会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 2. 发明申请
    • CONJUGATE FOR PHOTODYNAMIC DIAGNOSIS OR THERAPY AND METHOD FOR PREPARING SAME
    • 共轭用于光动力学诊断或治疗以及制备相同的方法
    • WO2012087040A3
    • 2012-10-04
    • PCT/KR2011009967
    • 2011-12-21
    • PANAXEM CO LTDNA KUNLI FANG YUANBAE BYOUNG CHAN
    • NA KUNLI FANG YUANBAE BYOUNG CHAN
    • A61K31/695A61K31/315A61K31/702A61K49/06A61K49/10A61K49/12C09B47/04
    • A61K47/4823A61K41/0071A61K49/0036A61K49/0054
    • The present invention relates to a conjugate of acetylated biocompatible polysaccharide and phthalocyanine compound for photodynamic diagnosis or therapy and to a method for preparing the same, and more particularly, to a conjugate for photodynamic diagnosis or therapy and to a method for preparing the same, in which biocompatible polysaccharide is acetylated and a phthalocyanine compound is bound to the acetylated polysaccharide. The conjugate for photodynamic diagnosis or therapy according to the present invention is characterized in that the polysaccharide is acetylated to improve solubility in a solvent and thus enable various chemical modifications, and the conjugate may specifically target tumor cells, has superior cancer cell selecting and accumulating capacity, and has excellent effects of killing cancer cells when near infrared ray is irradiated. The conjugate of the present invention may not show cytotoxicity for cells other than cancer cells even when near infrared ray is irradiated, and thus exhibits superior in vivo stability, and therefore, may be valuably used in disease diagnosis or therapy using photodynamics.
    • 本发明涉及用于光动力学诊断或治疗的乙酰化生物相容性多糖和酞菁化合物的缀合物及其制备方法,更具体地涉及用于光动力学诊断或治疗的缀合物及其制备方法, 该生物相容性多糖被乙酰化并且酞菁化合物与乙酰化多糖结合。 根据本发明的用于光动力学诊断或治疗的缀合物的特征在于多糖被乙酰化以提高在溶剂中的溶解度并因此能够进行各种化学修饰,并且该缀合物可以特异性靶向肿瘤细胞,具有优异的癌细胞选择和积聚能力 并且在接近红外线照射时具有杀死癌细胞的优异效果。 本发明的缀合物即使在照射近红外线时也不显示对癌细胞以外的细胞的细胞毒性,因此显示优异的体内稳定性,因此可以有价值地用于疾病诊断或使用光动力学的治疗。