERICK, Saadyah , MOGHA, Amit , DEBNATH, Shawon
IPC分类号： C07C49/223 , C07C49/255 , C07D249/04 , A61K31/12 , A61P25/28
摘要： The invention relates to novel curcumin derivatives in which one or two of the phenolic groups have been modified to comprise (A) triazole and oligo-ethylene glycol (OEG) unit, (B) amide unit, or (C) OEG/carbohydrate structural unit. The water/plasma solubility of curcumin is improved by attaching water-soluble molecules such as polyethylene glycol (PEG) and sugar derivatives.
摘要翻译：（A）三唑和低聚乙二醇（OEG）单元，（B）酰胺单元或者（C）OEG /碳水化合物结构单元。姜黄素的水/血浆溶解度通过附着水溶性分子如聚乙二醇（PEG）和糖衍生物而得到改善。

9. 发明申请

WO2009073050A3 USE OF CURCUMIN TO BLOCK BRAIN TUMOR FORMATION IN VIVO 审中-公开
公开(公告)号：WO2009073050A3
公开(公告)日：2009-06-11
申请号：PCT/US2008/009053
申请日：2008-07-25
申请人： RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK , BANERJEE, Probal , RAJA, Krishnaswami Sambasivan
发明人： BANERJEE, Probal , RAJA, Krishnaswami Sambasivan
IPC分类号： A61K36/9066 , A61P35/00 , A61P35/04
摘要： The présent invention provides compositions and methods of using curcumin or curcumin derivatives or analogs to activate the pro-apoptotic enzymes caspase-3/7 in cancer cells. The présent invention also provides formulations of curcumin or derivatives or analogs with increased solubility or improved bioavailability. The formulations may be administered to a subject such that high concentrations of therapeutically effective curcumin compounds resuit in the subject' s bloodstream. The invention thus involves the use of curcumin or curcumin derivatives or analogs to diminish cancer cell growth, decrease tumor size, prevent tumor formation, and to reduce or prevent cancer or tumor cell invasion or metastasis into a tissue, e.g., into the nervous System and especially the brain, of a subject. The instant invention may be used prophylactically to prevent tumor formation or metastasis, as a monotherapy to treat existing tumors, after surgery to prevent récurrence of tumors or in conjunction with conventional cancer thérapies to improve patient prognosis and reduce side-effects.

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